PubHawk
Cancer Sci April 2018 PMID 29369461

Modulation of AKR1C2 by curcumin decreases testosterone production in prostate cancer.

Hisamitsu Ide, Yan Lu, Takahiro Noguchi, Satoru Muto, Hiroshi Okada, Suguru Kawato, Shigeo Horie

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Mentions

57
Peak: 3 in Oct 2020
across 3 sources since Oct 2020

Extended reach

786,371
potential audience

Total likes

15,363

Video views

763,034

Mentions per month

Oct 2020 – Aug 2025

Where it's discussed

  • News35 articles
  • X / Twitter20 posts
  • YouTube2 videos

AI synopsis

What people are saying

The overall tone reflects skepticism and concern, exemplified by comments like 'dikkatli kullanım' (use cautiously) and warnings about side effects, which indicates a cautious attitude rather than strong support or interest. Words like 'yan etkisi' (side effects) and phrases warning against continuous use suggest users are more focused on potential risks than on the scientific findings of the article.

AgreementLow agreement

Most posts seem skeptical or dismissive of the publication, especially with comments warning about negative effects of herbal supplements like zerdeçal (turmeric).

InterestNeutral interest

The discussions show moderate interest, primarily focusing on the warnings and side effects rather than the scientific content itself.

EngagementLow engagement

Posts are somewhat superficial, mostly sharing warnings or personal opinions without deep scientific engagement or detailed analysis.

ImpactLow impact

The social discussions appear to have limited influence, mainly raising caution rather than advocating for the research's implications or exploring potential therapeutic benefits.

Abstract in brief

  • The study found that curcumin, a natural compound, can inhibit the growth of prostate cancer cells by lowering testosterone and dihydrotestosterone levels, mainly through decreasing the expression of proteins involved in hormone synthesis.
  • Curcumin treatment increased the expression of AKR1C2, an enzyme that helps break down testosterone, which supports the reduction in androgen levels in both cell lines and mouse models, ultimately inducing cancer cell death.
  • Overall, the findings suggest that curcumin could be a promising natural therapy for prostate cancer because it suppresses local hormone production that fuels cancer growth.]
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Top posts

Most liked on X and Bluesky
Nejjazdemir0606
@nejjazdemir0606 · X

Zerdeçal'ın 7 ETKİSİ ve YAN ETKİSİ: Bu Durumlarda Zerdeçal Kullanmayın! https://t.co/oWpMF31EzC @YouTube aracılığıyla DİKKAT ZERDEÇAL kullananlar izlesin bence bi çok yan etkisi varmış

Oct 16, 2020 · 6 likes · 1 share · 3,943 followers View post →
Faruk £RT£N
@faruk_ertn · X

5) Yine yapılan bir çalışmada bilinçsiz şekilde zerdeçal kullanımı erkekler de testosteron seviyesinin düşmesine neden olabilir. Bu yüzden erkekler uzun süre yoğun dozda zerdeçal kullanımında dikkatli olmalı. Kaynak: https://t.co/iF9Lk3qy4U https://t.co/5CAQGgXC6Y

Nov 5, 2020 · 5 likes · 286 followers View post →
HAKan Peçel
@hakanpecel · X

@drahmetrasim @SEHVANKAR Baharatları abartmadan dengeli kullanmalı. Etkilerini abartıp, gereksiz beklentilere girmemeli.

Dec 16, 2020 · 4 likes · 3 shares · 1,324 followers View post →
Andrzej Dunowski
@AndrzejDunowski · X

@Laweta2 Proszę sobie to obejrzeć https://t.co/gTZLEtuViJ

Aug 16, 2023 · 3 likes · 1 share · 162 followers View post →
Robomir
@Robomir1 · X

@OwskyTaaz https://t.co/nLTsH2Lix6

Dec 1, 2024 · 2 likes · 1,437 followers View post →
HAKan Peçel
@hakanpecel · X

@UzunDr @talaydidem Dikkatli kullanım... https://t.co/d4WZ44XrMn

Mar 17, 2021 · 2 likes · 2 shares · 1,324 followers View post →

All mentions

Lori Del Regno
@LoriRegno · X

@watchfuldefend @LeddyLLC https://t.co/VjrISlSBNE

Aug 23, 2025 · 965 followers View post →
Lori Del Regno
@LoriRegno · X

@Sidsidsides @LeddyLLC https://t.co/VjrISlSBNE

Aug 23, 2025 · 965 followers View post →
Robomir
@Robomir1 · X

@OwskyTaaz https://t.co/nLTsH2Lix6

Dec 1, 2024 · 2 likes · 1,437 followers View post →
ⓧ Maτi ₿ˢᵛ
@CryptoM4TI · X

@CryptoTubylec https://t.co/I3OuswVuEW

Jan 27, 2024 · 122 followers View post →
Andrzej
@Andrzej28275539 · X

RT @AndrzejDunowski: @Laweta2 Proszę sobie to obejrzeć https://t.co/gTZLEtuViJ

Aug 17, 2023 · 1 share · 1,827 followers View post →
Andrzej Dunowski
@AndrzejDunowski · X

