December 2017 PMID 28972892

Brain functional connectivity patterns in children and adolescents with gender dysphoria: Sex-atypical or not?

Nienke M Nota, Baudewijntje P C Kreukels, Martin den Heijer, Dick J Veltman, Peggy T Cohen-Kettenis, Sarah M Burke, Julie Bakker

Mentions

69
Peak: 21 in Nov 2022
across 3 sources since Feb 2019

Extended reach

192,339
potential audience

Total likes

595

Video views

4,508

Mentions per month

Feb 2019 – Sep 2025

Where it's discussed

  • X / Twitter63 posts
  • News4 articles
  • YouTube2 videos

AI synopsis

What people are saying

The discussions reflect a strong consensus that the study provides evidence supporting biological differences in trans youth, with examples like mentions of 'brain functional connectivity patterns' aligning with experienced gender, and commentary on how these findings challenge assertions that gender identity is purely a matter of ideology. The tone varies from scientific to passionate, emphasizing the relevance and impact of the research on social and scientific narratives.

AgreementModerate agreement

Most discussions support the idea that brain connectivity patterns in trans youth align with their experienced gender, citing the study as evidence.

InterestHigh interest

The topic attracts high interest, with many engaging deeply and referencing scientific research and debates on gender identity.

EngagementModerate engagement

Posts often include detailed references to specific research findings, methods, and implications, indicating active engagement.

ImpactModerate impact

The discussions seem to influence opinions about the biological basis of gender dysphoria, contributing to ongoing debates and policy considerations.

Abstract in brief

  • The study investigates how brain connectivity patterns differ in children and adolescents with gender dysphoria (GD) compared to their peers, finding that brain network differences become more apparent during adolescence and puberty.
  • It shows that trans girls and trans boys exhibit functional connectivity patterns similar to their experienced gender, especially in adolescent groups, while prepubertal children do not display these differences.
  • The research suggests that these brain connectivity changes related to GD develop with age and puberty rather than being present from early childhood.]

Top posts

Most liked on X and Bluesky
Sammy
@NeuroSGS · X

In a famous study, the authors compared prepubertal and adolescent children, then suggest sex atypical cerebral differentiation occurs within these individuals. https://t.co/xmO7T5HtGH

Jul 19, 2022 · 288 likes · 20 shares · 12,137 followers View post →
Sammy
@NeuroSGS · X

Here is a famous study, often cited in blog posts, that suggests transgender individuals have resting-state functional brain activation more in line with their "gender identity" Let's take a look

Nov 9, 2022 · 57 likes · 18 shares · 12,137 followers View post →
Sammy
@NeuroSGS · X

@SportingNest @SwipeWright Bakker is famous for not controlling for sexuality. For instance, in the study below she only found atypicality in the adolescent cohort (almost exclusively homosexual and ALL on GnRHa). https://t.co/xmO7T5HtGH

Nov 6, 2022 · 22 likes · 12,137 followers View post →
A. P. Schulz
@ap_schulz · X

@gargoylesingrey @logical_psycho_ 12) Nota, Kreukels, den Heijer, Veltman, Cohen-Kettenis, Burke, & Bakker, (2017). Brain functional connectivity patterns in children and adolescents with gender dysphoria: Sex-atypical or not?. Psychoneuroendocrinology, 86, 187–195. https://t.co/rpUwyqlM5v

Apr 16, 2023 · 5 likes · 3,263 followers View post →
VooDoo
@DearVooDoo · X

@sleepyvolk @badwald @CaroleQuintaine @Frontieresmedia @grok Être trans n'est pas une "idée", c'est une réalité reconnue par la science. Des études neurologiques montrent que le cerveau des personnes trans a des similitudes avec celui du genre auquel elles s'identifient. https://t.co/6eAGf01vrn

Apr 3, 2025 · 2 likes · 2,954 followers View post →
Reject Metric
@MetricReject · X

@CrapWalking @brand_orc you'll note again if you actually look at the study rather than the press release (https://t.co/UBpwCjHmbD) that "Reported sexual orientation varied" and there is no mention of handedness at all in either the study group or the control groups this is a very easy tell

Mar 13, 2023 · 2 likes · 1,986 followers View post →

All mentions

笹本正明
@miesasamoto64 · X

@OZlzOpMaDTl0XQo @benineko0211 @zaelefty Sammyが挙げてるこれらの論文は「脳に性差がある」「トランスの脳は経験的性に近い傾向を示す」「身体の性と異なる傾向を示す」ことを述べた論文ですよ。 Sammyがそれに反論してるスレッドです。 https://t.co/I1VlwZHKvA https://t.co/tcJXGb0dFF

