Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes.
The group exhibits strong support and curiosity, with discussions referencing technical studies like Ethan Russo’s 2016 paper, citing historical and scientific examples of cannabis use, and emphasizing the potential for new treatments. Words like 'support,' 'important,' and references to scientific evidence and historical context reveal a high level of engagement and perceived impact.
AgreementStrong agreement
Most discussions strongly support the article’s thesis, referencing its findings and emphasizing the importance of considering endocannabinoid deficiency in treatment-resistant syndromes.
InterestHigh interest
The discussions show high interest, with many users engaging deeply, sharing related research, and reflecting on medical implications.
EngagementHigh engagement
Posts demonstrate high engagement through sharing studies, scientific explanations, historical references, and personal testimonies about the significance of the findings.
ImpactHigh impact
The widespread and detailed conversations suggest a significant impact on community perspectives, with users framing the research as potentially transformative for understanding and treating chronic conditions.
Abstract in brief
The article discusses the theory that a clinical endocannabinoid deficiency may underlie treatment-resistant pain syndromes such as migraine, fibromyalgia, and irritable bowel syndrome, which often share symptoms like hyperalgesia and central sensitization.
Initially proposed in 2001 based on genetic and symptom overlap, recent research now provides more robust evidence, such as altered endocannabinoid levels in cerebrospinal fluid and evidence of endocannabinoid system hypofunction in conditions like PTSD.
The theory suggests that deficiencies in endocannabinoids like anandamide may contribute to these syndromes’ pathology, and that targeting this system with cannabinoid-based therapies could potentially offer symptomatic relief.]
@marydsoco @David_Cormack Here’s a 12th century mosaic of Jesus healing the blind. Please note the cannabis tree. Here’s a scientific explanation https://t.co/TqQ3A9FPRq and here’s a scientific explanation for deficiencies/illnesses https://t.co/qFnmHLwPhD https://t.co/Vz7NQs6qVx
Dec 9, 2019 · 29 likes · 10 shares · 702 followersView post →
CC
Canna Claus
@ClarkeBitter · X
Cannabinoid deficiency syndrome should be spoken about FAR more than so called cannabis dependency syndrome, because the latter does not exist. ✌️
Clinical Endocannabinoid Deficiency
In 2016, Russo published a study entitled "Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in #Migraine, #Fibromyalgia, Irritable Bowel, & Other Treatment-Resistant Syndromes."
Nov 14, 2021 · 7 likes · 6 shares · 12,263 followersView post →
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WeRateWeed™
@WeedRaters · X
In addition to #fibromyalgia & #IBS, other disorders that may fall under Clinical Endocannabinoid Deficiency include cystic fibrosis, #neuropathy, phantom limb pain, #glaucoma, #dysmenorrhea, repetitive #miscarriages, #PTSD, #bipolar disease & many others. https://t.co/jsQhcczx0d https://t.co/Aod3MFPCgd
Mar 12, 2019 · 6 likes · 2 shares · 1,973 followersView post →
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Milla
@MillieAnhouilh · X
Spannendes Thema....
https://t.co/ihSAwnjHq3
(Ethan B. Russo. Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes.) #verfassungsWEEDrig
Feb 3, 2020 · 4 likes · 1 share · 508 followersView post →
RB
Roy Biggins
@RoyBiggins3 · X
@CoDoc442 Because a cannabinoid deficiency can cause irritable bowel syndrome.
Cannabis is the cure.
https://t.co/YZHwk8m87i
Dr. DawnElise Snipes discusses the triggers and effects of migraines, offering valuable tips for managing this condition. She is an expert in mental health counseling with international training experience. This video…
This episode explores the connection between cannabis and migraines, highlighting historical use, recent research, and the potential of THC and CBD to impact migraine pathways, supported by clinical trial findings and…
RT @tstopford: @marydsoco @David_Cormack Here’s a 12th century mosaic of Jesus healing the blind. Please note the cannabis tree. Here’s a s…
Nov 26, 2025 · 10 shares · 702 followersView post →
CF
Cedar Gulch Farms
@CedarGulchFarms · X
@medsavage @IAGuy06 @MAstronomers If it's a "drug", explain why we can have a "deficiency".
Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes
https://t.co/0RqbsKvEE5
Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes
pmc.ncbi.nlm.nih.gov/articles/PMC...
Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes
https://t.co/zF5Y0PgcAA
Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes - PubMed https://t.co/I5ikwQg0CI
Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes - PMC https://t.co/MTnORhIdTe
RT @tstopford: @marydsoco @David_Cormack Here’s a 12th century mosaic of Jesus healing the blind. Please note the cannabis tree. Here’s a s…
Mar 19, 2024 · 10 shares · 864 followersView post →
JL
Juan T. Llibre
@OrejaDeZumbador · X
@DickTracy1988 ¿Te basta con una publicacion del NATIONAL INSTITUTE OF HEALTH DEL GOBIERNO DE USA?
NO SE PUEDE NEGAR LA EXISTENCIA
DEL SISTEMA CANABINOIDE HUMANO.
Tiene funciones específicas para proteger el cuerpo. Negarlo es negar lo que la medicina ha descubierto.
https://t.co/3d77kc6cMu
@AddictChapstick @MotherNature @SnarlyMae @atrupar You're right, it isn't evidence; my decision to use it was based on medical studies. Here are two.
https://t.co/R5hhVBXbER
https://t.co/htNhMAFLou
Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, I…
"pathophysiology suggests that a clinical endocannabinoid deficiency might characterize their origin" Eat the 550 nutrients to heal sick
https://t.co/toDjLU3nJ4
@Santiagoinlv @MythinformedMKE @MZHemingway https://t.co/RAZsAASs0o
#endocannabinoidsystem deficiency AND #Programmedpromiscuity =
#psychosexualambiguity
Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, #IrritableBowel & Other Treatment-Resistant Syndromes
@terejoyce @Prolotario1 The END
#endocannabinoidsystem
#endocannabinoidsystemdeficiency
Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes
Ethan B Russo.
https://t.co/RAZsAASZPW
@akuuttigeriatri @TeppoSyvarila @Kaeaentoepuoli @NevalainenOlli @SinakinB @kailintunen @Liberaalipuolue @MattiMuukkonen Huomioiden koko ihmisen endokannabinoidijärjestelmän merkityksen ihmiselle, vaikuttaa väitteesi kannabiksen neurotoksisuudesta aika kaukaa haetuilta. https://t.co/062O9ZaNXT
RT @tstopford: @marydsoco @David_Cormack Here’s a 12th century mosaic of Jesus healing the blind. Please note the cannabis tree. Here’s a s…
Feb 20, 2023 · 10 shares · 2,083 followersView post →
GO
Greenthumb_one
@Greenthumb_one · X
Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and OtherTreatment-Resistant Syndromes
https://t.co/9Hih27kH5V
Feb 12, 2023 · 1 like · 4,509 followersView post →
CW
Canna World
@CannaWorld4 · X
Preventative medicine - just a shift of paradigm away
Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes
https://t.co/M6cEMMO9Tp
Feb 9, 2023 · 1 like · 21,364 followersView post →
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MrWolf48449241
@MrWolf48449241 · X
@GuardianAus Ask your GP if they're allowed, or willing, to prescribe centuries old practices for dealing with, among other things, sleep disorders.
https://t.co/2CGPOtZwzF
@MathewLeonardi @SofiaMakieva @zoyaalii_ @EndometriosisUK @HelenLucyMc @EndoDundee @EndoEdition A #pharmacometabolomics saliva based validation tool to detect differences in the #endocannabinoid system (#ECS) in patients with endo vs non-sufferers? ECS implicated in endo & many comorbidities:
https://t.co/E4v5bc9MlH
https://t.co/14fWwCItbg
https://t.co/OOYu9Ch8d3
Mar 26, 2022 · 3 likes · 1 share · 1,123 followersView post →
SS
Sam's Wellness Shop
@SamsWellShop · X
RT @CannabisCourse1: Clinical Endocannabinoid Deficiency
2016: Study re endocannabinoid deficiency: "Clinical #Endocannabinoid Deficiency…
Clinical Endocannabinoid Deficiency
2016: Study re endocannabinoid deficiency: "Clinical #Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in #Migraine, #Fibromyalgia, Irritable Bowel, Other Treatment-Resistant Syndromes."
Feb 18, 2022 · 2 likes · 1 share · 1,182 followersView post →
AP
Andrew Proudfoot
@ProudyMan1 · X
@kearnsneuro What’s your view on the pathway being: EBV ➡️ Clinical Endocannabinoid Deficiency ➡️ MS ?
