PubHawk
February 2018 PMID 29119217

Psilocybin with psychological support for treatment-resistant depression: six-month follow-up.

R L Carhart-Harris, M Bolstridge, C M J Day, J Rucker, R Watts, D E Erritzoe, M Kaelen, B Giribaldi, M Bloomfield, S Pilling, J A Rickard, B Forbes, A Feilding, D Taylor, H V Curran

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Mentions

136
Peak: 10 in Jul 2019
across 5 sources since Jan 2019

Extended reach

1,200,884
potential audience

Total likes

16,803

Video views

900,045

Mentions per month

Jan 2019 – Aug 2025

Where it's discussed

  • News70 articles
  • X / Twitter40 posts
  • Blogs16 articles
  • YouTube6 videos
  • Facebook4 posts

AI synopsis

What people are saying

The overall tone shows a mix of cautious optimism and skepticism; posts like 'studies met 20 personen en een zelfrapportingsmaat zonder controlegroep' reflect doubts about the study's rigor, while comments such as 'research about using psilocybin...has had extremely promising results' indicate recognition of its potential impact. The choice of words like 'impress' and 'bad take' highlights a tone of critique and curiosity, shaping the modest yet meaningful overall sentiment.

AgreementModerate agreement

Most discussions acknowledge the study's promising findings, with some skepticism about its limitations, reflected in phrases like 'don’t impress me much' and mentions of the need for more evidence.

InterestModerate interest

The discussions show average interest, referencing the study directly and hinting at ongoing debates and scientific curiosity, but without enthusiastic praise or deep dives into methodology.

EngagementNeutral engagement

Participants seem to primarily share opinions and fleeting comments rather than in-depth analysis, indicating moderate levels of engagement.

ImpactModerate impact

The discussions suggest that the publication could influence views on treatment options, with some users calling it 'game-changing' and highlighting its potential implications, although some dismiss the overall influence.

Abstract in brief

  • The study involved 20 patients with treatment-resistant depression who received two doses of psilocybin in a supportive setting, and results showed significant reduction in depressive symptoms that lasted up to 6 months, with a good safety profile.
  • Symptom improvements were especially notable in the first 5 weeks after treatment, with a majority of patients responding or going into remission, and these effects remained stable over time, correlating with the quality of the psychedelic experience.
  • Although the study suggests that psilocybin could be a promising treatment for depression unresponsive to other methods, the authors note that more rigorous double-blind clinical trials are needed to confirm these findings.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Matan Arbel-Groissman
@ArbleMatan · X

תרופות דיכאון מקובלות. זאת במקביל לעובדה שאין לפסילוציבין שום אפקט שלילי פזיולוגי (בניגוד לתרופות הדיכאון הקיימות). ופה אני נאלץ לאכול את הכובע מהפוסט הקודם. נכון להיום (ונעשה כבר לא מעט מחקר בנושא) אין שום השפעה שלילית פזיולוגית לא לטווח קצר ולא לטווח->https://t.co/F8tlRpGBKS

May 7, 2023 · 54 likes · 6,925 followers View post →
Brian D. Earp, Ph.D.
@briandavidearp · X

Psilocybin with psychological support for treatment-resistant depression: six-month follow-up | SpringerLink https://t.co/XlasicYTOL

Jul 2, 2019 · 19 likes · 7 shares · 26,108 followers View post →
Lonni Besançon
@lonnibesancon · X

A pretty cool article here on the effect of magic mushrooms on depression from @rachelschraer. Too bad the article doesn't link to the study itself though. Previous research was already conducted on this: https://t.co/mNzuaaiX8r https://t.co/8PLSsCOYKb https://t.co/ggMDZP6hO9

Apr 15, 2021 · 9 likes · 3 shares · 15,049 followers View post →
its_lit
@litibanana · X

Interesting food for thought

Jul 19, 2020 · 5 likes · 245 followers View post →
Greenthumb_one
@Greenthumb_one · X