Sep 8, 2025 · 192 followers View post →
Glass_Joe1000101
@70s_stache6969 · X

RT @NeuroSGS: Here is a famous study, often cited in blog posts, that suggests transgender individuals have resting-state functional brain…

Jul 18, 2025 · 18 shares · 109 followers View post →
Robert Brown
@Livingmasterkey · X

@CsEmma1503 @kittykataleya @BryanLand111980 @LoveAGuineaPig @eugene147852 @PacedFitness @bluestein https://t.co/62LPddEziA

Apr 3, 2025 · 77 followers View post →
VooDoo
@DearVooDoo · X

@sleepyvolk @badwald @CaroleQuintaine @Frontieresmedia @grok Être trans n'est pas une "idée", c'est une réalité reconnue par la science. Des études neurologiques montrent que le cerveau des personnes trans a des similitudes avec celui du genre auquel elles s'identifient. https://t.co/6eAGf01vrn

Apr 3, 2025 · 2 likes · 2,954 followers View post →
Saltinochang
@saltinochang · X

@KamuiRougiard @thepaulleslie @WintersPolitics https://t.co/oiyHDvwPkS https://t.co/LD6loDzvGZ https://t.co/I7ipM0UQpL https://t.co/XXKiz2uclc https://t.co/qe9p44fKkk https://t.co/00uP3in3d2 https://t.co/d3h7PpXkbp https://t.co/yTqkh2MtZT Want me to do more of your homework? Any more research you need done?

Mar 13, 2025 · 3 followers View post →
Winnowing Wind
@WinnowingWind · X

@MuskIsADeadbeat @NeuroSGS @BobWhencer @TransJusticeOrg @oulidapo @Sackless_Jack Sammy posted the following. None of them are pre-prints. Anyone can click and see for themselves. Why lie? https://t.co/d6IZxBFpmp https://t.co/ZE0WpT3UQR https://t.co/9C3n3rv3sK https://t.co/Z7AzhsZhfp https://t.co/EgCnCONkmF https://t.co/VY1WCmJyeZ

Nov 26, 2024 · 2 likes · 484 followers View post →
Juan
@JuanEs1eban · X

@caos_suspendido @Patrioticos_RD Y que tal si te digo que no eres objetivo sino irrespetuoso. En el estudio "Brain functional connectivity patterns in children and adolescents with gender dysphoria: Sex-atypical or not?" Se muestra que el cerebro trans es diferente.

Jun 27, 2024 · 972 followers View post →
Psiana
@PsianaEspeon · X

@Daseinsuhr @Frollein_VogelV Nein, die Studie ist diese. Leider habe ich darauf keinen vollen Zugriff. Allerdings wird sie in meinem oben verlinkten Tweet diskutiert. https://t.co/zfjsl4CWw3

May 14, 2024 · 62 followers View post →
Valor and value, courage and heart
@Dagawd1000 · X

@SamusEevee @JandarSunstar69 @Susan4Freedom @SereneArc @Daderp1242389 @TappinGrassley @ZackFord https://t.co/5AvbemX98C

Sep 28, 2023 · 39 followers View post →
LaFrancaFranca
@TheLaFranky · X

@GuercioRosi @fabioaffinito @bravimabasta https://t.co/2OruGdhsLm Questo è il sunto dello studio

Sep 10, 2023 · 278 followers View post →
Whisper
@VVh1sp3r · X

@WeAreMikeJ @CatGirlTheta @mxhwd345 @ryanmichael2023 @JDM_Twit @joncoopertweets Oops here’s another https://t.co/H8mSq7Wpwl

Jun 4, 2023 · 1 like · 628 followers View post →
Kiara
@Kiara_lbt · X

@D4S_D1NG @Wieser_J_ @teck_85 @welt Ist sehr wohl daran beteiligt als welches Geschlecht man sich identifiziert da es eine eigene Geschlechtsidentität haben kann. https://t.co/cDGuc1oZan

Apr 18, 2023 · 51 followers View post →
A. P. Schulz
@ap_schulz · X

@gargoylesingrey @logical_psycho_ 12) Nota, Kreukels, den Heijer, Veltman, Cohen-Kettenis, Burke, & Bakker, (2017). Brain functional connectivity patterns in children and adolescents with gender dysphoria: Sex-atypical or not?. Psychoneuroendocrinology, 86, 187–195. https://t.co/rpUwyqlM5v

Apr 16, 2023 · 5 likes · 3,263 followers View post →
Reject Metric
@MetricReject · X

