Interested in understanding more about substrate utilization and metabolic flexibility across different populations?. In this article @GeorgeABrooks3 and I show some interesting data including for the 1st time, data from Tour de France cyclists
Assessment of Metabolic Flexibility by Means of Measuring Blood Lactate, Fat, and Carbohydrate Oxidation Responses to Exercise in Professional Endurance Athletes and Less-Fit Individuals.
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The overall tone reflects high interest and engagement, with examples like mentions of the detailed protocols, graphs adapted from the study, and references to practical applications like zone 2 training. Words such as 'must read,' 'GOLD,' and 'impressed' convey strong appreciation and perceived significance, indicating that the discussions are both technical and enthusiastic about the paper’s impact on fitness and metabolic health.
Most discussions support the study’s findings, emphasizing its relevance and alignment with existing knowledge about metabolic flexibility.
Numerous posts express high interest, citing the paper’s methodology, implications, and connection to athletic performance and health.
Posts include detailed references to the methodology, graphs, and applications, indicating deep engagement with the research.
The discussions suggest the research could influence exercise routines, metabolic assessments, and understanding of mitochondrial function, though some see it as more foundational than immediately transformative.
Abstract in brief
- The study compares metabolic flexibility in endurance athletes, moderately active individuals, and those with metabolic syndrome, showing that athletes have higher fat oxidation (FATox) and lower blood lactate levels (La), indicating better mitochondrial function.
- There is a strong inverse relationship between FATox and La across all groups, suggesting that higher fat metabolism is associated with lower lactate accumulation during exercise, which reflects healthier mitochondrial activity.
- Measuring blood lactate and fat oxidation during exercise offers an effective way to assess mitochondrial oxidative capacity and metabolic flexibility across different populations.]
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Most liked on X and BlueskyJust published in @SportsMedicineJ Comment on: “Assessment of Metabolic Flexibility by Means of Measuring Blood Lactate, Fat, and Carbohydrate Oxidation Responses to Exercise in Professional Endurance Athletes and Less-Fit Individuals" https://t.co/794rROLbR7
Here's nice graph I adapted from @doctorinigo 's 2018 paper. This clearly illustrates the difference in fax oxidation between different demographics. I highly recommend you read the whole paper, it's GOLD https://t.co/VU4s2BKsW9 https://t.co/WSlOOrjV5r
3. Then we can indirectly assess the mitochondrial function, bioenergetics and metabolic flexibility in a non-invasive way. @GeorgeABrooks3 and I show it in this published article. https://t.co/ILaistJjLd https://t.co/7GnO5kH5m8
@kilianj @Alan_Couzens @TuckerGoodrich @maximumcharacte @tednaiman Metabolic flexibility is key. It is at the epicenter of my training and nutrition philosophy. It all is about mitochondrial function. This is a recommended read from our research. We just finished a study with biopsies will publish soon https://t.co/Nu89wYVtRm
@rccycling_usa Testing your mitochondrial function during exercise would be helpful:https://t.co/ILaistsgJd and https://t.co/R1eJD9hhW0
All mentions
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What Does It Really Mean to Be Metabolically Flexible? In this week's episode of Beyond Healthspan, we break down one of the most influential papers in exercise physiology: “Assessment of Metabolic Flexibility by Means of Measuring Blood Lactate, Fat, and Carbohydrate Oxidation https://t.co/fqo5DbKM2i
What Does It Really Mean to Be Metabolically Flexible? In this week's episode of Beyond Healthspan, we break down one of the most influential papers in exercise physiology: “Assessment of Metabolic Flexibility by Means of Measuring Blood Lactate, Fat, and Carbohydrate Oxidation https://t.co/3r71lIVJXK
