PubHawk
Gut January 2018 PMID 29089382

Long-term proton pump inhibitors and risk of gastric cancer development after treatment for : a population-based study.

Ka Shing Cheung, Esther W Chan, Angel Y S Wong, Lijia Chen, Ian C K Wong, Wai Keung Leung

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Mentions

224
Peak: 12 in Sep 2021
across 6 sources since Feb 2018

Extended reach

120,242
potential audience

Total likes

71

Video views

6,014

Mentions per month

Feb 2018 – May 2025

Where it's discussed

  • News143 articles
  • Facebook38 posts
  • X / Twitter26 posts
  • Blogs12 articles
  • Reddit3 posts
  • YouTube2 videos

AI synopsis

What people are saying

The overall tone reveals a mix of curiosity and concern, with posts like 'Interesting article' and mentions of the risks associated with long-term PPI use, such as increased gastric cancer risk. Words like 'risky' and the call to reconsider how we label PPIs reflect a cautious but engaged attitude toward the study's implications, indicating balanced support and concern about public health influence.

AgreementModerate agreement

Most discussions acknowledge the study and its findings, with some expressing concern or caution, leading to a generally supportive stance.

InterestHigh interest

Many posts highlight the relevance of the research, especially given public concerns about medication safety, showing high interest.

EngagementModerate engagement

Participants reference specific results and express opinions on medication use, indicating moderate engagement, but few delve deeply into scientific details.

ImpactModerate impact

Several discussions suggest the potential influence of the study on public perceptions and prescribing habits, hinting at a modest to moderate impact.

Abstract in brief

  • The study found that long-term use of proton pump inhibitors (PPIs) is linked to an increased risk of developing gastric cancer, especially in individuals infected with Helicobacter pylori (HP), even after HP eradication therapy.
  • Researchers used a large health database from Hong Kong, selecting adults treated for HP infection, and found that PPI use increased gastric cancer risk, with the risk rising with longer durations of PPI use.
  • The analysis showed that PPI use was associated with a significantly higher hazard ratio for gastric cancer compared to non-use, whereas histamine2 receptor antagonists (H2RAs) did not increase the risk, suggesting a specific connection between PPIs and gastric cancer.
Read the full abstract

Top posts

Most liked on X and Bluesky
Juan Pablo (JP) Arab, MD 
@juanpabloarab · X

Interesting article

Sep 25, 2021 · 29 likes · 13 shares · 5,496 followers View post →
Gustavo Domeniconi
@gdomeni · X

Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: a population-based study | Gut https://t.co/0zqJWQEpOA

Nov 1, 2020 · 5 likes · 3 shares · 934 followers View post →
Chris Lo
@chrislowh · X

@salonium True though they have to be presented and explained in the right way. Got patients coming to me refusing to take medications for peptic ulcer coz of this paper: https://t.co/lq6wSkPtV9 Publicizing medical knowledge without clarifying their doubts would cause ppl to panic.

Oct 23, 2022 · 2 likes · 188 followers View post →
Ciekawość.Nauka i Natura
@nauka_natura · X

Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: a population-based study | Gut https://t.co/kPcWG1Cmo2

Sep 29, 2019 · 1 like · 1,238 followers View post →
スモーキー
@tourer_pipokun · X

https://t.co/r2ubjZkKwf https://t.co/Tk1iijGAvh ピロリ菌の検査よりも、胃酸の分泌を抑制するPPI（プロトンポンプ阻害薬）の胃癌リスク増大の国民に指摘を知らせる事の方が先決だと思いますね。 リンク先は両者とも香港の研究報告例 https://t.co/sUbe66UI9g

Jun 25, 2023 · 1 like · 1,075 followers View post →
Gut Journal
@Gut_BMJ · X

RT @gdomeni: Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: a population-…

Nov 2, 2020 · 3 shares · 31,415 followers View post →

All mentions

Greg Nurse
@gregnurseenx · X

Riesgo de desarrollo de cáncer por uso prolongado de IBP como el "Omeprazol". https://t.co/Qb5khsxjsD

May 30, 2025 · 179 followers View post →
スモーキー
@tourer_pipokun · X

https://t.co/r2ubjZkKwf https://t.co/Tk1iijGAvh ピロリ菌の検査よりも、胃酸の分泌を抑制するPPI（プロトンポンプ阻害薬）の胃癌リスク増大の国民に指摘を知らせる事の方が先決だと思いますね。 リンク先は両者とも香港の研究報告例 https://t.co/sUbe66UI9g

Jun 25, 2023 · 1 like · 1,075 followers View post →
Kanishk Dudeja
@kanishkdudeja · X

@AdiG1993 @anujtiwari11 https://t.co/yZkbGLTbfH https://t.co/9rZH0hL3Kx

Jan 3, 2023 · 1,267 followers View post →
Chris Lo
@chrislowh · X

@salonium True though they have to be presented and explained in the right way. Got patients coming to me refusing to take medications for peptic ulcer coz of this paper: https://t.co/lq6wSkPtV9 Publicizing medical knowledge without clarifying their doubts would cause ppl to panic.

