September 2017 PMID 28978032

Vitamin C and Doxycycline: A synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs).

Ernestina Marianna De Francesco, Gloria Bonuccelli, Marcello Maggiolini, Federica Sotgia, Michael P Lisanti

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Mentions

49
Peak: 16 in Apr 2023
across 3 sources since Jul 2020

Extended reach

271,836
potential audience

Total likes

128

Video views

108

Mentions per month

Jul 2020 – Jul 2025

Where it's discussed

  • X / Twitter46 posts
  • YouTube2 videos
  • Bluesky1 posts

AI synopsis

What people are saying

The discussions demonstrate a generally positive outlook, with users citing examples like Doxycycline’s ability to inhibit cancer growth and combining it with Vitamin C to enhance effectiveness. Words like 'potential,' 'effective,' and phrases about 'starving' cancer stem cells suggest a recognition of meaningful impact, while references to natural products and clinical contexts show moderate engagement with detailed implications.

AgreementModerate agreement

Most discussions acknowledge the potential of the combination therapy and agree with its promising approach against cancer stem cells.

InterestModerate interest

Posts show moderate interest, with discussions about Doxycycline’s repurposing and its role in cancer treatment, but some are more speculative.

EngagementModerate engagement

Comments reference various aspects such as mechanisms, natural products, and clinical implications, indicating active interest and some in-depth engagement.

ImpactModerate impact

The conversations highlight the therapy’s potential to significantly alter treatment strategies, especially through targeting resistant cancer cells.

Abstract in brief

  • The study introduces a new treatment strategy that combines Doxycycline, which impairs mitochondrial function in cancer stem cells (CSCs), with Vitamin C, which targets the cells' glycolytic pathway, to more effectively eliminate CSCs and prevent resistance.
  • Doxycycline treatment reduces mitochondrial protein production, forcing CSCs to become more glycolytic and less flexible metabolically, which makes them more vulnerable when combined with other therapies.
  • Researchers identified additional drugs that can target CSCs resistant to Doxycycline, creating a comprehensive combination approach to starve and kill these cancer cells more efficiently.]

Top posts

Most liked on X and Bluesky
Mikhail V. Blagosklonny, MD PhD Professor Oncology
@Blagosklonny · X

Vitamin C and Doxycycline: A synthetic lethal combination therapy targeting metabolic flexibility in cancer stem ce… https://t.co/U1iKGhLv4v

Jan 3, 2024 · 38 likes · 2 shares · 22,286 followers View post →
Dr. Jackie Stone
@DrJackieStone · X

@KLVeritas We have seen patients with severe COVID turn around on 300 000iu of Vitamin D intramuscularly (available from India). Intravenous Vitamin C in combination with doxycycline is also remarkably effective in cancer patients. https://t.co/ZdATE0IOI3

Apr 16, 2023 · 33 likes · 13 shares · 7,419 followers View post →
FloridaSharkman2.0
@FLsharkman · X

@toobaffled Research suggests doxycycline can inhibit cancer cell growth, reduce bone metastasis, and even enhance the effectiveness of other chemotherapy drugs. +Vitamin C https://t.co/77wRiQ1O3q.

Jun 10, 2025 · 10 likes · 2 shares · 27,392 followers View post →
Rene Sugar
@renesugar · X

Vitamin C and Doxycycline: A synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs) https://t.co/K6auKl3p1O https://t.co/exxfqPbIIZ

Oct 9, 2023 · 10 likes · 2 shares · 3,970 followers View post →
Rene Sugar
@renesugar · X

https://t.co/K6auKkLfNG "identified two natural products (Vitamin C and Berberine) and six clinically-approved drugs, for metabolically targeting the Doxycycline-resistant CSC population (Atovaquone, Irinotecan, Sorafenib, Niclosamide, Chloroquine, and Stiripentol)." https://t.co/rv9j3q6HQB

Jul 22, 2020 · 8 likes · 3 shares · 3,970 followers View post →
FloridaSharkman2.0
@FLsharkman · X

@basednorthbrah Doxycycline, an antibiotic, is being investigated for its potential anti-cancer properties, particularly in targeting cancer stem cells (CSCs). Research suggests it can inhibit CSC propagation,

Jun 23, 2025 · 4 likes · 2 shares · 27,392 followers View post →

All mentions

FloridaSharkman2.0
@FLsharkman · X

@means69982 @saylahachey Doxycycline

Jul 17, 2025 · 2 likes · 27,392 followers View post →
badpharmakicker.bsky.social
@badpharmakicker.bsky.social · Bluesky

Vitamin C and Doxycycline: A synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs) pmc.ncbi.nlm.nih.gov/articles/PMC...

