Modulation of Astrocyte Activity by Cannabidiol, a Nonpsychoactive Cannabinoid.

Abstract in brief

• The text discusses the role of astrocytes, a type of brain cell, and how they can be targeted for neurotherapy, with a focus on the cannabinoid system and its nonpsychoactive compound, cannabidiol (CBD).
• CBD does not directly activate the main cannabinoid receptors (CB1 and CB2), but it influences astrocyte activity, often suppressing overactivation in various brain injury and disease models like stroke, Alzheimer’s, multiple sclerosis, nerve injury, epilepsy, and schizophrenia.
• The collected research indicates that CBD can reduce inflammation and harmful signaling in astrocytes, promoting neuroprotection and potentially improving central nervous system functions in these conditions.