BMC Med Res Methodol December 2017 PMID 29207961

When and how should multiple imputation be used for handling missing data in randomised clinical trials - a practical guide with flowcharts.

Janus Christian Jakobsen, Christian Gluud, Jørn Wetterslev, Per Winkel

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Mentions

44
Peak: 10 in May 2024
across 5 sources since Jun 2020

Extended reach

35,624
potential audience

Total likes

104

Video views

405

Mentions per month

Jun 2020 – Nov 2024

Where it's discussed

  • X / Twitter28 posts
  • YouTube10 videos
  • Facebook2 posts
  • News2 articles
  • Blogs2 articles

AI synopsis

What people are saying

Many discussions emphasize the significance of proper missing data management, with phrases like 'helpful paper' and mentions of its practical flowcharts, indicating interest in applying these methods. The tone suggests a cautious but positive perception about the article's utility, with users showing curiosity about the implications for research quality and bias reduction.

AgreementModerate agreement

Most discussions support the importance of proper handling of missing data and the usefulness of the article, though some show tentative or cautious approval.

InterestModerate interest

Posts indicate moderate curiosity, referencing the practical aspects of the guide and mentioning related concepts like missing data and statistical power.

EngagementModerate engagement

Several discussions mention the application of methods like multiple imputation, implying active consideration of the article's methods and implications.

ImpactModerate impact

Participants recognize the article’s relevance to improving research practices in clinical trials, perceiving it as potentially influential for methodology improvement.

Abstract in brief

  • Handling missing data in randomized clinical trials is crucial because it can bias results if not managed properly, and the best approach depends on understanding why data is missing.
  • The authors recommend planning for missing data from the start of the trial, using methods like multiple imputation and sensitivity analyses to reduce bias, and they provide practical flowcharts to guide researchers through the decision process.
  • Effective handling involves understanding the mechanisms causing missing data, carefully selecting analytical methods, and following structured steps during analysis to ensure valid and reliable results.

Top posts

Most liked on X and Bluesky
Ryohei Yamamoto@物価3倍の国
@so_flat · X

欠測割合がどのくらいまで多重補完するか? MIの意思決定に欠測割合40%カットオフにしたフローチャートの論文(2017) https://t.co/SxtgyiRLIQ Harrellらは、どのような割合でもMIをやったほうがよいというニュアンス https://t.co/IIF3O8dEyw

May 30, 2024 · 58 likes · 12 shares · 1,248 followers View post →
Anders Granholm
@andersgranholm · X

#MethodMonday 27: Missing data in clinical trials https://t.co/XgSDr0rkD5 https://t.co/9qDM8gftgF Missing data in trials decreases statistical power and may lead to bias, as those with missing data are often different from those without. 1/..

Jul 3, 2023 · 24 likes · 5 shares · 1,201 followers View post →
Jennifer Reed
@DrJenniferReed · X

Writing up a randomized controlled trial (#RCT), helpful paper on missing data approaches: https://t.co/GrOgXuS8Vs

Jun 6, 2020 · 8 likes · 2,003 followers View post →
Dr. Guy Prochilo
@GuyProchilo · X

@JamesEBartlett https://t.co/CIxoiEH9i2

Feb 9, 2021 · 6 likes · 1 share · 2,974 followers View post →
Kazuki Yoshida
@kaz_yos · X

@NoahHaber @tmorris_mrc @ProfMattFox https://t.co/j04CExIzSP I’m leaving this here to see what people think https://t.co/zAA3ppT3lH

Sep 4, 2020 · 3 likes · 5,592 followers View post →
A/Prof Kristen Gibbons
@DrKGibbons · X

A little #FridayFunny heading into the weekend

Jan 27, 2023 · 2 likes · 269 followers View post →

All mentions

Dr. Guy Prochilo
@GuyProchilo · X

Jakobsen, J. C., Gluud, C., Wetterslev, J., & Winkel, P. (2017). When and how should multiple imputation be used for handling missing data in randomised clinical trials—A practical guide with flowcharts. BMC Med Res Methodol, 17(1), Article 1. https://t.co/ujpFVFma2F

