N Engl J Med January 2018 PMID 29129157

Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct.

Raul G Nogueira, Ashutosh P Jadhav, Diogo C Haussen, Alain Bonafe, Ronald F Budzik, Parita Bhuva, Dileep R Yavagal, Marc Ribo, Christophe Cognard, Ricardo A Hanel, Cathy A Sila, Ameer E Hassan, Monica Millan, Elad I Levy, Peter Mitchell

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Mentions

305
Peak: 18 in Oct 2021
across 6 sources since Jan 2018

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611,164
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AI synopsis

What people are saying

Discussions emphasize the groundbreaking nature of extending thrombectomy windows, citing specific trials like DAWN and DEFUSE-3, and using emphatic expressions such as 'stunning' and 'revolutionary,' which reflect high interest and acknowledgment of the publication's potential impact.

AgreementStrong agreement

Most discussions strongly support the findings and implications of the publication, highlighting its revolutionary impact on stroke treatment.

InterestHigh interest

Posts demonstrate high curiosity and enthusiasm, referencing key trials like DAWN and DEFUSE-3, and discussing the extended window for thrombectomy.

EngagementHigh engagement

Many discussions delve into trial details, imaging techniques, and clinical implications, showing deep engagement with the subject matter.

ImpactHigh impact

The consensus indicates that this publication could significantly alter stroke management practices worldwide.

Top posts

Most liked on X and Bluesky
SVIN Research Registry
@SVINRegistry · X

Thrombectomy 6-24 Hours after #Stroke with a Mismatch btw Deficit & Infarct https://t.co/vNqm16lwyL Celebrating #WorldStrokeDay2021 with this classic, the DAWN trial. Raul Nogueira, @TudorGJovin @AshuPJadhav @DiogoHaussen @dyavagal @dliebesk @AmeerEHassan @marcriboj @svinsociety https://t.co/Sfp8sdfKHI

Oct 29, 2021 · 80 likes · 19 shares · 925 followers View post →
Andrew Althouse
@ADAlthousePhD · X

3. the DAWN trial is a favorite of mine for introducing the concept of adaptive trials in a relatively gentle, digestible way: https://t.co/SlPEiePEYX

Jan 14, 2021 · 11 likes · 1 share · 11,042 followers View post →
Gray Moonen
@GrayMoonen · X

2. Stroke care has fundamentally changed. Mechanical thrombectomy is now, in many centres standard of care and I was lucky to do two weeks with @albertjin at @KingstonHSC to see this life-saving treatment: https://t.co/8Qui5VYtIa

Mar 28, 2019 · 9 likes · 1,383 followers View post →
Neha Dangayach MD MSCR FAAN FANA FCCP FCCM FNCS
@drdangayach · X

#chestchat T1: #Stroke: Thrombectomy is the gold standard for ELVO #stroke https://t.co/4xxNGZNnBO Dawn and Defuse-3: window extended to 24 hours for thrombectomy https://t.co/7qEIrtYs2y Extend tpa window to 9 hours? https://t.co/Ux4rTEIwUJ

Dec 19, 2019 · 7 likes · 2 shares · 6,040 followers View post →
J Gordon Boyd
@jgordonboyd · X

@dwmessenger @TheSGEM If you're allowing non-EM people to chime in on topics they might think relevant to your work, I think the DAWN trial (endovascular therapy for acute stroke 6-24h after symptom onset) revolutionized practice. Wake up strokes are now an emergency! https://t.co/fdZdI9VLTl

Apr 23, 2020 · 7 likes · 3,925 followers View post →
Dr. Danya Khoujah
@DanyaKhoujah · X

Neuro lit updates w @MDmiamimike #RMWC19 DAWN and DIFFUSE-3: extending the window for revascularization in stroke w/ evidence of mismatch on imaging up to 24 h https://t.co/OfcvjCcj1Y https://t.co/LXhnHCU0w2 #FOAMed @RockyMtnEM

Feb 24, 2019 · 7 likes · 2 shares · 3,274 followers View post →

All mentions

UTRGV ScholarWorks
@UScholarworks · X

Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct https://t.co/6AFeW573Ri

Jan 23, 2025 · 119 followers View post →
江川悟史 | Satoshi Egawa, MD, PhD, FNCS
@Satoshi_Egawa · X

