Prog Neurobiol September 2017 PMID 28576664

Uncertainty and stress: Why it causes diseases and how it is mastered by the brain.

Achim Peters, Bruce S McEwen, Karl Friston

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Mentions

110

Peak: 14 in Nov 2022

across 6 sources since Jun 2019

Extended reach

134,267

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Total likes

121

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261

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Jun 2019 – Jun 2025

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What people are saying

The overall discussions show strong alignment and curiosity about the article’s ideas, with examples like mentions of the 'predictive brain' and how stress disrupts brain development, revealing deep engagement through technical and philosophical references. Words like 'fascinating,' 'key to understanding,' and 'great insights' emphasize both interest and perceived impact.

AgreementStrong agreement

Most discussions recognize the importance of the paper and agree with its emphasis on the connection between stress, uncertainty, and health, showing strong support for its insights.

InterestHigh interest

The posts demonstrate high interest through mentions of how the paper offers valuable insights for neuroscience, mental health, and even philosophical perspectives like Stoicism and Buddhism.

EngagementHigh engagement

Many discussions reference specific concepts such as the 'free energy principle,' Bayesian functions, and implications for mental and physical health, indicating deep engagement.

ImpactHigh impact

The discussions highlight the paper's potential to influence diverse fields like AI, aging, and mental health strategies, emphasizing its high significance.

Abstract in brief

The text explains that stress, defined as uncertainty, arises when our brains anticipate outcomes that differ from what we expect, and reducing this uncertainty requires a lot of mental energy.
It introduces the "free energy principle," suggesting that our brains constantly work to minimize surprise or uncertainty to stay organized, but this process demands extra energy, especially in unpredictable situations.
When the brain can't effectively reduce uncertainty, it can lead to health problems like impaired memory, diabetes, and cardiovascular issues due to prolonged energy stress on the body.]

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All mentions

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E. H. A.

@Marsutol · X

Peters, A., McEwen, B. S., & Friston, K. (2017). Uncertainty and stress: Why it causes diseases and how it is mastered by the brain. Progress in Neurobiology, 156, 164-188. doi: 10.1016/j.pneurobio.2017.05.004

Aug 24, 2024 · 35 followers View post →

GUT-AI Foundation — AI/acc

@GUT_AI_F · X

RT @Neurosyncretic_: A great computational neuroscience paper to draw some insights for optimal strategy selection from { #AGI, #antiaging,…

Apr 18, 2024 · 1 share · 392 followers View post →

Amanda Parsons (M.ED)

@Amanda_Parsons · X

RT @FndPortal: Uncertainty and stress: Why it causes diseases and how it is mastered by the brain https://t.co/zp3crwCqyd

Apr 11, 2024 · 1 share · 1,161 followers View post →

FND Portal - is no longer on X

@FndPortal · X

Uncertainty and stress: Why it causes diseases and how it is mastered by the brain https://t.co/zp3crwCqyd

Apr 10, 2024 · 4 likes · 1 share · 6,926 followers View post →

Noke - cybernetics/acc

@Neurosyncretic_ · X

A great computational neuroscience paper to draw some insights for optimal strategy selection from { #AGI, #antiaging, #activeInference } Uncertainty and stress: Why it causes diseases and how it is mastered by the brain https://t.co/raqIN3UFbG # My inferences: https://t.co/MqRPvxZFwO

Feb 12, 2024 · 4 likes · 1 share · 314 followers View post →

Noke - cybernetics/acc

@Neurosyncretic_ · X

Feb 12, 2024 · 314 followers View post →

Jozsef

@VoidsIncision · X

Figure from “Uncertainty and Stress: Why it Causes Disease and How the Brain Masters it” by Peters, McEwen, and Friston. https://t.co/4Z3JcrxuM2

Aug 21, 2023 · 1 like · 286 followers View post →

stephen LoRusso

@stephenLoRusso2 · X

RT @agingdoc1: Uncertainty and stress: Why it causes diseases and how it is mastered by the brain https://t.co/lQywZkDmaZ https://t.co/m6W…

