Lean ME, Leslie WS, Barnes AC, et al. Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster- randomised trial. Lancet 2018;391:541–551 Lean MEJ, et al Lancet Diabetes Endocrinol 2019;7:344–355
Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial.
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Many discussions highlight the effectiveness of the weight management program, with users noting that '46% put T2D into remission' and emphasizing the importance of weight loss as a treatment option. Phrases such as 'impressive clinical trial' and 'weight loss should be the first line of treatment' further underscore the enthusiasm and urgency in adopting the findings. This choice of wording, along with a generally optimistic tone, suggests participants view the study as a crucial step in diabetes management.
A majority of discussions reflect a positive reception towards the findings of the publication, indicating a general agreement with its conclusions.
Many participants express a high level of interest, referencing various aspects of the study and its implications for diabetes management.
While some discussions are informative, not all participants engage deeply; references to the study exist without extensive personal reflection.
The conversations indicate a belief that the study has significant implications for diabetes treatment and management.
Abstract in brief
- Type 2 diabetes is a lifelong chronic condition, and this study, called DiRECT, explored whether a weight management program in primary care could help achieve remission from diabetes.
- Participants aged 20-65 with type 2 diabetes were either given an intensive weight management program or received standard care, with outcomes focused on significant weight loss and diabetes remission measured after 12 months.
- Results showed that 24% of those in the weight management group lost 15 kg or more, while no one in the standard care group achieved this level of weight loss.
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Most liked on X and BlueskyImponerende klinisk forsøg (Lancet, 2018), som viser at halvdelen kan blive fri for type 2-diabetes i almen praksis, hvis man stopper med diabetes- og blodtryksmedicin og i stedet indfører et struktureret, diætbaseret vægttabs-program.
One of the most successful outpatient dietary weight loss trials in history relied almost exclusively on ultra-processed foods for the vast majority of the observed weight loss. Cope. ¯\_(ツ)_/¯ https://t.co/2E0u4JjYId
2型糖尿病が被検者の実験で、 ・糖尿病食で糖尿病が改善したのは4% ・825〜853kcal/日の食事を数カ月続けると86%が糖尿病を治せた と報告されています。糖尿病の方は摂取カロリーの見直しをしてみても良いかもしれませんね。 https://t.co/c3zmqHOB9O
Twin Cycles Hypothesis: https://t.co/VX9vm8p1Xh Personal Fat Threshold: https://t.co/gmXATyQojA Counterpoint Study: https://t.co/DEYthgE3B2 Counterbalance Study: https://t.co/Y8pcmBxlXA DiRECT Trial: https://t.co/2E0u4JBzzL DiRECT Two-Year Follow-up: https://t.co/z7TQipbb5F https://t.co/esq1uGUly4
@FoodFirst_Ty Counterpoint: https://t.co/DEYthgE3B2 Counterbalance: https://t.co/gnKJtWxBhc DiRECT Trial: https://t.co/2E0u4JBzzL https://t.co/z7TQipbb5F Reviews: https://t.co/gmXATyQojA https://t.co/UAaYN5xXTp https://t.co/UfdPBWtHwQ This is pretty much all of Roy Taylor's work.
All mentions
Managing Type 2 Diabetes: Can Weight Loss Lead to Remission?
Impact of Weight Loss on Health and Diabetes Remission
Did you know losing just 3% of your body weight offers significant health benefits? This video discusses how a 5% weight loss can improve blood pressure and reduce the risk of depression. We also examine findings from…
Type 2 Diabetes Isn’t Always Forever — Here’s Proof
https://t.co/3mtpJI4nq2
1. DIRECT Trial (Diabetes Remission Clinical Trial) First major publication: Title: Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial Journal: The Lancet, 2018 PMID: 29221645 Follow-up 2-year results: PMID:
@Pl4ntbased @TyRBeal This study showed great results for weight loss-shakes. So there's that. https://t.co/vniAoyVAZo
primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial. →https://t.co/xbftzamOao #MedEd #HealthTips https://t.co/Tpb5wmDEGd
https://t.co/IjD5GFQV8y #JJCLIP https://t.co/OUFrLV2FSd
Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial - The Lancet https://t.co/qwXcUMTwSY
https://t.co/NtZKMC9rDu Volkserkrankung Diabetes - Heilbar oder Unaufhaltsam?
