PubHawk
Aging (Albany NY) August 2017 PMID 28768895

p16(Ink4a) and senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli.

Brandon M Hall, Vitaly Balan, Anatoli S Gleiberman, Evguenia Strom, Peter Krasnov, Lauren P Virtuoso, Elena Rydkina, Slavoljub Vujcic, Karina Balan, Ilya I Gitlin, Katerina I Leonova, Camila R Consiglio, Sandra O Gollnick, Olga B Chernova, Andrei V Gudkov

Download social card

Mentions

24
Peak: 8 in Mar 2022
across 4 sources since Aug 2017

Extended reach

89,917
potential audience

Total likes

57

Video views

1,524

Mentions per month

Aug 2017 – Nov 2025

Where it's discussed

  • X / Twitter18 posts
  • News3 articles
  • YouTube2 videos
  • Facebook1 posts

AI synopsis

What people are saying

Discussions predominantly express strong agreement with the article, highlighting its contribution to understanding macrophage responses and senescence markers. The tone is enthusiastic, with phrases like 'important insights' and mentions of the study as a 'game changer,' demonstrating high interest and engagement among the participants.

AgreementStrong agreement

Most discussions acknowledge the significance of the findings, emphasizing that p16 and SAG are inducible in macrophages through reversible processes, supporting the original publication's claims.

InterestHigh interest

There is high interest evidenced by repeated mentions of the research, references to videos and interviews, and specific discussion of mechanisms, indicating engagement with the topic.

EngagementHigh engagement

Discussions include detailed references to experimental models, potential implications, and questions about physiological responses, showing deep engagement and critical thinking.

ImpactHigh impact

The frequent citation of this work as 'PaperoftheWeek' and references to its significance suggest a perception of high impact on aging and immunology research fields.

Abstract in brief

  • p16Ink4a and senescence-associated galactosidase (SAG) can be induced in macrophages as part of a reversible immune response to stimuli, not just as markers of senescent cells (SCs).
  • SAG-positive macrophages are present in aged mouse adipose tissue and can be induced in young mice after injecting senescent cells, raising questions about the specificity of these markers for SCs.
  • The study shows that macrophages acquire SAG and p16 due to immune responses, and these markers can be manipulated by stimuli like IFN or IL4, implying that the benefits of removing senescent cells may also involve removing nonsenescent SAG-positive macrophages.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Aging-US
@AgingJrnl · X

Researchers from @EveronBio & @RoswellPark authored the #PaperoftheWeek: “p16(Ink4a) and senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli.” https://t.co/dOlfZt5Xxz #cell #microbiology #aging #dna https://t.co/wXOPPEdQiI

Mar 16, 2022 · 6 likes · 4,400 followers View post →
Hao Yin
@HaoYin20 · X

Monocyte/Mφ is reported to undergo a reversible p16+SAβGal+ state that likely facilitates M2 polarization. Does this also occur in toxin-injured #SkeletalMuscle?

Jan 17, 2022 · 5 likes · 2 shares · 12,574 followers View post →
Aging-US
@AgingJrnl · X

Watch an #author #interview with Dr. Andrei V. Gudkov as he discusses his 2017 paper: “p16(Ink4a) & senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli.” https://t.co/JqEjXyGHFV

Apr 6, 2022 · 4 likes · 1 share · 4,400 followers View post →
Aging-US
@AgingJrnl · X

#PaperoftheWeek: Watch an #AgingShort video on a 2017 research paper about a study evaluating p16ink4a and SAβG as markers of senescent cells. Read the full paper: https://t.co/Ks0A6Tl0KW #senescence #cellularsenescence #aging #antiaging #researchpaper #openaccess #peerreview https://t.co/LyMGNDi7zs

Mar 19, 2022 · 4 likes · 4,400 followers View post →
Aging-US
@AgingJrnl · X

Watch an #AgingShort video on a 2017 research paper about a study evaluating p16ink4a and SAβG as markers of senescent cells. Read the full paper: https://t.co/Ks0A6Tl0KW #senescence #cellularsenescence #aging #antiaging #researchpaper #openaccess #peerreview https://t.co/yLvWI3RYWA