Nov 22, 2022 · 12 shares · 208 followers View post →

encyclomedia

@encyclomedia7 · X

RT @agingdoc1: Uncertainty and stress: Why it causes diseases and how it is mastered by the brain https://t.co/lQywZkDmaZ https://t.co/m6W…

Nov 22, 2022 · 12 shares · 126 followers View post →

Slawomir

@Slawomi18369321 · X

RT @agingdoc1: Uncertainty and stress: Why it causes diseases and how it is mastered by the brain https://t.co/lQywZkDmaZ https://t.co/m6W…

Nov 22, 2022 · 12 shares · 85 followers View post →

Armen Minasian

@ArmenMinasian3 · X

Uncertainty and stress: Why it causes diseases and how it is mastered by the brain https://t.co/RXaORqi8WB

Nov 22, 2022 · 24 followers View post →

Second Foundation ⚛️

@1stOrator · X

RT @agingdoc1: Uncertainty and stress: Why it causes diseases and how it is mastered by the brain https://t.co/lQywZkDmaZ https://t.co/m6W…

Nov 22, 2022 · 12 shares · 655 followers View post →

Armando Ribeiro

@Armando_Ribeiro · X

RT @agingdoc1: Uncertainty and stress: Why it causes diseases and how it is mastered by the brain https://t.co/lQywZkDmaZ https://t.co/m6W…

Nov 22, 2022 · 12 shares · 5,044 followers View post →

Mahdis

@sofr1na · X

RT @agingdoc1: Uncertainty and stress: Why it causes diseases and how it is mastered by the brain https://t.co/lQywZkDmaZ https://t.co/m6W…

Nov 22, 2022 · 12 shares · 109 followers View post →

Rafael Radaeli

@rfradaeli · X

RT @agingdoc1: Uncertainty and stress: Why it causes diseases and how it is mastered by the brain https://t.co/lQywZkDmaZ https://t.co/m6W…

Nov 22, 2022 · 12 shares · 382 followers View post →

Yurii

@Yurii08720681 · X

RT @agingdoc1: Uncertainty and stress: Why it causes diseases and how it is mastered by the brain https://t.co/lQywZkDmaZ https://t.co/m6W…

Nov 22, 2022 · 12 shares · 34 followers View post →

Doménica Cevallos R.

@Domecevallos92 · X

RT @agingdoc1: Uncertainty and stress: Why it causes diseases and how it is mastered by the brain https://t.co/lQywZkDmaZ https://t.co/m6W…

Nov 22, 2022 · 12 shares · 2,242 followers View post →

Lisa Vlad

@LisaVlad2 · X

RT @agingdoc1: Uncertainty and stress: Why it causes diseases and how it is mastered by the brain https://t.co/lQywZkDmaZ https://t.co/m6W…

Nov 22, 2022 · 12 shares · 104 followers View post →

Jeffrey Gross, M.D.

@DrJeffreyGross · X

RT @agingdoc1: Uncertainty and stress: Why it causes diseases and how it is mastered by the brain https://t.co/lQywZkDmaZ https://t.co/m6W…

Nov 22, 2022 · 12 shares · 47 followers View post →

eldsentinel- pandemüde

@eldSentinel · X

RT @agingdoc1: Uncertainty and stress: Why it causes diseases and how it is mastered by the brain https://t.co/lQywZkDmaZ https://t.co/m6W…

Nov 22, 2022 · 12 shares · 53 followers View post →

Agingdoc

@agingdoc1 · X

Uncertainty and stress: Why it causes diseases and how it is mastered by the brain https://t.co/lQywZkDmaZ https://t.co/m6WN2AM3oJ

Nov 22, 2022 · 31 likes · 12 shares · 42,619 followers View post →

Sam Wass

@ProfSamWass · X

Jun 1, 2022 · 17 likes · 1 share · 2,316 followers View post →

Flâneur

@GROEMODEL · X

@livelongerworld Elegantly elaborated in this seminal paper: https://t.co/pnPdfiY1aj

May 21, 2022 · 1 like · 451 followers View post →

Chris Djurtoft

@ChrisDjurtoft · X

Uncertainty and stress: Why it causes diseases and how it is mastered by the brain. https://t.co/BuOKeDLnc8