Jun 30, 2025 View post →
Rosa
@RosaRosario326 · X

RT @FLsharkman: @basednorthbrah Doxycycline, an antibiotic, is being investigated for its potential anti-cancer properties, particularly in…

Jun 23, 2025 · 2 shares · 6,201 followers View post →
FloridaSharkman2.0
@FLsharkman · X

@basednorthbrah Doxycycline, an antibiotic, is being investigated for its potential anti-cancer properties, particularly in targeting cancer stem cells (CSCs). Research suggests it can inhibit CSC propagation,

Jun 23, 2025 · 4 likes · 2 shares · 27,392 followers View post →
Katie
@maidenpgh · X

RT @FLsharkman: @toobaffled Research suggests doxycycline can inhibit cancer cell growth, reduce bone metastasis, and even enhance the effe…

Jun 10, 2025 · 2 shares · 495 followers View post →
One Patriot, Under God
@DebiFuller50557 · X

RT @FLsharkman: @toobaffled Research suggests doxycycline can inhibit cancer cell growth, reduce bone metastasis, and even enhance the effe…

Jun 10, 2025 · 2 shares · 616 followers View post →
FloridaSharkman2.0
@FLsharkman · X

@toobaffled Research suggests doxycycline can inhibit cancer cell growth, reduce bone metastasis, and even enhance the effectiveness of other chemotherapy drugs. +Vitamin C https://t.co/77wRiQ1O3q.

Jun 10, 2025 · 10 likes · 2 shares · 27,392 followers View post →
Otomo
@GravityParticle · X

RT @a_kruschke: @exosome May I add my beloved Doxy to your soup? ;) https://t.co/2RShwutiyu

Mar 13, 2025 · 2 shares · 1,021 followers View post →
Dr. Thomas Ichim
@exosome · X

RT @a_kruschke: @exosome May I add my beloved Doxy to your soup? ;) https://t.co/2RShwutiyu

Mar 13, 2025 · 2 shares · 35,004 followers View post →
A.Kruschke
@a_kruschke · X

@exosome May I add my beloved Doxy to your soup? ;) https://t.co/2RShwutiyu

Mar 13, 2025 · 3 likes · 2 shares · 1,492 followers View post →
Issei Taiki
@PotatoesInOrbit · X

@LewDrakePhD @Mybleukrewe @iAnonPatriot Nice. I didn't know about doxycycline repurposing https://t.co/jHax1fODwz . U forgot about glutamine / protein intake limiting.

Dec 21, 2024 · 474 followers View post →
ElevateYmind
@ElevateYmind · X

@BioavailableNd Vitamin C and Doxycycline: A synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs) https://t.co/jJXMktKdPd

Nov 21, 2024 · 6 followers View post →
mike_morbius
@mike_morbius · X

@TRICHFUN @DaveFi_369 @toddram3 @MakisMD Doxy is anticancer. https://t.co/G8JtonroaA

Oct 22, 2024 · 3 likes · 2,197 followers View post →
Rheumatoid Regeneration
@BeatRAnow · X

Vitamin C and Doxycycline: A synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs).⠀ This type of metabolic Achilles' heel will allow us and others to more effectively "starve" the CSC population.⠀ ⠀ https://t.co/C1FhffzgtP https://t.co/a6vAGvAkq5

Oct 10, 2024 · 75 followers View post →
Chris Milbank
@ChrisMilbank · X

RT @VitaApro: @ChrisMilbank @PharmacyUpdateO https://t.co/fWUoVFZglY

May 26, 2024 · 1 share · 45,890 followers View post →
Apro Vita
@VitaApro · X

@ChrisMilbank @PharmacyUpdateO https://t.co/fWUoVFZglY

May 26, 2024 · 4 likes · 1 share · 4,142 followers View post →
Greenlandshark
@greenlandsharky · X