RT @Neurocrit_univ: 急性虚血性脳卒中と神経集中治療15

Aug 27, 2024 · 1 share · 1,852 followers View post →
Neurocritical Care University
@Neurocrit_univ · X

急性虚血性脳卒中と神経集中治療15

Aug 25, 2024 · 7 likes · 1 share · 672 followers View post →
Pharmacy Podcast Network
@PharmacyPodcast · X

RT @PharmacyToDose:

Mar 21, 2024 · 1 share · 29,716 followers View post →
Pharmacy To Dose: The Critical Care Podcast
@PharmacyToDose · X

Mar 20, 2024 · 2 likes · 1 share · 6,835 followers View post →
Pharmacy To Dose: The Critical Care Podcast
@PharmacyToDose · X

Mar 18, 2024 · 6,835 followers View post →
Хранитель реальности
@KosterNews · X

@momentovmori 1. Диссекция 2. Доказанных методов профилактики инсультов вообще нет, только вторичная. 3. Скорее наоборот, тромболизис в 4.5 часа, а реканализация - 24 часа https://t.co/o1UBw574iG

Dec 10, 2023 · 191 followers View post →
Ruslan Oliinyk
@OliinykMD · X

52 in 52 - #39: DAWN - Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct https://t.co/ygAeX3KWRH

Sep 3, 2023 · 36 followers View post →
Saad
@asbeutah1 · X

@AANmember Here are a couple of massive trials that show just how stunning thrombolectomy is (major shoutout to all the neurointerventionalists) DAWN trial (doi: 10.1056/NEJMoa1706442) ANGEL-ASPECT trial (doi: 10.1056/NEJMoa2213379) SELECT 2 trial (doi: 10.1056/NEJMoa2214403) https://t.co/XhvgGGbwu5

Jul 29, 2023 · 2 likes · 772 followers View post →
Derek Smith
@proton_spin · X

2/ Major stroke trials using CT/MR perfusion DAWN 2018 https://t.co/AAXsrhabFU DEFUSE-3 2018 https://t.co/NSep3zFxKL EXTEND 2019 https://t.co/Lz8ww9uX0a

Feb 20, 2022 · 2 likes · 1,729 followers View post →
J
@JuanCossmic · X

RT @SeeFisch: WOW! WOW!! WOW!! WOW!!! Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct | NEJM ht…

Feb 12, 2022 · 13 shares · 110 followers View post →
Francis Deng, MD
@francisdeng · X

In the DAWN trial, an inclusion criterion was ICA or MCA-M1 occlusion. M1-M2 junction was defined by the bifurcation. Some probably didn't get the memo: there were 5 patients enrolled (out of 206) that the core lab judged to actually have M2 occlusions. https://t.co/0xVvkwHFax https://t.co/s4HsOesqfF

Nov 26, 2021 · 6 likes · 16,946 followers View post →
IL
@italolinfante · X

RT @SVINRegistry: Thrombectomy 6-24 Hours after #Stroke with a Mismatch btw Deficit & Infarct https://t.co/vNqm16lwyL Celebrating #WorldStr…

Nov 16, 2021 · 19 shares · 5,567 followers View post →
mohammed_moneim
@mohammed_moneim · X

RT @SVINRegistry: Thrombectomy 6-24 Hours after #Stroke with a Mismatch btw Deficit & Infarct https://t.co/vNqm16lwyL Celebrating #WorldStr…

Nov 5, 2021 · 19 shares · 165 followers View post →
Carla Vera
@Carlahvc · X

RT @SVINRegistry: Thrombectomy 6-24 Hours after #Stroke with a Mismatch btw Deficit & Infarct https://t.co/vNqm16lwyL Celebrating #WorldStr…

Oct 30, 2021 · 19 shares · 79 followers View post →
inbra
@hitoyoshi11 · X

Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct | NEJM https://t.co/jY1tZHLWns

