Br J Sports Med February 2018 PMID 29018060

Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis.

Xiaoqian Liu, Gustavo C Machado, Jillian P Eyles, Varshini Ravi, David J Hunter

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Mentions

173
Peak: 7 in Nov 2022
across 5 sources since Jan 2019

Extended reach

1,274,464
potential audience

Total likes

4,400

Video views

246,267

Mentions per month

Jan 2019 – May 2025

Where it's discussed

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AI synopsis

What people are saying

The discussions show a strong consensus that widely-used supplements such as glucosamine, chondroitin, and collagen have minimal clinical benefits for osteoarthritis, with users referencing recent meta-analyses and emphasizing evidence-based conclusions. The tone and word choices reflect a shift from skepticism to reliance on scientific evidence, indicating the publication's potential to impact opinions on supplement use.

AgreementStrong agreement

Most discussions reinforce the study's conclusion that common supplements lack significant long-term benefits for osteoarthritis, showing strong consensus.

InterestHigh interest

Comments demonstrate high interest, with users referencing multiple studies and meta-analyses, discussing specific supplements like collagen, glucosamine, and Boswellia.

EngagementHigh engagement

Many discussions include detailed critiques of supplement efficacy, referencing scientific evidence, and debating implications, indicating deep engagement.

ImpactHigh impact

Contrary to some earlier beliefs in supplement effectiveness, users highlight evidence-based findings, suggesting the publication may influence public and medical perceptions.

Abstract in brief

  • The review analyzed 69 studies on 20 different dietary supplements for osteoarthritis, finding that some (like collagen hydrolysate, passion fruit peel extract, curcumin, pycnogenol, and L-carnitine) showed significant pain relief in the short term.
  • At medium term, green-lipped mussel extract and undenatured type II collagen provided clinically important pain reduction, but none of the supplements showed long-term benefits.
  • Overall, supplements had moderate short-term effects on pain and physical function, with no major safety concerns, though the quality of evidence varied from very low to high.

Top posts

Most liked on X and Bluesky
персональный тренер математических моделей
@QuantStrength · X

... не показывают традиционной для биологических систем зависимости "доза-эффект", что вызывает вопросы. Даже для этого специфичного случая последний метаанализ делает очень осторожный вывод: "The overall quality of evidence was moderate to very low." https://t.co/E0EGwOlJ0b

Aug 28, 2022 · 373 likes · 2 shares · 7,479 followers View post →
E3Rehab
@E3Rehab · X

“The most widely used supplements (eg, glucosamine, chondroitin) do not provide a clinically important effect on osteoarthritis” https://t.co/vG5dVlJ4oW “Currently, there is no good evidence to support the use of glucosamine for hip or knee OA..” https://t.co/KBmyJiyBOY

Nov 14, 2022 · 23 likes · 5 shares · 16,988 followers View post →
د. حسين الهمل|Dr.Hussain ALHamal
@alhamalhu · X

هذه المكملات كحال اي دواء موجود في الصيدلية، اخذها بشكل مبالغ به قد يؤثر على اجهزة الجسم مثل الكبد والكلى لذلك ينصح باستشارة الطبيب قبل اخذ اي من هذه المكملات تمت https://t.co/3h3ch9PJlD

Jun 11, 2022 · 18 likes · 1 share · 59,003 followers View post →
Stuart Phillips (he/him)
@mackinprof · X

@juliannejtaylor @CaloriesProper @NanciGuestRDPhD @coffeeordie71 The belief in pain relief is big - 30-40% response rate in most trials even in placebo groups! Collagen has been around for a while and still no major trial showing efficacy. Like glucosamine and condroitin... initial hype, but largely ineffective https://t.co/Yz0Pt9357P

Mar 30, 2021 · 8 likes · 1 share · 56,060 followers View post →
IberianCitizen
@IberianCitizen · X

@Samuel36916439 Partiendo d la pérdida d peso, ejercicio y una alimentación sin ultraprocesados con aporte pescado y verduras como base, colágeno, vitamina D, C, curcumina y jengibre. #osteoartritis https://t.co/FVlYSYNkTq https://t.co/Ec7B0dzM1J https://t.co/kJOFSabIUe https://t.co/Ek76vkDGQt https://t.co/aXxUQtgDAS

Nov 19, 2022 · 7 likes · 2 shares · 12,901 followers View post →
Ale Garcia
@GYM_EXTREMO · X

No generan efectos clínicamente importantes sobre el dolor y la función articular en los seguimientos a mediano y largo plazo. https://t.co/HtCF7Hqs2n