@AndrzejDunowski @CK_inzynier @blueeyedboy88 @PludowskiLukasz Wystarczy 9 tygodni na KAŻDEJ diecie prowadzącej do spadku wagi o 10-15 procent-Badania Roy Taylor i in. https://t.co/g2VxRiwKSQ
RT @upRootNutrition: One of the most successful outpatient dietary weight loss trials in history relied almost exclusively on ultra-process…
RT @upRootNutrition: One of the most successful outpatient dietary weight loss trials in history relied almost exclusively on ultra-process…
RT @upRootNutrition: One of the most successful outpatient dietary weight loss trials in history relied almost exclusively on ultra-process…
One of the most successful outpatient dietary weight loss trials in history relied almost exclusively on ultra-processed foods for the vast majority of the observed weight loss. Cope. ¯\_(ツ)_/¯ https://t.co/2E0u4JjYId
RT @igoreckert: @ElieJarrougeMD @MohammedAlo These patients are in peer-reviewed medical papers: https://t.co/svUSPFSES3 Weight loss cause…
@ElieJarrougeMD @MohammedAlo These patients are in peer-reviewed medical papers: https://t.co/svUSPFSES3 Weight loss causes diabetes reversal with a very clear dose-response relationship. The fact that diabetes can be prevented, managed or reversed by weight loss and lifestyle modification does not mean
@NullifyMAGALies @KinseyKat1 @ryanbeed @RICHLS8 @richykirsh @michellewither6 @Vickie627 @ahrehead @WondersNorbit @Dooooooooooodie @FiendInno @AdorablePodcast @o518o518 @Resistenzanow @abortivus @ArchLuminous @jimaw63 @8BrianVogel4 @2024fighter @hoothathuh @KirchoffSh62598 @TW175663056 @cbeckj @EMNODAERTTONOD @kim_because @MichelleinAZ602 @Badams820 @PaulStetson13 @OzzieMalone1 @WhiteRonin22 @BabeTruth2 @MichaelSteidel @PatricktheB @lastword4me2a @Jcatsgots9 @DOnyali26 @proundpapaof3 @Wanderinglord @SophiaBianchi99 @DocDeezWhat @LGiancano @_DarleneBoyd @IamGhostOfTick1 @4horseshoesbw @VinceGottalotta @HamRadioJoe @GenChaoticGood
https://t.co/Bz5CW3sOwz
@RickTheV1 @XDB500 @Veganella_ @environmentonig Whoa, friendly fire. Those diets are based for T2DM remission. https://t.co/2E0u4JkwxL
@XDB500 @trist_cole Here’s a put up or shut up challenge. Refute this literature on fat threshold as the mechanism for DM2 and supporting trials. https://t.co/jKq7vAPghe https://t.co/pIFoeJHe7n https://t.co/bjcAk4kBYj https://t.co/PSl2sSV3n5 https://t.co/bmMw35YsxN
@MacroFour @_advg_ @ScepticalDoctor @HPG_Farmer @lowcarbGP And I am truly curious. https://t.co/X9zKpktjYI Diabetes remission was achieved in 68 (46%) participants in the intervention group and six (4%) participants in the control group
RT @the_beardedsina: @GBlewusi Yes, there are a ton of them 1. https://t.co/v3k8fxef9M 2. https://t.co/ynOVKjvNro 3. https://t.co/WD6ABy4M…
@GBlewusi Yes, there are a ton of them 1. https://t.co/v3k8fxef9M 2. https://t.co/ynOVKjvNro 3. https://t.co/WD6ABy4M20 4. https://t.co/LVDVnPmMyp 5. https://t.co/bln02WynZj
@bakrantz Also I question your claim regarding simply cutting carbs. Weight loss in general (no matter if you lower carbs or fats) improves all pertinent markers for diabetes. https://t.co/bjcAk4kBYj https://t.co/PSl2sSV3n5 https://t.co/bmMw35YsxN https://t.co/8mmOiepiJS
RT @FoodFirst_Ty: @adambailes007 @zachinpractice @RetrogradeAgain Much more likely related to chronic energy overconsumption and adipose th…
@adambailes007 @zachinpractice @RetrogradeAgain Much more likely related to chronic energy overconsumption and adipose threshold. https://t.co/pIFoeJHe7n https://t.co/bjcAk4kBYj https://t.co/PSl2sSV3n5 https://t.co/bmMw35YsxN https://t.co/8mmOiepiJS https://t.co/jKq7vAPghe
Professor Roy Taylor’s work is truly remarkable. Recently I got through reading his clinical trials and recommend them to anyone interested in diabetes. Start Here: https://t.co/p1hr0TpaN6 https://t.co/QNYLNdvWjr https://t.co/knlFG8TIbV
Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial https://t.co/6ow0N5C71q
@ScepticalDoctor E.g: - https://t.co/FTJBYA27JM - https://t.co/RRxfbW94ab - DOI: 10.1016/S0140-6736(17)33102-1 - DOI: 10.1016/S2213-8587(19)30068-3 - DOI: 10.1111/dme.12116
Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial - The Lancet https://t.co/jRYFUd6ZfE
Referências: 1. Lean, M. E., Leslie, W. S., Barnes, A. C., Brosnahan, N., Thom, G., McCombie, L., ... & Taylor, R. (2017). Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial. The Lancet, 391(10120), 541-551.