May 19, 2022 · 4 likes · 4,400 followers View post →
Aging-US
@AgingJrnl · X

Watch an #author #interview with Dr. Andrei V. Gudkov as he discusses his 2017 paper: “p16(Ink4a) & senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli.” https://t.co/JqEjXyGHFV

May 17, 2022 · 4 likes · 4,400 followers View post →

All mentions

Dark Brandon Rises
@iamgabbarson · X

RT @AgingJrnl: Watch an #AgingShort video on a 2017 research paper about a study evaluating p16ink4a and SAβG as markers of senescent cells…

Jun 19, 2022 · 1 share · 545 followers View post →
Aging-US
@AgingJrnl · X

Watch an #AgingShort video on a 2017 research paper about a study evaluating p16ink4a and SAβG as markers of senescent cells. Read the full paper: https://t.co/Ks0A6Tl0KW #senescence #cellularsenescence #aging #antiaging #researchpaper #openaccess #peerreview https://t.co/Bti95prIZU

Jun 19, 2022 · 2 likes · 1 share · 4,400 followers View post →
Aging-US
@AgingJrnl · X

Watch an #AgingShort video on a 2017 research paper about a study evaluating p16ink4a and SAβG as markers of senescent cells. Read the full paper: https://t.co/Ks0A6Tl0KW #senescence #cellularsenescence #aging #antiaging #researchpaper #openaccess #peerreview https://t.co/yLvWI3RYWA

May 19, 2022 · 4 likes · 4,400 followers View post →
Aging-US
@AgingJrnl · X

Watch an #author #interview with Dr. Andrei V. Gudkov as he discusses his 2017 paper: “p16(Ink4a) & senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli.” https://t.co/JqEjXyGHFV

May 17, 2022 · 4 likes · 4,400 followers View post →
Aging-US
@AgingJrnl · X

Watch an #AgingShort video on a 2017 research paper about a study evaluating p16ink4a and SAβG as markers of senescent cells. Read the full paper: https://t.co/Ks0A6Tl0KW #senescence #cellularsenescence #aging #antiaging #researchpaper #openaccess #peerreview https://t.co/qlfNkHYAy6

Apr 16, 2022 · 4,400 followers View post →
Johns Hopkins Frailty Science #FrailtyFighter
@FrailtyScience · X

RT @AgingJrnl: Watch an #author #interview with Dr. Andrei V. Gudkov as he discusses his 2017 paper: “p16(Ink4a) & senescence-associated β-…

Apr 6, 2022 · 1 share · 2,269 followers View post →
Aging-US
@AgingJrnl · X

Watch an #author #interview with Dr. Andrei V. Gudkov as he discusses his 2017 paper: “p16(Ink4a) & senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli.” https://t.co/JqEjXyGHFV

Apr 6, 2022 · 4 likes · 1 share · 4,400 followers View post →
Aging-US
@AgingJrnl · X

#PaperoftheWeek: Watch an #AgingShort video on a 2017 research paper about a study evaluating p16ink4a and SAβG as markers of senescent cells. Read the full paper: https://t.co/Ks0A6Tl0KW #senescence #cellularsenescence #aging #antiaging #researchpaper #openaccess #peerreview https://t.co/LyMGNDi7zs

Mar 19, 2022 · 4 likes · 4,400 followers View post →
Roswell Park
@RoswellPark · X

RT @AgingJrnl: Researchers from @EveronBio and @RoswellPark authored Aging's #PaperoftheWeek, entitled, "p16(Ink4a) and senescence-associat…

Mar 18, 2022 · 1 share · 19,990 followers View post →
Aging-US
@AgingJrnl · X

Researchers from @EveronBio and @RoswellPark authored Aging's #PaperoftheWeek, entitled, "p16(Ink4a) and senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli." Read the full paper: https://t.co/dOlfZt5Xxz https://t.co/4GwRiRlhtB