Jul 3, 2020 · 5 likes · 2 shares · 98,946 followers View post →

All mentions

tokatti
@tokatti_ · X

クルクミン(ただしデータは少ない) L-カルニチン(ただしデータは少ない) パッションフルーツエキス ウコン根エキス(ただしデータは少ない) ジメチルスルホン ボスウェリアセラタ樹脂エキス https://t.co/qekB698BCE #自分用メモ

Aug 15, 2024 · 189 followers View post →
Dr Richard Palmquist
@DrRPalmquist · X

Review Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis #passionfruitpeel #arthritis #seasonal https://t.co/wfdtxLxtyZ

Aug 2, 2024 · 1 like · 4,742 followers View post →
Colin O’Malley
@comaly93g42b84 · X

@julia_doubleday I used to be very much into heavy weight training and long runs + HIIT. My joints took a beating, whenever I stopped using MSM, chondroiton and high dose MSM, I couldn’t stand the joint pain. My suggestion is those 2 plusmegadoses of MSM. https://t.co/BOg9nIFaht https://t.co/FUaYF9MMbG

May 28, 2024 · 2,622 followers View post →
Kunal | Online Fitness Coach
@LiftToGetRipped · X

@thesneha_ Even latest meta-analysis concluded its long term significance on osteoarthritis is questionable https://t.co/zKfOmpfql5

Jan 30, 2024 · 243 followers View post →
Jeffrey Peng, MD
@JeffreyPengMD · X

The results of this study were consistent with a prior 2018 study that looked at over 20 supplements commonly used to treat symptomatic osteoarthritis. Boswellia extract was among the standouts with large effect sizes on pain reduction. https://t.co/tOXH7uMNIZ

Nov 4, 2023 · 1,553 followers View post →
しげトレ|パーソナルトレーニング整体
@geppi_0827 · X

2018年のLiuらによるシステマティックレビューでは、"最も広く使用されているサプリメント(例えば、グルコサミン、コンドロイチン)は、変形性関節症に対して臨床的に重要な効果をもたらさない "と結論を出しました。 https://t.co/Z0rkCKPkMX https://t.co/hWfAL5df5n

Oct 24, 2023 · 1 like · 506 followers View post →
DrRPalmquist
@DrPalmquist · X

Passion fruit peel is one natural agent with osteoarthritis benefits. I love putting it in tea. https://t.co/fckRnfxxTT

Oct 13, 2023 · 3,167 followers View post →
Jeffrey Peng, MD
@JeffreyPengMD · X

The results of this study were consistent with a prior 2018 study that looked at over 20 supplements commonly used to treat symptomatic osteoarthritis. Boswellia extract was among the standouts with large effect sizes on pain reduction. https://t.co/tOXH7uMNIZ

Sep 2, 2023 · 1,553 followers View post →
Stuart Phillips (he/him)
@mackinprof · X

@PrimaryCarePAC Right in line with all evidence Dave! https://t.co/Yz0Pt9357P Supplements had no clinically important effects on pain and function at medium-term and long-term follow-ups.

May 21, 2023 · 1 like · 56,060 followers View post →
เต่าบิน
@teabin25454465 · X

RT @E3Rehab: “The most widely used supplements (eg, glucosamine, chondroitin) do not provide a clinically important effect on osteoarthriti…

Dec 26, 2022 · 5 shares · 19 followers View post →
Dr. Litol
@drlitolsalud · X

RT @IberianCitizen: @Samuel36916439 Partiendo d la pérdida d peso, ejercicio y una alimentación sin ultraprocesados con aporte pescado y ve…

Dec 17, 2022 · 2 shares · 27 followers View post →
IberianCitizen
@IberianCitizen · X

RT @IberianCitizen: @Samuel36916439 Partiendo d la pérdida d peso, ejercicio y una alimentación sin ultraprocesados con aporte pescado y ve…

Nov 19, 2022 · 2 shares · 12,901 followers View post →
IberianCitizen
@IberianCitizen · X

@Samuel36916439 Partiendo d la pérdida d peso, ejercicio y una alimentación sin ultraprocesados con aporte pescado y verduras como base, colágeno, vitamina D, C, curcumina y jengibre. #osteoartritis https://t.co/FVlYSYNkTq https://t.co/Ec7B0dzM1J https://t.co/kJOFSabIUe https://t.co/Ek76vkDGQt https://t.co/aXxUQtgDAS

Nov 19, 2022 · 7 likes · 2 shares · 12,901 followers View post →
R.A
@raan62 · X

RT @E3Rehab: “The most widely used supplements (eg, glucosamine, chondroitin) do not provide a clinically important effect on osteoarthriti…