@Laweta2 Proszę sobie to obejrzeć https://t.co/gTZLEtuViJ

Aug 16, 2023 · 3 likes · 1 share · 162 followers View post →
Rafał Szczepański
@Madcat1975 · X

@alchemiczka73 @Czaroit1 Niestety jest Pani w błędzie. https://t.co/ptpD31J4rk

Mar 28, 2023 · 1 like · 1,065 followers View post →
BayHiç
@bayhic01 · X

https://t.co/4FrotKPiNh

Oct 31, 2022 · 183 followers View post →
Doğan Kardeş
@DoganKardes69 · X

Zerdeçal'ın 7 ETKİSİ ve YAN ETKİSİ: Bu Durumlarda Zerdeçal Kullanmayın! https://t.co/ZPyGb1tQ12 @YouTube aracılığıyla

Oct 26, 2022 · 1,188 followers View post →
BayHiç
@bayhic01 · X

https://t.co/4FrotKxHoH

Oct 13, 2022 · 183 followers View post →
BayHiç
@bayhic01 · X

https://t.co/4FrotKPiNh

Sep 11, 2022 · 183 followers View post →
Didem Talay☄
@talaydidem · X

RT @hakanpecel: @UzunDr @talaydidem Dikkatli kullanım... https://t.co/d4WZ44XrMn

Mar 18, 2021 · 2 shares · 1,853 followers View post →
BAH
@berrakpecel · X

RT @hakanpecel: @UzunDr @talaydidem Dikkatli kullanım... https://t.co/d4WZ44XrMn

Mar 17, 2021 · 2 shares · 1,351 followers View post →
HAKan Peçel
@hakanpecel · X

@UzunDr @talaydidem Dikkatli kullanım... https://t.co/d4WZ44XrMn

Mar 17, 2021 · 2 likes · 2 shares · 1,324 followers View post →
Zekiye Türk
@turkzekiye1 · X

RT @hakanpecel: @drahmetrasim @SEHVANKAR Baharatları abartmadan dengeli kullanmalı. Etkilerini abartıp, gereksiz beklentilere girmemeli.

Dec 17, 2020 · 3 shares · 1,649 followers View post →
ERAY TEZER
@TezerEray · X

RT @hakanpecel: @drahmetrasim @SEHVANKAR Baharatları abartmadan dengeli kullanmalı. Etkilerini abartıp, gereksiz beklentilere girmemeli.

Dec 16, 2020 · 3 shares · 2,666 followers View post →
HAKan Peçel
@hakanpecel · X

@drahmetrasim @SEHVANKAR Baharatları abartmadan dengeli kullanmalı. Etkilerini abartıp, gereksiz beklentilere girmemeli.

Dec 16, 2020 · 4 likes · 3 shares · 1,324 followers View post →
Faruk £RT£N
@faruk_ertn · X

5) Yine yapılan bir çalışmada bilinçsiz şekilde zerdeçal kullanımı erkekler de testosteron seviyesinin düşmesine neden olabilir. Bu yüzden erkekler uzun süre yoğun dozda zerdeçal kullanımında dikkatli olmalı. Kaynak: https://t.co/iF9Lk3qy4U https://t.co/5CAQGgXC6Y

Nov 5, 2020 · 5 likes · 286 followers View post →
Tuna
@yasaamgucu · X

RT @nejjazdemir0606: Zerdeçal'ın 7 ETKİSİ ve YAN ETKİSİ: Bu Durumlarda Zerdeçal Kullanmayın! https://t.co/oWpMF31EzC @YouTube aracılığıyla…

Oct 16, 2020 · 1 share · 624 followers View post →
Nejjazdemir0606
@nejjazdemir0606 · X

Zerdeçal'ın 7 ETKİSİ ve YAN ETKİSİ: Bu Durumlarda Zerdeçal Kullanmayın! https://t.co/oWpMF31EzC @YouTube aracılığıyla DİKKAT ZERDEÇAL kullananlar izlesin bence bi çok yan etkisi varmış

Oct 16, 2020 · 6 likes · 1 share · 3,943 followers View post →