Nutr Metab Cardiovasc Dis December 2017 PMID 29174025

A systematic review of the effect of dietary saturated and polyunsaturated fat on heart disease.

P M Clifton, J B Keogh

Mentions

60
Peak: 7 in Feb 2021
across 6 sources since Dec 2019

Extended reach

56,550
potential audience

Total likes

33

Video views

92

Mentions per month

Dec 2019 – Dec 2025

Where it's discussed

  • X / Twitter32 posts
  • News15 articles
  • Instagram9 posts
  • YouTube2 videos
  • Facebook1 posts
  • TikTok1 posts

AI synopsis

What people are saying

Discussions reflect high engagement and interest through references to comprehensive reviews and data, such as mentions of multiple systematic analyses and meta-analyses from 2017 showing lower CHD events with healthier fats, with some posts questioning the causal links. The tone varies from supportive to skeptical, emphasizing both the importance and ongoing controversy surrounding dietary fats' effects on heart disease.

AgreementModerate agreement

Most discussions recognize the systematic review's findings that replacing saturated fats with healthier fats reduces heart disease risk, indicating general agreement.

InterestHigh interest

Posts show strong interest, with many participants referencing meta-analyses, systematic reviews, and citing specific data and studies.

EngagementHigh engagement

Several posts deeply engage by debating methodologies, questioning old beliefs, and citing multiple sources and large data sets, reflecting thoughtful involvement.

ImpactModerate impact

While the conversations highlight significant evidence supporting dietary fat replacements, some skepticism and debate suggest the influence is substantial but not universally accepted.

Abstract in brief

  • Recent research since 2010 shows that replacing saturated fat with polyunsaturated fats (PUFA) or monounsaturated fats (MUFA) can lower the risk of heart disease and death.
  • Replacing saturated fat with whole grains reduces heart events, but substituting with sugar or starch can increase them.
  • Simply reducing saturated fat and replacing it with carbohydrates doesn’t necessarily decrease heart disease or related deaths, but replacing it with healthier fats or high-quality carbs does.]

Top posts

Most liked on X and Bluesky
Shaun Ward
@MyNutritionSci · X

There are multiple comprehensive studies showing that isocalorically swapping saturated fat for unsaturated fats or complex carbs reduces CVD risk. This is not a controversial point of discussion. https://t.co/HqfSUQeA1Y https://t.co/HqfSUQeA1Y https://t.co/S1vXov4izd

Feb 3, 2021 · 15 likes · 5 shares · 2,384 followers View post →
Atomsk's Sanakan
@AtomsksSanakan · X

@mattwridley Re: "This reminds me of the decades-long drive to associate heart disease with dietary fat, based on faulty and flimsy early studies that were never revisited and checked."

May 28, 2025 · 7 likes · 2 shares · 3,355 followers View post →
Andrew
@awr4645 · X

@saladeaufromage Systematic Review, 2017: "Replacing saturated fat with PUFA, MUFA or high-quality carbohydrate will lower CHD events" Surely by the logic you've just presented, this conclusion would be impossible if PUFA and MUFA were causal factors of CHD events? How https://t.co/jvh1CsCc9t

Apr 26, 2020 · 1 like · 2,921 followers View post →
Master of None
@_H_amsss · X

@Factor__B اینجا رو ببین: یه متااتالیزه که میگه جایگزین کردن چربی های اشباع با pufa ریسک قلبی رو کاهش میده https://t.co/KzumdHJMZ6

Mar 28, 2021 · 1 like · 1,308 followers View post →
Theresa Furey May
@Theresa_May_PhD · X

@MonkeyYoda1 @DrFrankLipman Review in 2017, SFA replaced by carbs vs MUFAs / PUFAs, https://t.co/h38LuSje3F

Oct 21, 2022 · 1 like · 1,184 followers View post →
John Gillespie
@DrGillespie_GP · X

@SBakerMD @djwilso Wrong- replacment studies do show reduced CVD when replaced with whole grains. https://t.co/nqxTNjfAoG

Feb 2, 2021 · 1 like · 1,065 followers View post →

All mentions

Alan Plotzker, MD
@AlanPlotzker · X

@siobhan_huggins @dylanarmbruste3 @HHSGov @NBCNews @SecKennedy The effects of unsaturated vs saturated fats in the human diet are one of the most studied things in nutrition. You have to simply ignore massive amounts of data in favor of vibes to wind up at “beef tallow good” https://t.co/rn41WLUMVn

Aug 13, 2025 · 2,304 followers View post →
(((Dorit Reiss)))
@doritmi · X

RT @AtomsksSanakan: @mattwridley Re: "This reminds me of the decades-long drive to associate heart disease with dietary fat, based on fault…

May 28, 2025 · 2 shares · 14,959 followers View post →
Atomsk's Sanakan
@AtomsksSanakan · X

RT @AtomsksSanakan: @mattwridley Re: "This reminds me of the decades-long drive to associate heart disease with dietary fat, based on fault…

May 28, 2025 · 2 shares · 3,355 followers View post →
Atomsk's Sanakan
@AtomsksSanakan · X

@mattwridley Re: "This reminds me of the decades-long drive to associate heart disease with dietary fat, based on faulty and flimsy early studies that were never revisited and checked."

