Front Endocrinol (Lausanne) July 2017 PMID 28775711

Thyroid Allostasis-Adaptive Responses of Thyrotropic Feedback Control to Conditions of Strain, Stress, and Developmental Programming.

Apostolos Chatzitomaris, Rudolf Hoermann, John E Midgley, Steffen Hering, Aline Urban, Barbara Dietrich, Assjana Abood, Harald H Klein, Johannes W Dietrich

Mentions

40
Peak: 5 in Sep 2019
across 5 sources since Apr 2019

Extended reach

70,459
potential audience

Total likes

89

Video views

3,353

Mentions per month

Apr 2019 – Jun 2023

Where it's discussed

  • X / Twitter31 posts
  • Blogs3 articles
  • YouTube2 videos
  • Facebook2 posts
  • Reddit2 posts

AI synopsis

What people are saying

Several discussions exemplify a thoughtful examination of the article, with people referencing related research reviews, the significance of allostatic responses during critical illness, and psychiatric conditions. For instance, terms like 'complex networks' and 'adaptive responses' are used thoughtfully to emphasize the scientific depth, reflecting a high level of interest and engagement. The tone is informative and scholarly, contributing to a nuanced understanding of how thyroid functions adapt under different stress conditions.

AgreementModerate agreement

Many posts acknowledge the importance or relevance of the publication, with some explicitly referencing the concept of thyroid allostasis and its significance in different medical conditions.

InterestHigh interest

Posts demonstrate high curiosity by discussing complex mechanisms like the hypothalamic-pituitary-thyroid feedback loop, and referencing related conditions such as critical illness or psychiatric disorders.

EngagementHigh engagement

Several discussions delve into detailed interpretations of the research, mentioning specific phenomena like NTIS, TACITUS, and the adaptive responses of thyroid regulation, indicating deep cognitive involvement.

ImpactModerate impact

While the influence of the publication appears notable among those in the field of endocrinology and mental health, the overall immediate impact perception is moderate, as the posts are more analytical and theoretical rather than describing direct clinica

Abstract in brief

  • This article explains how the hypothalamus-pituitary-thyroid system adapts to different types of stress, such as illness, energy deprivation, and psychosocial factors, through a process called thyroid allostasis, which involves changing thyroid hormone levels to help the body cope.
  • It distinguishes between different stress responses: type 1 allostasis occurs during illness and energy deficits, leading to decreased thyroid hormone levels, while type 2 allostasis, associated with psychosocial stress and other conditions, can cause an opposite adaptive response.
  • The paper also discusses the nonthyroidal illness syndrome (NTIS) or TACITUS, a common pattern in hospitalized patients where thyroid hormone levels are altered—decreased in severe illness or during recovery—and emphasizes the importance of understanding these adaptive mechanisms for accurate diagnosis and treatment.]

Top posts

Most liked on X and Bluesky
Johannes W. Dietrich
@drjwdietrich · X

@RolandSB13 @dirkcremer @KJPGehrden @degampraesident Auch bei den ebenfalls häufigen #allostatisch​en Reaktionen (die gerade für #Psychiatrie und #Psychosomatik von besonderer Bedeutung sind), ist die #TSH-Bestimmung wenig geeignet, hier aber eher aus Gründen der #Spezifität als der #Sensitivität. https://t.co/3cfcPtEA7B

May 13, 2022 · 7 likes · 1,144 followers View post →
Johannes W. Dietrich
@drjwdietrich · X

The #setpoint of #thyroid #homeostasis may be elevated in the acute phase of #schizophrenia spectrum disorders. This reflects type 2 #allostatic_load. https://t.co/3cfcPtEA7B https://t.co/83e0DgQIQe https://t.co/7gNpy0HBV8

Feb 24, 2022 · 6 likes · 2 shares · 1,144 followers View post →
Dr Ashutosh Mishra MD
@Ashutos15050433 · X