Sep 2, 2024 · 1 like · 2,974 followers View post →
サカナ
@pj_jdttm_mj_ · X

RT @so_flat: 欠測割合がどのくらいまで多重補完するか? MIの意思決定に欠測割合40%カットオフにしたフローチャートの論文(2017) https://t.co/SxtgyiRLIQ Harrellらは、どのような割合でもMIをやったほうがよいというニュアンス…

Jul 17, 2024 · 12 shares · 34 followers View post →
西山 菜々子 nanako nishiyama
@ninako75 · X

RT @so_flat: 欠測割合がどのくらいまで多重補完するか? MIの意思決定に欠測割合40%カットオフにしたフローチャートの論文(2017) https://t.co/SxtgyiRLIQ Harrellらは、どのような割合でもMIをやったほうがよいというニュアンス…

Jun 1, 2024 · 12 shares · 219 followers View post →
Shintaro Togashi
@shintarotogashi · X

RT @so_flat: 欠測割合がどのくらいまで多重補完するか? MIの意思決定に欠測割合40%カットオフにしたフローチャートの論文(2017) https://t.co/SxtgyiRLIQ Harrellらは、どのような割合でもMIをやったほうがよいというニュアンス…

Jun 1, 2024 · 12 shares · 356 followers View post →
Biostat student
@bioststd · X

RT @so_flat: 欠測割合がどのくらいまで多重補完するか? MIの意思決定に欠測割合40%カットオフにしたフローチャートの論文(2017) https://t.co/SxtgyiRLIQ Harrellらは、どのような割合でもMIをやったほうがよいというニュアンス…

May 31, 2024 · 12 shares · 32 followers View post →
てぃも@目標サブ3
@oyster_nomimono · X

RT @so_flat: 欠測割合がどのくらいまで多重補完するか? MIの意思決定に欠測割合40%カットオフにしたフローチャートの論文(2017) https://t.co/SxtgyiRLIQ Harrellらは、どのような割合でもMIをやったほうがよいというニュアンス…

May 31, 2024 · 12 shares · 271 followers View post →
上の階の住人がうるさい。
@3103ainz1 · X

RT @so_flat: 欠測割合がどのくらいまで多重補完するか? MIの意思決定に欠測割合40%カットオフにしたフローチャートの論文(2017) https://t.co/SxtgyiRLIQ Harrellらは、どのような割合でもMIをやったほうがよいというニュアンス…

May 31, 2024 · 12 shares · 248 followers View post →
迫田 季也 | Toshiya SAKODA
@sakoda091 · X

RT @so_flat: 欠測割合がどのくらいまで多重補完するか? MIの意思決定に欠測割合40%カットオフにしたフローチャートの論文(2017) https://t.co/SxtgyiRLIQ Harrellらは、どのような割合でもMIをやったほうがよいというニュアンス…

May 31, 2024 · 12 shares · 1,091 followers View post →
Ryuhei So
@RyuheiSo · X

RT @so_flat: 欠測割合がどのくらいまで多重補完するか? MIの意思決定に欠測割合40%カットオフにしたフローチャートの論文(2017) https://t.co/SxtgyiRLIQ Harrellらは、どのような割合でもMIをやったほうがよいというニュアンス…

May 31, 2024 · 12 shares · 992 followers View post →
hidaka
@sakuranolabo · X

RT @so_flat: 欠測割合がどのくらいまで多重補完するか? MIの意思決定に欠測割合40%カットオフにしたフローチャートの論文(2017) https://t.co/SxtgyiRLIQ Harrellらは、どのような割合でもMIをやったほうがよいというニュアンス…

May 31, 2024 · 12 shares · 491 followers View post →
Shotaro Mizuno
@shm372110851532 · X

RT @so_flat: 欠測割合がどのくらいまで多重補完するか? MIの意思決定に欠測割合40%カットオフにしたフローチャートの論文(2017) https://t.co/SxtgyiRLIQ Harrellらは、どのような割合でもMIをやったほうがよいというニュアンス…

May 30, 2024 · 12 shares · 17 followers View post →
Shimo
@Shimo_hematol · X

RT @so_flat: 欠測割合がどのくらいまで多重補完するか? MIの意思決定に欠測割合40%カットオフにしたフローチャートの論文(2017) https://t.co/SxtgyiRLIQ Harrellらは、どのような割合でもMIをやったほうがよいというニュアンス…