@CrapWalking @brand_orc you'll note again if you actually look at the study rather than the press release (https://t.co/UBpwCjHmbD) that "Reported sexual orientation varied" and there is no mention of handedness at all in either the study group or the control groups this is a very easy tell

Mar 13, 2023 · 2 likes · 1,986 followers View post →
Brandon Taylor
@0ffBr4nd · X

RT @NeuroSGS: In a famous study, the authors compared prepubertal and adolescent children, then suggest sex atypical cerebral differentiati…

Mar 3, 2023 · 20 shares · 39 followers View post →
Tem Tempo ⭐️
@Opaopa13 · X

@Megain_s @dodgson_sally @LGBwiththeT @ChristineRebst1 5 seconds of Google later: https://t.co/mk0BeGWY9o

Feb 26, 2023 · 1 like · 601 followers View post →
Patronus
@Patronu87220295 · X

RT @NeuroSGS: In a famous study, the authors compared prepubertal and adolescent children, then suggest sex atypical cerebral differentiati…

Jan 14, 2023 · 20 shares · 77 followers View post →
ribrib
@ribrib010 · X

RT @NeuroSGS: In a famous study, the authors compared prepubertal and adolescent children, then suggest sex atypical cerebral differentiati…

Jan 13, 2023 · 20 shares · 2,242 followers View post →
Okan
@Rootthrower89 · X

@hoser_ya Science proves otherwise https://t.co/iBrhDVdFx8

Dec 19, 2022 · 19 followers View post →
aurora
@auroraa428 · X

@StoneyGuardian @LousyJester @zaelefty “activist site”, hah https://t.co/7spOlpGeXu https://t.co/5Q2F4FAwgf https://t.co/aKGEIgTy8z https://t.co/msveBDRd33 https://t.co/ibohtV7B4O https://t.co/TtTvQ02nfC https://t.co/DBv6gRUTKu https://t.co/14H9MDYh1e https://t.co/UMWcBkjVZH https://t.co/4p2xbn9Lj6

Nov 17, 2022 · 605 followers View post →
Sammy
@NeuroSGS · X

RT @NeuroSGS: Here is a famous study, often cited in blog posts, that suggests transgender individuals have resting-state functional brain…

Nov 13, 2022 · 18 shares · 12,137 followers View post →
HereHare
@HereHareHa · X

RT @NeuroSGS: Here is a famous study, often cited in blog posts, that suggests transgender individuals have resting-state functional brain…

Nov 13, 2022 · 18 shares · 2,215 followers View post →
Ana
@Anas_Sloth · X

RT @NeuroSGS: Here is a famous study, often cited in blog posts, that suggests transgender individuals have resting-state functional brain…

Nov 13, 2022 · 18 shares · 511 followers View post →
Natasha Rostov
@NatashaRostov5 · X

RT @NeuroSGS: Here is a famous study, often cited in blog posts, that suggests transgender individuals have resting-state functional brain…

Nov 10, 2022 · 18 shares · 421 followers View post →
Unnie
@MEVring · X

RT @NeuroSGS: Here is a famous study, often cited in blog posts, that suggests transgender individuals have resting-state functional brain…

Nov 10, 2022 · 18 shares · 828 followers View post →
Steven
@Steven96235409 · X

RT @NeuroSGS: Here is a famous study, often cited in blog posts, that suggests transgender individuals have resting-state functional brain…

Nov 10, 2022 · 18 shares · 108 followers View post →
Archidamia of Lacedaemonia
@Archilacedae · X

RT @NeuroSGS: Here is a famous study, often cited in blog posts, that suggests transgender individuals have resting-state functional brain…

Nov 10, 2022 · 18 shares · 3,218 followers View post →
Speckasand
@Speckasand · X

RT @NeuroSGS: Here is a famous study, often cited in blog posts, that suggests transgender individuals have resting-state functional brain…

Nov 9, 2022 · 18 shares · 267 followers View post →
Yo, aquí
@yo_estoica · X

RT @NeuroSGS: Here is a famous study, often cited in blog posts, that suggests transgender individuals have resting-state functional brain…

Nov 9, 2022 · 18 shares · 1,512 followers View post →
itsallariddle
@itsallariddle · X

RT @NeuroSGS: Here is a famous study, often cited in blog posts, that suggests transgender individuals have resting-state functional brain…

Nov 9, 2022 · 18 shares · 3,098 followers View post →
Queste
@Queste49660435 · X

RT @NeuroSGS: Here is a famous study, often cited in blog posts, that suggests transgender individuals have resting-state functional brain…

Nov 9, 2022 · 18 shares · 27 followers View post →
Cynthia Breheny
@PTElephant · X

RT @NeuroSGS: Here is a famous study, often cited in blog posts, that suggests transgender individuals have resting-state functional brain…

