PubHawk
Int J Nanomedicine April 2018 PMID 29416330

Nanomedical studies of the restoration of nitric oxide/peroxynitrite balance in dysfunctional endothelium by 1,25-dihydroxy vitamin D - clinical implications for cardiovascular diseases.

Alamzeb Khan, Hazem Dawoud, Tadeusz Malinski

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Mentions

15
Peak: 4 in Feb 2022
across 5 sources since Apr 2020

Extended reach

17,076
potential audience

Total likes

220

Video views

5,175

Mentions per month

Apr 2020 – May 2025

Where it's discussed

  • X / Twitter9 posts
  • YouTube2 videos
  • News2 articles
  • Facebook1 posts
  • Blogs1 articles

AI synopsis

What people are saying

The discussions reflect a general agreement on the significance of vitamin D in restoring nitric oxide balance in dysfunctional endothelium, with some posts emphasizing the innovative use of nanotechnology and implications for treatment, while others discuss dosage and safety considerations, highlighting a nuanced but active engagement with the research.

AgreementModerate agreement

Most discussions express support or interest in the article's findings about vitamin D's role in cardiovascular health, with some highlighting potential benefits and mechanisms.

InterestModerate interest

Posts show moderate interest, discussing potential effects and scientific methods, indicating engagement but not strong enthusiasm.

EngagementModerate engagement

The discussions include technical references like eNOS, NO balance, and nanotechnology, showing a decent level of technical engagement.

ImpactModerate impact

Participants imply that the research could influence treatment approaches or understanding of cardiovascular health, suggesting moderate impact.

Abstract in brief

  • The study explores how 125-dihydroxy vitamin D helps restore the balance between nitric oxide (NO) and peroxynitrite (ONOO) in dysfunctional endothelium, which is linked to hypertension and cardiovascular diseases, using nanosensors to measure these molecules in endothelial cells.
  • Vitamin D treatment improved the NO-ONOO balance by restoring the function of endothelial nitric oxide synthase (eNOS) and reducing the overexpression of enzymes like NADPH oxidase, leading to increased protective NO levels and decreased harmful ONOO, effectively reversing endothelial dysfunction.
  • These findings suggest that vitamin D may have potential as a therapeutic agent for hypertension and other cardiovascular conditions, including heart attack and stroke, by protecting endothelial health and improving blood vessel function.]
Read the full abstract

Top posts

Most liked on X and Bluesky
tune
@keisuke4713 · X

NOとペルオキシ亜硝酸の濃度バランスとり、内皮機能改善に役立つ https://t.co/LzbUpWz8w5 機能不全の内皮細胞におけるNO/peroxynitrite balance回復 1,25-OH3 -心血管疾患の臨床的意義 https://t.co/LzbUpWz8w5 ビタミンD3⇨細胞保護NO↑細胞傷害性ONOO↓ ⇨非結合のeNOS・内皮機能回復 https://t.co/AeDJyqYPyC

Feb 14, 2022 · 3 likes · 1 share · 3,749 followers View post →
Pandemie der manipulierten Zahlen
@radikaleminderh · X

@Martin10823736 @BhaskusMaximus @ihealthcoach_hh Deswegen ist ja auch eine tägliche Gabe sinnvoller bzw. in bestimmten Situationen auf drei Gaben verteilt. https://t.co/sKCDcvOjmg Die EFSA gibt ja ein safe upper limit von 4000iu/Tag an, selbst wenn man anderweitig Vitamin D aufnimmt(Nahrung/Sonne).

Oct 24, 2021 · 3 likes · 193 followers View post →
tune
@keisuke4713 · X

1,25-ジヒドロキシビタミンD3による機能不全内皮における一酸化窒素/ペルオキシ亜硝酸バランス回復:心血管疾患の臨床的意義 https://t.co/LzbUpWRhKd ビタミンD3 細胞保護NO↑細胞毒性ONOO↓⇨非結合eNOSと内皮機能を回復 高血圧、心不全、心筋梗塞、心血管障害、脳卒中、糖尿病などに有益証明される？ https://t.co/qPWNLMdu2L

Feb 20, 2022 · 2 likes · 1 share · 3,749 followers View post →
KETARU
@KETARU · X

@zev_dr メモ)　ビタミンD と心血管 https://t.co/KPQ1H3UC5w https://t.co/XI4JCBYw1M

Jun 12, 2024 · 1 like · 29 followers View post →
David Cullen
@DavidCu87627414 · X

https://t.co/1Fq68wRBCV Other intresting potential effects of Vitamin D importance.