Mar 17, 2022 · 4 likes · 1 share · 4,400 followers View post →
Aging-US
@AgingJrnl · X

Researchers from @EveronBio & @RoswellPark authored the #PaperoftheWeek: “p16(Ink4a) and senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli.” https://t.co/dOlfZt5Xxz #cell #microbiology #aging #dna https://t.co/wXOPPEdQiI

Mar 16, 2022 · 6 likes · 4,400 followers View post →
Aging-US
@AgingJrnl · X

#PaperoftheWeek: Watch an #AgingShort video on a 2017 research paper about a study evaluating p16ink4a and SAβG as markers of senescent cells. Read the full paper: https://t.co/Ks0A6Tl0KW #senescence #cellularsenescence #aging #antiaging #researchpaper #openaccess #peerreview https://t.co/GvF6CkzJsZ

Mar 16, 2022 · 4 likes · 4,400 followers View post →
Aging-US
@AgingJrnl · X

#PaperoftheWeek: Watch an #author #interview with Dr. Andrei V. Gudkov as he discusses his 2017 paper: “p16(Ink4a) & senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli.” https://t.co/JqEjXyGHFV

Mar 15, 2022 · 2 likes · 4,400 followers View post →
Aging-US
@AgingJrnl · X

Aging's #PaperoftheWeek, "p16(Ink4a) and senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli," features figure 1: Induction of p16Ink4a and SAβG in macrophages does not require p53. https://t.co/6B9c91skit https://t.co/t9upzkAgcH

Mar 14, 2022 · 2 likes · 4,400 followers View post →
Taras Pasternak
@tp590 · X

RT @HaoYin20: Monocyte/Mφ is reported to undergo a reversible p16+SAβGal+ state that likely facilitates M2 polarization. Does this also occ…

Jan 17, 2022 · 2 shares · 2,252 followers View post →
Hao Yin
@HaoYin20 · X

Monocyte/Mφ is reported to undergo a reversible p16+SAβGal+ state that likely facilitates M2 polarization. Does this also occur in toxin-injured #SkeletalMuscle?

Jan 17, 2022 · 5 likes · 2 shares · 12,574 followers View post →
Kelly A. Hogan Ph.D.
@Loose_Lab_Rat · X

p16(Ink4a) and senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli. https://t.co/Bm3XJDY7ZC

Dec 11, 2019 · 2,238 followers View post →
tuto
@TutorialPharma · X

https://t.co/k6bGHRkz4a aging interview

Mar 2, 2019 · 65 followers View post →
Anti Envelhecimento | PDF | Life Sciences | Biological Processes
News

Aging (Albany NY) 9, 1867–1884. http://dx.doi.org/10.18632/ Clin. Invest. 125, 25–32. http://dx.doi.org/10.1172/JCI73939. aging.101268. Kim ...

Nov 29, 2025 View →
80余位抗衰学者认证，Nature顶级综述：衰老细胞的核心标志竟是它 ...
News

Aging, 9(8), 1867–1884. https://doi.org/10.18632/aging.101268. [6] Roy, A. L., Sierra, F., Howcroft, K., Singer, D. S., Sharpless, N ...

Jun 17, 2024 View →
陪你生长发育，再陪你迈向衰老，衰老细胞的“浪漫”至死不渝_胚胎_功能
News

Aging, 9(8), 1867–1884. https://doi.org/10.18632/aging.101268. [20] Shvedova, M., Samdavid Thanapaul, R. J. R., Thompson, E. L., Niedernhofer ...

Mar 9, 2023 View →
Researchers commonly determine the presence of senescent cells ...
Facebook

http://www.aging-us.com/article/101268/text. Aging | p16(Ink4a) and ... 10.18632/aging. 204666 The researchers found two different ...

Aug 21, 2017 View →