January 2018 PMID 29097494

Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors.

Bertrand Routy, Emmanuelle Le Chatelier, Lisa Derosa, Connie P M Duong, Maryam Tidjani Alou, Romain Daillère, Aurélie Fluckiger, Meriem Messaoudene, Conrad Rauber, Maria P Roberti, Marine Fidelle, Caroline Flament, Vichnou Poirier-Colame, Paule Opolon, Christophe Klein

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Mentions

121

Peak: 9 in Sep 2025

across 8 sources since Jan 2018

Extended reach

74,288

potential audience

Total likes

744

Video views

15,707

Mentions per month

Jan 2018 – Dec 2025

Where it's discussed

Facebook49 posts
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LinkedIn20 posts
X / Twitter18 posts
Blogs4 articles
YouTube2 videos
Instagram2 posts
Reddit1 posts

AI synopsis

What people are saying

The overall sentiment reflects strong agreement and high interest, evidenced by references to scientific papers, mentions of bacteria like Akkermansia, and discussions about how the microbiome may improve immunotherapy outcomes. Word choices such as 'science shows,' 'important,' and 'game changer' indicate both engagement and perceived significance, which contributes to the high scores across all categories.

AgreementModerate agreement

Most discussions support the idea that the microbiome significantly affects immunotherapy outcomes, with many citing prior research and emphasizing the relevance.

InterestHigh interest

Posts show high curiosity and enthusiasm, referencing specific bacteria like Akkermansia muciniphila and discussing potential for improving treatment success.

EngagementHigh engagement

Many discussions provide detailed insights, citing studies, mechanisms, and implications, demonstrating deep involvement.

ImpactHigh impact

The emphasis on scientific findings, references to major studies, and implications for cancer treatment highlight a belief that this research could influence clinical practices.

Abstract in brief

The gut microbiome plays a crucial role in determining the effectiveness of PD1-based immunotherapy for epithelial tumors, with abnormalities in microbiome composition linked to primary resistance to treatment.
Antibiotic use can reduce the clinical benefits of immune checkpoint inhibitors in cancer patients, suggesting that healthy gut bacteria are important for therapy success.
Fecal microbiota transplantation (FMT) from responders to non-responders can improve immunotherapy outcomes by enhancing immune responses, especially when combined with oral supplementation that boosts interleukin-12 and T cell recruitment to tumors.

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All mentions

Gut Microbiome's Role in Enhancing Cancer Immunotherapy Effectiveness

Discover groundbreaking research on how gut bacteria influence immunotherapy success and how diet and microbiome health can help prevent and fight cancer. Learn about therapies like fecal transplants and foods that…

FOODS & DRINKS · Oct 7, 2025 15,546 views

Standardizing Gut Microbiome Testing for Clinical Application

This episode features Dr Gianluca Ianiro MD PhD discussing advances in gut microbiome testing for medical use, emphasizing the need for standardization to improve clinical utility and outcomes in therapies like FMT and…

ISAPPScience · May 7, 2025 161 views

Marie

@suveroeigen70 · X

RT @microviolist: 이미 2018년도에 면역항암제가 잘 듣는 사람들에게 장내미생물이 중요한 역할을 하는 것 같고 그 중 Akkermansia muciniphila라는 종이 중요한 역할을 하는 것 같다는 논문이 사이언스에 실렸었죠. 그래서…

Jul 14, 2025 · 3 shares · 49 followers View post →

바이오매니아

@microviolist · X

Jul 14, 2025 · 2 likes · 3 shares · 5,426 followers View post →

Harry Sokol

@h_sokol · X

Jul 2, 2024 · 2 likes · 3,410 followers View post →

Catherine Crenn

@catherine_crenn · X

@CamillaFab @laurieandi22 @SandraR74620515 https://t.co/2kkZ41z4cD

Apr 9, 2024 · 1,390 followers View post →

腎臓屋のひとりごと(腎Net)