Oct 29, 2021 · 35 followers View post →
NEUROLOGY
@Neurology · X

RT @SVINRegistry: Thrombectomy 6-24 Hours after #Stroke with a Mismatch btw Deficit & Infarct https://t.co/vNqm16lwyL Celebrating #WorldStr…

Oct 29, 2021 · 19 shares · 3,930 followers View post →
UPittStroke
@PittStroke · X

RT @SVINRegistry: Thrombectomy 6-24 Hours after #Stroke with a Mismatch btw Deficit & Infarct https://t.co/vNqm16lwyL Celebrating #WorldStr…

Oct 29, 2021 · 19 shares · 3,375 followers View post →
Pratiek
@drshahpratik74 · X

RT @SVINRegistry: Thrombectomy 6-24 Hours after #Stroke with a Mismatch btw Deficit & Infarct https://t.co/vNqm16lwyL Celebrating #WorldStr…

Oct 29, 2021 · 19 shares · 1,055 followers View post →
Shahram Majidi, MD
@MajidiShahram · X

RT @SVINRegistry: Thrombectomy 6-24 Hours after #Stroke with a Mismatch btw Deficit & Infarct https://t.co/vNqm16lwyL Celebrating #WorldStr…

Oct 29, 2021 · 19 shares · 1,834 followers View post →
TESLA Stroke Trial
@TESLATrial · X

RT @SVINRegistry: Thrombectomy 6-24 Hours after #Stroke with a Mismatch btw Deficit & Infarct https://t.co/vNqm16lwyL Celebrating #WorldStr…

Oct 29, 2021 · 19 shares · 570 followers View post →
Thanakit Pongpitakmetha, MD, MSc (getcud)
@getcud · X

RT @SVINRegistry: Thrombectomy 6-24 Hours after #Stroke with a Mismatch btw Deficit & Infarct https://t.co/vNqm16lwyL Celebrating #WorldStr…

Oct 29, 2021 · 19 shares · 1,392 followers View post →
María A. Moro
@MariAngelesMoro · X

RT @SVINRegistry: Thrombectomy 6-24 Hours after #Stroke with a Mismatch btw Deficit & Infarct https://t.co/vNqm16lwyL Celebrating #WorldStr…

Oct 29, 2021 · 19 shares · 1,062 followers View post →
Mehdi Bouslama, MD, MSc
@BouslamaMd · X

RT @SVINRegistry: Thrombectomy 6-24 Hours after #Stroke with a Mismatch btw Deficit & Infarct https://t.co/vNqm16lwyL Celebrating #WorldStr…

Oct 29, 2021 · 19 shares · 1,027 followers View post →
Ameer E. Hassan
@AmeerEHassan · X

RT @SVINRegistry: Thrombectomy 6-24 Hours after #Stroke with a Mismatch btw Deficit & Infarct https://t.co/vNqm16lwyL Celebrating #WorldStr…

Oct 29, 2021 · 19 shares · 5,215 followers View post →
WINN
@WomenInNeuroIR · X

RT @SVINRegistry: Thrombectomy 6-24 Hours after #Stroke with a Mismatch btw Deficit & Infarct https://t.co/vNqm16lwyL Celebrating #WorldStr…

Oct 29, 2021 · 19 shares · 2,121 followers View post →
Juan M. Arredondo
@RcJuanMaa · X

RT @SVINRegistry: Thrombectomy 6-24 Hours after #Stroke with a Mismatch btw Deficit & Infarct https://t.co/vNqm16lwyL Celebrating #WorldStr…

Oct 29, 2021 · 19 shares · 515 followers View post →
Thanh Nguyen
@NguyenThanhMD · X

RT @SVINRegistry: Thrombectomy 6-24 Hours after #Stroke with a Mismatch btw Deficit & Infarct https://t.co/vNqm16lwyL Celebrating #WorldStr…

Oct 29, 2021 · 19 shares · 9,361 followers View post →
Stroke AHA/ASA
@StrokeAHA_ASA · X

RT @SVINRegistry: Thrombectomy 6-24 Hours after #Stroke with a Mismatch btw Deficit & Infarct https://t.co/vNqm16lwyL Celebrating #WorldStr…

