Rare day 2-2-22 reminds us how researchers like @BrianVarisco work to slow disease progression in #rare #geneticdiseases like alpha1 antitrypsin deficiency https://t.co/KSaJ6UcVtJ
Role for Cela1 in Postnatal Lung Remodeling and Alpha-1 Antitrypsin-Deficient Emphysema.
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Apr 2019 – Feb 2022Where it's discussed
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X / Twitter10 posts
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YouTube2 videos
AI synopsis
What people are saying
Many discussions refer to the importance of Cela1 in preventing or treating lung damage, with phrases like 'targeting CELA1' and mentions of 'protecting from lung damage,' showing a high interest. The tone is optimistic and focused on the potential clinical impact, such as slowing disease progression or developing therapies, which indicates a moderate yet meaningful influence of the research on ongoing scientific conversations.
Most discussions express support or highlight the significance of targeting Cela1 for lung health, indicating general agreement with the research's potential.
The posts demonstrate high interest by focusing on specific health issues like COPD and AAT deficiency, emphasizing the relevance of the findings.
Participants engage by sharing related research images, emphasizing therapeutic implications, and referencing ongoing research efforts.
The discussions suggest that the research could influence future treatment approaches for lung diseases caused by elastin degradation.
Abstract in brief
- Cela1 is a digestive enzyme involved in lung development and remodeling, particularly affecting elastin, a key lung structural protein, and plays a role in lung elasticity and regeneration.
- In studies with mice, Cela1 was shown to degrade elastin and contribute to lung elastase activity that depends on lung stretch, with its activity being neutralized by alpha1 antitrypsin (AAT); deficiency of AAT leads to emphysema and increased Cela1 activity.
- Targeting Cela1 with therapies could help prevent or treat emphysema caused by AAT deficiency, as mice without Cela1 were protected from lung damage, highlighting Cela1's importance in lung health and disease.]
Top posts
Most liked on X and BlueskyNew Release: Targeting CELA1 in AAT Deficiency #raredisease #AAT #Cela1 #KF4 #medart #medicaleducation #medicalanimation #sciart #maya #vray #cincychildrens https://t.co/WQGgI9mEb3
New Release: Targeting CELA1 in COPD #raredisease #COPD #Cela1 #KF4 #medart #medicaleducation #medicalanimation #sciart #maya #vray #cincychildrens https://t.co/URqaC5AhPW
RT @CincyKidsInvent: Rare day 2-2-22 reminds us how researchers like @BrianVarisco work to slow disease progression in #rare #geneticdisea…
RT @CincyKidsMedArt: New Release: Targeting CELA1 in COPD #raredisease #COPD #Cela1 #KF4 #medart #medicaleducation #medicalanimation #sciar…
RT @CincyKidsMedArt: New Release: Targeting CELA1 in AAT Deficiency #raredisease #AAT #Cela1 #KF4 #medart #medicaleducation #medicalanimati…
All mentions
Targeting CELA1 to Halt COPD Progression Using Anti-ELastase Therapy
Difficulty Breathing COPD Emphysema and the Potential for antiCELA1 Antibodies to Halt Progression of this Respiratory Disease. Cincinnati Children's researcher Dr. Brian Varisco explores antiCELA1 antibodies as a…
Targeting CELA1 to Treat AAT Deficiency-Related Emphysema
This video discusses the role of CELA1 in lung remodeling and emphysema caused by AAT deficiency. Targeting CELA1 with monoclonal antibodies may help prevent or treat lung damage in this genetic condition.
RT @CincyKidsMedArt: New Release: Targeting CELA1 in AAT Deficiency #raredisease #AAT #Cela1 #KF4 #medart #medicaleducation #medicalanimati…
RT @CincyKidsMedArt: New Release: Targeting CELA1 in AAT Deficiency #raredisease #AAT #Cela1 #KF4 #medart #medicaleducation #medicalanimati…
RT @CincyKidsMedArt: New Release: Targeting CELA1 in AAT Deficiency #raredisease #AAT #Cela1 #KF4 #medart #medicaleducation #medicalanimati…
RT @CincyKidsMedArt: New Release: Targeting CELA1 in COPD #raredisease #COPD #Cela1 #KF4 #medart #medicaleducation #medicalanimation #sciar…
New Release: Targeting CELA1 in COPD #raredisease #COPD #Cela1 #KF4 #medart #medicaleducation #medicalanimation #sciart #maya #vray #cincychildrens https://t.co/URqaC5AhPW
RT @CincyKidsMedArt: New Release: Targeting CELA1 in AAT Deficiency #raredisease #AAT #Cela1 #KF4 #medart #medicaleducation #medicalanimati…
New Release: Targeting CELA1 in AAT Deficiency #raredisease #AAT #Cela1 #KF4 #medart #medicaleducation #medicalanimation #sciart #maya #vray #cincychildrens https://t.co/WQGgI9mEb3
RT @CincyKidsInvent: Rare day 2-2-22 reminds us how researchers like @BrianVarisco work to slow disease progression in #rare #geneticdisea…
Rare day 2-2-22 reminds us how researchers like @BrianVarisco work to slow disease progression in #rare #geneticdiseases like alpha1 antitrypsin deficiency https://t.co/KSaJ6UcVtJ
Role for Cela1 in Postnatal Lung Remodeling and Alpha-1 Antitrypsin-Deficient Emphysema. https://t.co/4HVLVQU3cy
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