January 2018 PMID 29375577

Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?

Tamas Fulop, Anis Larbi, Gilles Dupuis, Aurélie Le Page, Eric H Frost, Alan A Cohen, Jacek M Witkowski, Claudio Franceschi

Download social card

Mentions

33
Peak: 6 in Jul 2019
across 6 sources since Feb 2018

Extended reach

407,193
potential audience

Total likes

4,340

Video views

145,671

Mentions per month

Feb 2018 – Aug 2026

Where it's discussed

  • X / Twitter13 posts
  • Facebook13 posts
  • YouTube4 videos
  • Instagram1 posts
  • News1 articles
  • Blogs1 articles

AI synopsis

What people are saying

The collection reflects a cautious, exploratory discussion about the article, with participants largely noting the bidirectional relationship between immunosenescence and inflammaging and debating whether such aging processes might be adaptive. Word choice ranges from neutral summaries to contrarian takes, with several posts using qualifiers like “contrarian,” “risk,” or “not buy it yet,” signaling critical engagement. The tone emphasizes nuance (e.g., “two sides of the same coin”) and invites reconsideration of immune-aging strategies, rather than plain endorsement or rejection, indicating a thoughtful scholarly discussion about the article’s framing and implications.

AgreementNeither agree nor disagree

Overall mixed views; several posts acknowledge a bidirectional link and possible adaptive aspects but few advocate strong endorsement of the optimistic framing. No post outright rejects; most are cautious or simply informative.

InterestModerate interest

Moderate to high curiosity is evident; multiple posts reference contrarian take and call for caution, indicating sustained interest in the topic rather than casual scrolling.

EngagementModerate engagement

Posts show engagement through tagging, quoting, and brief commentary, with some skepticism and calls for careful interpretation, suggesting thoughtful rather than superficial engagement.

ImpactModerate impact

Inconclusive about real-world impact; some posts suggest future research directions and clinical considerations, while others are descriptive. Overall potential impact is moderate to high but not definitive.

Abstract in brief

  • Immunosenescence and inflammaging are interconnected processes that involve age-related decline and chronic inflammation in the immune system, traditionally viewed as harmful and linked to age-related diseases.
  • Recent perspectives suggest that these immune changes may be adaptive or necessary for extending lifespan, rather than solely detrimental, implying they are essential for survival and longevity.
  • Instead of trying to reverse immune aging, current approaches should focus on maintaining immune homeostasis and function to promote healthy aging and improve overall quality of life in the elderly.]

Top posts

Most liked on X and Bluesky
Frontiers
@FrontiersIn · X

Researchers described recent advances in complex relationship between #immune system & #aging, suggesting #immunosenescence & inflamm-aging are 2 sides of same phenomenon &, when not dysregulated, they're essential for #longevity.@FrontImmunol Free read: https://t.co/SEQ0ZASSHF https://t.co/ZViXjXUsz7

Apr 29, 2019 · 46 likes · 25 shares · 90,068 followers View post →
Frontiers
@FrontiersIn · X

Researchers described recent advances in complex relationship between #immune system & #aging, suggesting #immunosenescence & inflamm-aging are 2 sides of same phenomenon &, when not dysregulated, they're essential for #longevity.@FrontImmunol Free read: https://t.co/SEQ0ZASSHF https://t.co/YEyU29GjQs

Jul 31, 2019 · 14 likes · 11 shares · 90,068 followers View post →
Agingdoc
@agingdoc1 · X

@mike_lustgarten @GShunchun @Mangan150 The causal evidence from interventional models (eg- as cited) is indeed strong in both directions Less well their relative %. Thus, as with chronic inflammation, bidirectional positive feed-forward suggest optimal Rx addresses both sides of causality: https://t.co/1F88axmwjh

Sep 10, 2020 · 2 likes · 42,564 followers View post →
José Luis Ricón Fernández de la Puente
@ArtirKel · X

@AdamMarblestone A fun contrarian take I found https://t.co/QcC3lILMIN "CMV infection may be considered a recurrent stimulation that maintains a sustained immunological alertness that favors a better immune response"+inflammaging as a Good Thing. Don't buy it yet

Jun 25, 2020 · 1 like · 22,459 followers View post →
Justin Kiness
@JustinKiness · X