Oct 23, 2022 · 2 likes · 188 followers View post →
Oliver jean
@Oliverjean8 · X

RT @juanpabloarab: Interesting article

Sep 26, 2021 · 13 shares · 10 followers View post →
Microbiome Research Centre
@MRC_microbiome · X

RT @juanpabloarab: Interesting article

Sep 26, 2021 · 13 shares · 2,932 followers View post →
Prof. Nick Talley
@Prof_NickTalley · X

RT @juanpabloarab: Interesting article

Sep 26, 2021 · 13 shares · 6,417 followers View post →
XiaoTao JIANG
@Titus12629950 · X

RT @juanpabloarab: Interesting article

Sep 26, 2021 · 13 shares · 379 followers View post →
Emad El-Omar
@emadelomar · X

RT @juanpabloarab: Interesting article

Sep 26, 2021 · 13 shares · 3,867 followers View post →
Gut Journal
@Gut_BMJ · X

RT @juanpabloarab: Interesting article

Sep 26, 2021 · 13 shares · 31,415 followers View post →
Benjamin Chan
@DoctorBenChan · X

RT @juanpabloarab: Interesting article

Sep 26, 2021 · 13 shares · 1,830 followers View post →
Dr. Saneya
@Saneya_2810 · X

RT @juanpabloarab: Interesting article

Sep 26, 2021 · 13 shares · 1,444 followers View post →
Anuraag Jena
@DrAnuraagJ · X

RT @juanpabloarab: Interesting article

Sep 26, 2021 · 13 shares · 4,471 followers View post →
Metabolism and Target Organ Damage
@MetabolismAnd · X

RT @juanpabloarab: Interesting article

Sep 26, 2021 · 13 shares · 824 followers View post →
Gastro RTs
@GastroRTs · X

RT @juanpabloarab: Interesting article

Sep 25, 2021 · 13 shares · 1,999 followers View post →
Juan Pablo (JP) Arab, MD 
@juanpabloarab · X

Interesting article

Sep 25, 2021 · 29 likes · 13 shares · 5,496 followers View post →
Emad El-Omar
@emadelomar · X

RT @gdomeni: Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: a population-…

Nov 4, 2020 · 3 shares · 3,867 followers View post →
healthyanddiet
@healthyanddiet1 · X

RT @gdomeni: Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: a population-…

Nov 2, 2020 · 3 shares · 95 followers View post →
Gut Journal
@Gut_BMJ · X

RT @gdomeni: Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: a population-…

Nov 2, 2020 · 3 shares · 31,415 followers View post →
a Sandra Rg
@dietistarealist · X

Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: a population-based study https://t.co/hMauDfXj5x

Nov 2, 2020 · 3,195 followers View post →
Gustavo Domeniconi
@gdomeni · X

Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: a population-based study | Gut https://t.co/0zqJWQEpOA

Nov 1, 2020 · 5 likes · 3 shares · 934 followers View post →
Prashanth Gokare
@pgokare · X

Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: a population-based study https://t.co/c21on3byZO

Apr 13, 2020 · 27 followers View post →
Prashanth Gokare
@pgokare · X

Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: a population-based study https://t.co/c21on3byZO

Oct 3, 2019 · 27 followers View post →
Enfermera Dudacionista
@DueDiet · X

Deberíamos empezar por dejar de llamarlos en algunos ámbitos "Protectores del estómago". Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: a population-based study #Bmj #ibp #gut https://t.co/Jxqh8XLTxo

Sep 30, 2019 · 7,861 followers View post →
Ciekawość.Nauka i Natura
@nauka_natura · X

Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: a population-based study | Gut https://t.co/kPcWG1Cmo2

Sep 29, 2019 · 1 like · 1,238 followers View post →
ABE SEIYA
@seiyaabe · X

Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: a population-based study. - PubMed - NCBI https://t.co/yISPYsNjA8 ピロリ除菌後にPPIを使うと胃がんリスクが2.44倍になる

Jan 6, 2019 · 1,441 followers View post →