Pharmacotherapy March 2018 PMID 29377216

The Safety and Efficacy of Low-Dose Naltrexone in the Management of Chronic Pain and Inflammation in Multiple Sclerosis, Fibromyalgia, Crohn's Disease, and Other Chronic Pain Disorders.

Denise K Patten, Bob G Schultz, Daniel J Berlau

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Mentions

59
Peak: 5 in Oct 2025
across 8 sources since May 2020

Extended reach

59,200
potential audience

Total likes

933

Video views

33,321

Mentions per month

May 2020 – Dec 2025

Where it's discussed

  • TikTok29 posts
  • X / Twitter14 posts
  • Facebook8 posts
  • Reddit3 posts
  • YouTube2 videos
  • LinkedIn1 posts
  • News1 articles
  • Blogs1 articles

AI synopsis

What people are saying

Overall, the discussions reflect a cautious yet hopeful attitude towards low-dose naltrexone, with posts citing research articles and considering its safety profile. The tone combines factual references with personal comments, showing moderate engagement and acknowledgment of the treatment's potential impact on chronic pain management.

AgreementModerate agreement

Most discussions seem to support or acknowledge the potential benefits of low-dose naltrexone, highlighting its safety and possible anti-inflammatory effects.

InterestModerate interest

Participants show moderate curiosity, mentioning specific conditions like long COVID, autoimmune responses, and comparing it to other treatments, indicating some level of interest.

EngagementModerate engagement

The posts involve specific references to research articles, personal considerations, and clinical applications, demonstrating a reasonable depth of engagement.

ImpactModerate impact

The discussions suggest a recognition of the treatment's potential significance in managing chronic pain and inflammation, which could influence future research or clinical practice.

Abstract in brief

  • Low-dose naltrexone is used offlabel to treat chronic pain and inflammation in diseases like multiple sclerosis, Crohn's disease, and fibromyalgia, potentially offering pain relief and anti-inflammatory effects by inhibiting certain immune cells.
  • Current evidence suggests that low-dose naltrexone is safe and well-tolerated, but most studies are based on subjective reports such as improved quality of life or reduced pain, with limited objective data.
  • More rigorous controlled trials are needed to confirm its effectiveness, as the existing research is inconclusive, and healthcare providers should be aware of its limited proven benefits when considering it for treatment.]

Top posts

Most liked on X and Bluesky
Patty Irigoyen
@PatriciaIrigo10 · X

@Blitz_y Safer thing to try is low dose naltrexone. I believe that a lot of ‘chronic Lyme’ people are fibromyalgia-like, who knows what inciting etiology was. Could be Lyme, It definitely gives autoimmune arthritis in predisposed. https://t.co/WRuf79YL5o

Dec 18, 2020 · 6 likes · 1,620 followers View post →
Troy Roach
@Canal1point5 · X

@Nick_Wellings @Naomi_D_Harvey I doubt you can make LDN at home. I do not take it... But I think this dr from Israel explains it very well. Similar to Nicotine... You may feel worse first https://t.co/ST1ocYwOfU

Sep 4, 2023 · 3 likes · 1,626 followers View post →
SUDs PharmD Trainees
@SUDsPharmD_APPE · X

Low-dose naltrexone may provide analgesic and anti-inflammatory effects which could help patients with chronic pain and/or inflammatory conditions such as fibromyalgia and Crohn’s disease #OTILT by: @RadhaPharmD https://t.co/iDMHh1Wfap

May 27, 2020 · 3 likes · 1 share · 188 followers View post →
J Peace 3
@JPeaceJPeace · X

@AutonomicBrad https://t.co/077kdWR7Gv

Jun 18, 2024 · 1 like · 576 followers View post →
Robert “Kelly” Brumbelow
@RKBrum · X

@Gormogons @phaupert14850 If only you knew some doctors or medical personnel;) Assuming you have already gone low carb, low purine, have you considered starting at 1.5 mg of Naltrexone and titrating up to probably 4.5? Really cuts out the inflammation. https://t.co/hzYgI3Syn0

Jul 26, 2023 · 1 like · 284 followers View post →
sat kartar
@satka2 · X

@TRextasyBand @Rhino_Records ANTI-OPIATE for LONG COVID? - with Dr. John Campbell https://t.co/gtJtWFtACM via @YouTube Love the wilbs..wish id seen them live!

