November 2017 PMID 29238290

Intermittent Fasting Protects against Alzheimer's Disease Possible through Restoring Aquaporin-4 Polarity.

Jingzhu Zhang, Zhipeng Zhan, Xinhui Li, Aiping Xing, Congmin Jiang, Yanqiu Chen, Wanying Shi, Li An

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Mentions

27
Peak: 5 in Nov 2019
across 5 sources since Nov 2019

Extended reach

38,283
potential audience

Total likes

88

Video views

2,745

Mentions per month

Nov 2019 – Oct 2022

Where it's discussed

  • News10 articles
  • X / Twitter9 posts
  • Facebook5 posts
  • Blogs2 articles
  • YouTube1 videos

AI synopsis

What people are saying

The overall tone indicates strong support and curiosity, exemplified by remarks like 'Intermittent fasting is the greatest discovery' and references to mechanisms such as aquaporin-4 and the glymphatic system. Words like 'transformed' and 'game changer' reflect excitement, while mentions of personal benefits suggest active engagement with the research's potential impact.

AgreementModerate agreement

Most discussions express strong support or positive attitudes towards the article's findings, with some claiming intermittent fasting as a transformative discovery.

InterestHigh interest

Posts show high interest, with several individuals sharing personal experiences, potential health benefits, and enthusiasm about the research.

EngagementModerate engagement

The discussions reflect some depth, referencing mechanisms like the glymphatic system and aquaporin-4 function, indicating thoughtful engagement with the scientific content.

ImpactModerate impact

Participants believe the findings could have significant implications for health, especially in preventing or managing Alzheimer's disease and related neurodegenerative conditions.

Abstract in brief

  • Intermittent fasting (IF) may help protect against Alzheimer's disease (AD) by restoring the proper distribution (polarity) of aquaporin-4 (AQP4) in the brain, which is important for clearing amyloid beta (A) plaques.
  • The study suggests that IF increases levels of hydroxybutyrate, which inhibits histone deacetylase 3 (HDAC3) and affects the ratio of AQP4 isoforms (M1 and M23), leading to improved AQP4 function and reduced amyloid accumulation.
  • The findings also indicate that microRNA130a (miR130a) plays a key role in regulating AQP4 isoforms and HDAC3, with IF and hydroxybutyrate boosting miR130a levels to support brain health and cognitive function in AD models.

Top posts

Most liked on X and Bluesky
Phedias Diamandis
@pdiamandisii · X

Imagine there was a #diet that could help manage obesity, bulk up your #brain's #memory center and potentially fight off #AlzheimersDisease all at once! Learn more about the positive #neuro benefits of #fasting and #ketosis by tuning into #NeuroscIQ https://t.co/QgyuLgWvhE

Nov 23, 2019 · 6 likes · 3 shares · 689 followers View post →
rubicon59
@rubicon59 · X

Wow. At least in mice: Intermittent Fasting Protects against Alzheimer's Disease Possible through Restoring Aquaporin-4 Polarity. - PubMed - NCBI https://t.co/8Av0nWp2Wk

Mar 6, 2020 · 3 likes · 21,374 followers View post →
Maurício Lima
@dj_surfista · X

#Jejum intermitente protege contra a doença de #Alzheimer. https://t.co/HrotFmcEme

Oct 16, 2022 · 3 likes · 746 followers View post →
Dr Kevin Lee
@dr_kevinlee · X

Proposed one mechanism of benefit of #IntermittentFasting in #Alzheimers #alzheimersdisease due to improved Aquaporin-4 function part of #glymphatic system https://t.co/lbtgkuuXVi

Oct 15, 2022 · 1 share · 5,439 followers View post →
Runjan Chetty
@RunjanChetty · X

RT @pdiamandisii: Imagine there was a #diet that could help manage obesity, bulk up your #brain's #memory center and potentially fight off…

Nov 23, 2019 · 3 shares · 3,428 followers View post →
Trevor D. McKee PhD
@tdmckee · X

RT @pdiamandisii: Imagine there was a #diet that could help manage obesity, bulk up your #brain's #memory center and potentially fight off…

Nov 23, 2019 · 3 shares · 2,186 followers View post →

All mentions

Maurício Lima
@dj_surfista · X

#Jejum intermitente protege contra a doença de #Alzheimer. https://t.co/HrotFmcEme

Oct 16, 2022 · 3 likes · 746 followers View post →
Almighty Keto Diet
@KetoDiet365 · X

RT @dr_kevinlee: Proposed one mechanism of benefit of #IntermittentFasting in #Alzheimers #alzheimersdisease due to improved Aquaporin-4 fu…

Oct 16, 2022 · 1 share · 805 followers View post →
Dr Kevin Lee
@dr_kevinlee · X

Proposed one mechanism of benefit of #IntermittentFasting in #Alzheimers #alzheimersdisease due to improved Aquaporin-4 function part of #glymphatic system https://t.co/lbtgkuuXVi

Oct 15, 2022 · 1 share · 5,439 followers View post →
rubicon59
@rubicon59 · X

Wow. At least in mice: Intermittent Fasting Protects against Alzheimer's Disease Possible through Restoring Aquaporin-4 Polarity. - PubMed - NCBI https://t.co/8Av0nWp2Wk

Mar 6, 2020 · 3 likes · 21,374 followers View post →
Phedias Diamandis
@pdiamandisii · X

@tdmckee @GarmireGroup I'll put it this way. Intermittent fast is the single greatest (re)discovery I made in my life. I've been doing it for 5 years this new year and it transformed my body, mind and spirit. No APP needed. Find out more https://t.co/QgyuLgWvhE

Dec 29, 2019 · 689 followers View post →
Raniah Alqawahmed
@Raniagaw · X

RT @pdiamandisii: Imagine there was a #diet that could help manage obesity, bulk up your #brain's #memory center and potentially fight off…

Nov 25, 2019 · 3 shares · 154 followers View post →
Runjan Chetty
@RunjanChetty · X

RT @pdiamandisii: Imagine there was a #diet that could help manage obesity, bulk up your #brain's #memory center and potentially fight off…

Nov 23, 2019 · 3 shares · 3,428 followers View post →
Trevor D. McKee PhD
@tdmckee · X

RT @pdiamandisii: Imagine there was a #diet that could help manage obesity, bulk up your #brain's #memory center and potentially fight off…

Nov 23, 2019 · 3 shares · 2,186 followers View post →
Phedias Diamandis
@pdiamandisii · X

Imagine there was a #diet that could help manage obesity, bulk up your #brain's #memory center and potentially fight off #AlzheimersDisease all at once! Learn more about the positive #neuro benefits of #fasting and #ketosis by tuning into #NeuroscIQ https://t.co/QgyuLgWvhE

Nov 23, 2019 · 6 likes · 3 shares · 689 followers View post →