Psilocybin with psychological support for treatment-resistant depression: six-month follow-up https://t.co/oiKWIp96fD @BeckleyResearch @RCarhartHarris @TheDailyShroom https://t.co/JrIVZIGuWl https://t.co/bBiZARrHhS

Aug 28, 2020 · 2 likes · 4,510 followers View post →
ravital
@kavitalrofman · X

@bIondiewasabi research about using psilocybin (shrooms) for treatment-resistant depression has had extremely promising results, bad take dude https://t.co/1kJRNDCe5l https://t.co/r92pawd3Aw

Aug 5, 2020 · 2 likes · 248 followers View post →

All mentions

Wouter Duyck
@wduyck · X

@lievendoclo @TomDeSmet23 Studies met 20 personen en een zelfrapportingsmaat zónder controlegroep https://t.co/D1sphjQxfN - dont impress me much hoor. Dan wéét je dat het niet werkt. Allicht was er een controlegroep en is die verdwenen

Aug 14, 2025 · 24,541 followers View post →
Robin Carhart-Harris
@RCarhartHarris · X

@bluejaunt100 @WiringTheBrain Data gets heavily confounded after a short study ends but here are some data: https://t.co/jchgqNqNLY

Oct 16, 2024 · 65,411 followers View post →
Robin Carhart-Harris
@RCarhartHarris · X

@epikrisa @WiringTheBrain Perhaps but perhaps you can mute symptoms but mute the individual more generally and not all folk like that: https://t.co/jchgqNqNLY

Oct 16, 2024 · 1 like · 65,411 followers View post →
mossein
@mxssein · X

@business It’s an old study https://t.co/QOtQ7PftrJ

Sep 2, 2023 · 2,589 followers View post →
jula
@ARTlP0P · X

@60dcito @OtraPendeja sii obvio, no voy a tratar de convencer a nadie pero hay muchísimos estudios científicos (y de hecho ya se esta probando en personas), dejo un estudio bastante completo https://t.co/xz69O4zEj7 y hay muchos más info https://t.co/7ECPRPLY13 aca por si a alguien le interesa

Aug 26, 2023 · 4,619 followers View post →
Matan Arbel-Groissman
@ArbleMatan · X

תרופות דיכאון מקובלות. זאת במקביל לעובדה שאין לפסילוציבין שום אפקט שלילי פזיולוגי (בניגוד לתרופות הדיכאון הקיימות). ופה אני נאלץ לאכול את הכובע מהפוסט הקודם. נכון להיום (ונעשה כבר לא מעט מחקר בנושא) אין שום השפעה שלילית פזיולוגית לא לטווח קצר ולא לטווח->https://t.co/F8tlRpGBKS

May 7, 2023 · 54 likes · 6,925 followers View post →
Fustbariclation
@fustbariclation · X

@EikoFried I think there are a lot of studies that show very positive results, they vary in their construction, I agree, but I think it's difficult to remain entirely sceptical. What about this one: https://t.co/jxFIKWR0BD

May 12, 2022 · 2,159 followers View post →
Down The Rabbit Hole ( Fella )
@brian_schneide · X

@EATTHER01271082 @MitchBlake70 @washingtonpost https://t.co/0JNS4EkJIt

May 4, 2022 · 1,306 followers View post →
Michael Haichin
@MichaelHaichin · X

RT @LukeJelen: @PhilCorlett1 @m_wall LP: first 12 open-label participants (QIDS) Psychopharmacology (https://t.co/wRq5pHLe8q) : final 19 op…

Apr 11, 2022 · 1 share · 3,714 followers View post →
Luke Jelen
@LukeJelen · X

@PhilCorlett1 @m_wall LP: first 12 open-label participants (QIDS) Psychopharmacology (https://t.co/wRq5pHLe8q) : final 19 open-label participants (QIDS) Sci Rep: (same) 19 open-label participants (QIDS) Nat. med.: (same) 19 open-label participants + those from the escitalopram/psilocybin RCT (?BDI?)