Thyroid function Test. Chatzitomaris, A. et al. (2017) ‘Thyroid allostasis-adaptive responses of thyrotropic feedback control to conditions of strain, stress, and developmental programming’, Frontiers in Endocrinology, 8(JUL), pp. 1–28. doi: 10.3389/fendo.2017.00163 https://t.co/fRlFHRijUc

Nov 13, 2020 · 3 likes · 1,218 followers View post →
Johannes W. Dietrich
@drjwdietrich · X

@SPINATeam ...and it confirms our own earlier observations in the #NHANES dataset. https://t.co/3cfcPtEA7B https://t.co/83e0DgQIQe https://t.co/2toIo270dg

May 20, 2021 · 3 likes · 1 share · 1,144 followers View post →
Johannes W. Dietrich
@drjwdietrich · X

@drraviele @Dominik_Linz @ABollmannMD @rafavidalperez @AnastasiaSMihai @MDTolgaAksu @JonPicciniSr @PrashSanders @LuigiDiBiaseMD @TJaredBunch Another question is if type 2 #thyroid #allostasis in obesity could be an independent mediator for the development of atrial fibrillation. High T3 syndrome due to allostatic load might be a previously overlooked key actor. @dr_pmueller https://t.co/3cfcPtEA7B

Nov 16, 2020 · 3 likes · 1,144 followers View post →
Johannes W. Dietrich
@drjwdietrich · X

@aliloweth @MaryS58459511 @ThyroidBritish @britishthyroid @Soc_Endo @ETA_Thyroid @ThyroidTrust @AmThyroidAssn @youngdiab @SfE_thyronet Regarding allostatic responses of the feedback loop, which may raise or reduce TSH secretion, I would like to refer to our own review article from 2017. https://t.co/3cfcPtEA7B

Jun 11, 2023 · 3 likes · 1 share · 1,144 followers View post →

All mentions

Mary S
@MaryS58459511 · X

RT @drjwdietrich: @aliloweth @MaryS58459511 @ThyroidBritish @britishthyroid @Soc_Endo @ETA_Thyroid @ThyroidTrust @AmThyroidAssn @youngdiab…

Jun 11, 2023 · 1 share · 632 followers View post →
Johannes W. Dietrich
@drjwdietrich · X

@aliloweth @MaryS58459511 @ThyroidBritish @britishthyroid @Soc_Endo @ETA_Thyroid @ThyroidTrust @AmThyroidAssn @youngdiab @SfE_thyronet Regarding allostatic responses of the feedback loop, which may raise or reduce TSH secretion, I would like to refer to our own review article from 2017. https://t.co/3cfcPtEA7B

Jun 11, 2023 · 3 likes · 1 share · 1,144 followers View post →
AQUA FONTIS Study
@StudyAqua · X

@Age_and_Ageing Recently, the name "Thyroid allostasis in critical illness, tumours and uraemia" (TACITUS) has been suggested. It may be more appropriate. See https://t.co/TilY9IIScS for a review article.

Apr 8, 2023 · 46 followers View post →
Johannes W. Dietrich
@drjwdietrich · X

@5ter_Timo_vl @HDstabil 2. Generell sind Typ-1- und Typ-2-allostatische Reaktionen des #Hypophyse​n-#Schildrüse​n-#Regelkreis​es zu berücksichtigen, gerade bei kritischer Erkrankung und #ICU-Therapie. #Allostase https://t.co/3cfcPtEA7B https://t.co/OwfopCixbT

Mar 8, 2023 · 1 like · 1,144 followers View post →
Johannes W. Dietrich
@drjwdietrich · X

@richcollins This review articles summarises some of the scenarios involved: https://t.co/3cfcPtF7X9

Nov 6, 2022 · 2 likes · 1,144 followers View post →
Johannes W. Dietrich
@drjwdietrich · X

@RolandSB13 @dirkcremer @KJPGehrden @degampraesident Auch bei den ebenfalls häufigen #allostatisch​en Reaktionen (die gerade für #Psychiatrie und #Psychosomatik von besonderer Bedeutung sind), ist die #TSH-Bestimmung wenig geeignet, hier aber eher aus Gründen der #Spezifität als der #Sensitivität. https://t.co/3cfcPtEA7B