What Does It Really Mean to Be Metabolically Flexible? In this week's episode of Beyond Healthspan, we break down one of the most influential papers in exercise physiology: “Assessment of Metabolic Flexibility by Means of Measuring Blood Lactate, Fat, and Carbohydrate Oxidation https://t.co/zQgvDno7GZ
What Does It Really Mean to Be Metabolically Flexible? In this week's episode of Beyond Healthspan, we break down one of the most influential papers in exercise physiology: “Assessment of Metabolic Flexibility by Means of Measuring Blood Lactate, Fat, and Carbohydrate Oxidation https://t.co/NvI8fRHk0B
RT @healthspanmed: What Does It Really Mean to Be Metabolically Flexible? In this week's episode of Beyond Healthspan, we break down one o…
What Does It Really Mean to Be Metabolically Flexible? In this week's episode of Beyond Healthspan, we break down one of the most influential papers in exercise physiology: “Assessment of Metabolic Flexibility by Means of Measuring Blood Lactate, Fat, and Carbohydrate Oxidation https://t.co/YXnQz81peU
@cfs_research @CorAndME @Caitshith @microbeminded2 @PutrinoLab I would be really interested to see a longditudinal study looking at this in LC vs matched sedentary controls. @RobWust was this something considered during your "Muscle abnormalities worsen after post-exertional malaise in long COVID" study? https://t.co/LdIxTPC02h
@Gearoidmuar https://t.co/5UEw0lB4AW
https://t.co/zMl7U2SR5W
Assessment of Metabolic Flexibility by Means of Measuring Blood Lactate, Fat, and Carbohydrate Oxidation Responses … https://t.co/dWrVgzqodf
Chart from @doctorinigo classic paper. A must read: https://t.co/2WcEMEZpy8
@summitsportssci @Paddy_Barrett Of course. They are from our article here: https://t.co/ILaistrITF Thanks!
@heyououthereoyo @Alan_Couzens doi: 10.1007/s40279-017-0751-x. (San Millán & Brooks, 2018) According to these authors protocol: 10'/+35w with 15' warm-up to >100w. would you share theirs? Thanks
@JensHKvassheim @doctorinigo I believe he covers some of this in this paper https://t.co/9cdo0jsoP6
RT @johngetstrong: @doctorinigo Full paper here: https://t.co/2WcEMEZpy8
Assessment of Metabolic Flexibility by Means of Measuring Blood Lactate, Fat, and Carbohydrate Oxidation Responses to Exercise in Professional Endurance Athletes and Less-Fit Individuals | SpringerLink https://t.co/9cdo0jrQZy
@doctorinigo Full paper here: https://t.co/2WcEMEZpy8
@v0running Gracias! Este es el link https://t.co/ILaistrITF
@Hill_Runner @Alan_Couzens https://t.co/r8lIAAwUad
@chandler_gentry @Alan_Couzens from: https://t.co/EYmoFCkfpQ
@exceedhergrasp1 @SEPfieldPatient @drmclphillips @nicknorwitz @siobhan_huggins @realDaveFeldman @AdrianSotoMota @angryhacademic @maureviv Yes, that's a sign of not being fit. See @doctorinigo 's work: https://t.co/PCYIwXR5Fj It can be fixed, that's what the @DrPhilMaffetone Method is for... https://t.co/s77qhncghF
Mitochondrial flexibility in athletes and non-athletes https://t.co/pXJ444SxAI
RT @doctorinigo: @rccycling_usa Testing your mitochondrial function during exercise would be helpful:https://t.co/ILaistsgJd and https://t.…
RT @doctorinigo: @AlphaBetaAnil I would recommend reading the methodology I developed and currently using: One link here: https://t.co/ILai…
RT @doctorinigo: @AlphaBetaAnil I would recommend reading the methodology I developed and currently using: One link here: https://t.co/ILai…
@rccycling_usa Testing your mitochondrial function during exercise would be helpful:https://t.co/ILaistsgJd and https://t.co/R1eJD9hhW0
@AlphaBetaAnil I would recommend reading the methodology I developed and currently using: One link here: https://t.co/ILaistsgJd and the other one, my publication from las week here:https://t.co/R1eJD9hhW0
RT @SeanSeale: Here's nice graph I adapted from @doctorinigo 's 2018 paper. This clearly illustrates the difference in fax oxidation betwee…
@feelthebyrn1 @doctorinigo @DirkFriel So awesome! @doctorinigo mentioned in pods preferring top zn2 as a stimulus. Would love to see where he puts zn2 annotating curves in https://t.co/oAMXboB3HS. Not sure how consistent w/ others “zn2” boundaries. As @olavaleksander recently said, precision key as volume increases.
