J Agric Food Chem November 2017 PMID 28942644

An Endocannabinoid Uptake Inhibitor from Black Pepper Exerts Pronounced Anti-Inflammatory Effects in Mice.

Inés Reynoso-Moreno, Israel Najar-Guerrero, Noé Escareño, Mario Eduardo Flores-Soto, Jürg Gertsch, Juan Manuel Viveros-Paredes

Mentions

5
Peak: 1 in Aug 2020
across 3 sources since Aug 2020

Extended reach

160,922
potential audience

Total likes

8,380

Video views

159,617

Mentions per month

Aug 2020 – Jun 2024

Where it's discussed

  • YouTube2 videos
  • Reddit2 posts
  • X / Twitter1 posts

AI synopsis

What people are saying

Discussions reflect a recognition of the potential health benefits of black pepper compounds, often mentioning terms like 'anti-inflammatory' and 'promising', which convey cautious optimism. Some posts directly reference the complex pharmacology involved, illustrating moderate engagement and interest, but the overall tone remains exploratory rather than definitive.

AgreementModerate agreement

Most discussions highlight the promising anti-inflammatory effects of compounds in black pepper, indicating general agreement with the study's findings.

InterestModerate interest

Posts show moderate interest, with few explicitly expressing curiosity or excitement, but some mention potential health benefits and scientific significance.

EngagementModerate engagement

Similarly, there is some depth in comments about molecular pathways or implications, but overall, engagement remains somewhat superficial with limited detailed analysis.

ImpactNeutral impact

Comments suggest the research is interesting but not viewed as immediately transformative for health or medicine, resulting in a neutral impact score.

Abstract in brief

  • Guineensine, a compound found in black and long peppers, inhibits endocannabinoid uptake and shows strong anti-inflammatory effects in mice, including reducing pain, edema, and cytokine production.
  • The compound induces catalepsy and hypothermia, effects that are mediated through the CB1 receptor, but it also exhibits CB1-independent actions like hypolocomotion, and interacts with dopamine, serotonin, and sigma receptors, indicating a complex pharmacology.
  • These findings suggest that guineensine's anti-inflammatory and pain-relief properties might contribute to the health benefits associated with consuming black pepper and could involve multiple molecular pathways.

Top posts

Most liked on X and Bluesky
Woody Nist
@Woodynist · X

An Endocannabinoid Uptake Inhibitor from Black Pepper Exerts Pronounced Anti-Inflammatory Effects in Mice | Journal of Agricultural and Food Chemistry https://t.co/saxea4jzMs

Dec 17, 2021 · 1,306 followers View post →

All mentions

Woody Nist
@Woodynist · X

An Endocannabinoid Uptake Inhibitor from Black Pepper Exerts Pronounced Anti-Inflammatory Effects in Mice | Journal of Agricultural and Food Chemistry https://t.co/saxea4jzMs

Dec 17, 2021 · 1,306 followers View post →