Nov 15, 2022 · 5 shares · 185 followers View post →
Madhan Ramanathan
@sportsphysiouk · X

RT @E3Rehab: “The most widely used supplements (eg, glucosamine, chondroitin) do not provide a clinically important effect on osteoarthriti…

Nov 14, 2022 · 5 shares · 1,146 followers View post →
Jean-Pascal Grenier
@Jp_mednphysio · X

RT @E3Rehab: “The most widely used supplements (eg, glucosamine, chondroitin) do not provide a clinically important effect on osteoarthriti…

Nov 14, 2022 · 5 shares · 317 followers View post →
E3Rehab
@E3Rehab · X

“The most widely used supplements (eg, glucosamine, chondroitin) do not provide a clinically important effect on osteoarthritis” https://t.co/vG5dVlJ4oW “Currently, there is no good evidence to support the use of glucosamine for hip or knee OA..” https://t.co/KBmyJiyBOY

Nov 14, 2022 · 23 likes · 5 shares · 16,988 followers View post →
DrRPalmquist
@DrPalmquist · X

Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis - PubMed https://t.co/fckRnffoFL

Nov 12, 2022 · 1 like · 3,167 followers View post →
Shivva_Rudra
@Shivva_Rudra · X

RT @QuantStrength: ... не показывают традиционной для биологических систем зависимости "доза-эффект", что вызывает вопросы. Даже для этого…

Aug 29, 2022 · 2 shares · 342 followers View post →
полупидорский праздник мести
@woman_or_plant · X

RT @QuantStrength: ... не показывают традиционной для биологических систем зависимости "доза-эффект", что вызывает вопросы. Даже для этого…

Aug 29, 2022 · 2 shares · 865 followers View post →
персональный тренер математических моделей
@QuantStrength · X

... не показывают традиционной для биологических систем зависимости "доза-эффект", что вызывает вопросы. Даже для этого специфичного случая последний метаанализ делает очень осторожный вывод: "The overall quality of evidence was moderate to very low." https://t.co/E0EGwOlJ0b

Aug 28, 2022 · 373 likes · 2 shares · 7,479 followers View post →
د. حسين الهمل|Dr.Hussain ALHamal
@alhamalhu · X

هذه المكملات كحال اي دواء موجود في الصيدلية، اخذها بشكل مبالغ به قد يؤثر على اجهزة الجسم مثل الكبد والكلى لذلك ينصح باستشارة الطبيب قبل اخذ اي من هذه المكملات تمت https://t.co/3h3ch9PJlD

Jun 11, 2022 · 18 likes · 1 share · 59,003 followers View post →
Nachabal
@nachabal · X

RT @GYM_EXTREMO: No generan efectos clínicamente importantes sobre el dolor y la función articular en los seguimientos a mediano y largo pl…

May 12, 2022 · 2 shares · 617 followers View post →
sara.art
@saraart4 · X

RT @DrPalmquist: Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis - PubMed “collagen hydrolysate, pas…

Nov 25, 2021 · 8,509 followers View post →
DrRPalmquist
@DrPalmquist · X

Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis - PubMed “collagen hydrolysate, passion fruit peel extract, Curcuma longa extract, Boswellia serrata extract, curcumin, pycnogenol and L-carnitine)” best effects https://t.co/fckRnffoFL

Nov 25, 2021 · 4 likes · 3,167 followers View post →
Nanci Guest PhD, RD, CSCS
@NanciGuestRDPhD · X

RT @mackinprof: @CarbAppropriate @NanciGuestRDPhD @juliannejtaylor @coffeeordie71 Peptides absorbed, I would never deny. Skin... ok, but no…

Apr 1, 2021 · 1 share · 10,518 followers View post →
Stuart Phillips (he/him)
@mackinprof · X

@CarbAppropriate @NanciGuestRDPhD @juliannejtaylor @coffeeordie71 Peptides absorbed, I would never deny. Skin... ok, but not the original point. Joint health, no convincing data, https://t.co/Yz0Pt9357P Muscle - total

Apr 1, 2021 · 1 share · 56,060 followers View post →
Stuart Phillips (he/him)
@mackinprof · X

@mboyle1959 @CaloriesProper @juliannejtaylor @NanciGuestRDPhD @coffeeordie71 Have a look at this meta https://t.co/Yz0Pt9kFZn and the conclusions

Mar 31, 2021 · 1 like · 56,060 followers View post →
Nanci Guest PhD, RD, CSCS
@NanciGuestRDPhD · X

RT @mackinprof: @juliannejtaylor @CaloriesProper @NanciGuestRDPhD @coffeeordie71 The belief in pain relief is big - 30-40% response rate in…