May 13, 2022 · 7 likes · 1,144 followers View post →
Dr. Shashank Joshi
@AskDrShashank · X

RT @drjwdietrich: The #setpoint of #thyroid #homeostasis may be elevated in the acute phase of #schizophrenia spectrum disorders. This refl…

Feb 24, 2022 · 2 shares · 32,526 followers View post →
Agnes Ayton
@AgnesAyton · X

RT @drjwdietrich: The #setpoint of #thyroid #homeostasis may be elevated in the acute phase of #schizophrenia spectrum disorders. This refl…

Feb 24, 2022 · 2 shares · 7,403 followers View post →
Johannes W. Dietrich
@drjwdietrich · X

The #setpoint of #thyroid #homeostasis may be elevated in the acute phase of #schizophrenia spectrum disorders. This reflects type 2 #allostatic_load. https://t.co/3cfcPtEA7B https://t.co/83e0DgQIQe https://t.co/7gNpy0HBV8

Feb 24, 2022 · 6 likes · 2 shares · 1,144 followers View post →
Johannes W. Dietrich
@drjwdietrich · X

@mendesthiagob What makes the interpretation even more complex is the fact that the #allostatic pattern of #NTIS / #ESS / #TACITUS depends on the phase of #illness. In acute disease it is slightly different from that in wasting syndrome. https://t.co/3cfcPtEA7B https://t.co/xkDbFDdold

Aug 15, 2021 · 2 likes · 1,144 followers View post →
AQUA FONTIS Study
@StudyAqua · X

@DavySRan A comprehensive introduction has been published as an open access article: https://t.co/TilY9IIScS

Aug 9, 2021 · 1 like · 46 followers View post →
Johannes W. Dietrich
@drjwdietrich · X

@FionaPWME @dr_kevinlee The full text of this paper is freely available from https://t.co/3cfcPtEA7B

Aug 8, 2021 · 1,144 followers View post →
Dr Kevin Lee
@dr_kevinlee · X

@FionaPWME @drjwdietrich And is it surprising that one of the energy balancing systems we have- Thyroid - has allostasis responses https://t.co/LmBFyIjroo https://t.co/kJnbvomPeW

Aug 8, 2021 · 1 like · 5,441 followers View post →
Johannes W. Dietrich
@drjwdietrich · X

@Herzspitze @rosarote_viggo Frage: Warum Lithium? Bipolare Erkrankung? Depression? Leider ist die Schilddrüsenfunktion bei affektiven Erkrankungen schwierig zu beurteilen, Typ-1-Allostase bei Depression, mitunter Typ 2 bei bipolaren Störungen. https://t.co/83e0DgQIQe

Jul 15, 2021 · 1,144 followers View post →
Johannes W. Dietrich
@drjwdietrich · X

For comparison, we observed a positive correlation between #BMI and #JTI in the large #NHANES dataset. https://t.co/3cfcPtEA7B 2/4 https://t.co/JT5GS65SQW

Jun 1, 2021 · 3 likes · 1,144 followers View post →
SPINA Team
@SPINATeam · X

RT @drjwdietrich: @SPINATeam ...and it confirms our own earlier observations in the #NHANES dataset. https://t.co/3cfcPtEA7B https://t.co/8…

May 20, 2021 · 1 share · 125 followers View post →
Johannes W. Dietrich
@drjwdietrich · X

@SPINATeam ...and it confirms our own earlier observations in the #NHANES dataset. https://t.co/3cfcPtEA7B https://t.co/83e0DgQIQe https://t.co/2toIo270dg

May 20, 2021 · 3 likes · 1 share · 1,144 followers View post →
Johannes W. Dietrich
@drjwdietrich · X

@EThyroidCancer Substitution therapy of low-T3 sydrome remains to represent a controvery. https://t.co/83e0DgQIQe https://t.co/94fbtrrzAl

Feb 20, 2021 · 1 like · 1,144 followers View post →
Johannes W. Dietrich
@drjwdietrich · X