RT @Medicinmanden: Imponerende klinisk forsøg (Lancet, 2018), som viser at halvdelen kan blive fri for type 2-diabetes i almen praksis, hvi…
RT @Medicinmanden: Imponerende klinisk forsøg (Lancet, 2018), som viser at halvdelen kan blive fri for type 2-diabetes i almen praksis, hvi…
RT @Medicinmanden: Imponerende klinisk forsøg (Lancet, 2018), som viser at halvdelen kan blive fri for type 2-diabetes i almen praksis, hvi…
Imponerende klinisk forsøg (Lancet, 2018), som viser at halvdelen kan blive fri for type 2-diabetes i almen praksis, hvis man stopper med diabetes- og blodtryksmedicin og i stedet indfører et struktureret, diætbaseret vægttabs-program.
In fact, his RCT put patients on a severely calorie-restricted diet intervention, containing 59% carbohydrates (a lot of carbohydrates), which resulted in 46% of intervention group patients being put on type 2 diabetes remission. https://t.co/CLVcpY5bC7
@SeamusMulsow @KenDBerryMD https://t.co/yp0FkdRc22 https://t.co/ICWdzLabVP https://t.co/tG9ElRGX3M https://t.co/OSb12kDRHl https://t.co/oI4xPGnwpI
まあ、この論文を読んだときには、わりと衝撃があった。 Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised tri… https://t.co/IjD5GFQV8y
RT @IshiyakuApp: 2型糖尿病が被検者の実験で、 ・糖尿病食で糖尿病が改善したのは4% ・825〜853kcal/日の食事を数カ月続けると86%が糖尿病を治せた と報告されています。糖尿病の方は摂取カロリーの見直しをしてみても良いかもしれませんね。 https:/…
RT @IshiyakuApp: 2型糖尿病が被検者の実験で、 ・糖尿病食で糖尿病が改善したのは4% ・825〜853kcal/日の食事を数カ月続けると86%が糖尿病を治せた と報告されています。糖尿病の方は摂取カロリーの見直しをしてみても良いかもしれませんね。 https:/…
2型糖尿病が被検者の実験で、 ・糖尿病食で糖尿病が改善したのは4% ・825〜853kcal/日の食事を数カ月続けると86%が糖尿病を治せた と報告されています。糖尿病の方は摂取カロリーの見直しをしてみても良いかもしれませんね。 https://t.co/c3zmqHOB9O
@JohnnyScott234 @DoctorTro This https://t.co/DJxHXYnm4K? 46% put T2D into remission, yet only 24% lost 15kg or more. I don't see any mentioning of liver fat stores. Again, I don't see evidence that fat loss CAUSED diabetes remission.
