PubHawk
J Am Coll Cardiol December 2017 PMID 29103847

5-Year Outcomes After Left Atrial Appendage Closure: From the PREVAIL and PROTECT AF Trials.

Vivek Y Reddy, Shephal K Doshi, Saibal Kar, Douglas N Gibson, Matthew J Price, Kenneth Huber, Rodney P Horton, Maurice Buchbinder, Petr Neuzil, Nicole T Gordon, David R Holmes

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Mentions

22
Peak: 2 in Feb 2023
across 5 sources since Feb 2019

Extended reach

156,143
potential audience

Total likes

1,764

Video views

152,571

Mentions per month

Feb 2019 – Mar 2024

Where it's discussed

  • News9 articles
  • Facebook5 posts
  • X / Twitter4 posts
  • YouTube2 videos
  • Reddit2 posts

AI synopsis

What people are saying

Discussions revolve around technical aspects of the study, such as the influence of the Watchman device on all-cause mortality and its engineering considerations, with posts like the coauthor's request for further explanation and a comment on the device's potential, demonstrating moderate curiosity and recognition of significance without strong consensus or controversy.

AgreementNeither agree nor disagree

The discussions show some support and curiosity but also acknowledge ongoing questions about outcomes, indicating neutral agreement.

InterestModerate interest

Participants express interest, especially the coauthor wanting to discuss specific results and others referencing the effectiveness of the device.

EngagementModerate engagement

Engagement is moderate, with posts mentioning the trials, asking for explanations, and referencing technical aspects like all-cause mortality and engineering considerations.

ImpactModerate impact

The conversations hint at the importance of the findings, especially around long-term effects and device evaluation, though they don’t convey immediate widespread implications.

Abstract in brief

  • The PREVAIL and PROTECT AF clinical trials studied the effectiveness of the Watchman device for left atrial appendage closure (LAAC) in preventing strokes in atrial fibrillation patients, showing similar outcomes to warfarin but with different complication rates.
  • The 5-year follow-up data revealed that the combined results from both trials indicated comparable rates of stroke and other embolic events between LAAC and warfarin, with some variations in specific endpoints, and the warfarin group unexpectedly had a very low stroke rate.
  • Overall, while LAAC with the Watchman device appeared effective for stroke prevention, especially over a long-term period, nuances in trial results suggest it may have a slightly higher risk of ischemic stroke, highlighting the importance of patient-specific treatment considerations.
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Top posts

Most liked on X and Bluesky
Simon Rowe
@DrSimonRowe · X

@bobepidemiology Most medical device trials have engineering aspects to them. The left atrial appendage closure (WATCHMAN) device underwent an RCT a while back: https://t.co/aZp0azeMeW

Feb 26, 2023 · 4 likes · 738 followers View post →
MCW IM Chief Residents
@Mcw_Medchiefs · X

Aug 25, 2023 · 2 likes · 982 followers View post →
David M Kent
@Tufts_PACE · X

@drjohnm @Sensible__Med @f2harrell i was going to point you in the direction of that article, since I am a coauthor. But can you also explain the effect of LAAO on all cause mortality in this study? https://t.co/kFBMsJIQoW

Feb 26, 2023 · 2 likes · 863 followers View post →
ぽん@
@pharma_pon · X

左心耳閉鎖デバイスはwfよりも有効な可能性がある https://t.co/plOYbzBK6S

Feb 5, 2019 · 1 share · 988 followers View post →

All mentions

MCW IM Chief Residents
@Mcw_Medchiefs · X

Aug 25, 2023 · 2 likes · 982 followers View post →
David M Kent
@Tufts_PACE · X

@drjohnm @Sensible__Med @f2harrell i was going to point you in the direction of that article, since I am a coauthor. But can you also explain the effect of LAAO on all cause mortality in this study? https://t.co/kFBMsJIQoW

Feb 26, 2023 · 2 likes · 863 followers View post →
Simon Rowe
@DrSimonRowe · X

@bobepidemiology Most medical device trials have engineering aspects to them. The left atrial appendage closure (WATCHMAN) device underwent an RCT a while back: https://t.co/aZp0azeMeW

Feb 26, 2023 · 4 likes · 738 followers View post →
ぽん@
@pharma_pon · X

左心耳閉鎖デバイスはwfよりも有効な可能性がある https://t.co/plOYbzBK6S

Feb 5, 2019 · 1 share · 988 followers View post →