Mar 1, 2022 · 401 followers View post →

James Wiltshire

@JimmytheHands · X

https://t.co/goNfxMpG6S This article by Friston 2017 starts the journey off. Heavy reading but some great points relevant to setting the scene. Basically, it states that we have prior beliefs that we build up over the course of our lives. 1/n

Feb 14, 2022 · 2 likes · 168 followers View post →

expiredcoprs

@expiredcoprs · X

RT @Fswoapplicant: Uncertainty and stress: Why it causes diseases and how it is mastered ... https://t.co/ejRXHOvN78 @marcomendicino @Jenn…

Aug 24, 2021 · 10 shares · 1,044 followers View post →

expiredcoprs

@expiredcoprs · X

RT @Fswoapplicant: Uncertainty and stress: Why it causes diseases and how it is mastered ... https://t.co/ejRXHOvN78 @marcomendicino @Jenn…

Aug 19, 2021 · 10 shares · 1,044 followers View post →

expiredcoprs

@expiredcoprs · X

RT @Fswoapplicant: Uncertainty and stress: Why it causes diseases and how it is mastered ... https://t.co/ejRXHOvN78 @marcomendicino @Jenn…

Aug 13, 2021 · 10 shares · 1,044 followers View post →

expiredcoprs

@expiredcoprs · X

RT @Fswoapplicant: Uncertainty and stress: Why it causes diseases and how it is mastered ... https://t.co/ejRXHOvN78 @marcomendicino @Jenn…

Aug 9, 2021 · 10 shares · 1,044 followers View post →

expiredcoprs

@expiredcoprs · X

RT @Fswoapplicant: Uncertainty and stress: Why it causes diseases and how it is mastered ... https://t.co/ejRXHOvN78 @marcomendicino @Jenn…

Aug 6, 2021 · 10 shares · 1,044 followers View post →

expiredcoprs

@expiredcoprs · X

RT @Fswoapplicant: Uncertainty and stress: Why it causes diseases and how it is mastered ... https://t.co/ejRXHOvN78 @marcomendicino @Jenn…

Aug 3, 2021 · 10 shares · 1,044 followers View post →

Victim_of_BrokenSystem

@LipikaBanerjee9 · X

RT @Fswoapplicant: Uncertainty and stress: Why it causes diseases and how it is mastered ... https://t.co/ejRXHOvN78 @marcomendicino @Jenn…

Aug 3, 2021 · 10 shares · 26 followers View post →

kaurdeep

@kaurdee26422943 · X

RT @Fswoapplicant: Uncertainty and stress: Why it causes diseases and how it is mastered ... https://t.co/ejRXHOvN78 @marcomendicino @Jenn…

Aug 3, 2021 · 10 shares · 12 followers View post →

SMu

@SamanMu · X

RT @Fswoapplicant: Uncertainty and stress: Why it causes diseases and how it is mastered ... https://t.co/ejRXHOvN78 @marcomendicino @Jenn…

Aug 3, 2021 · 10 shares · 76 followers View post →

Bhushan Ravaliya

@BushmanRav · X

RT @Fswoapplicant: Uncertainty and stress: Why it causes diseases and how it is mastered ... https://t.co/ejRXHOvN78 @marcomendicino @Jenn…

Aug 3, 2021 · 10 shares · 13 followers View post →

Fsw applicant

@Fswoapplicant · X

Aug 3, 2021 · 6 likes · 10 shares · 455 followers View post →

Gonzalo Parra

@GonzaParra_ · X

"Uncertainty and stress: Why it causes diseases and how it is mastered by the brain" https://t.co/oCcBebJ1DY

Jul 14, 2021 · 8 likes · 3,383 followers View post →

@harimeyy · X

RT @rhughesjones: #Uncertainty and #stress: Why it causes diseases and how it is mastered by the brain Fascinating paper from Friston and…

Feb 25, 2021 · 1 share · 146 followers View post →

Richard Hughes-Jones

@rhughesjones · X

#Uncertainty and #stress: Why it causes diseases and how it is mastered by the brain Fascinating paper from Friston and Co: https://t.co/OiuwkScNJ2 https://t.co/u82ESphIot