RT @SeanSeale: Here's nice graph I adapted from @doctorinigo 's 2018 paper. This clearly illustrates the difference in fax oxidation betwee…
Here's nice graph I adapted from @doctorinigo 's 2018 paper. This clearly illustrates the difference in fax oxidation between different demographics. I highly recommend you read the whole paper, it's GOLD https://t.co/VU4s2BKsW9 https://t.co/WSlOOrjV5r
RT @doctorinigo: @Paddy_Barrett The figure from our paper here
RT @doctorinigo: @Paddy_Barrett The figure from our paper here
@Paddy_Barrett The figure from our paper here
@BenCoveSC @feelthebyrn1 @doctorinigo This one I think. https://t.co/W2mCTb4t6C Available to read at - https://t.co/qfHwTkUvSp
@drscottyk @DrNadolsky My pleasure... this is a terrific paper. https://t.co/1gbFkEJF1v
RT @LeoMorton: @pkedrosky I know you’ve seen this but others may be interested in @doctorinigo study: https://t.co/A05xjqI2uI
@pkedrosky I know you’ve seen this but others may be interested in @doctorinigo study: https://t.co/A05xjqI2uI
@DrJDknows_stuff @dantaylor688 @Alan_Couzens I recommend you to read this article from @doctorinigo and @GeorgeABrooks3. https://t.co/zntKYuZGDE. Super interesting to see how lactate levels change in different population (professionals athletes, moderate active athletes and people with metabolic syndrome)
Puedes conocer a qué intensidad se encuentra tu zona de FATmax mediante un medidor de lactato. Coincide con el aumento de los niveles de lactato (en comparación con los niveles basales). Fuente: https://t.co/STfmi3YBiP
@JohanTanman @dwrowland To graphically see (one image is worth thousand of words) how lactate is both: -Less produced⬇️ -More used⬆️ In fit individuals vs not. I love this article from @doctorinigo https://t.co/Yp9xHWQgU2 https://t.co/xuz7DRqM8E
@StephenSeiler @doctorinigo @Toptimum_Perfor @Alan_Couzens I saw 15' @100W for the warm up and then 35W increase every 10' in the article "Assessment of Metabolic Flexibility by Means of Measuring Blood Lactate, Fat, and Carbohydrate Oxidation Responses to Exercise in Professional Endurance Athletes and Less-Fit Individuals."
Gráfico 2. Datos obtenidos del artículo “Assessment of Metabolic Flexibility by Means of Measuring Blood Lactate, Fat, and Carbohydrate Oxidation Responses to Exercise in Professional Endurance Athletes and Less-Fit Individuals” (1)
Gráfico 1. Datos obtenidos del artículo “Assessment of Metabolic Flexibility by Means of Measuring Blood Lactate, Fat, and Carbohydrate Oxidation Responses to Exercise in Professional Endurance Athletes and Less-Fit Individuals” (1)
@javiersilli @koldobain @tri_rober @IgnaBroomr No sé de dónde salen ese tipo de afirmaciones. Saludos y gracias por el comentario. https://t.co/wU4YA7KwmX https://t.co/hLYjDXnPnZ
@doctorinigo & Brooks 2018 on explaining the concept of metabolic flexibility, factors affexting it, measuring it & changes in metabolic flexibility according to fitness&health status: https://t.co/AFOyxndcxv
@EliasLehtonen @PauMoreno10 Curious of your thoughts on methodology and findings in this article relative to fatox, carbox, and lactate. Relationship bw fatox and lactate appears strongly negatively correlated. Fatmax may or may not be relevant here. Sorry ahead not full text link. https://t.co/HPVuxlxL1g
RT @monferrermarin1: Just published in @SportsMedicineJ Comment on: “Assessment of Metabolic Flexibility by Means of Measuring Blood Lact…
RT @monferrermarin1: Just published in @SportsMedicineJ Comment on: “Assessment of Metabolic Flexibility by Means of Measuring Blood Lact…
RT @monferrermarin1: Just published in @SportsMedicineJ Comment on: “Assessment of Metabolic Flexibility by Means of Measuring Blood Lact…
RT @monferrermarin1: Just published in @SportsMedicineJ Comment on: “Assessment of Metabolic Flexibility by Means of Measuring Blood Lact…