https://t.co/4CDYNAGKbX
https://t.co/E4v5bc9MlH
https://t.co/pp2d1rFtvu
RT @RobbinsGroupLLC: Clinical Endocannabinoid Deficiency
In 2016, Russo published a study entitled "Clinical Endocannabinoid Deficiency Re…
Nov 15, 2021 · 6 shares · 1,682 followersView post →
A
AmericannaBlunt♡˖
@AmeriCannaBlunt · X
RT @RobbinsGroupLLC: Clinical Endocannabinoid Deficiency
In 2016, Russo published a study entitled "Clinical Endocannabinoid Deficiency Re…
Nov 15, 2021 · 6 shares · 18,525 followersView post →
T
TheHealthyChap
@healthy_chap · X
RT @RobbinsGroupLLC: Clinical Endocannabinoid Deficiency
In 2016, Russo published a study entitled "Clinical Endocannabinoid Deficiency Re…
Nov 15, 2021 · 6 shares · 251 followersView post →
HL
Higher Learning LV
@HigherLvtm · X
RT @RobbinsGroupLLC: Clinical Endocannabinoid Deficiency
In 2016, Russo published a study entitled "Clinical Endocannabinoid Deficiency Re…
Nov 15, 2021 · 6 shares · 1,778 followersView post →
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Calvin
@Calrtipper · X
RT @RobbinsGroupLLC: Clinical Endocannabinoid Deficiency
In 2016, Russo published a study entitled "Clinical Endocannabinoid Deficiency Re…
Nov 14, 2021 · 6 shares · 15,605 followersView post →
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Rick
@tripprrr · X
RT @RobbinsGroupLLC: Clinical Endocannabinoid Deficiency
In 2016, Russo published a study entitled "Clinical Endocannabinoid Deficiency Re…
Nov 14, 2021 · 6 shares · 24,913 followersView post →
GR
Gooey Rabinski
@RobbinsGroupLLC · X
Clinical Endocannabinoid Deficiency
In 2016, Russo published a study entitled "Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in #Migraine, #Fibromyalgia, Irritable Bowel, & Other Treatment-Resistant Syndromes."
Nov 14, 2021 · 7 likes · 6 shares · 12,263 followersView post →
TP
The Higher Learning LV Podcast
@TheHLLVPodcast · X
One of our favorite Quick Read articles > https://t.co/abZZMVl9jp
"2016: Russo study re ECS deficiency: 'Clinical #Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in #Migraine, #Fibromyalgia, Irritable Bowel, & Other Treatment-Resistant Syndromes.'"
One of our favorite Quick Read articles > https://t.co/abZZMVCKaX
"2016: Russo study re ECS deficiency: 'Clinical #Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in #Migraine, #Fibromyalgia, Irritable Bowel, & Other Treatment-Resistant Syndromes.'"
Oct 4, 2021 · 2 likes · 1,182 followersView post →
TP
The Higher Learning LV Podcast
@TheHLLVPodcast · X
One of our favorite Quick Read articles > https://t.co/abZZMVCKaX
"2016: Russo study re ECS deficiency: 'Clinical #Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in #Migraine, #Fibromyalgia, Irritable Bowel, & Other Treatment-Resistant Syndromes.'"
One of our favorite Quick Read articles > https://t.co/abZZMVCKaX
"2016: Russo study re ECS deficiency: 'Clinical #Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in #Migraine, #Fibromyalgia, Irritable Bowel, & Other Treatment-Resistant Syndromes.'"
One of our favorite Quick Read articles > https://t.co/WppOwn3Grz
"2016: Russo study re ECS deficiency: 'Clinical #Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in #Migraine, #Fibromyalgia, Irritable Bowel, & Other Treatment-Resistant Syndromes.'" https://t.co/hi9pwTgLWT
Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes - PubMed https://t.co/Vh1j995DBx
Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes https://t.co/zcY095938l
RT @tstopford: @marydsoco @David_Cormack Here’s a 12th century mosaic of Jesus healing the blind. Please note the cannabis tree. Here’s a s…
Jan 30, 2021 · 10 shares · 19,949 followersView post →
C
charity479
@charity479 · X
Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes https://t.co/bQN6PGS1BX
Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes https://t.co/jUJ1IpqByo
Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes
https://t.co/CVo73twm4W
Spannendes Thema....
https://t.co/ihSAwnjHq3
(Ethan B. Russo. Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes.) #verfassungsWEEDrig
Feb 3, 2020 · 4 likes · 1 share · 508 followersView post →
TS
tadhg stopford
@tstopford · X
@marydsoco @David_Cormack Here’s a 12th century mosaic of Jesus healing the blind. Please note the cannabis tree. Here’s a scientific explanation https://t.co/TqQ3A9FPRq and here’s a scientific explanation for deficiencies/illnesses https://t.co/qFnmHLwPhD https://t.co/Vz7NQs6qVx
Dec 9, 2019 · 29 likes · 10 shares · 702 followersView post →
BC
Blue Harvest CBD
@blueharvestcbd · X
The endocannabinoid system is our body’s network of receptors that act to moderate pain, the immune system, mood, sleep, appetite and memory. As a rule, when things are out of whack in our bodies, it tells us.