Oct 29, 2021 · 19 shares · 37,574 followers View post →
Dileep R. Yavagal
@dyavagal · X

RT @SVINRegistry: Thrombectomy 6-24 Hours after #Stroke with a Mismatch btw Deficit & Infarct https://t.co/vNqm16lwyL Celebrating #WorldStr…

Oct 29, 2021 · 19 shares · 3,127 followers View post →
SVIN
@svinsociety · X

RT @SVINRegistry: Thrombectomy 6-24 Hours after #Stroke with a Mismatch btw Deficit & Infarct https://t.co/vNqm16lwyL Celebrating #WorldStr…

Oct 29, 2021 · 19 shares · 10,628 followers View post →
SVIN Research Registry
@SVINRegistry · X

Thrombectomy 6-24 Hours after #Stroke with a Mismatch btw Deficit & Infarct https://t.co/vNqm16lwyL Celebrating #WorldStrokeDay2021 with this classic, the DAWN trial. Raul Nogueira, @TudorGJovin @AshuPJadhav @DiogoHaussen @dyavagal @dliebesk @AmeerEHassan @marcriboj @svinsociety https://t.co/Sfp8sdfKHI

Oct 29, 2021 · 80 likes · 19 shares · 925 followers View post →
Andrew Althouse
@ADAlthousePhD · X

@SolomonKurz So these may be a little niche/specific to my own interests, but for your consideration...the DAWN trial (https://t.co/SlPEiePEYX) has a very nice Supplemental appendix describing the whole trial design and model:

Mar 15, 2021 · 5 likes · 11,042 followers View post →
José Luis Santiago
@JLSantiagoG · X

menor deterioro posterior neurológico y no hubo diferencia en la frecuencia de hemorragia intracerebral entre los 2 grupos. Sin embargo, la mortalidad a 90 días fue casi la misma entre los 2 grupos. DOI: 10.1056/NEJMoa1706442 DOI: 10.1186/s12883-019-1428-x https://t.co/6MBbpAy7iT

Mar 6, 2021 · 1,091 followers View post →
CIRSE European Trainee Forum
@ETF_IRtrainees · X

Part II of important thrombectomy studies Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit an Infarct (DAWN) https://t.co/Ye9fVbsDiU #topicofthemonth #neurointervention https://t.co/FQkbL0gnW8

Mar 4, 2021 · 1 like · 1,562 followers View post →
Protik Islam-Jakobsson
@ikitorp · X

RT @ADAlthousePhD: 3. the DAWN trial is a favorite of mine for introducing the concept of adaptive trials in a relatively gentle, digestibl…

Jan 15, 2021 · 1 share · 1,233 followers View post →
Andrew Althouse
@ADAlthousePhD · X

3. the DAWN trial is a favorite of mine for introducing the concept of adaptive trials in a relatively gentle, digestible way: https://t.co/SlPEiePEYX

Jan 14, 2021 · 11 likes · 1 share · 11,042 followers View post →
J Gordon Boyd
@jgordonboyd · X

@dwmessenger @TheSGEM If you're allowing non-EM people to chime in on topics they might think relevant to your work, I think the DAWN trial (endovascular therapy for acute stroke 6-24h after symptom onset) revolutionized practice. Wake up strokes are now an emergency! https://t.co/fdZdI9VLTl

Apr 23, 2020 · 7 likes · 3,925 followers View post →
Jessica Smith
@Jessica28997812 · X

Learned that the DAWN Trial changed the game in stroke treatment. #cincyai https://t.co/xokvNeUWoY

Apr 3, 2020 View post →
Binod Wagle
@binodbinodwagle · X

DAWN trial helped unfortunate stroke patient with hope for better life: Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct | NEJM https://t.co/9PMUxYYbbq #UMKCRCT

Feb 5, 2020 · 65 followers View post →
Doctor Gold
@yourdoctorgold · X

@LactatedRingers It’s not a perfect answer but 50% are functionally independent at 90 days where only 13% of the control group (tPA) were. https://t.co/D6XrXxrPYb