RT @monferrermarin1: Just published in @SportsMedicineJ Comment on: “Assessment of Metabolic Flexibility by Means of Measuring Blood Lact…
RT @monferrermarin1: Just published in @SportsMedicineJ Comment on: “Assessment of Metabolic Flexibility by Means of Measuring Blood Lact…
RT @monferrermarin1: Just published in @SportsMedicineJ Comment on: “Assessment of Metabolic Flexibility by Means of Measuring Blood Lact…
RT @monferrermarin1: Just published in @SportsMedicineJ Comment on: “Assessment of Metabolic Flexibility by Means of Measuring Blood Lact…
RT @monferrermarin1: Just published in @SportsMedicineJ Comment on: “Assessment of Metabolic Flexibility by Means of Measuring Blood Lact…
RT @monferrermarin1: Just published in @SportsMedicineJ Comment on: “Assessment of Metabolic Flexibility by Means of Measuring Blood Lact…
RT @monferrermarin1: Just published in @SportsMedicineJ Comment on: “Assessment of Metabolic Flexibility by Means of Measuring Blood Lact…
RT @monferrermarin1: Just published in @SportsMedicineJ Comment on: “Assessment of Metabolic Flexibility by Means of Measuring Blood Lact…
Just published in @SportsMedicineJ Comment on: “Assessment of Metabolic Flexibility by Means of Measuring Blood Lactate, Fat, and Carbohydrate Oxidation Responses to Exercise in Professional Endurance Athletes and Less-Fit Individuals" https://t.co/794rROLbR7
For its assessment, longer stages are required. For example, I was impressed by the 35W every 10-min stage that @doctorinigo carried out across populations with different metabolic characteristics (from pro-cyclists to MtS individuals): https://t.co/ySftbx0wSu
@AlexJLeaf The opposite actually: 80% carbs at >90% VO2peak and RER>200 precisely because top endurance athletes are optimally adapted for fat oxidation. The capacity of an endurance athlete to oxidize fat may be the best marker of performance. See e.g. https://t.co/boiJaedR3g
For those interested in my zone 2 cycling routine. It takes inspiration from the study by @doctorinigo Here is the paper, podcast links below. https://t.co/5UEw0lB4AW @suranwee
RT @doctorinigo: @NATURAUL @PauMoreno10 @TStellingwerff @SamImpey_ @JamesyMorton @sweatscience Agree, it is complex as all measurements are…
RT @doctorinigo: @NATURAUL @PauMoreno10 @TStellingwerff @SamImpey_ @JamesyMorton @sweatscience Agree, it is complex as all measurements are…
@NATURAUL @PauMoreno10 @TStellingwerff @SamImpey_ @JamesyMorton @sweatscience Agree, it is complex as all measurements are based on indirect parameters. In my case, my interest is less in mechanical efficiency and more in bioenergetics & substrate utilization. Brooks & I published this paper which may help https://t.co/ILaistJjLd
@roydanroy @david_madras @strydrunning https://t.co/6VhkDpDSiT
@doctorinigo From the findings of your 2018 paper with Prof Brooks, whatever the name of the centre, the end treatments offered could be pretty much the same? 80% zone 2 and 20% HIIT. This protocol seems to give results whatever the objective. https://t.co/6VhkDpDSiT
@Mangan150 @gravitonspin @hubermanlab https://t.co/mI0d3QLDaA
RT @LowCarbEP: "We believe that measurements of FATox rate during exercise provide an indirect method to assess metabolic flexibility & oxi…
RT @LowCarbEP: "We believe that measurements of FATox rate during exercise provide an indirect method to assess metabolic flexibility & oxi…
RT @LowCarbEP: "We believe that measurements of FATox rate during exercise provide an indirect method to assess metabolic flexibility & oxi…
"We believe that measurements of FATox rate during exercise provide an indirect method to assess metabolic flexibility & oxidative capacity across individuals of widely different metabolic capabilities" Research: https://t.co/eVnp9WkwwW
RT @doctorinigo: @MVAitor Thank you Aitor for the mention!