reference: https://t.co/bsHE191JFN https://t.co/jzdbQTIefe
"Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes"
- Ethan B. Russo
Join my group here to learn... https://t.co/X5ChePPfIz
Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes https://t.co/Qq6rmSQSHe
@MaraBG Isn't it great you can get the word maladies into a tweet or conversation! Dr Ethan Russo on the other hand gets it into journals in an MC context: Love it! https://t.co/E4v5bbRD7z
Jul 30, 2019 · 1 like · 1,123 followersView post →
CD
Connie Docekal
@DocekalConnie · X
Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes https://t.co/ImfjOgUfSi
Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes https://t.co/CVo73twm4W
Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes https://t.co/HLNNN95T8r
Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes https://t.co/ImfjOhbRgS
uhnanihmuss: RT @SeedBankME: Cannabis Science:
Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes
#Cannabis
https://t.co/QgQPRIzR4N
RT @SeedBankME: Cannabis Science:
Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibro…
Jun 10, 2019 · 1 share · 1,741 followersView post →
CD
Cannabis Seed Bank of ME • R&D
@SeedBankME · X
Cannabis Science:
Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes
#Cannabis
https://t.co/dfguEfvh51
Jun 9, 2019 · 3 likes · 1 share · 2,594 followersView post →
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Ros
@ros_tinkler · X
RT @DocekalConnie: Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irrita…
Jun 1, 2019 · 1 share · 3,470 followersView post →
CD
Connie Docekal
@DocekalConnie · X
Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes https://t.co/ImfjOhbRgS
Jun 1, 2019 · 2 likes · 1 share · 10 followersView post →
GL
gina lynch
@lynch_gina · X
Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes https://t.co/TsCFsJFYDc
Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes https://t.co/5bFiO7ldfG
Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes https://t.co/V0OdnjNwyw
Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes https://t.co/zgFSW2ou8f
Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes https://t.co/rOiDOLMCEZ
Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes
https://t.co/ygNxIdSleG
WOW - this is interesting and hits close to home for me! #fibromyalgia #chronicpain #cbd #migraine
A 2016 study suggested that a lack of endocannabinoids — neurotransmitters that bind to cannabinoid receptors — may be at the root o…https://t.co/XI2XYnAVpW https://t.co/1rmMsTzyZ1
In addition to #fibromyalgia & #IBS, other disorders that may fall under Clinical Endocannabinoid Deficiency include cystic fibrosis, #neuropathy, phantom limb pain, #glaucoma, #dysmenorrhea, repetitive #miscarriages, #PTSD, #bipolar disease & many others. https://t.co/jsQhcczx0d https://t.co/Aod3MFPCgd
Mar 12, 2019 · 6 likes · 2 shares · 1,973 followersView post →
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WeRateWeed™
@WeedRaters · X
Does clinical endocannabinoid deficiency lead to chronic diseases like #migraine, #fibromyalgia, #IBS & other treatment-resistant syndromes?
There is commonality in symptomatology & overlap in the affected populations with possible common pathophysiology. https://t.co/b47l5o0nwG https://t.co/JNkAhDI7q4
Mar 11, 2019 · 2 likes · 1 share · 1,973 followersView post →
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CannaLytica
@CannaLytica · X
In his 2016 paper in Cannabis and Cannabinoids Research, @ICCI_science's Ethan Russo lays out the range of medical problems that may result from #EndocannabinoidSystem dysfunction, treatable with #Cannabinoids. Funding, regulation, research. #MMJ
https://t.co/O3y9cWCJuK
Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes | Cannabis and Cannabinoid Research https://t.co/6imDnTg6D0
https://www.liebertpub. com/doi/pdf/10.1089/can.2016.0009 Prior to the ban,Agricultural Hemp was the primary source worldwide for paper, clothing, rope and ...
Cannabis Therapeutics and The Future of | PDF | Medical Cannabis ...
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Cannabis Cannabinoid Res. 1, 154–165. Cardiovascular effects of marijuana and synthetic cannabinoids: the good, doi: 10.1089/can.2016.0009 the bad, and ...
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and communication, but those who do often can use to modify their voice and communica- ... 10.1089/trgh.2017.0023. Lane, A., & Wilson, T. A. (2020) ...
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... can also explore whether citizen movements alone, absent external ... 10.1353/jod.2016.0009. GO TO REFERENCE. Crossref · Web of Science · Google ...
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