May 28, 2025 · 7 likes · 2 shares · 3,355 followers View post →
Atomsk's Sanakan
@AtomsksSanakan · X

@grok @mattwridley What 2017 meta-analysis? https://t.co/fS0d0xrsOB 2017: "Replacement of saturated fat with linoleic acid lowers CHD deaths as well." "Replacement of saturated fat with high quality carbohydrate lowers CHD events." https://t.co/DiKUDsCsNr https://t.co/m9w5m4C2Kw

May 26, 2025 · 3,355 followers View post →
Atomsk's Sanakan
@AtomsksSanakan · X

@mattwridley Yet randomized controlled trials showed otherwise. https://t.co/QqEqqF22pc 2017: https://t.co/DiKUDsCsNr https://t.co/45uNtbiPtG

May 26, 2025 · 3,355 followers View post →
Tomas Heard
@tomasheard · X

@hbarmy__ @trailcompassion @DonnyKruger1 @nutrition_facts This paper, which you can see in full on scihub, shows 2291 papers, 67 systematic reviews. The synthesized evidence: high sat fat diet = higher mortality, replacing with PUFA = 19% lower mortality. How is that "precisely zero evidence"? https://t.co/SoUNHJsTxV

Sep 10, 2024 · 1 like · 375 followers View post →
Tomas Heard
@tomasheard · X

@hbarmy__ @trailcompassion @DonnyKruger1 @nutrition_facts "High saturated fat intake... is associated with an 8-13% higher mortality and replacement of saturated fat with any carbohydrate, PUFA and MUFA is associated with lower mortality with PUFA being more effective than MUFA" https://t.co/SoUNHJsTxV

Sep 10, 2024 · 375 followers View post →
Miguel The Vegan
@miguelthevegan · X

@AsarCadyn This isn’t just Alice’s opinion. https://t.co/shSMgmqYOg https://t.co/BhhOykfXRf https://t.co/Wsmte4QbJn

Apr 19, 2024 · 799 followers View post →
Nelly F
@Nelly_F_Fitness · X

@MohammedAlo I'll add two more: https://t.co/XjjedmSToz https://t.co/WVTkWrWqyc

Mar 13, 2023 · 5 followers View post →
STFFN
@DuymSteffen · X

@criticalsfl @maxlugavere https://t.co/xxFbT89HIE We can both play cherrypick the data that complies with our idea. The general consensus when you look at all data is that there is not compelling evidence seed oils are the cause of all evil. It's mostly neutral or positive.

Mar 6, 2023 · 110 followers View post →
Biomass Bob
@SentientBlobBob · X

@PeterFaberSP @CakeNutrition https://t.co/lbaMFgsVuR

Feb 26, 2023 · 812 followers View post →
Theresa Furey May
@Theresa_May_PhD · X

@MonkeyYoda1 @DrFrankLipman Review in 2017, SFA replaced by carbs vs MUFAs / PUFAs, https://t.co/h38LuSje3F

Oct 21, 2022 · 1 like · 1,184 followers View post →
Dingo Yarin
@2023Hiker · X

@cyrustabery @SBakerMD Very. https://t.co/RM2SiRLgKT

Aug 13, 2022 · 6 followers View post →
Biomass Bob
@SentientBlobBob · X

@netmonketo @FrogHarmless @MacroFour @ElieJarrougeMD https://t.co/lbaMFgaMgJ

Aug 7, 2022 · 812 followers View post →
Matt Goodheart
@matt_goodheart · X

@MacroFour https://t.co/pPIWocxqQr

Jul 28, 2022 · 6,697 followers View post →
Biomass Bob
@SentientBlobBob · X

@JackLassiter007 @drcateshanahan https://t.co/C8Dg8Fjg60 replacement of saturated fat with any carbohydrate, PUFA and MUFA is associated with lower mortality with PUFA being more effective than MUFA (19% reduction versus 11%).