Apr 11, 2022 · 1 like · 1 share · 1,004 followers View post →
Tom Zimbardo
@TomMostlyZen · X

@DJSicFanny @TheDailyShroom I wouldnt say there’s no evidence, there’s just not very much evidence yet. This study showed it helped some people with long-standing depression, and there was a TV documentary where people talked about their experiences with the psilocybin https://t.co/tRiv3wKBdu

Mar 7, 2022 · 1 like · 6,314 followers View post →
بونوبوی فکور
@Pensive_Bonobo · X

@xoo_roos خب FDA بیشتر از اینکه یک نهاد تحقیقاتی باشه، یک نهاد قانونیه. و سیاست هم روی تصمیمات اون بی‌تأثیر نیست. در ضمن، فرآیند تایید FDA بسیار طولانیه و بعضن تا ۱۰ سال طول می‌کشه. https://t.co/WYmrIZGTp2 https://t.co/GKEaV3RD9X https://t.co/nvktepcrV8 https://t.co/0qDbd4Pqkk

Sep 2, 2021 · 187 followers View post →
Fiona French, freedom is bliss
@benzosarebad · X

RT @recover2renew: @DuthieAlyne Yeah ... The gang of

Apr 21, 2021 · 1 share · 6,867 followers View post →
recovery&renewal
@recover2renew · X

@DuthieAlyne Yeah ... The gang of

Apr 21, 2021 · 1 like · 1 share · 4,162 followers View post →
MAC-A-DAY-DAY
@daydreamingmian · X

RT @lonnibesancon: A pretty cool article here on the effect of magic mushrooms on depression from @rachelschraer. Too bad the article doesn…

Apr 15, 2021 · 3 shares · 400 followers View post →
Thomas George
@thomasg_grizzle · X

RT @lonnibesancon: A pretty cool article here on the effect of magic mushrooms on depression from @rachelschraer. Too bad the article doesn…

Apr 15, 2021 · 3 shares · 21,962 followers View post →
Lonni Besançon
@lonnibesancon · X

A pretty cool article here on the effect of magic mushrooms on depression from @rachelschraer. Too bad the article doesn't link to the study itself though. Previous research was already conducted on this: https://t.co/mNzuaaiX8r https://t.co/8PLSsCOYKb https://t.co/ggMDZP6hO9

Apr 15, 2021 · 9 likes · 3 shares · 15,049 followers View post →
JPA
@JPAsunset · X

@jcthemd @LetiLagertha @FitzgeraldSTA Here many people do this. Works great! https://t.co/X9Oh7DI7KI

Feb 19, 2021 · 1,092 followers View post →
conibunny
@_callmeconi · X

https://t.co/8ziEQ3XzL5

Feb 11, 2021 · 856 followers View post →
Olivia Love
@HealingLivMama · X

@clarkflavor @JHPsychedelics @JAMAPsych See for instance https://t.co/gjiXG0NHOs

Nov 25, 2020 · 860 followers View post →
Plastic Shaman
@Entheogenist · X

RT @Entheogenist: https://t.co/mK2TlPzHMj

Oct 17, 2020 · 1 share · 396 followers View post →
Greenthumb_one
@Greenthumb_one · X

Psilocybin with psychological support for treatment-resistant depression: six-month follow-up https://t.co/oiKWIp96fD @BeckleyResearch @RCarhartHarris @TheDailyShroom https://t.co/JrIVZIGuWl https://t.co/bBiZARrHhS

Aug 28, 2020 · 2 likes · 4,510 followers View post →
Plastic Shaman
@Entheogenist · X

https://t.co/mK2TlPzHMj

Aug 20, 2020 · 1 share · 396 followers View post →
ravital
@kavitalrofman · X

@bIondiewasabi research about using psilocybin (shrooms) for treatment-resistant depression has had extremely promising results, bad take dude https://t.co/1kJRNDCe5l https://t.co/r92pawd3Aw

Aug 5, 2020 · 2 likes · 248 followers View post →
Sansero Life Sciences
@Sansero_Life · X