May 30, 2024 · 12 shares · 51 followers View post →
Ryohei Yamamoto@物価3倍の国
@so_flat · X

欠測割合がどのくらいまで多重補完するか? MIの意思決定に欠測割合40%カットオフにしたフローチャートの論文(2017) https://t.co/SxtgyiRLIQ Harrellらは、どのような割合でもMIをやったほうがよいというニュアンス https://t.co/IIF3O8dEyw

May 30, 2024 · 58 likes · 12 shares · 1,248 followers View post →
Marion Campbell
@MarionKCampbell · X

RT @andersgranholm: #MethodMonday 27: Missing data in clinical trials https://t.co/XgSDr0rkD5 https://t.co/9qDM8gftgF Missing data in tria…

Jul 6, 2023 · 5 shares · 4,938 followers View post →
Mari Takashima
@MariDTakashima · X

RT @andersgranholm: #MethodMonday 27: Missing data in clinical trials https://t.co/XgSDr0rkD5 https://t.co/9qDM8gftgF Missing data in tria…

Jul 4, 2023 · 5 shares · 337 followers View post →
RXKEVING
@KNRXRX · X

RT @andersgranholm: #MethodMonday 27: Missing data in clinical trials https://t.co/XgSDr0rkD5 https://t.co/9qDM8gftgF Missing data in tria…

Jul 3, 2023 · 5 shares · 357 followers View post →
Peter Nydahl
@NydahlPeter · X

RT @andersgranholm: #MethodMonday 27: Missing data in clinical trials https://t.co/XgSDr0rkD5 https://t.co/9qDM8gftgF Missing data in tria…

Jul 3, 2023 · 5 shares · 4,889 followers View post →
Anders Granholm
@andersgranholm · X

#MethodMonday 27: Missing data in clinical trials https://t.co/XgSDr0rkD5 https://t.co/9qDM8gftgF Missing data in trials decreases statistical power and may lead to bias, as those with missing data are often different from those without. 1/..

Jul 3, 2023 · 24 likes · 5 shares · 1,201 followers View post →
Y.Yanagisawa (Tokuda)
@yanagi12sawa20 · X

あとでよむ。 https://t.co/QJSr1ODhBW

Feb 19, 2023 · 1 like · 700 followers View post →
Renan Rocha
@rwgrocha · X

When and how should multiple imputation be used for handling missing data in randomised clinical trials – a practical guide with flowcharts. https://t.co/uWvnBbEWTo

Feb 8, 2023 · 221 followers View post →
A/Prof Kristen Gibbons
@DrKGibbons · X

A little #FridayFunny heading into the weekend

Jan 27, 2023 · 2 likes · 269 followers View post →
hidaka
@sakuranolabo · X

When and how should multiple imputation be used for handling missing data in randomised clinical trials – a practical guide with flowcharts https://t.co/jBWHN0LbVU

May 28, 2022 · 491 followers View post →
hidaka
@sakuranolabo · X

無作為化臨床試験における解析に限らず基本的に大事なことでは? https://t.co/mgl7gReahg

May 28, 2022 · 491 followers View post →
司徒
@szetoinsitu · X

RT @GuyProchilo: @JamesEBartlett https://t.co/CIxoiEH9i2

Feb 9, 2021 · 1 share · 1,841 followers View post →
Dr. Guy Prochilo
@GuyProchilo · X

@JamesEBartlett https://t.co/CIxoiEH9i2

Feb 9, 2021 · 6 likes · 1 share · 2,974 followers View post →
Dr. Michelle Byrne
@24michelle · X

@akhilanekkanti @drkatemills This might be helpful but I haven't read it yet! https://t.co/i0qATv8Wi2

Jan 20, 2021 · 551 followers View post →
Kazuki Yoshida
@kaz_yos · X

@NoahHaber @tmorris_mrc @ProfMattFox https://t.co/j04CExIzSP I’m leaving this here to see what people think https://t.co/zAA3ppT3lH

Sep 4, 2020 · 3 likes · 5,592 followers View post →
Jennifer Reed
@DrJenniferReed · X

Writing up a randomized controlled trial (#RCT), helpful paper on missing data approaches: https://t.co/GrOgXuS8Vs

Jun 6, 2020 · 8 likes · 2,003 followers View post →