@CKD_pharmacist · X

これって、すでに常識なんかなぁ〜

Mar 3, 2024 · 1 like · 1,212 followers View post →

Toto007

@Toto_Lille · X

@Oliviersanstom @TheRealZeRoY @raoult_didier Science Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors cité par +3000 chercheurs

Aug 9, 2023 · 71 followers View post →

Jarushka Naidoo

@DrJNaidoo · X

Feb 13, 2023 · 6 likes · 11,478 followers View post →

Madam Mitochondria

@Madam_Mito · X

@exosome @StevenMetaverse https://t.co/N8N3Mp3nZW Akkermansia M. Again. I’ll stop, it’s just so cool.

Jan 8, 2023 · 1 like · 10,895 followers View post →

Molecular Oncology

@MolOncology · X

Gut microbiome influence efficacy of PD-1 based immunotherapy against epithelial tumours https://t.co/S2STF0gR68

Apr 7, 2022 · 2,213 followers View post →

Carra Simpson Ph.D

@carrasimpson · X

@BenSiranosian @MicrobiomeVIF Here it is! https://t.co/H0HfEHA3SP PD-1 and PD-L1.

Mar 10, 2022 · 1,114 followers View post →

Jonathan Cedernaes

@JCedernaes · X

6/ These findings add to prior studies – e.g. also @ScienceMagazine – re. the role of the #microbiome in clinical outcomes in cancer patients: – Epithelial tumors, nonresponders had ⬇️ levels of Akkermansia muciniphila https://t.co/eeKiXPfu1W – Melanoma: https://t.co/gxxpXUoSj5

Dec 26, 2021 · 1 share · 3,115 followers View post →

YodaTheThird

@DrissAyadi2 · X

@LeptOBDS @EvskyLeman @aartkaa @OMariano0 @raoult_didier Mais oui bien sûr les fameuses revues prédatrices que sont Science et AMS https://t.co/D8xu6LkYLY https://t.co/B8zOf5eWcC https://t.co/UdPSYaS2PE

Nov 5, 2021 View post →

Dr.jamesveltmeyer

@DJamesveltmeyer · X

RT @BiotechLimo: #cancer patients on #immunotherapy need to have a good #microbiome Take @DAILYBODYRESTOR https://t.co/xC0uIvZdbr

Sep 23, 2021 · 1 share · 4,361 followers View post →

Dr L Boominathan PhD

@DrLBoominathan · X

Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors https://t.co/9SoCcVYAod https://t.co/V9HUkHGpq5

Feb 5, 2021 · 895 followers View post →

Caspy7

@caspy7 · X

Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors https://t.co/pS2smoqp7N

Jan 9, 2020 · 150 followers View post →

PF Anderson @pfanderson@disabled.social

@pfanderson · X

Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors. https://t.co/UdRwU7UKEt

Dec 29, 2019 · 1 like · 10,745 followers View post →

Ģirts Šķenders

@seermais · X

Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors https://t.co/wBieoZsjKZ

Jun 20, 2019 · 47 followers View post →

Tatsuki Aikyo

@urakuramubon · X

The commensal microbiome is associated with anti–PD-1 efficacy in metastatic melanoma patients https://t.co/ktiE6QUjQk Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors https://t.co/ob7TP68QKk

May 28, 2019 · 985 followers View post →

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Science 359(6371), 91-97. DOI: 10.1126/science.aan3706; Gopalakrishnan, V., et al (2018) Gut microbiome modulates response to anti–PD-1 ...

Jan 8, 2018 View →

Possibile correlazione tra batteri intestinali buoni e risposta a

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Science 2017; eaan3706; doi: 10.1126/science.aan3706. leggi. Ti è piaciuto l'articolo? Condividilo: x. Tags: batteri intestinali · immunoterapia ...