Feb 2, 2020 · 1 like · 1,144 followers View post →
Mahmoud Alsomali
@mahmoud_427 · X

RT @drdangayach: #chestchat T1: #Stroke: Thrombectomy is the gold standard for ELVO #stroke https://t.co/4xxNGZNnBO Dawn and Defuse-3: wind…

Dec 19, 2019 · 2 shares · 1,315 followers View post →
Chris Carroll MD
@ChrisCarrollMD · X

RT @drdangayach: #chestchat T1: #Stroke: Thrombectomy is the gold standard for ELVO #stroke https://t.co/4xxNGZNnBO Dawn and Defuse-3: wind…

Dec 19, 2019 · 2 shares · 20,169 followers View post →
Neha Dangayach MD MSCR FAAN FANA FCCP FCCM FNCS
@drdangayach · X

#chestchat T1: #Stroke: Thrombectomy is the gold standard for ELVO #stroke https://t.co/4xxNGZNnBO Dawn and Defuse-3: window extended to 24 hours for thrombectomy https://t.co/7qEIrtYs2y Extend tpa window to 9 hours? https://t.co/Ux4rTEIwUJ

Dec 19, 2019 · 7 likes · 2 shares · 6,040 followers View post →
Philippe Violon
@docteursante · X

En cas d'AVC, pouvoir déboucher mécaniquement une artère cérébrale permet de faire passer le % de patients indépendants après 3 mois de 13 à 49% ! Une révolution. https://t.co/duHEiJWYmA #urgences #sante

Dec 10, 2019 · 1 like · 18 followers View post →
Kaishauna Guidry, MD, HMDC
@DrMamaKai · X

RT @PrasannaTadi: @DrMamaKai @IDdocAdi @iamritu @Mummin8r @DrSuperSalty @GermHunterMD @DrPoorman @Vilavaite @StSenka @WaelBarsoumMD @spiceb…

Aug 31, 2019 · 1 share · 2,285 followers View post →
Dr. Prasanna Tadi M.D, FAAN, FAHA, Coach, Speaker,
@PrasannaTadi · X

@DrMamaKai @IDdocAdi @iamritu @Mummin8r @DrSuperSalty @GermHunterMD @DrPoorman @Vilavaite @StSenka @WaelBarsoumMD @spiceboxtravels @nursekelsey @AboutPediatrics @empathsupreme @KarenSibertMD @IAmDrIbrahim @NaanDerthaal @cardiojaydoc02 @biljana_parapid @KaraPepperMD https://t.co/SDPVsGSuzG

Aug 31, 2019 · 1 like · 1 share · 2,049 followers View post →
SCCM SE Region
@SCCMSE · X

RT @SummitCritCare: Dr. Nogueira led the @NEJM #DawnTrial showing remarkable benefits for stroke therapy 6-24 hours after onset #CCS19 ht…

Apr 18, 2019 · 3 shares · 1,003 followers View post →
Aarti Sarwal, FNCS, FAAN, FCCM, RPNI, Professor
@aartisarwal · X

RT @SummitCritCare: Dr. Nogueira led the @NEJM #DawnTrial showing remarkable benefits for stroke therapy 6-24 hours after onset #CCS19 ht…

Apr 18, 2019 · 3 shares · 4,826 followers View post →
Greg Martin
@gsmartinmd · X

RT @SummitCritCare: Dr. Nogueira led the @NEJM #DawnTrial showing remarkable benefits for stroke therapy 6-24 hours after onset #CCS19 ht…

Apr 18, 2019 · 3 shares · 5,764 followers View post →
Critical Care Summit
@SummitCritCare · X

Dr. Nogueira led the @NEJM #DawnTrial showing remarkable benefits for stroke therapy 6-24 hours after onset #CCS19 https://t.co/sEifqzx87m https://t.co/V2d2zwHzPO

Apr 18, 2019 · 4 likes · 3 shares · 1,493 followers View post →
Jawad Khalifeh, MD
@jkhalifeh_md · X

RT @ADAlthousePhD: @laure_wynants DAWN was a really cool trial design that had provisions for adaptive enrichment (which were not needed) a…