Mar 30, 2021 · 1 share · 10,518 followers View post →
Stuart Phillips (he/him)
@mackinprof · X

@juliannejtaylor @CaloriesProper @NanciGuestRDPhD @coffeeordie71 The belief in pain relief is big - 30-40% response rate in most trials even in placebo groups! Collagen has been around for a while and still no major trial showing efficacy. Like glucosamine and condroitin... initial hype, but largely ineffective https://t.co/Yz0Pt9357P

Mar 30, 2021 · 8 likes · 1 share · 56,060 followers View post →
Stuart Phillips (he/him)
@mackinprof · X

@CaloriesProper @juliannejtaylor @NanciGuestRDPhD @coffeeordie71 https://t.co/Yz0Pt9357P no real evidence for efficacy in OA

Mar 30, 2021 · 2 likes · 56,060 followers View post →
Stuart Phillips (he/him)
@mackinprof · X

@juliannejtaylor @NanciGuestRDPhD @coffeeordie71 It’s mostly junk science. Meta-analysis - no effect. https://t.co/Yz0Pt9357P

Mar 30, 2021 · 56,060 followers View post →
Stuart Phillips (he/him)
@mackinprof · X

@juliannejtaylor @SailorLapin @langernutrition Evidence-based answer, no it doesn't https://t.co/Yz0Pt9357P effects transient at best, trivial in magnitude in most cases. Don't waste your money IMO

Dec 16, 2020 · 4 likes · 56,060 followers View post →
Joel Prowting, PhD CSCS
@JoelProwting · X

RT @mackinprof: @JoelProwting @APNMjournal But in-line with recent meta-analysis: https://t.co/Yz0Pt9357P Supplements had no clinically imp…

Jul 4, 2020 · 1 share · 159 followers View post →
Stuart Phillips (he/him)
@mackinprof · X

@JoelProwting @APNMjournal But in-line with recent meta-analysis: https://t.co/Yz0Pt9357P Supplements had no clinically important effects on pain and function at medium-term and long-term follow-ups. Remember glucosamine, chondroitin... #hype>#evidence

Jul 3, 2020 · 4 likes · 1 share · 56,060 followers View post →
Ale Garcia
@GYM_EXTREMO · X

No generan efectos clínicamente importantes sobre el dolor y la función articular en los seguimientos a mediano y largo plazo. https://t.co/HtCF7Hqs2n

Jul 3, 2020 · 5 likes · 2 shares · 98,946 followers View post →
Stuart Phillips (he/him)
@mackinprof · X

@madmaxsomm @APNMjournal Supplements had no clinically important effects on pain and function at medium-term and long-term follow-ups. https://t.co/Yz0Pt9357P

Jul 3, 2020 · 4 likes · 56,060 followers View post →
Marcos-FitRebelde
@FITrebelde · X

@MANUELVISO1 Hay bastante evidencia, metaanálisis incluso ;) https://t.co/9gBnttQ5U5

Jan 30, 2020 · 3 likes · 1 share · 98,767 followers View post →
Marcos-FitRebelde
@FITrebelde · X

@brucart @MANUELVISO1 @cescept Te puedes fiar :) https://t.co/9gBnttyuvv

Jan 30, 2020 · 1 like · 98,767 followers View post →
Pk
@perpsw · X

RT @claudiaegl92: The most widely used supplements (eg, glucosamine, chondroitin) do not provide a clinically important effect on osteoarth…

Apr 15, 2019 · 2 shares · 122 followers View post →
SystematicReviewBot
@EvidenceRobot · X

RT @claudiaegl92: The most widely used supplements (eg, glucosamine, chondroitin) do not provide a clinically important effect on osteoarth…

Apr 15, 2019 · 2 shares · 6,702 followers View post →
Claudia Guillén-López MD
@claudiaegl92 · X

The most widely used supplements (eg, glucosamine, chondroitin) do not provide a clinically important effect on osteoarthritis. Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis https://t.co/8W40Yw7vbu

Apr 15, 2019 · 1 like · 2 shares · 781 followers View post →
Stuart Phillips (he/him)
@mackinprof · X

@Meat_Matter_Pod @CaloriesProper @kevinnbass @AlexFerentinos7 @AlexJLeaf @DavidHealth @mightbeanybody @JenniferSygo @NBCNews @ChrisMasterjohn @ValtsuH https://t.co/4zH2WRstnO Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis: Supplements had no clinically important effects on pain and function at medium-term and long-term follow-ups. (collagen included)

Jan 20, 2019 · 56,060 followers View post →