The digital discussions emphasize the importance of the gut microbiome in modulating responses to cancer immunotherapy, with phrases like 'improved responses' and 'beneficial gut bacteria' indicating recognition of the study's significance. The tone varies from supportive to curious, reflecting interest in potential clinical applications and ongoing scientific debates about specific bacteria, which underscores the moderate yet meaningful impact of the article.
AgreementModerate agreement
Most comments acknowledge the research's findings that the gut microbiome influences immunotherapy responses, with some debates about specific bacterial species involved.
InterestHigh interest
Discussions show high curiosity about the gut microbiome's role and implications for cancer treatment, indicating strong engagement with the topic.
EngagementModerate engagement
Many posts reference the scientific publication and its broader implications, suggesting meaningful engagement rather than superficial commentary.
ImpactModerate impact
The discussions imply that understanding and manipulating the gut microbiome could significantly impact cancer treatment approaches.
Abstract in brief
The study found that melanoma patients who responded to anti-PD1 immunotherapy had a more diverse and different composition of gut microbiome, especially with higher levels of Ruminococcaceae bacteria, compared to nonresponders.
Functional analysis showed that beneficial gut bacteria in responders had enhanced metabolic pathways that may support better immune responses.
Immune profiling and experiments with germ-free mice indicated that a favorable gut microbiome could boost systemic and anti-tumor immunity, suggesting potential to improve cancer treatment outcomes by manipulating gut bacteria.]
#ECCMID2023 Your gut microbiome seems to module your response to anti-PD-1 immunotherapy https://t.co/KpEDsqFlAW but there has been little agreement on which species are driving these effects https://t.co/GuayoXYn9Y
#BAĞIRSAK #BAKTERİLERİ #KANSER
#TEDAVİSİNİ #DESTEKLİYOR
➡️ Fransız ve ABD'li araştırmacılar, sindirim sisteminde yaşayan faydalı bakterilerin kanser tedavisinde tümörlerin küçülmesini sağladığını belirtiyorlar.
Kaynak : ⏬
https://t.co/Bj47Tl5jMk
https://t.co/WniUrUJOSG (94) https://t.co/qtk0vo6rkd
Wargo led a team to discover that patients w metastatic #melanoma had improved responses to immunotherapy if they had a more diverse population of microbes or an abundance of certain types of bacteria in their gut. These findings were published in Science. https://t.co/6ujhaM2x36
This study highlights how a diverse and beneficial gut microbiome, especially with higher Ruminococcaceae levels, correlates with better melanoma response to anti-PD-1 immunotherapy. Insights into microbiome…
This study shows that melanoma patients responding to anti-PD1 therapy have more diverse gut microbiomes, especially Ruminococcaceae bacteria. Transferring these bacteria to mice improved tumor response, highlighting…
Health Journey explores how eggs and gut bacteria may influence cancer risk. Recent research links diet, gut microbiome diversity, and certain bacteria with potential effects on immune response and cancer development.
Gopalakrishnan et al. and Matson et al. independently found that the gut microbiome composition of melanoma patients was associated with response to anti-PD-1 therapy.
This was a major conceptual shift.
The biomarker was not only in the tumor.
Source: https://t.co/4Uu6J9bZdJ
#ECCMID2023 Your gut microbiome seems to module your response to anti-PD-1 immunotherapy https://t.co/KpEDsqFlAW but there has been little agreement on which species are driving these effects https://t.co/GuayoXYn9Y
Wargo led a team to discover that patients w metastatic #melanoma had improved responses to immunotherapy if they had a more diverse population of microbes or an abundance of certain types of bacteria in their gut. These findings were published in Science. https://t.co/6ujhaM2x36
#BAĞIRSAK #BAKTERİLERİ #KANSER
#TEDAVİSİNİ #DESTEKLİYOR
➡️ Fransız ve ABD'li araştırmacılar, sindirim sisteminde yaşayan faydalı bakterilerin kanser tedavisinde tümörlerin küçülmesini sağladığını belirtiyorlar.
Kaynak : ⏬
https://t.co/Bj47Tl5jMk
https://t.co/WniUrUJOSG (94) https://t.co/qtk0vo6rkd
Science 2018;359:97–103. doi: 10.1126/science.aan4236 Matson V et al. The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma ...
Bacterial antagonism in host-associated microbial communities
News
Science. 21 Sep 2018. Vol 361, Issue 6408. DOI: 10.1126/science.aat2456 ... 10.1126/science.aan4236. GO TO REFERENCE. Crossref · PubMed · Web of Science.
Gut microbiome modulates response to anti–PD-1 immunotherapy ...
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... 10.1126/science.aan4236 · PREVIOUS ARTICLE. Gut microbiome influences ... Science 348, 80–86 (2015). Crossref · PubMed · Web of Science · Google Scholar. a ...
(Page numbers not final at time of first release) 1 - Science
News
Science 10.1126/science.aan4236 (2017). First release: 2 November 2017 www.sciencemag.org. (Page numbers not final at time of first release) 1. Page 2. First ...
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