RT @Blagosklonny: Vitamin C and Doxycycline: A synthetic lethal combination therapy targeting metabolic flexibility in cancer stem ce… http…

Jan 5, 2024 · 2 shares · 327 followers View post →
Mikhail V. Blagosklonny, MD PhD Professor Oncology
@Blagosklonny · X

Vitamin C and Doxycycline: A synthetic lethal combination therapy targeting metabolic flexibility in cancer stem ce… https://t.co/U1iKGhLv4v

Jan 3, 2024 · 38 likes · 2 shares · 22,286 followers View post →
tanya
@tanya99234675 · X

@Bel_B30 Vitamin C and Doxycycline: A synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs) https://t.co/po6N1bptW9

Dec 29, 2023 · 12 followers View post →
Brandon A. Trean
@Immortalinquiry · X

Vitamin C and Doxycycline: A synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs) https://t.co/IDX63NJUTu

Dec 9, 2023 · 1 like · 713 followers View post →
Jenn030303
@Jenn030303 · X

RT @renesugar: https://t.co/K6auKkLfNG "identified two natural products (Vitamin C and Berberine) and six clinically-approved drugs, for m…

Oct 10, 2023 · 3 shares · 892 followers View post →
Two Margarets
@The2Margarets · X

RT @renesugar: Vitamin C and Doxycycline: A synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs…

Oct 9, 2023 · 2 shares · 707 followers View post →
Rene Sugar
@renesugar · X

Vitamin C and Doxycycline: A synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs) https://t.co/K6auKl3p1O https://t.co/exxfqPbIIZ

Oct 9, 2023 · 10 likes · 2 shares · 3,970 followers View post →
Imelda
@BadCompany02 · X

Jun 2, 2023 · 44 followers View post →
Rene Sugar
@renesugar · X

RT @renesugar: https://t.co/K6auKkLfNG "identified two natural products (Vitamin C and Berberine) and six clinically-approved drugs, for m…

May 18, 2023 · 3 shares · 3,970 followers View post →
Rene Sugar
@renesugar · X

Vitamin C and Doxycycline: A synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs) https://t.co/W891blp0Rm

May 18, 2023 · 3,970 followers View post →
Lisa
@malteresa · X

RT @DrJackieStone: @KLVeritas We have seen patients with severe COVID turn around on 300 000iu of Vitamin D intramuscularly (available from…

Apr 17, 2023 · 13 shares · 697 followers View post →
Liz Clough
@197liz · X

RT @DrJackieStone: @KLVeritas We have seen patients with severe COVID turn around on 300 000iu of Vitamin D intramuscularly (available from…

Apr 17, 2023 · 13 shares · 1,335 followers View post →
MKRathi
@mkrathi2012 · X

RT @DrJackieStone: @KLVeritas We have seen patients with severe COVID turn around on 300 000iu of Vitamin D intramuscularly (available from…

Apr 17, 2023 · 13 shares · 711 followers View post →
Lynnbeachbum
@lynnluvsbeach · X

RT @DrJackieStone: @KLVeritas We have seen patients with severe COVID turn around on 300 000iu of Vitamin D intramuscularly (available from…

Apr 16, 2023 · 13 shares · 2,966 followers View post →
sara goldie
@mazymae60 · X

RT @DrJackieStone: @KLVeritas We have seen patients with severe COVID turn around on 300 000iu of Vitamin D intramuscularly (available from…

Apr 16, 2023 · 13 shares · 1,916 followers View post →
Nikchillin
@dozychick1 · X

RT @DrJackieStone: @KLVeritas We have seen patients with severe COVID turn around on 300 000iu of Vitamin D intramuscularly (available from…

Apr 16, 2023 · 13 shares · 150 followers View post →
janet
@janetobikeller · X

RT @DrJackieStone: @KLVeritas We have seen patients with severe COVID turn around on 300 000iu of Vitamin D intramuscularly (available from…

