Low-level red LED light inhibits hyperkeratinization and inflammation induced by unsaturated fatty acid in an in vitro model mimicking acne.

Abstract in brief

• The study investigates how low doses of red LED light (0.2, 0.5, and 1.2 Joules per square centimeter) can reduce inflammation and hyperkeratinization in an in vitro acne model by decreasing inflammatory cytokine IL-1 and improving epidermal barrier function.
• Results showed that red LED light significantly lowered IL-1 levels and reduced stratum corneum thickening caused by oleic acid, a substance used to mimic acne inflammation, indicating its potential to treat acne by targeting key pathological features.
• Overall, the findings suggest that lower doses of red light therapy could be a safe and effective alternative for managing acne-related inflammation and skin overgrowth, with fewer side effects compared to higher doses used in clinical settings.]