@dr_kevinlee @ProfDocHealth The BMI correlates to SPINA-GD and Jostel's TSH index. We have shown this with the NHANES dataset a few years ago. https://t.co/zeHVlGtUK4

Jan 9, 2021 · 1,144 followers View post →
Johannes W. Dietrich
@drjwdietrich · X

@ProfDocHealth @dr_kevinlee We have written a review article including this topic a few years ago: https://t.co/3cfcPtEA7B

Jan 9, 2021 · 1 like · 1,144 followers View post →
Johannes W. Dietrich
@drjwdietrich · X

@drraviele @Dominik_Linz @ABollmannMD @rafavidalperez @AnastasiaSMihai @MDTolgaAksu @JonPicciniSr @PrashSanders @LuigiDiBiaseMD @TJaredBunch Another question is if type 2 #thyroid #allostasis in obesity could be an independent mediator for the development of atrial fibrillation. High T3 syndrome due to allostatic load might be a previously overlooked key actor. @dr_pmueller https://t.co/3cfcPtEA7B

Nov 16, 2020 · 3 likes · 1,144 followers View post →
Dr Ashutosh Mishra MD
@Ashutos15050433 · X

Thyroid function Test. Chatzitomaris, A. et al. (2017) ‘Thyroid allostasis-adaptive responses of thyrotropic feedback control to conditions of strain, stress, and developmental programming’, Frontiers in Endocrinology, 8(JUL), pp. 1–28. doi: 10.3389/fendo.2017.00163 https://t.co/fRlFHRijUc

Nov 13, 2020 · 3 likes · 1,218 followers View post →
Johannes W. Dietrich
@drjwdietrich · X

@JenHSebring https://t.co/83e0DgQIQe may be helpful.

Aug 26, 2020 · 1,144 followers View post →
AQUA FONTIS Study
@StudyAqua · X

RT @drjwdietrich: #Hypothalamic neurons integrate multiple afferences to the set point of #thyroid #homeostasis and encode it as #TRH. http…

Sep 10, 2019 · 4 shares · 46 followers View post →
AQUA FONTIS Study
@StudyAqua · X

RT @SimThyrTeam: Simulations w/ #SimThyr help to understand central components of #TACITUS syndrome. #NTIS #Thyroid #TACITUS_Syndrome https…

Sep 10, 2019 · 4 shares · 46 followers View post →
AQUA FONTIS Study
@StudyAqua · X

RT @drjwdietrich: Different conditions and diseases predispose to type 1 and type 2 #thyroid #allostasis, respectively. https://t.co/eGC83i…

Sep 10, 2019 · 4 shares · 46 followers View post →
AQUA FONTIS Study
@StudyAqua · X

RT @drjwdietrich: #NTIS has two related, but distinct phenotypes, #TACITUS in acute #disease and #WastingSyndrome in chronic #illness. http…

Sep 10, 2019 · 2 shares · 46 followers View post →
AQUA FONTIS Study
@StudyAqua · X

RT @drjwdietrich: Complex networks linking #amygdala & #hypothalamus mediate type 2 #Thyroid_Allostasis in #PTSD & #PsychiatricDisease http…

Sep 10, 2019 · 5 shares · 46 followers View post →
thyroidie
@thyroidie · X

RT @CanadianThyroid: Don't be blinded by TSH. Look at the #T3 and T4 disorders that TSH cannot see. Chatzitomaris et al(2017). "Thyroid All…

Apr 21, 2019 · 4 shares · 166 followers View post →
Johannes W. Dietrich
@drjwdietrich · X

RT @CanadianThyroid: Don't be blinded by TSH. Look at the #T3 and T4 disorders that TSH cannot see. Chatzitomaris et al(2017). "Thyroid All…

Apr 20, 2019 · 4 shares · 1,144 followers View post →
17 Cytokines
@ProfoundFatigue · X

RT @drjwdietrich: Low #T3 and high reverse T3 mark the endocrine signature of #Thyroid_Allostasis in #starvation. #rT3 #Leptin https://t.c…

Apr 2, 2019 · 4 shares · 888 followers View post →