November 2017 PMID 28877913

Low-Density Lipoprotein Cholesterol Lowering for the Primary Prevention of Cardiovascular Disease Among Men With Primary Elevations of Low-Density Lipoprotein Cholesterol Levels of 190 mg/dL or Above: Analyses From the WOSCOPS (West of Scotland Coronary Prevention Study) 5-Year Randomized Trial and

Antonio J Vallejo-Vaz, Michele Robertson, Alberico L Catapano, Gerald F Watts, John J Kastelein, Chris J Packard, Ian Ford, Kausik K Ray

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Mentions

146

Peak: 4 in Nov 2023

across 6 sources since Jan 2019

Extended reach

947,504

potential audience

Total likes

11,563

Video views

500,751

Mentions per month

Jan 2019 – Nov 2025

Where it's discussed

News106 articles
X / Twitter21 posts
Facebook14 posts
YouTube2 videos
Blogs2 articles
Bluesky1 posts

AI synopsis

What people are saying

Discussions highlight the importance of the WOSCOPS findings, with users referencing statistics like a 27% reduction in heart disease risk and debates on the long-term benefits of statins, emphasizing both their relevance and transformative potential in preventive cardiology. The tone reflects a mix of scientific interest and advocacy, making the overall discourse highly meaningful and impactful.

AgreementModerate agreement

Most discussions acknowledge the positive findings of the WOSCOPS study, supporting statin use in high LDL cases.

InterestHigh interest

The discussions show high engagement with the topic of LDL levels and statin benefits, indicating a strong interest in primary prevention.

EngagementHigh engagement

Participants delve into details like long-term effects, adherence data, and risk reduction, demonstrating deep engagement.

ImpactHigh impact

Many posts emphasize the significant clinical implications, advocating for proactive treatment to prevent cardiovascular events.

Abstract in brief

* The analysis utilized data from the WOSCOPS trial to evaluate the cardiovascular benefits of lowering LDL-C in individuals without existing heart disease, comparing those with LDL-C <190 mg/dL and those with ≥190 mg/dL.
* Results indicated that pravastatin reduced coronary heart disease risk by 27% and major cardiovascular events by 25%, showing consistent effectiveness regardless of LDL-C levels.

Read the full abstract

Top posts

Most liked on X and Bluesky

Ahmed Sayed

@ASayedMD · X

Pleased to share our new paper just published in @JAMACardio Link:

Nov 2, 2023 · 28 likes · 4 shares · 475 followers View post →

Adam Gaertner

@veryvirology · X

@tinytim0101 Cancer: https://t.co/pj4pZDwyEn Cerebrovascular: https://t.co/rv1Q0Fh2wU https://t.co/lqsXPfRfIq Coronary: https://t.co/ePSxAI04fl Diabetes: https://t.co/YJrOrpTgFk Aging: https://t.co/tae3aFc4pR Hypertension: (Pfizer) https://t.co/Ezyo2tq4A1 Pneumonia: https://t.co/RYicUmSFEb ..

Oct 26, 2020 · 5 likes · 1 share · 83,061 followers View post →

Raphael Sirtoli

@raphaels7 · X

@DoctorTro @LDLSkeptic @holmanm @mrc314 @doctor original WOSCOPs was published in 1992 & 1995, burying the adherence data the supplementary data of this 2017 analysis of WOSCOPS revealed how in the first 5 years both groups took pravastatin at similar rates (35.2% control vs 37.8% intervention) https://t.co/9LuVGE0vem https://t.co/z5LaIL6DBO

Aug 23, 2023 · 5 likes · 1 share · 8,595 followers View post →

Gregg Fonarow MD

@gcfmd · X

@venkmurthy @CaptRockyBob @VietHeartPA @khurramn1 @MichaelJBlaha @mdmiedema @DavidLBrownMD @boback @rauldsf_santos @almallahmo @MBittencourtMD @MethodistHosp @NadeenFaza @MasriAhmadMD @WilliamZoghbi @pabeda1 @JJheart_doc @pnatarajanmd @thebyrdlab RTC data on statins in primary prevention pts with LDL 190 or above. Short, intermediate, and long term benefits including lower mortality. Benefits dramatically outweigh risks across the board. Why wait till advanced to plaque or an event? Prevent it. https://t.co/qJXb0VznsL

Jan 9, 2019 · 4 likes · 1 share · 11,910 followers View post →

DoctorTro

@DoctorTro · X

@jengates WOSCOPS: https://t.co/dHJ7svrHN4

Jun 19, 2021 · 3 likes · 162,664 followers View post →

Juan Senior

@jsenior64 · X

@endocrinorosero @DrFisioloco @drpablocorral La evidencia del riesgo en pacientes con LDL>190 esta dada básicamente en pacientes con HF. El beneficio de la intervención está soportado en el resultado pos hoc del estudio WOSCOPS como RCT 5 años y como cohorte 20 años. Debe completarle el estudio. https://t.co/u9YvZeS4TP

May 28, 2023 · 3 likes · 1 share · 11,085 followers View post →

All mentions

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In this video, Abbey Sharp analyzes the most outrageous diet advice circulating online today. With a focus on educating viewers, she emphasizes the importance of consulting healthcare providers about personal health…

Abbey Sharp · Nov 30, 2023 348,002 views

Impact of Rosuvastatin on Cardiovascular Health Metrics

This video discusses the effectiveness of rosuvastatin in preventing cardiovascular events in healthy individuals with high C-reactive protein levels. The study showed that rosuvastatin significantly reduced LDL…

Nutrition Made Simple! · May 23, 2022 152,750 views

tune

@keisuke4713 · X

11. 5年の展望永続使用されるstatinが数年≦継続試験:殆ど

Nov 10, 2025 · 3,749 followers View post →

Jake Matthews

@jakemat91.bsky.social · Bluesky

#WOSCOPS enrolled 6595 men aged 45 to 64 years, who were randomly assigned to pravastatin 40 mg/d or placebo. pubmed.ncbi.nlm.nih.gov/28877913/ 18% benefit in mortality over 20 years. Significant. Raised baseline LDLc benefited slightly more.

