PubHawk
Annu Rev Nutr August 2017 PMID 28826372

β-Hydroxybutyrate: A Signaling Metabolite.

John C Newman, Eric Verdin

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Mentions

48
Peak: 9 in Jul 2021
across 5 sources since Jun 2019

Extended reach

1,713,552
potential audience

Total likes

28,723

Video views

1,503,212

Mentions per month

Jun 2019 – Jul 2025

Where it's discussed

  • News18 articles
  • X / Twitter14 posts
  • YouTube9 videos
  • Facebook4 posts
  • Blogs3 articles

AI synopsis

What people are saying

The discussions mainly revolve around the role of BHB as a signaling molecule, with references to prominent scientists like Dr. Newman and David Sinclair, and mention of studies on gene splicing and metabolism, which reflect a strong interest in scientific details. The tone is analytical and curious, with some posts sharing personal health challenges, indicating engagement with practical implications of the research, but the overall emphasis remains on understanding BHB's biological significance and potential benefits.

AgreementModerate agreement

Most posts acknowledge the significance of BHB and its related research, referencing influential scientists and studies, which indicates general support or recognition of its value.

InterestHigh interest

The discussions show high engagement with topics like gene research, metabolic pathways, and diet strategies, reflecting strong curiosity about the subject.

EngagementModerate engagement

Posts include mentions of specific molecular mechanisms, personal challenges, and reviews, suggesting a moderate level of detailed engagement with the science and practical applications.

ImpactModerate impact

While some discussions highlight potential health benefits, diet implications, and scientific advancements, the overall impact appears moderate, emphasizing interest rather than immediate transformative change.

Abstract in brief

  • Hydroxybutyrate (BHB) is a ketone body produced in the liver from fats, mainly used to supply energy to tissues when glucose levels are low, such as during fasting or prolonged exercise.
  • Beyond its role as an energy source, BHB also acts as a signaling molecule that influences cellular functions, gene expression, and interacts with the environment, potentially affecting health and aging.
  • These mechanisms of BHB are important for understanding how the body adapts to dietary stress and may have implications for treating various diseases and understanding the aging process.
Read the full abstract

Top posts

Most liked on X and Bluesky
文月宵(ケトン人)
@fumizukishou_bc · X

ケト代謝はグルコジェニックに比べてNAD総量が高く維持されますよって話 DNAの修復や老化に関わる話ぞ グルコさんと雑ケトさん、どんまい。 https://t.co/WqKNKbDV4d https://t.co/sarrxdR7nn

Nov 21, 2021 · 6 likes · 2 shares · 723 followers View post →
Beef Ent.
@BeefEnt · X

https://t.co/TBpN0HOH5c

Jul 6, 2021 · 2 likes · 135,738 followers View post →
Brandon Roberts, PhD, MBA, CSCS, TSAC-F, FISSN
@BM_Roberts_SkM · X

Of course Dr. Newman’s seminal ketone work played a role https://t.co/hqgHiiJ9L0

Nov 15, 2022 · 2 likes · 1,597 followers View post →
Andrew Koutnik, Ph.D.
@AKoutnik · X

Ketogenic Diet? -anti-cancer reports: https://t.co/2euyBZDXrE -mitigate atrophy in low-IGF-1/insulin environments: see pub cites -multifactorial potential: https://t.co/nKvY7inGB0). -Problem: Compliance, Lifestyle Change, Potential Weight Loss 11/n

Apr 14, 2020 · 1 like · 7,149 followers View post →
Coach Brandon Neilson
@CoachNeilson_FB · X

I do have to credit @ThomasDeLauer for this 48hr fast. He’s putting on the challenge. Here is a link to the challenge https://t.co/oK9TjyPuWl

Jul 10, 2021 · 1 like · 1,197 followers View post →
Brady Holmer
@Brady_H · X

@jerryteixeira @CakeNutrition @MichaelAlbertMD Great review here: https://t.co/sB1rCldlkF

