Genome Biol August 2017 PMID 28800781

Knowledge-guided gene prioritization reveals new insights into the mechanisms of chemoresistance.

Amin Emad, Junmei Cairns, Krishna R Kalari, Liewei Wang, Saurabh Sinha

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Peak: 1 in Sep 2017

across 3 sources since Sep 2017

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110

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Sep 2017 – Feb 2021

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AI synopsis

What people are saying

The items highlight technical aspects like ProGENI and knowledge integration, with mentions of conferences such as Cold Spring Harbor Lab, suggesting a focus on scientific advancement. Words like 'discuss' and 'via' imply informational exchange rather than passionate advocacy, reflecting a neutral tone and moderate interest.

AgreementNeither agree nor disagree

Most discussions seem neutral or mildly positive, with little indication of strong disagreement or skepticism about the publication.

InterestModerate interest

Participants show some curiosity, especially regarding new methods like ProGENI and their applications.

EngagementModerate engagement

Conversations include references to specific techniques and conferences, indicating a moderate level of interaction and engagement.

ImpactNeutral impact

The discussions acknowledge the significance of gene prioritization and its potential impact, but do not express overwhelming enthusiasm.

Abstract in brief

Identifying genes that predict tumor cell sensitivity to chemotherapy is important for personalized cancer treatment and understanding drug mechanisms.
A new method called ProGENI was developed to identify these impactful genes, using both gene expression data and existing knowledge of protein interactions.
ProGENI improved predictions of drug sensitivity significantly and identified genes that can help overcome drug resistance, with around 73% of highly predicted genes affecting drug responses in tested cancer cell lines.

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All mentions

Gene Prioritization for Chemoresistance Using ProGENI and KnowEnG

Presentation on KnowEnG platform and ProGENI, a novel method for gene prioritization related to cancer drug response, highlighting improved predictions of drug sensitivity and insights into chemoresistance mechanisms.

Amin Emad · Sep 5, 2017 99 views

Didar Mura

@DidarMurad1 · X

Talk on ProGENI and KnowEnG at Cold Spring Harbor Lab 2016 https://t.co/wNUpUZ7RRF via @YouTube

Feb 26, 2021 · 1 like · 11 followers View post →