Nov 9, 2022 · 18 shares · 6,040 followers View post →
Ella Androphobia #LetWomenSpeak
@e_androphobia · X

RT @NeuroSGS: Here is a famous study, often cited in blog posts, that suggests transgender individuals have resting-state functional brain…

Nov 9, 2022 · 18 shares · 628 followers View post →
Zachary Elliott
@zaelefty · X

RT @NeuroSGS: Here is a famous study, often cited in blog posts, that suggests transgender individuals have resting-state functional brain…

Nov 9, 2022 · 18 shares · 51,708 followers View post →
Tom
@nachtfalter_05 · X

RT @NeuroSGS: Here is a famous study, often cited in blog posts, that suggests transgender individuals have resting-state functional brain…

Nov 9, 2022 · 18 shares · 187 followers View post →
Sammy
@NeuroSGS · X

Here is a famous study, often cited in blog posts, that suggests transgender individuals have resting-state functional brain activation more in line with their "gender identity" Let's take a look

Nov 9, 2022 · 57 likes · 18 shares · 12,137 followers View post →
SuiHuaLian7
@DeO_Lia7 · X

RT @NeuroSGS: In a famous study, the authors compared prepubertal and adolescent children, then suggest sex atypical cerebral differentiati…

Nov 8, 2022 · 20 shares · 890 followers View post →
Sammy
@NeuroSGS · X

@SportingNest @SwipeWright Bakker is famous for not controlling for sexuality. For instance, in the study below she only found atypicality in the adolescent cohort (almost exclusively homosexual and ALL on GnRHa). https://t.co/xmO7T5HtGH

Nov 6, 2022 · 22 likes · 12,137 followers View post →
D
@Dthom_98 · X

RT @NeuroSGS: In a famous study, the authors compared prepubertal and adolescent children, then suggest sex atypical cerebral differentiati…

Nov 6, 2022 · 20 shares · 32 followers View post →
Ian
@IanAdAstra · X

RT @NeuroSGS: In a famous study, the authors compared prepubertal and adolescent children, then suggest sex atypical cerebral differentiati…

Nov 6, 2022 · 20 shares · 4,083 followers View post →
HbO21221
@HbO21221 · X

RT @NeuroSGS: In a famous study, the authors compared prepubertal and adolescent children, then suggest sex atypical cerebral differentiati…

Jul 20, 2022 · 20 shares · 414 followers View post →
|Una Tista| |Slav adult human female|
@TistaUna · X

RT @NeuroSGS: In a famous study, the authors compared prepubertal and adolescent children, then suggest sex atypical cerebral differentiati…

Jul 20, 2022 · 20 shares · 227 followers View post →
Parents with Inconvenient Truths about Trans
@pittparents · X

RT @NeuroSGS: In a famous study, the authors compared prepubertal and adolescent children, then suggest sex atypical cerebral differentiati…

Jul 20, 2022 · 20 shares · 15,022 followers View post →
Parents of Desisters
@DesisterParents · X

RT @NeuroSGS: In a famous study, the authors compared prepubertal and adolescent children, then suggest sex atypical cerebral differentiati…

Jul 19, 2022 · 20 shares · 3,754 followers View post →
Brandon Taylor
@0ffBr4nd · X

RT @NeuroSGS: In a famous study, the authors compared prepubertal and adolescent children, then suggest sex atypical cerebral differentiati…

Jul 19, 2022 · 20 shares · 39 followers View post →
lipeepipol
@lipeepipol · X

RT @NeuroSGS: In a famous study, the authors compared prepubertal and adolescent children, then suggest sex atypical cerebral differentiati…

Jul 19, 2022 · 20 shares · 568 followers View post →
kit27woof
@kit27woof · X

RT @NeuroSGS: In a famous study, the authors compared prepubertal and adolescent children, then suggest sex atypical cerebral differentiati…

Jul 19, 2022 · 20 shares · 92 followers View post →
Dollop
@dollopojjam · X

RT @NeuroSGS: In a famous study, the authors compared prepubertal and adolescent children, then suggest sex atypical cerebral differentiati…

Jul 19, 2022 · 20 shares · 2,971 followers View post →
Wdi_Colombia
@WdiColombia · X

RT @NeuroSGS: In a famous study, the authors compared prepubertal and adolescent children, then suggest sex atypical cerebral differentiati…

Jul 19, 2022 · 20 shares · 2,236 followers View post →
Ginger
@63_susan · X

RT @NeuroSGS: In a famous study, the authors compared prepubertal and adolescent children, then suggest sex atypical cerebral differentiati…