Dec 1, 2017 View →

Gut bacteria influenced response to checkpoint inhibitors | MDedge

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FROM SCIENCE. The gut microbome may influence responses to immune ... 2 doi: 10.1126/science.aan3706). Analysis of the gut microbiome in ...

Nov 14, 2017 View →

Aleix Pàmies - La flora intestinal afecta al éxito de la inmunoterapia ...

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Science 10.1126/science.aan3706 (2017). V. Gopalakrishnan et al., 'Gut microbiome impacts response to anti-PD-1 immunotherapy in melanoma ...

Nov 13, 2017 View →

Darmbakterien spielen mit | PZ – Pharmazeutische Zeitung

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... 10.1126/science.aan3706). Die Forscher betrachteten 249 Patienten, die aufgrund von fortgeschrittenen Krebserkrankungen mit einer Anti-PD-1 ...

Nov 8, 2017 View →

Gut bacteria may make or break your chances of cancer treatment ...

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Science, 2017. DOI: 10.1126/science.aan3706 (About DOIs).

Nov 5, 2017 View →

r/science on Reddit: Gut bacteria 'boost' cancer therapy - Patients ...

Science 02 Nov 2017: eaan3706. DOI: 10.1126/science.aan3706. Link: http://science.sciencemag.org/content/early/2017/11/01/science.aan3706.

Nov 3, 2017 View →

四篇Science共同揭秘PD-1/PD-L1免疫療法對多種癌症患者無效的 ...

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... 10.1126/science.aan3706 DOI:10.1126/science.aan4236 DOI:10.1126/science.aac4255 DOI: 10.1126/science.aad1329 http://www.sciencemag.org/news ...

Nov 3, 2017 View →

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10.1126/science. aan3706 & V. GOPALAKRISHNAN ET AL. 10.1126/ science.aan4236. 574 BACKLASH AFTER SHUTDOWN OF. SWISS ASTRONOMY INSTITUTE.

Nov 3, 2017 View →

Unveiling gut microbes' influence on cancer patient response to ...

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American Association for the Advancement of Science (AAAS). Journal: Science; DOI: 10.1126/science.aan3706. Keywords. /Health and medicine ...

Nov 2, 2017 View →

腸内微生物は免疫療法に対するがん患者の反応にどのような影響を ...

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aan3706. Disclaimer: AAAS and EurekAlert! are not responsible for the ... 10.1126/science.aan3706. Keywords. /Health and medicine/Clinical ...

Nov 2, 2017 View →

肠道微生物如何影响癌症病人对免疫疗法的反应| EurekAlert!

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American Association for the Advancement of Science (AAAS). Journal: Science; DOI: 10.1126/science.aan3706. Keywords. /Health and medicine ...

Nov 2, 2017 View →

La flora intestinal afecta al éxito de la inmunoterapia contra el cáncer

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Science 10.1126/science.aan3706 (2017). V. Gopalakrishnan et al., 'Gut microbiome impacts response to anti-PD-1 immunotherapy in melanoma ...

Nov 2, 2017 View →

From a molecular genetic standpoint, it is now understood that no ...

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Science 2018;359:91–7. 10.1126/science.aan3706 [PubMed] [CrossRef] [Google Scholar] 35. Gopalakrishnan V, Spencer CN, Nezi L, et al. . Gut ...

Sep 28, 2017 View →

So what is Neutropenia I hear some of you ask. As Dymathy heads ...

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... Science, 2018. DOI: 10.1126/science.aan3706 ✓ Higher abundance of A. muciniphila = better survival + response to treatment in cancer ...

Aug 29, 2016 View →

1) Dr. William G. von Peters, OMD, NMD, PhD, has formulated a ...

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... Science, 2018. DOI: 10.1126/science.aan3706 ✓ Higher abundance of A. muciniphila = better survival + response to treatment in cancer ...

Apr 5, 2013 View →

Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors.

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Gut Microbiome's Role in Enhancing Cancer Immunotherapy Effectiveness

Standardizing Gut Microbiome Testing for Clinical Application