Jun 12, 2021 · 27,277 followers View post →

All mentions

Brandon Roberts, PhD, MBA, CSCS, TSAC-F, FISSN
@BM_Roberts_SkM · X

Of course Dr. Newman’s seminal ketone work played a role https://t.co/hqgHiiJ9L0

Nov 15, 2022 · 2 likes · 1,597 followers View post →
The Never Diet
@ZsoltNagy7 · X

@renatodumbra @Uncensored_ie @BioLayne Well I'm sure you heard of the work of @davidasinclair @eatlikeanimals etc If not here is summary on how bhb effects the body https://t.co/skGu2tMv2E

May 2, 2022 · 1,401 followers View post →
T. Morimura
@hushmark · X

RT @fumizukisho_nnc: ケト代謝はグルコジェニックに比べてNAD総量が高く維持されますよって話 DNAの修復や老化に関わる話ぞ グルコさんと雑ケトさん、どんまい。 https://t.co/WqKNKbDV4d https://t.co/sarrxdR7…

Nov 21, 2021 · 2 shares · 1,080 followers View post →
文月宵(ケトン人)
@fumizukishou_bc · X

ケト代謝はグルコジェニックに比べてNAD総量が高く維持されますよって話 DNAの修復や老化に関わる話ぞ グルコさんと雑ケトさん、どんまい。 https://t.co/WqKNKbDV4d https://t.co/sarrxdR7nn

Nov 21, 2021 · 6 likes · 2 shares · 723 followers View post →
Kennywayne
@0kennywayne · X

New Keto Holy Grail | Gene Splicing and DNA Study https://t.co/dcDTYs6DYL via @YouTube

Aug 3, 2021 · 96 followers View post →
Devorah Firestone ✡
@devorahf · X

@ThomasDeLauer Cool ! New Keto Holy Grail | Gene Splicing and DNA Study https://t.co/XAdtRNhwxr via @YouTube

Jul 31, 2021 · 3,631 followers View post →
David Thomas
@davidthomasweb · X

https://t.co/M9fcUWyLio https://t.co/VBHVphGASN What's the Best Weight Loss Method for Men Over 50? Cutting down weight and burning calories can be difficult especially for men who are over the age of 50.

Jul 31, 2021 · 3 followers View post →
Cheo (Chāy Ō)
@CheoWalker · X

Thomas DeLauer New Keto Holy Grail | Gene Splicing and DNA Study https://t.co/BxDrsTZFdz #keto

Jul 31, 2021 · 348 followers View post →
Coach Brandon Neilson
@CoachNeilson_FB · X

I do have to credit @ThomasDeLauer for this 48hr fast. He’s putting on the challenge. Here is a link to the challenge https://t.co/oK9TjyPuWl

Jul 10, 2021 · 1 like · 1,197 followers View post →
Beef Ent.
@BeefEnt · X

https://t.co/TBpN0HOH5c

Jul 6, 2021 · 2 likes · 135,738 followers View post →
Brianna Stubbs
@BriannaStubbs · X

@ifbacongrewont1 @americanaging Its a long one but this review summaries what we know about BHB itself- how it is metabolized, how it modifies receptor activity and how it affects gene expression - that might answer some of the questions about what molecularly is having an effect https://t.co/e6H3jH6Lcp

Jun 22, 2021 · 4,030 followers View post →
Brady Holmer
@B_Holmer · X

@jerryteixeira @CakeNutrition @MichaelAlbertMD Great review here: https://t.co/sB1rCldlkF

Jun 12, 2021 · 26,064 followers View post →
Brady Holmer
@Brady_H · X

@jerryteixeira @CakeNutrition @MichaelAlbertMD Great review here: https://t.co/sB1rCldlkF

Jun 12, 2021 · 27,277 followers View post →
Andrew Koutnik, Ph.D.
@AKoutnik · X

Ketogenic Diet? -anti-cancer reports: https://t.co/2euyBZDXrE -mitigate atrophy in low-IGF-1/insulin environments: see pub cites -multifactorial potential: https://t.co/nKvY7inGB0). -Problem: Compliance, Lifestyle Change, Potential Weight Loss 11/n

Apr 14, 2020 · 1 like · 7,149 followers View post →