Jul 19, 2022 · 20 shares · 4,695 followers View post →
Sammy
@NeuroSGS · X

In a famous study, the authors compared prepubertal and adolescent children, then suggest sex atypical cerebral differentiation occurs within these individuals. https://t.co/xmO7T5HtGH

Jul 19, 2022 · 288 likes · 20 shares · 12,137 followers View post →
Blonde Polish Chick
@Clements37167 · X

@AnnaKarenina96 @RudyAuerbach @Aaron_GDAC https://t.co/zn4sAPC8Zr

May 1, 2022 · 547 followers View post →
Leia Bryant the Redneck Feminist⚢☭ ΘΔ
@LeiaBryant13 · X

RT @rumia_uru: @TraherneJoe @TFherder @DontCallMe_CIS_ @absol_silverbee @Subliminality_ @smokinfed Don't call me pet. https://t.co/sQLZiuVi…

Jun 27, 2021 · 1,623 followers View post →
Leia Bryant the Redneck Feminist⚢☭ ΘΔ
@LeiaBryant13 · X

RT @rumia_uru: @TraherneJoe @TFherder @DontCallMe_CIS_ @absol_silverbee @Subliminality_ @smokinfed Don't call me pet. https://t.co/sQLZiuVi…

Jun 20, 2021 · 1,623 followers View post →
Rumia Uru
@rumia_uru · X

@TraherneJoe @TFherder @DontCallMe_CIS_ @absol_silverbee @Subliminality_ @smokinfed Don't call me pet. https://t.co/sQLZiuVi7b https://t.co/NVOjZ5JrGZ

Jun 20, 2021 · 1 like · 33 followers View post →
Loló
@loallalla · X

@missmilfs @laurenbitso @BellonaRad https://t.co/wBTrHWcEwh https://t.co/HvVhJqDum4

Apr 6, 2021 · 142 followers View post →
яebel яebel
@_Hardw1red · X

@Darrechex @SerquelBastard @gara_polo @FridayTrrs @wsantizo @__kamikz @andrexohe Sobre el dimorfismo sexual y los cerebros de la gente trans: https://t.co/z3qIn5TUVq https://t.co/szVknt5sU6 https://t.co/WNo3lNYxoO https://t.co/6tzinI2nwO Biología, no ideología

Jul 7, 2020 · 393 followers View post →
Sanson Carrasco
@WlkngCntradctn · X

@mar_keaton @Superpaperclip @SSTrihan @_wingback @MorenitaKlient @Pawpels @moby_dickhead @jk_rowling Aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaand another https://t.co/xsCiRyxBwC "Within these networks adolescent transgirls showed FC patterns similar to their experienced gender (female). Also adolescent transboys showed a FC pattern similar to their experienced gender (male)"

Jun 7, 2020 · 2 likes · 339 followers View post →
Frau Claus
@ClaudiaLuisa16 · X

RT @ClaudiaLuisa16: @A_nicht_nichtA @Tagesspiegel @Queerspiegel @HumboldtUni m) „Brain functional connectivity patterns in children and ad…

Jul 23, 2019 · 1 share · 3,238 followers View post →
Frau Claus
@ClaudiaLuisa16 · X

@A_nicht_nichtA @Tagesspiegel @Queerspiegel @HumboldtUni m) „Brain functional connectivity patterns in children and adolescents with gender dysphoria: Sex-atypical or not?“, Psychoneuroendocrinology, 2017; 86; 187-195 Smith, Hunger, Derntl, Haber, "The transsexual brain – A review of findings on the neural basis of transsexualism",

Jul 23, 2019 · 1 share · 3,238 followers View post →
Cindy Womack
@ArmyofWomack · X

RT @IsYitzack: @ChaiKovsky @MagsVisaggs That was harder than I expected. Found the paper: https://t.co/4AKT8C5qPy "Artificial" doesn't appe…

May 27, 2019 · 1 share · 3,036 followers View post →
IsYitzack
@IsYitzack · X

@ChaiKovsky @MagsVisaggs That was harder than I expected. Found the paper: https://t.co/4AKT8C5qPy "Artificial" doesn't appear in the paper, but they may not be using a layman buzz word.

May 27, 2019 · 1 like · 1 share · 62 followers View post →
Frau Claus
@ClaudiaLuisa16 · X

@taz_news „Brain functional connectivity patterns in children and adolescents with gender dysphoria: Sex-atypical or not?“, Psychoneuroendocrinology, 2017; 86; 187-195 Warum zur Hölle sollten also Kinder ihr Geschlecht nicht kennen? So ein Bullshit.

Feb 26, 2019 · 3,238 followers View post →