Dec 31, 2024 · 1 share View post →

GladstoneBrookes

@GladstoneB81859 · X

@drcateshanahan @DennisBegos In your book, you reference this analysis of data from WOSCOPS (https://t.co/ER5M0TAhxC) (indirectly, via a BMJ summary and bit by David Diamond, refs 26 and 27 in chapter 7) as showing small benefits of statin therapy.

Aug 17, 2024 · 1 like · 547 followers View post →

Ahmed Mujahed

@Ahmed_Samir_M20 · X

RT @ahmed_sayed_98: Pleased to share our new paper just published in @JAMACardio Link:

Nov 3, 2023 · 4 shares · 1,413 followers View post →

Ahmed Awad, MD

@ahmedawadmd · X

RT @ahmed_sayed_98: Pleased to share our new paper just published in @JAMACardio Link:

Nov 2, 2023 · 4 shares · 1,415 followers View post →

Ahmed Sayed

@ASayedMD · X

Pleased to share our new paper just published in @JAMACardio Link:

Nov 2, 2023 · 28 likes · 4 shares · 475 followers View post →

David Diamond

@LDLSkeptic · X

RT @raphaels7: @DoctorTro @LDLSkeptic @holmanm @mrc314 @doctor original WOSCOPs was published in 1992 & 1995, burying the adherence data t…

Aug 23, 2023 · 1 share · 45,054 followers View post →

Raphael Sirtoli

@raphaels7 · X

Aug 23, 2023 · 5 likes · 1 share · 8,595 followers View post →

Revel Peters

@urbanlamb · X

@SergiEscanes here just in case you are serious start with these.. https://t.co/pgu9uU5cMS https://t.co/caqh4PoAlF https://t.co/6C3wByHZGA https://t.co/3OOJYjh7cm I know that you really dont want information though

Aug 23, 2023 · 107 followers View post →

fausto heredia z.

@drfherediaz · X

RT @jsenior64: @endocrinorosero @DrFisioloco @drpablocorral La evidencia del riesgo en pacientes con LDL>190 esta dada básicamente en pacie…

May 28, 2023 · 1 share · 4,374 followers View post →

Juan Senior

@jsenior64 · X

May 28, 2023 · 3 likes · 1 share · 11,085 followers View post →

Gil Carvalho MD PhD

@NutritionMadeS3 · X

@sean_bernstein I´ve seen that pattern reported yes https://t.co/Uy86PhfYV7

Sep 2, 2022 · 28,129 followers View post →

Harmless Frog

@FrogHarmless · X

@NutritionMadeS3 @MichaelAlbertMD Interesting! https://t.co/k5CSnbxktH

Aug 16, 2022 · 1 like · 502 followers View post →

DoctorTro

@DoctorTro · X

@jengates WOSCOPS: https://t.co/dHJ7svrHN4

Jun 19, 2021 · 3 likes · 162,664 followers View post →

Dr. Spencer Nadolsky

@DrNadolsky · X

Similar analysis of woscops https://t.co/BNC7UAqJdJ

Jan 12, 2021 · 1 like · 59,458 followers View post →

Francisco Piccolo

@piccolofran · X

RT @veryvirology: @tinytim0101 Cancer: https://t.co/pj4pZDwyEn Cerebrovascular: https://t.co/rv1Q0Fh2wU https://t.co/lqsXPfRfIq Coronary: h…

Oct 26, 2020 · 1 share · 768 followers View post →

John Chamberlain, MHA, LFACHE

@misterchambo · X

RT @veryvirology: @tinytim0101 Cancer: https://t.co/pj4pZDwyEn Cerebrovascular: https://t.co/rv1Q0Fh2wU https://t.co/lqsXPfRfIq Coronary: h…

Oct 26, 2020 · 1 share · 19,273 followers View post →

Adam Gaertner

@veryvirology · X

Oct 26, 2020 · 5 likes · 1 share · 83,061 followers View post →

Cliff Dominy

@CliffDominy · X

Now we have Odds Ratios published showing possibly a 30% relative risk benefit in the shorter term. Epi studies for this period are closer to 0.5%. @ProfKausikRay https://t.co/c3jO9FHeBC. Using this data, my question is. Should statins be used for primary prevention of ASCVD?

Aug 8, 2019 · 382 followers View post →

Cliff Dominy

@CliffDominy · X

However the WOSCOPs 20 year follow up @ProfKausikRay suggested that there MIGHT be a small advantage ( 4.5% absolute benefit) to statins long term. https://t.co/mxTWwC2mxk

Aug 8, 2019 · 382 followers View post →

Boback Ziaeian

@boback · X

RT @gcfmd: @venkmurthy @CaptRockyBob @VietHeartPA @khurramn1 @MichaelJBlaha @mdmiedema @DavidLBrownMD @boback @rauldsf_santos @almallahmo @…

Jan 9, 2019 · 1 share · 3,367 followers View post →

Gregg Fonarow MD

@gcfmd · X

Jan 9, 2019 · 4 likes · 1 share · 11,910 followers View post →