Science September 2017 PMID 28935799

Interacting amino acid replacements allow poison frogs to evolve epibatidine resistance.

Rebecca D Tarvin, Cecilia M Borghese, Wiebke Sachs, Juan C Santos, Ying Lu, Lauren A O'Connell, David C Cannatella, R Adron Harris, Harold H Zakon

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Peak: 8 in Nov 2023

across 5 sources since Sep 2017

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The discussions show strong interest and engagement through references to specific biological processes, such as amino acid changes enabling toxin resistance in frogs, and examples of animals adapting to their poisons. The tone varies from scientific curiosity to awe at evolutionary complexity, contributing to the overall perception of high interest and engagement with a meaningful, though moderate, societal impact.

AgreementModerate agreement

Many discussions recognize the significance of the research, with some showing amazement at the biological mechanisms involved, indicating general support and interest in the findings.

InterestHigh interest

Posts express high curiosity about the biological and evolutionary aspects, especially regarding how frogs develop toxin resistance and its implications, reflecting a strong engagement with the subject matter.

EngagementHigh engagement

Users delve into details, referencing the scientific mechanisms, the evolution of resistance, and even mentioning related animal behaviors, demonstrating deep engagement.

ImpactModerate impact

While some discussions highlight the fascinating nature and potential implications for understanding evolution and toxin resistance, the overall perceived direct impact on broader society appears moderate, focusing more on scientific curiosity than practi

Abstract in brief

Poison frogs develop resistance to their own toxins, like epibatidine, through specific amino acid changes in their nervous system receptors.
These changes help reduce the toxin's effect but can impair normal receptor function, which is then restored by further genetic modifications unique to different frog lineages.
The study shows that these multiple genetic adaptations enable poison frogs to evolve effective chemical defenses while maintaining essential biological functions.]

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All mentions

The Biology of Poison Dart Frogs and Toxin Resistance Mechanisms

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Poison Frogs' Toxin Resistance Through Protein Adaptations

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Poison Dart Frogs and Mites: Nature's Chemical Defense Mechanisms

Poison dart frogs are small vibrantly colored amphibians known for their toxic skin and incredible defense mechanisms. This video explores their habitat, diet, reproduction, and the science behind their deadly toxins…

Fact Wild · Sep 4, 2025 14 views

paul daniel zink

@ThiefNtheKnight · X

https://t.co/ndnh7Y1Gdq

Aug 14, 2025 · 1,192 followers View post →

Transylvanian Jack

@VVampire66918 · X

@darremans242 @CG_FrogTony https://t.co/j91VVGLyp2

Aug 2, 2025 · 2 likes · 369 followers View post →

Nikki Mariah Carey

@NikkiGraham8224 · X

Why do u think POSIONOUS frogs exist.. bc they are exist bc evil got into them and why I didnt make creatures like this but DID and ILL TELL U WHY bc they are what is gonna be eating all the species that are here in the HUMAN form and iN LARGER SIZES so https://t.co/tSgqdyhkDq

Jul 30, 2025 · 85 followers View post →

de vangrailmaaier (ACVODA)

@plopnl · X

@simonmaechling @JKLund_Official Its also cool how some animals have adopted to use them for their own advantage. Like the poison dart frog that gets its poison from its diet https://t.co/N9NuIs12JV

May 21, 2025 · 2 likes · 1,743 followers View post →

MARK KOVENFIRE

@kovenfire · X

https://t.co/QBLbhQl5JJ

Mar 13, 2025 · 209 followers View post →

Hiei_stan

@Hiei_stan · X

que video bom! unico animal venenoso que me atacou ate agora foi o serumano. um bicho que possui um veneno bem diferente... Como animais venenosos não se envenenam? | Minuto da Terra https://t.co/PKqgtlSK8u via @YouTube

Feb 18, 2025 · 1 like · 282 followers View post →

Maria Carolina Passos

@_mariacarolina · X

relações (pouco) tóxicas https://t.co/U3an9nZi84

Jan 31, 2025 · 1 like · 887 followers View post →

Minuto da Terra

@MinutoDaTerra · X

Jan 31, 2025 · 1 like · 3,006 followers View post →

Grand Master Darx

@thechosendarx · X

@DragonChaseJav https://t.co/8M7m6f6m2a

Jul 30, 2024 · 3 likes · 1,894 followers View post →

mulder_manson

@mulder_manson · X

Who knew

Apr 28, 2024 · 5 likes · 1,444 followers View post →

Rod Sam Molder

@GuiverMiguel · X

The Insane Biology of: The Poison Dart Frog https://t.co/D2pYnRbh85 a través de @YouTube

Feb 6, 2024 · 1 like · 149,812 followers View post →

Aakash Hanumanth

@AakashHanumant1 · X

https://t.co/SHwNQHzAWR inform julia koch,Athina onassis,Elon musk,E.charpenteir,Paula naravez,Alice walton that there was a time aakashhanumanth was searching to attain that frogs&was ready to pay any price to buy the frogs for gifting it to iLLiterates who disguised as teachers

Dec 25, 2023 · 155 followers View post →

Heat Chacer

@RasFyha · X

https://t.co/IbsbZ726HY

Dec 1, 2023 · 32 followers View post →

Esteban Reñe Licon

@er_licon · X

These along with sea turtles have been my favorite animals since I was a kid. The Insane Biology of: The Poison Dart Frog https://t.co/SAPfPIW5hI via @YouTube

Nov 27, 2023 · 1 followers View post →

Nick Quick

@heynickquick · X

@lintreadertim @porterryan_ Definitely NOT this one: https://t.co/QaHru8DteE

Nov 26, 2023 · 85 followers View post →

All Saints' Biology

@AllSaintsBiol · X

https://t.co/60gI1BHJPF

Nov 26, 2023 · 20 followers View post →

dkdk459

@dkdk459 · X

https://t.co/R0EZDn4C1l

Nov 26, 2023 · 17,482 followers View post →

*Dr. Drew Nagy

@DrewNagy1 · X

RT @WPCUniv: Poison Dart Frog (props to Mme. François): https://t.co/0IIThhEwTD

Nov 25, 2023 · 1 share · 1,061 followers View post →

WPC University

@WPCUniv · X

Poison Dart Frog (props to Mme. François): https://t.co/0IIThhEwTD

Nov 25, 2023 · 1 like · 1 share · 55 followers View post →

kodiakbear

@kodiakbear1969 · X

Real Science https://t.co/yjMUbtwBW1

Nov 25, 2023 · 96 followers View post →

Chacruna Latinoamérica

@ChacrunaLa · X

Para este #ViernesDePlantasYHongosSagrados, exploraremos el extraño y maravilloso mundo de las ranas venenosas

Sep 15, 2023 · 1 like · 2,846 followers View post →

Gaetano Lardieri

@EntheoG108 · X

https://t.co/VdDVUD1alW

Sep 15, 2023 · 167 followers View post →

Chacruna Institute

@Chacruna_Inst · X

For #SacredPlantAndFungiFriday, let’s explore the weird and wonderful world of poison dart frogs

Sep 15, 2023 · 12,574 followers View post →

Dr Zelieann Rivera Craig

@zrcraig · X

@ScienceNerdSACR This is the paper that got me interested! https://t.co/zORXUTaQOR

Dec 26, 2020 · 1 like · 473 followers View post →