Apr 5, 2019 · 1 share · 1,454 followers View post →
Andrew Althouse
@ADAlthousePhD · X

@laure_wynants DAWN was a really cool trial design that had provisions for adaptive enrichment (which were not needed) and early stopping (which did happen because the treatment was hugely effective): https://t.co/g5lbxVbJ6H

Apr 5, 2019 · 3 likes · 1 share · 11,042 followers View post →
Daniel Ricotta, MD, SFHM
@DanielRicottaMD · X

RT @BIDMC_IM: @DanielRicottaMD @zahirkanjee @BIDMChealth @bidhospitalists @JAMA_current @rbganatra @BostonChiefs @NEJM @zahirkanjee @bidhos…

Mar 29, 2019 · 1 share · 1,362 followers View post →
BIDMC IM Residency
@BIDMC_IM · X

@DanielRicottaMD @zahirkanjee @BIDMChealth @bidhospitalists @JAMA_current @rbganatra @BostonChiefs @NEJM @zahirkanjee @bidhospitalists - pursue thrombectomy for select patients with acute stroke for 6-24 hrs out of last known well https://t.co/jA1AdU7GRm

Mar 29, 2019 · 2 likes · 1 share · 3,499 followers View post →
Gray Moonen
@GrayMoonen · X

2. Stroke care has fundamentally changed. Mechanical thrombectomy is now, in many centres standard of care and I was lucky to do two weeks with @albertjin at @KingstonHSC to see this life-saving treatment: https://t.co/8Qui5VYtIa

Mar 28, 2019 · 9 likes · 1,383 followers View post →
Ahmed_Ak97
@ahmed_ak97 · X

This article suggests #thrombectomy as a procedure to be performed on #stroke patients 6-24hrs after the onset. The disability outcome has been attenuated in the group who received thrombectomy and standard care versus standard care alone #biom4180 https://t.co/tfCCuhrUuo

Mar 11, 2019 · 1 like · 16 followers View post →
Robbie Paulsen
@robbiepaulsen · X

@SamMarek2 #cincyai DAWN Trial used MRI or CTP for pts with last known well w/in 6-24 hours and a large vessel occlusion. Thrombectomy in pts with large salvageable territory reduced disability (49 vs 13% functional independence at 90 days) but not mortality. https://t.co/GCyzHYnTRY

Mar 10, 2019 · 322 followers View post →
Almansour
@malmansour81 · X

RT @DanyaKhoujah: Neuro lit updates w @MDmiamimike #RMWC19 DAWN and DIFFUSE-3: extending the window for revascularization in stroke w/ evid…

Feb 24, 2019 · 2 shares · 214 followers View post →
Maite Huisintveld (she/her)
@Maiteanna · X

RT @DanyaKhoujah: Neuro lit updates w @MDmiamimike #RMWC19 DAWN and DIFFUSE-3: extending the window for revascularization in stroke w/ evid…

Feb 24, 2019 · 2 shares · 793 followers View post →
Dr. Danya Khoujah
@DanyaKhoujah · X

Neuro lit updates w @MDmiamimike #RMWC19 DAWN and DIFFUSE-3: extending the window for revascularization in stroke w/ evidence of mismatch on imaging up to 24 h https://t.co/OfcvjCcj1Y https://t.co/LXhnHCU0w2 #FOAMed @RockyMtnEM

Feb 24, 2019 · 7 likes · 2 shares · 3,274 followers View post →
GrupoDDM
@Grupo_DDM · X

Improving Outcomes in Stroke https://t.co/9LAZkVuspO vía @YouTube

Feb 21, 2019 · 2,482 followers View post →
Dr Michael JT Brooks
@michaeljtbrooks · X

For acute ischaemic stroke patients, going clot-fishing is looking like the way forward. In this paper, patients with a large perfusion defect but smaller infarct did well from thrombectomy. CT perfusion head > thrombectomy = New gold standard? https://t.co/z0pKHh64la

Jan 16, 2019 · 346 followers View post →
movedoc
@movedoc · X

Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct | NEJM https://t.co/PwWLFWeK4Q

Jan 2, 2019 · 485 followers View post →