Jan 26, 2024 · 1 like · 131 followers View post →

All mentions

Davey James
@dvyjms · X

ANTI-OPIATE for LONG COVID? - with Dr. John Campbell https://t.co/KjCQK4RgP9 via @YouTube

Mar 7, 2025 · 17 followers View post →
J Peace 3
@JPeaceJPeace · X

@AutonomicBrad https://t.co/077kdWR7Gv

Jun 18, 2024 · 1 like · 576 followers View post →
Shawn Gallagher
@ChildbirthJoy · X

About low dose naltrexone (LDN) which is off patent (therefore cheap). It is extraordinarily safe as the main side effect is vivid dreams that usually resolves quickly. LDN can't be used if someone is taking opiates for pain relief. @Johnincarlisle https://t.co/VJHmQKW1ey https://t.co/EjTsYXHpmu

Apr 17, 2024 · 1,622 followers View post →
Nix P
@NixP330 · X

The Safety and Efficacy of Low‐Dose Naltrexone in the Management of Chronic Pain and Inflammation in MS, Fibromyalgia, Crohn's Disease, and Other Chronic Pain Disorders - Patten - 2018 - Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy https://t.co/vKgCUo0PTX

Apr 11, 2024 · 1 like · 36 followers View post →
sat kartar
@satka2 · X

ANTI-OPIATE for LONG COVID? - with Dr. John Campbell https://t.co/gtJtWFtACM via @YouTube have been put on this for my late covid autoimmune./vaccine response....

Jan 26, 2024 · 131 followers View post →
sat kartar
@satka2 · X

@TRextasyBand @Rhino_Records ANTI-OPIATE for LONG COVID? - with Dr. John Campbell https://t.co/gtJtWFtACM via @YouTube Love the wilbs..wish id seen them live!

Jan 26, 2024 · 1 like · 131 followers View post →
High_Hopes_Deep_Faith
@singpraypaint · X

https://t.co/nzwsp4Uaik

Dec 9, 2023 · 53 followers View post →
Troy Roach
@Canal1point5 · X

@Nick_Wellings @Naomi_D_Harvey I doubt you can make LDN at home. I do not take it... But I think this dr from Israel explains it very well. Similar to Nicotine... You may feel worse first https://t.co/ST1ocYwOfU

Sep 4, 2023 · 3 likes · 1,626 followers View post →
Robert “Kelly” Brumbelow
@RKBrum · X

@Gormogons @phaupert14850 If only you knew some doctors or medical personnel;) Assuming you have already gone low carb, low purine, have you considered starting at 1.5 mg of Naltrexone and titrating up to probably 4.5? Really cuts out the inflammation. https://t.co/hzYgI3Syn0

Jul 26, 2023 · 1 like · 284 followers View post →
J.A. Broersma
@JohnnyBG19 · X

@ThePixelChick70 @lentekriebel @sjaak_jacq Hier de link naar experimenten (off label) tegen long-covid en tegen het spike-eiwit dacht ik: https://t.co/nw1r5CSOFT (neem me niet kwalijk dat ik het niet nog een keer ga bekijken om te verifiëren)

Mar 11, 2023 · 7,873 followers View post →
PF Anderson @pfanderson@disabled.social
@pfanderson · X

The Safety and Efficacy of Low-Dose Naltrexone in the Management of Chronic Pain and Inflammation in Multiple Sclerosis, Fibromyalgia, Crohn's Disease, and Other Chronic Pain Disorders - PubMed https://t.co/ltjJaR95uL

May 27, 2022 · 10,749 followers View post →
Patty Irigoyen
@PatriciaIrigo10 · X

@Blitz_y Safer thing to try is low dose naltrexone. I believe that a lot of ‘chronic Lyme’ people are fibromyalgia-like, who knows what inciting etiology was. Could be Lyme, It definitely gives autoimmune arthritis in predisposed. https://t.co/WRuf79YL5o

Dec 18, 2020 · 6 likes · 1,620 followers View post →
Ramya
@RamyaPharmD · X

RT @SUDsPharmD_APPE: Low-dose naltrexone may provide analgesic and anti-inflammatory effects which could help patients with chronic pain an…

May 27, 2020 · 1 share · 539 followers View post →
SUDs PharmD Trainees
@SUDsPharmD_APPE · X

Low-dose naltrexone may provide analgesic and anti-inflammatory effects which could help patients with chronic pain and/or inflammatory conditions such as fibromyalgia and Crohn’s disease #OTILT by: @RadhaPharmD https://t.co/iDMHh1Wfap

May 27, 2020 · 3 likes · 1 share · 188 followers View post →
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