Jan 8, 2023 · 1,703 followers View post →
_24_com
@_24_com · X

RT @keisuke4713: NOとペルオキシ亜硝酸の濃度バランスとり、内皮機能改善に役立つ https://t.co/LzbUpWz8w5 機能不全の内皮細胞におけるNO/peroxynitrite balance回復 1,25-OH3 -心血管疾患の臨床的意義 htt…

Feb 14, 2022 · 1 share · 1,485 followers View post →

All mentions

KETARU
@KETARU · X

@zev_dr メモ)　ビタミンD と心血管 https://t.co/KPQ1H3UC5w https://t.co/XI4JCBYw1M

Jun 12, 2024 · 1 like · 29 followers View post →
tokatti
@tokatti_ · X

いったん循環器系の細胞がダメージを受けた場合、これを元にもどす方法はほとんど存在しない。しかし、ビタミンD3ならそれができるとのこと https://t.co/tTHdFS0nd0 #自分用メモ

Jun 12, 2024 · 189 followers View post →
David Cullen
@DavidCu87627414 · X

https://t.co/1Fq68wRBCV Other intresting potential effects of Vitamin D importance.

Jan 8, 2023 · 1,703 followers View post →
やっさん
@kuanyi_vet · X

RT @keisuke4713: 1,25-ジヒドロキシビタミンD3による機能不全内皮における一酸化窒素/ペルオキシ亜硝酸バランス回復:心血管疾患の臨床的意義 https://t.co/LzbUpWRhKd ビタミンD3 細胞保護NO↑細胞毒性ONOO↓⇨非結合eNOSと内皮機…

Feb 20, 2022 · 1 share · 728 followers View post →
tune
@keisuke4713 · X

1,25-ジヒドロキシビタミンD3による機能不全内皮における一酸化窒素/ペルオキシ亜硝酸バランス回復:心血管疾患の臨床的意義 https://t.co/LzbUpWRhKd ビタミンD3 細胞保護NO↑細胞毒性ONOO↓⇨非結合eNOSと内皮機能を回復 高血圧、心不全、心筋梗塞、心血管障害、脳卒中、糖尿病などに有益証明される？ https://t.co/qPWNLMdu2L

Feb 20, 2022 · 2 likes · 1 share · 3,749 followers View post →
_24_com
@_24_com · X

RT @keisuke4713: NOとペルオキシ亜硝酸の濃度バランスとり、内皮機能改善に役立つ https://t.co/LzbUpWz8w5 機能不全の内皮細胞におけるNO/peroxynitrite balance回復 1,25-OH3 -心血管疾患の臨床的意義 htt…

Feb 14, 2022 · 1 share · 1,485 followers View post →
tune
@keisuke4713 · X

NOとペルオキシ亜硝酸の濃度バランスとり、内皮機能改善に役立つ https://t.co/LzbUpWz8w5 機能不全の内皮細胞におけるNO/peroxynitrite balance回復 1,25-OH3 -心血管疾患の臨床的意義 https://t.co/LzbUpWz8w5 ビタミンD3⇨細胞保護NO↑細胞傷害性ONOO↓ ⇨非結合のeNOS・内皮機能回復 https://t.co/AeDJyqYPyC

Feb 14, 2022 · 3 likes · 1 share · 3,749 followers View post →
Pandemie der manipulierten Zahlen
@radikaleminderh · X

@Martin10823736 @BhaskusMaximus @ihealthcoach_hh Deswegen ist ja auch eine tägliche Gabe sinnvoller bzw. in bestimmten Situationen auf drei Gaben verteilt. https://t.co/sKCDcvOjmg Die EFSA gibt ja ein safe upper limit von 4000iu/Tag an, selbst wenn man anderweitig Vitamin D aufnimmt(Nahrung/Sonne).

Oct 24, 2021 · 3 likes · 193 followers View post →
The Healthy Living
@DulayKristian · X

Scientists use nanotechnology to show that Vitamin D signals nitric oxide to repair blood vessels https://t.co/ouVhDUlXFj https://t.co/XXQ5h3qT4G https://t.co/KCy1XK5wnf

Apr 28, 2020 · 28 followers View post →
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