Apr 16, 2023 · 13 shares · 3,100 followers View post →
AJRimmer
@sm3ghead · X

RT @DrJackieStone: @KLVeritas We have seen patients with severe COVID turn around on 300 000iu of Vitamin D intramuscularly (available from…

Apr 16, 2023 · 13 shares · 330 followers View post →
slick
@slick0901 · X

RT @DrJackieStone: @KLVeritas We have seen patients with severe COVID turn around on 300 000iu of Vitamin D intramuscularly (available from…

Apr 16, 2023 · 13 shares · 715 followers View post →
Fluffy Bunny
@FluffyB64978720 · X

RT @DrJackieStone: @KLVeritas We have seen patients with severe COVID turn around on 300 000iu of Vitamin D intramuscularly (available from…

Apr 16, 2023 · 13 shares · 911 followers View post →
Loupylou026
@Loupylou026 · X

RT @DrJackieStone: @KLVeritas We have seen patients with severe COVID turn around on 300 000iu of Vitamin D intramuscularly (available from…

Apr 16, 2023 · 13 shares · 3,861 followers View post →
Thomas Anthony III
@MeasslainteIRL · X

RT @DrJackieStone: @KLVeritas We have seen patients with severe COVID turn around on 300 000iu of Vitamin D intramuscularly (available from…

Apr 16, 2023 · 13 shares · 5,011 followers View post →
Night Owl
@Fieldofdreams04 · X

RT @DrJackieStone: @KLVeritas We have seen patients with severe COVID turn around on 300 000iu of Vitamin D intramuscularly (available from…

Apr 16, 2023 · 13 shares · 2,088 followers View post →
Patrick Allan
@palevell2 · X

RT @DrJackieStone: @KLVeritas We have seen patients with severe COVID turn around on 300 000iu of Vitamin D intramuscularly (available from…

Apr 16, 2023 · 13 shares · 4,275 followers View post →
Dr. Jackie Stone
@DrJackieStone · X

@KLVeritas We have seen patients with severe COVID turn around on 300 000iu of Vitamin D intramuscularly (available from India). Intravenous Vitamin C in combination with doxycycline is also remarkably effective in cancer patients. https://t.co/ZdATE0IOI3

Apr 16, 2023 · 33 likes · 13 shares · 7,419 followers View post →
Dr. Jackie Stone
@DrJackieStone · X

@VirusFighterVi1 - we have seen patients with severe COVID turn around on 300 000iu of Vitamin D intramuscularly (available from India). Intravenous Vitamin C in combination with doxycycline is also remarkably effective in cancer patients. https://t.co/ZdATE0IOI3

Apr 16, 2023 · 7,419 followers View post →
Christina
@ChristinaRLIEB · X

Vitamin C and Doxycycline: A synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs) - PubMed https://t.co/hIKXzvAZOR

May 2, 2022 · 1 like · 371 followers View post →
AT42020
@AT42020 · X

Vitamin C and Doxycycline: A synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs) - PubMed https://t.co/H4FNJRbrwG

Dec 28, 2021 · 2,207 followers View post →
Felix Scholkmann
@FScholkmann · X

Vitamin C and Doxycycline: A synthetic lethal combination therapy targeting metabolic flexibility in #cancer stem cells (CSCs) -> https://t.co/pu75le9gxH https://t.co/jxPpLflkP6

Jun 20, 2021 · 2 likes · 1,928 followers View post →
Oncotarget
@Oncotarget · X

RT @renesugar: https://t.co/K6auKkLfNG "identified two natural products (Vitamin C and Berberine) and six clinically-approved drugs, for m…

Aug 3, 2020 · 3 shares · 3,203 followers View post →
Rene Sugar
@renesugar · X

https://t.co/K6auKkLfNG "identified two natural products (Vitamin C and Berberine) and six clinically-approved drugs, for metabolically targeting the Doxycycline-resistant CSC population (Atovaquone, Irinotecan, Sorafenib, Niclosamide, Chloroquine, and Stiripentol)." https://t.co/rv9j3q6HQB

Jul 22, 2020 · 8 likes · 3 shares · 3,970 followers View post →