In a review published in Frontiers, researchers described the recent advances in the complex relationship between the immune system and aging. https://t.co/PckGdz2a9I

Nov 22, 2019 · 1 like · 2,951 followers View post →
Andrew Hob
@SithyPoo · X

@LongDesertTrain @gbosslet @jeremyfaust These kind of give the effect generically as well, there might be better introductions though https://t.co/oeEReZWDyJ https://t.co/6wwdlUYYKI https://t.co/UDdIqWEZA8

Dec 29, 2021 · 1 like · 121 followers View post →

All mentions

Lisa Foreman APRN-C
@findmeabluebird · X

@tia_loret @fitterhappierAJ Found this, just skimmed it so read at your own risk

Jul 27, 2022 · 4,048 followers View post →
Andrew Hob
@SithyPoo · X

@LongDesertTrain @gbosslet @jeremyfaust These kind of give the effect generically as well, there might be better introductions though https://t.co/oeEReZWDyJ https://t.co/6wwdlUYYKI https://t.co/UDdIqWEZA8

Dec 29, 2021 · 1 like · 121 followers View post →
Agingdoc
@agingdoc1 · X

@mike_lustgarten @GShunchun @Mangan150 The causal evidence from interventional models (eg- as cited) is indeed strong in both directions Less well their relative %. Thus, as with chronic inflammation, bidirectional positive feed-forward suggest optimal Rx addresses both sides of causality: https://t.co/1F88axmwjh

Sep 10, 2020 · 2 likes · 42,564 followers View post →
José Luis Ricón Fernández de la Puente
@ArtirKel · X

@AdamMarblestone A fun contrarian take I found https://t.co/QcC3lILMIN "CMV infection may be considered a recurrent stimulation that maintains a sustained immunological alertness that favors a better immune response"+inflammaging as a Good Thing. Don't buy it yet

Jun 25, 2020 · 1 like · 22,459 followers View post →
Greg Timblin
@gtimblin · X

"...pathways involved in energy production, use, and conservation by (innate) immune cells could be targets of choice for immune modulation in the elderly." https://t.co/9QUGfFtmI4

May 10, 2020 · 808 followers View post →
Justin Kiness
@JustinKiness · X

In a review published in Frontiers, researchers described the recent advances in the complex relationship between the immune system and aging. https://t.co/PckGdz2a9I

Nov 22, 2019 · 1 like · 2,951 followers View post →
Fabio Varon MD. MsC. PhD.
@FABIOVARON · X

RT @FrontiersIn: Researchers described recent advances in complex relationship between #immune system & #aging, suggesting #immunosenescenc…

Jul 31, 2019 · 11 shares · 3,056 followers View post →
Carlos Andrés Celis-Preciado
@pulmonology101 · X

RT @FrontiersIn: Researchers described recent advances in complex relationship between #immune system & #aging, suggesting #immunosenescenc…

Jul 31, 2019 · 11 shares · 4,339 followers View post →
Arc
@N3pheelim · X

RT @FrontiersIn: Researchers described recent advances in complex relationship between #immune system & #aging, suggesting #immunosenescenc…

Jul 31, 2019 · 11 shares · 263 followers View post →
Victoria
@TurnerDizzy · X

RT @FrontiersIn: Researchers described recent advances in complex relationship between #immune system & #aging, suggesting #immunosenescenc…

Jul 31, 2019 · 11 shares · 62 followers View post →
Frontiers
@FrontiersIn · X

Researchers described recent advances in complex relationship between #immune system & #aging, suggesting #immunosenescence & inflamm-aging are 2 sides of same phenomenon &, when not dysregulated, they're essential for #longevity.@FrontImmunol Free read: https://t.co/SEQ0ZASSHF https://t.co/YEyU29GjQs

Jul 31, 2019 · 14 likes · 11 shares · 90,068 followers View post →
Bryan Cobo
@bryancobo · X

RT @FrontiersIn: Researchers described recent advances in complex relationship between #immune system & #aging, suggesting #immunosenescenc…

Apr 29, 2019 · 25 shares · 346 followers View post →
Frontiers
@FrontiersIn · X

Researchers described recent advances in complex relationship between #immune system & #aging, suggesting #immunosenescence & inflamm-aging are 2 sides of same phenomenon &, when not dysregulated, they're essential for #longevity.@FrontImmunol Free read: https://t.co/SEQ0ZASSHF https://t.co/ZViXjXUsz7

Apr 29, 2019 · 46 likes · 25 shares · 90,068 followers View post →
Grupo de Inflamação e Senescencia Celular - Facebook
Facebook

https://www.frontiersin.org/articles/10.3389/fimmu.2017.01960/full · FRONTIERSIN.ORG. Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends ...