@jonbischke @TyRBeal @mackinprof @vanvlietphd @fleroy1974 @mario_kratz @davidludwigmd There are many supporting lines of evidence but here are two key papers. https://t.co/MdRIBsvTVN https://t.co/xjZTdRX21w
@endocrinorosero Doctor, el Estudio Direct, publicado por The Lancet en 2018, no cuenta? "Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial https://t.co/4EjMoLDT3G
Gestione del peso guidata dall'assistenza primaria per la remissione del diabete ditipo 2 (DiRECT) Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial. FONTE: https://pubmed.ncbi.nlm.nih. https://t.co/1abh8n2ZiD https://t.co/g4Rg6d6LVW
Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial https://t.co/64HRtnEbY0
Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial https://t.co/eWLKSkjd7w
Moving on, the final study I want to mention is Roy Taylor’s most recent: the year-long DiRECT study. This was the largest intervention by far, involving nearly 300 adults with T2DM from 49 separate primary care practices. https://t.co/D622WxRPSx
RT @CristobMorales: https://t.co/NvoZI0y7de Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cl…
https://t.co/NvoZI0y7de Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial https://t.co/STl72xk1X8
Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial https://t.co/x5rwEHhuMQ
رابط الدراسة للاطلاع : https://t.co/9gC17SYn1K
Why are you lying, Ragen Chastain? https://t.co/5Gjdumu6rv https://t.co/2JUTPXyf5X
En el grupo de intervención: ✅HBA1C ⬇️0.9% ✅ Antidiabéticos prescritos ⬇️ 0.8 ✅No hubo reducción en anti hipertensivos prescritos ✅ Mejoría en cuestionarios de calidad de vida https://t.co/wNacCzcQW3 https://t.co/CEHmWFt1le
RT @medinternajg: Lean ME, Leslie WS, Barnes AC, et al. Primary care-led weight management for remission of type 2 diabetes (DiRECT): an op…
RT @medinternajg: Lean ME, Leslie WS, Barnes AC, et al. Primary care-led weight management for remission of type 2 diabetes (DiRECT): an op…
RT @medinternajg: Lean ME, Leslie WS, Barnes AC, et al. Primary care-led weight management for remission of type 2 diabetes (DiRECT): an op…
RT @medinternajg: Lean ME, Leslie WS, Barnes AC, et al. Primary care-led weight management for remission of type 2 diabetes (DiRECT): an op…
Lean ME, Leslie WS, Barnes AC, et al. Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster- randomised trial. Lancet 2018;391:541–551 Lean MEJ, et al Lancet Diabetes Endocrinol 2019;7:344–355
@docdomeng Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial https://t.co/2bYh1ub5Km
@GrMeir @TomerAvital1 שאלה מצויינת. למעשה התרופות גורמות לרעב-לפחמימות ומאלצות את המטופלים לצרוך עוד פחמימות, כך שנוצר מעגל קסמים מזיק. חלק מהרופאים מבינים זאת ומשתמשים בשיטת DiRECT - הפחתת תרופות יחד עם שינוי אורח חיים https://t.co/rW3brVXxP7 הרופאים האלו אינם מוזמנים להרצות בכנסים ובקורסים שבחסות...
Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial - The Lancet https://t.co/JP4NwcVvwj
Twin Cycles Hypothesis: https://t.co/VX9vm8p1Xh Personal Fat Threshold: https://t.co/gmXATyQojA Counterpoint Study: https://t.co/DEYthgE3B2 Counterbalance Study: https://t.co/Y8pcmBxlXA DiRECT Trial: https://t.co/2E0u4JBzzL DiRECT Two-Year Follow-up: https://t.co/z7TQipbb5F https://t.co/esq1uGUly4
@REV_Insulin_Res @GoateeWoodson @houston_ron The one thing that seems to be consistent is weight loss, so it's a fair assumption IMO. And it's consistent with what both you seem to have experienced. https://t.co/aBMFrZ2Rjm https://t.co/cEwqC7HP1d https://t.co/SHZdoX6SUc
RT @drshahri:
RT @drshahri:
RT @drshahri:
RT @drshahri:
RT @drshahri:
@pannilak @flowtiina @Dr_ML_md En löytänyt kuin 1 v dataa Virrasta. Ihan kiinnostava, tietenkin. Joka tapauksessa ongelmia ovat satunnaistamisen puuttuminen ja valikoituminen jo alussa (kenellä on rahaa ja motivaatiota) ja vielä enemmän seurannassa. Parempi asetelma -> ks. DiRECT https://t.co/1Vzps0l7UM
Weight loss can put Type 2 diabetes into remission for at least two years – the latest findings from DiRECT https://t.co/e48GD9JLve
RT @The_Nutrivore: @FoodFirst_Ty Counterpoint: https://t.co/DEYthgE3B2 Counterbalance: https://t.co/gnKJtWxBhc DiRECT Trial: https://t.co/2…
RT @The_Nutrivore: @FoodFirst_Ty Counterpoint: https://t.co/DEYthgE3B2 Counterbalance: https://t.co/gnKJtWxBhc DiRECT Trial: https://t.co/2…
@FoodFirst_Ty Counterpoint: https://t.co/DEYthgE3B2 Counterbalance: https://t.co/gnKJtWxBhc DiRECT Trial: https://t.co/2E0u4JBzzL https://t.co/z7TQipbb5F Reviews: https://t.co/gmXATyQojA https://t.co/UAaYN5xXTp https://t.co/UfdPBWtHwQ This is pretty much all of Roy Taylor's work.