Read this study on the use of Psilocybin with psychological support for treatment-resistant depression: six-month follow-up. https://t.co/SNngevdMGT #psilocybin #mentalhealth #depression

Jul 29, 2020 · 95 followers View post →
its_lit
@litibanana · X

Interesting food for thought

Jul 19, 2020 · 5 likes · 245 followers View post →
Hope For The Dispirited Soul
@Hope4TheSoul · X

"Magic mushrooms" for TRD? Psilocybin With Psychological Support for Treatment-Resistant Depression: Six-Month Follow-Up https://t.co/lWJGiGJJ7o

Jul 7, 2020 · 12 followers View post →
Felipe el Rojo
@CortsFelipe · X

@hazelinha Es mucho mejor la psilocibina https://t.co/6Cge4AiZL7

Apr 11, 2020 · 341 followers View post →
DR LI Health
@latirina · X

Psilocybin with psychological support for treatment-resistant depression: six-month follow-up. - PubMed - NCBI https://t.co/S69ujnmOg9

Jan 4, 2020 · 200 followers View post →
Carl Parker
@CarlJParker · X

RT @briandavidearp: Psilocybin with psychological support for treatment-resistant depression: six-month follow-up | SpringerLink https://t.…

Jul 12, 2019 · 7 shares · 200 followers View post →
Daniel Rodger
@philosowhal · X

RT @briandavidearp: Psilocybin with psychological support for treatment-resistant depression: six-month follow-up | SpringerLink https://t.…

Jul 12, 2019 · 7 shares · 572 followers View post →
Sebastian Hendricks (he/him)
@Hearing4Kids · X

RT briandavidearp: RT briandavidearp: Psilocybin with psychological support for treatment-resistant depression: six-month follow-up | SpringerLink https://t.co/9WLa0s7iab

Jul 12, 2019 · 656 followers View post →
Brian D. Earp, Ph.D.
@briandavidearp · X

RT @briandavidearp: Psilocybin with psychological support for treatment-resistant depression: six-month follow-up | SpringerLink https://t.…

Jul 12, 2019 · 7 shares · 26,108 followers View post →
Sebastian Hendricks (he/him)
@Hearing4Kids · X

RT briandavidearp: RT JustinCaouette: Psilocybin with psychological support for treatment-resistant depression: six-month follow-up https://t.co/tmAbVhxKu9 ht briandavidearp

Jul 3, 2019 · 656 followers View post →
k3
@k3micah · X

RT @briandavidearp: Psilocybin with psychological support for treatment-resistant depression: six-month follow-up | SpringerLink https://t.…

Jul 2, 2019 · 7 shares · 341 followers View post →
unitambo
@unitambo · X

RT @briandavidearp: Psilocybin with psychological support for treatment-resistant depression: six-month follow-up | SpringerLink https://t.…

Jul 2, 2019 · 7 shares · 570 followers View post →
Tomasz Drabowicz
@tomdrabowicz · X

RT @briandavidearp: Psilocybin with psychological support for treatment-resistant depression: six-month follow-up | SpringerLink https://t.…

Jul 2, 2019 · 7 shares · 2,892 followers View post →
Sebastian Hendricks (he/him)
@Hearing4Kids · X

RT briandavidearp: Psilocybin with psychological support for treatment-resistant depression: six-month follow-up | SpringerLink https://t.co/9WLa0soTyL

Jul 2, 2019 · 656 followers View post →
Brian D. Earp, Ph.D.
@briandavidearp · X

Psilocybin with psychological support for treatment-resistant depression: six-month follow-up | SpringerLink https://t.co/XlasicYTOL

Jul 2, 2019 · 19 likes · 7 shares · 26,108 followers View post →
Dreamgbutterfly
@dreamgbutterfly · X

Psilocybin with psychological support for treatment-resistant depression: six-month follow-up https://t.co/3r4byOFirk

Jan 1, 2019 · 1 like · 82 followers View post →