Oct 24, 2026 View →
Premier Chiropractic West | Pearland TX - Facebook
Facebook

https://www.frontiersin.org/articles/10.3389/fimmu.2017.01960/full ** Always consult with a physician or healthcare practitioner with significant ...

Oct 24, 2026 View →
Can we “cure” ageing? An immunological perspective ... - Facebook
Facebook

Frontiers in Immunology, 8, 1960. http://doi. org/10.3389/fimmu.2017.01960 *** The immune system is the most important protective physiological ...

Aug 12, 2026 View →
Postmenopausal ovaries may play an unexpected role in immune ...
News

doi: 10.3389/fimmu.2017.01960. Lobo, RA, Gompel A. Management of menopause: a view towards prevention. Lancet Diabetes Endocrinol. 2022;10(6): ...

Jul 8, 2026 View →
The female immune system changes much more than that of men ...
Facebook

Frontiers in Immunology, 8, 1960. http://doi. org/10.3389/fimmu.2017.01960 *** The immune system is the most important protective physiological ...

Apr 18, 2026 View →
**[https://www.mdpi.com/2072-6643/16/22/3830](https://www.mdpi ...
Facebook

Frontiers in Immunology, 8, 1960. http://doi. org/10.3389/fimmu.2017.01960 *** The immune system is the most important protective physiological ...

Dec 19, 2025 View →
Układ odpornościowy starzeje się stopniowo, od dorosłości ...
Facebook

doi: 10.3389/fimmu.2017.01960 Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes? Tamas Fulop 1,*, Anis Larbi ...

Dec 6, 2025 View →
Feliz día de los abuelos - Facebook
Facebook

org/articles/10.3389/fimmu.2017.01960/full https://pubmed.ncbi.nlm.nih.gov/33193377/ https://pubmed.ncbi.nlm.nih.gov/30046148/ Contenido y ...

Aug 28, 2025 View →
we can slow, and even reverse, immune aging. By prioritizing sleep ...
Instagram

This process, called immunosenescence, is accelerated by chronic stress, poor sleep, ultra-processed diets, and inactivity. It leads to chronic ...

May 16, 2025 View →
# [Immune resilience despite inflammatory stress promotes longevity ...
Facebook

Frontiers in Immunology, 8, 1960. http://doi. org/10.3389/fimmu.2017.01960 *** The immune system is the most important protective physiological ...

Jun 25, 2023 View →
¡Feliz día de los abuelos! Durante el transcurso de la vida , el ...
Facebook

Si quieres conocer más sobre el tema , te compartimos las siguientes ligas: https://www.frontiersin.org/articles/10.3389/fimmu. 2017.01960 ...

Aug 28, 2022 View →
The Immunity Clock - Facebook
Facebook

Frontiers in Immunology, 8, 1960. http://doi. org/10.3389/fimmu.2017.01960 *** The immune system is the most important protective physiological ...

Oct 19, 2021 View →
Remodelling of the immune system with ageing. Disturbances in the ...
Facebook

org/10.3389/fimmu.2017.01960 *** The immune system is the most important protective physiological system of the organism. It has many ...

Mar 27, 2021 View →
What happens when an immunological memory is not created upon ...
Facebook

Frontiers in Immunology, 8, 1960. http://doi. org/10.3389/fimmu.2017.01960 *** The immune system is the most important protective physiological ...

Nov 13, 2020 View →
susceptibility. TCER-1 inhibits immunity only during fertile stages of ...
Facebook

Frontiers in Immunology, 8, 1960. http://doi. org/10.3389/fimmu.2017.01960 *** The immune system is the most important protective physiological ...

Jul 22, 2019 View →
Immunosenescence and Inflammaging, Two Sides of the Same Coin
Blogs

Link: https://doi.org/10.3389/fimmu.2017.01960. Comments. They propose caution towards the use of interleukin and growth hormone therapies to ...

Feb 6, 2018 View →