Feb 18, 2021 · 1 share · 2,245 followers View post →

Yohan J. John

@DrYohanJohn · X

@JesParent @balicea1 @KordingLab @tonychemero @CharlotteGuo5 The literature on stress, uncertainty and resilience may be relevant. Here is one review I just found, but there is a lot on this out there: https://t.co/U1i2qlrr4L

Jan 23, 2021 · 3 likes · 7,503 followers View post →

Ken Gusler

@kgusler · X

Uncertainty and stress: Why it causes diseases and how it is mastered by the brain - https://t.co/g2RVZgavb6

Dec 22, 2020 · 20,019 followers View post →

Ray Doraisamy

@forshaper · X

@AskYatharth The paper 'Uncertainty and stress: Why it causes diseases and how it is mastered by the brain' is the key to interpreting Buddhism, Daoism, Hinduism, Stoicism, Skepticism, etc, in terms of the free-energy principle and the predictive brain.

Dec 13, 2020 · 3 likes · 1,954 followers View post →

Maite Goicoechea

@Goicomaite · X

RT @argoicoechea: Uncertainty and Stress: Why It Causes Diseases and How It Is Mastered by the Brain https://t.co/aNmyIxpRAF

Jun 13, 2020 · 8 shares · 1,673 followers View post →

Goretti Aranburu

@gorettiaranb1 · X

RT @argoicoechea: Uncertainty and Stress: Why It Causes Diseases and How It Is Mastered by the Brain https://t.co/aNmyIxpRAF

Jun 13, 2020 · 8 shares · 1,678 followers View post →

Jules

@julianabrownie · X

RT @argoicoechea: Uncertainty and Stress: Why It Causes Diseases and How It Is Mastered by the Brain https://t.co/aNmyIxpRAF

Jun 13, 2020 · 8 shares · 276 followers View post →

Marilú Sacristán

@Lurnahiagodut · X

RT @argoicoechea: Uncertainty and Stress: Why It Causes Diseases and How It Is Mastered by the Brain https://t.co/aNmyIxpRAF

Jun 13, 2020 · 8 shares · 1,263 followers View post →

Arturo Goicoechea

@argoicoechea · X

Uncertainty and Stress: Why It Causes Diseases and How It Is Mastered by the Brain https://t.co/aNmyIxpRAF

Jun 13, 2020 · 26 likes · 8 shares · 10,944 followers View post →

Derya Ozer Kaya

@deryaozer2000 · X

RT @PaininMotion: In uncertain times, our brain uses different strategies to deal with stress and ensure physical & mental wellbeing. Great…

Apr 17, 2020 · 2 shares · 158 followers View post →

Pain in Motion

@PaininMotion · X

Apr 16, 2020 · 7 likes · 2 shares · 9,890 followers View post →

Chris Djurtoft

@ChrisDjurtoft · X

Uncertainty and stress: Why it causes diseases and how it is mastered... "The aim of the current paper is to disclose those neuroendocrine mechanisms that could fulfill Bayesian functions in regulating attention, learning, and habituation." https://t.co/9ytDppLtdA

Mar 29, 2020 · 401 followers View post →

Leonardo Rodríguez Lagos

@leo_rodriguezl · X

Uncertainty and stress: Why it causes diseases and how it is mastered ... https://t.co/cn2arqTChY

Mar 27, 2020 · 194 followers View post →

Padua Carobrez

@Paduacarobrez · X

Uncertainty and stress: Why it causes diseases and how it is mastered ... https://t.co/jEe2X3wUrn

Mar 17, 2020 · 2 likes · 1 share · 133 followers View post →

Osman Hayran

@hayran_osman · X

Uncertainty and stress: Why it causes diseases and how it is mastered ... https://t.co/r9mMgjpaGt

Jun 2, 2019 · 1 like · 169 followers View post →

Uncertainty and stress: Why it causes diseases and how it is mastered by the brain.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Tracing HIV's Origins: Early Diversification in Kinshasa

Overcoming Fear: Transforming Anxiety into an Ally for Personal Growth