May 16, 2022 · 812 followers View post →
Behemoth
@Behemot59691237 · X

@reallytanman Haha WRONG There's actually evidence that when saturated fats and Trans fats are replaced with PUFAs people live longer and have less CVD. https://t.co/wYk3Fmw7k9 https://t.co/wxudhMiWVP

Mar 9, 2022 · 26 followers View post →
Master of None
@_H_amsss · X

@Factor__B اینجا رو ببین: یه متااتالیزه که میگه جایگزین کردن چربی های اشباع با pufa ریسک قلبی رو کاهش میده https://t.co/KzumdHJMZ6

Mar 28, 2021 · 1 like · 1,308 followers View post →
Eve Beavers-Fain BSN MPH
@espacetimeNOT · X

RT @MyNutritionSci: There are multiple comprehensive studies showing that isocalorically swapping saturated fat for unsaturated fats or com…

Feb 4, 2021 · 5 shares · 1,187 followers View post →
galaxysplain
@galaxysplain · X

RT @MyNutritionSci: There are multiple comprehensive studies showing that isocalorically swapping saturated fat for unsaturated fats or com…

Feb 3, 2021 · 5 shares · 488 followers View post →
Bhopender Thakur
@TheBhupiThakur · X

RT @MyNutritionSci: There are multiple comprehensive studies showing that isocalorically swapping saturated fat for unsaturated fats or com…

Feb 3, 2021 · 5 shares · 1,394 followers View post →
Di Bella
@sam_at_thefarm · X

RT @MyNutritionSci: There are multiple comprehensive studies showing that isocalorically swapping saturated fat for unsaturated fats or com…

Feb 3, 2021 · 5 shares · 27 followers View post →
Tom Babington
@Tom_Babington1 · X

RT @MyNutritionSci: There are multiple comprehensive studies showing that isocalorically swapping saturated fat for unsaturated fats or com…

Feb 3, 2021 · 5 shares · 1,207 followers View post →
Shaun Ward
@MyNutritionSci · X

There are multiple comprehensive studies showing that isocalorically swapping saturated fat for unsaturated fats or complex carbs reduces CVD risk. This is not a controversial point of discussion. https://t.co/HqfSUQeA1Y https://t.co/HqfSUQeA1Y https://t.co/S1vXov4izd

Feb 3, 2021 · 15 likes · 5 shares · 2,384 followers View post →
John Gillespie
@DrGillespie_GP · X

@SBakerMD @djwilso Wrong- replacment studies do show reduced CVD when replaced with whole grains. https://t.co/nqxTNjfAoG

Feb 2, 2021 · 1 like · 1,065 followers View post →
اتانول
@ethamirnol · X

@Dampayi_sookhte در تحلیل نتایج یه مقاله فقط خوندن نتایج بدون توجه به چیزای کار اشتباهیه شما که انقد به مقاله علاقه‌مندید می‌تونید مقاله‌ی زیر رو مطالعه بفرمایید که جدیدتره و توسط مرجع معتبری هم چاپ شده https://t.co/yp3xHJzSwX

Sep 10, 2020 · 1,053 followers View post →
RahulJ3981
@RJalundhwala · X

@healthcoachkait Just going to leave this here. LDL: https://t.co/2pDD4rOCXA LDL: https://t.co/qOyOTT7hPC LDL: https://t.co/rcWDPLZaDO LDL: https://t.co/WuLQbSf2fT CVD: https://t.co/rwRAigoMB1 CHD: https://t.co/wl3CpcrHSj CHD: https://t.co/Mt4l6u1Ivi CHD: https://t.co/SqBUF66jNn 29149184/

Aug 8, 2020 · 1 like · 25 followers View post →
RahulJ3981
@RJalundhwala · X

@NoahRevoy Damn that's some tasty heart disease. LDL: https://t.co/2pDD4rOCXA LDL: https://t.co/qOyOTT7hPC LDL: https://t.co/rcWDPLZaDO LDL: https://t.co/WuLQbSf2fT CVD: https://t.co/rwRAigoMB1 CHD: https://t.co/wl3CpcrHSj CHD: https://t.co/Mt4l6u1Ivi CHD: https://t.co/SqBUF66jNn

Jun 16, 2020 · 1 like · 25 followers View post →
Rty
@isaac_fellick · X

@JohnnyPenso Systematic review alright? “Replacing saturated fat with PUFA, MUFA or high-quality carbohydrate will lower CHD events.” https://t.co/JiBF4KiIEe

May 10, 2020 · 225 followers View post →
Andrew
@awr4645 · X

@saladeaufromage Systematic Review, 2017: "Replacing saturated fat with PUFA, MUFA or high-quality carbohydrate will lower CHD events" Surely by the logic you've just presented, this conclusion would be impossible if PUFA and MUFA were causal factors of CHD events? How https://t.co/jvh1CsCc9t

Apr 26, 2020 · 1 like · 2,921 followers View post →
Kaan
@kaanturann · X

@AlpSirman https://t.co/h2tFnHS2Xz https://t.co/I3zy1qTE4d https://t.co/jlQKmGSdz7 Hepsinde olay aynı. Aynı şekilde European Society of Cardiology doi:10.1093/eurheartj/ehz455 şu yayını da etraflıca inceleyebilirsiniz.

Dec 21, 2019 · 122 followers View post →
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