Proc Natl Acad Sci U S A January 2018 PMID 29279395

Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA.

François Ferron, Lorenzo Subissi, Ana Theresa Silveira De Morais, Nhung Thi Tuyet Le, Marion Sevajol, Laure Gluais, Etienne Decroly, Clemens Vonrhein, Gérard Bricogne, Bruno Canard, Isabelle Imbert

Mentions

11
Peak: 3 in Mar 2020
across 3 sources since Feb 2020

Extended reach

10,948
potential audience

Total likes

47

Video views

5,321

Mentions per month

Feb 2020 – Apr 2023

Where it's discussed

  • X / Twitter5 posts
  • News4 articles
  • YouTube2 videos

AI synopsis

What people are saying

Overall, the discussions reflect a moderate consensus that the research sheds light on critical aspects of coronavirus biology, such as low mutation rates and the role of nsp14, with users emphasizing the correction of misinformation about viral destruction and treatment effectiveness. The tone is informational and corrective, highlighting the significance of structural insights while showing a cautious appreciation of the research's influence.

AgreementModerate agreement

Most discussions acknowledge the importance of the research, especially in clarifying misconceptions about coronavirus biology.

InterestModerate interest

The discussions show moderate interest, focusing on correcting false narratives and understanding the virus's mechanisms.

EngagementNeutral engagement

Comments tend to be brief and somewhat superficial; they express agreement but lack deep technical engagement.

ImpactModerate impact

The posts recognize the study's potential to influence understanding and discourse around viral stability and treatment challenges, indicating a moderate impact.

Abstract in brief

  • Coronaviruses are unique RNA viruses with large genomes (about 30 kb) and low mutation rates, which contribute to their stability.
  • nsp14, a crucial enzyme in Coronaviruses, has two functions: it methylates RNA and proofreads by removing mismatched nucleotides, ensuring genetic stability.
  • The study reveals how nsp14 interacts with nsp12 to manage RNA synthesis and proofreading, explaining the limited efficacy of the antiviral drug ribavirin, and presents a detailed structure of nsp14 that showcases its distinct features compared to other RNA viruses.

Top posts

Most liked on X and Bluesky
Reality Check Marker
@RealCheckMarker · X

@mrmickme @ejustin46 @_ppmv One of the false #TextbookVirus narratives being punted around is that SARS destroys cells. That's not true for any CoV. The other false narrative is that we stopped working on vaccine/treatment and "NOT A TEXTBOOK VIRUS" was our greatest obstacle. https://t.co/ROKb80LNVk https://t.co/qmtfFk4Knj

Apr 6, 2023 · 5 likes · 1 share · 5,354 followers View post →
KelseyJenkins333
@KJenkins333 · X

Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA | PNAS### CRISPER ⁦@realDonaldTrump⁩ https://t.co/JWdDSyy1NG

Mar 1, 2020 · 1 like · 1 share · 8 followers View post →
Mikha’el
@LlamaAloof · X

RT @RealCheckMarker: @mrmickme @ejustin46 @_ppmv One of the false #TextbookVirus narratives being punted around is that SARS destroys cells…

Apr 7, 2023 · 1 share · 177 followers View post →
Totally not serious
@ConcernedCana10 · X

@jenheemstra https://t.co/d6UWhaDmvJ

Mar 22, 2020 · 33 followers View post →

All mentions

Mikha’el
@LlamaAloof · X

RT @RealCheckMarker: @mrmickme @ejustin46 @_ppmv One of the false #TextbookVirus narratives being punted around is that SARS destroys cells…

Apr 7, 2023 · 1 share · 177 followers View post →
Reality Check Marker
@RealCheckMarker · X

@mrmickme @ejustin46 @_ppmv One of the false #TextbookVirus narratives being punted around is that SARS destroys cells. That's not true for any CoV. The other false narrative is that we stopped working on vaccine/treatment and "NOT A TEXTBOOK VIRUS" was our greatest obstacle. https://t.co/ROKb80LNVk https://t.co/qmtfFk4Knj

Apr 6, 2023 · 5 likes · 1 share · 5,354 followers View post →
Totally not serious
@ConcernedCana10 · X

@jenheemstra https://t.co/d6UWhaDmvJ

Mar 22, 2020 · 33 followers View post →
KelseyJenkins333
@KJenkins333 · X

RT @KJenkins333: Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA | PNAS### CRISPER ⁦@rea…

Mar 8, 2020 · 1 share · 8 followers View post →
KelseyJenkins333
@KJenkins333 · X

Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA | PNAS### CRISPER ⁦@realDonaldTrump⁩ https://t.co/JWdDSyy1NG

Mar 1, 2020 · 1 like · 1 share · 8 followers View post →
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