@MVAitor Thank you Aitor for the mention!
RT @doctorinigo: @Alan_Couzens @eshed_lin @maximumcharacte Agree, those FATox numbers from that paper correspond to more of a sedentary typ…
RT @doctorinigo: @Alan_Couzens @eshed_lin @maximumcharacte Agree, those FATox numbers from that paper correspond to more of a sedentary typ…
@CoenPM @GeorgeABrooks3 Brooks and I published this paper in 2018 on metabolic flexibility including athletes (to my knowledge the first one done with pro athletes) and recognized Kelley and Mandarino were way ahead of us for such metabolic flexibility term (2000) https://t.co/ILaistJjLd
@loekvossen https://t.co/wU4YA7KwmX https://t.co/PLTIH7Uazu
@loekvossen @Jeukendrup https://t.co/u3ubfEpd17 https://t.co/wU4YA7KwmX
RT @doctorinigo: Interested in understanding more about substrate utilization and metabolic flexibility across different populations?. In t…
RT @doctorinigo: 3. Then we can indirectly assess the mitochondrial function, bioenergetics and metabolic flexibility in a non-invasive way…
3. Then we can indirectly assess the mitochondrial function, bioenergetics and metabolic flexibility in a non-invasive way. @GeorgeABrooks3 and I show it in this published article. https://t.co/ILaistJjLd https://t.co/7GnO5kH5m8
RT @doctorinigo: Interested in understanding more about substrate utilization and metabolic flexibility across different populations?. In t…
RT @doctorinigo: Interested in understanding more about substrate utilization and metabolic flexibility across different populations?. In t…
RT @doctorinigo: Interested in understanding more about substrate utilization and metabolic flexibility across different populations?. In t…
RT @doctorinigo: Interested in understanding more about substrate utilization and metabolic flexibility across different populations?. In t…
RT @doctorinigo: Interested in understanding more about substrate utilization and metabolic flexibility across different populations?. In t…
RT @doctorinigo: Interested in understanding more about substrate utilization and metabolic flexibility across different populations?. In t…
RT @doctorinigo: Interested in understanding more about substrate utilization and metabolic flexibility across different populations?. In t…
RT @doctorinigo: Interested in understanding more about substrate utilization and metabolic flexibility across different populations?. In t…
RT @doctorinigo: Interested in understanding more about substrate utilization and metabolic flexibility across different populations?. In t…
RT @doctorinigo: Interested in understanding more about substrate utilization and metabolic flexibility across different populations?. In t…
RT @doctorinigo: Interested in understanding more about substrate utilization and metabolic flexibility across different populations?. In t…
Interested in understanding more about substrate utilization and metabolic flexibility across different populations?. In this article @GeorgeABrooks3 and I show some interesting data including for the 1st time, data from Tour de France cyclists
RT @doctorinigo: @kilianj @Alan_Couzens @TuckerGoodrich @maximumcharacte @tednaiman Metabolic flexibility is key. It is at the epicenter of…
RT @doctorinigo: @kilianj @Alan_Couzens @TuckerGoodrich @maximumcharacte @tednaiman Metabolic flexibility is key. It is at the epicenter of…
@kilianj @Alan_Couzens @TuckerGoodrich @maximumcharacte @tednaiman Metabolic flexibility is key. It is at the epicenter of my training and nutrition philosophy. It all is about mitochondrial function. This is a recommended read from our research. We just finished a study with biopsies will publish soon https://t.co/Nu89wYVtRm
@NATURAUL @JeroenSwart @MVAitor @Glut4Science This is an article Dr. Brooks and I published in 2018 in case it can help. One of the groups of the study was was made up of world tour cyclists https://t.co/Nu89wYVtRm
Excellent study by @doctorinigo and George A. Brooks on metabolic health (n=52). RESULTS: The fitter you are the better your ability to oxidize (burn) fat the lower your blood lactose level = the healthier your metabolism is. https://t.co/oD82YwFS80 #zerocarb #carnivoremonth
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