RT @PABLOLUNA: @DrGiovanniD Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised…
@DrGiovanniD Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial https://t.co/Xz5kwaWCh5
@ojyo_k Primary care-led weight management for remission of type 2 diabetesこの論文と王城聖帝の運動療法には心から感謝しています、66歳でデブでもないので、時間がかかり、何度も挫折しそうになりましたが、良かった。
Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial - The Lancet https://t.co/rwf3RZauNO
Pero... ¿no habíamos quedado en que la #diabetes se curaba perdiendo peso? Primary Care-Led Weight Management for Remission of Type 2 Diabetes (DiRECT): An Open-Label, Cluster-Randomised Trial - PubMed https://t.co/xbUliWWDfy https://t.co/dsFlCxTJme
RT @KevinH_PhD: @DrSarahHallberg @rebelhealth1 @bcorkey @ketonemics Evidence from the DiRECT study suggests that low carb diets are not the…
@BioLayne And before he pulls the “but you’re metabolically healthy” card - in the DiRECT trial, people put their T2DM in remission with 3 months of 125gms carb/day, and kept it in remission with a maintenance diet of ~300gms carb/day. Nuance and context. https://t.co/9zy4QVoDoT
RT @KevinH_PhD: @DrSarahHallberg @rebelhealth1 @bcorkey @ketonemics Evidence from the DiRECT study suggests that low carb diets are not the…
@DrSarahHallberg @rebelhealth1 @bcorkey @ketonemics Evidence from the DiRECT study suggests that low carb diets are not the *only way* for people with type 2 diabetes to achieve these goals. https://t.co/y1BbzK4zi6
@MacroFour @EAllen0417 @ScottVMeyers @bigfatsurprise I don't know why you're going off on NAFLD patho
RT @ferchobarb: Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial. htt…
Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial. https://t.co/fMyHKygsjr https://t.co/8UK7234xhP
RT @IntJObesity: Meet one of the members of the @IntJObesity editorial board, Professor @MEJLean. His recent papers on type 2 diabetes rem…
RT @IntJObesity: Meet one of the members of the @IntJObesity editorial board, Professor @MEJLean. His recent papers on type 2 diabetes rem…
Type 2 Diabetes - maybe we CAN put it into remission! (through #lifestyle) not medications. Primary care-led weight management for remission of type 2 #diabetes (DiRECT): an open-label, cluster-randomised trial https://t.co/G7nzWUyyKw
Further Reading Lean, M.E., Leslie, W.S., Barnes, A.C., Brosnahan, N., Thom, G., McCombie, L., Peters, C., Zhyzhneuskaya, S., Al-Mrabeh, A., Hollingsworth, K.G. and Rodrigues, A.M., 2017. Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label,
RT @IntJObesity: Meet one of the members of the @IntJObesity editorial board, Professor @MEJLean. His recent papers on type 2 diabetes rem…
@ZaherToumi I don't see any obvious issues with the design of this study (FWLIW
Seems a drastic regimen for 3 - 5 months but hard to argue with T2DM remission of almost 50%. https://t.co/TtfvpUimLC #diabetes #diet
Primary care-led weight management for remission of type 2 diabetes. https://t.co/rNtOn5ISAI 86% of people who lost 33 lbs or more had complete remission. Shouldn't weight loss be the _first_ line of treatment for obese people with Type 2 diabetes?
RT @IntJObesity: Meet one of the members of the @IntJObesity editorial board, Professor @MEJLean. His recent papers on type 2 diabetes rem…
@WSHT_ICU JC 11th Jan - Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial https://t.co/kA1Zrx3Tve
Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial - The Lancet https://t.co/OZyyQVYgQ6