August 2018 PMID 29420065

Role for Cela1 in Postnatal Lung Remodeling and Alpha-1 Antitrypsin-Deficient Emphysema.

Rashika Joshi, Andrea Heinz, Qiang Fan, Shuling Guo, Brett Monia, Christian E H Schmelzer, Anthony S Weiss, Matthew Batie, Harikrishnan Parameshwaran, Brian M Varisco

Mentions

12
Peak: 9 in Feb 2022
across 2 sources since Apr 2019

Extended reach

56,339
potential audience

Total likes

47

Video views

5,951

Mentions per month

Apr 2019 – Feb 2022

Where it's discussed

  • X / Twitter10 posts
  • YouTube2 videos

AI synopsis

What people are saying

Many discussions refer to the importance of Cela1 in preventing or treating lung damage, with phrases like 'targeting CELA1' and mentions of 'protecting from lung damage,' showing a high interest. The tone is optimistic and focused on the potential clinical impact, such as slowing disease progression or developing therapies, which indicates a moderate yet meaningful influence of the research on ongoing scientific conversations.

AgreementModerate agreement

Most discussions express support or highlight the significance of targeting Cela1 for lung health, indicating general agreement with the research's potential.

InterestHigh interest

The posts demonstrate high interest by focusing on specific health issues like COPD and AAT deficiency, emphasizing the relevance of the findings.

EngagementModerate engagement

Participants engage by sharing related research images, emphasizing therapeutic implications, and referencing ongoing research efforts.

ImpactModerate impact

The discussions suggest that the research could influence future treatment approaches for lung diseases caused by elastin degradation.

Abstract in brief

  • Cela1 is a digestive enzyme involved in lung development and remodeling, particularly affecting elastin, a key lung structural protein, and plays a role in lung elasticity and regeneration.
  • In studies with mice, Cela1 was shown to degrade elastin and contribute to lung elastase activity that depends on lung stretch, with its activity being neutralized by alpha1 antitrypsin (AAT); deficiency of AAT leads to emphysema and increased Cela1 activity.
  • Targeting Cela1 with therapies could help prevent or treat emphysema caused by AAT deficiency, as mice without Cela1 were protected from lung damage, highlighting Cela1's importance in lung health and disease.]

Top posts

Most liked on X and Bluesky
Cincinnati Children's Innovation Ventures
@CincyKidsInvent · X

Rare day 2-2-22 reminds us how researchers like @BrianVarisco work to slow disease progression in #rare #geneticdiseases like alpha1 antitrypsin deficiency https://t.co/KSaJ6UcVtJ

Feb 2, 2022 · 10 likes · 2 shares · 337 followers View post →
Cincinnati Children's Media Lab
@CincyKidsMedArt · X

New Release: Targeting CELA1 in AAT Deficiency #raredisease #AAT #Cela1 #KF4 #medart #medicaleducation #medicalanimation #sciart #maya #vray #cincychildrens https://t.co/WQGgI9mEb3

Feb 4, 2022 · 3 likes · 4 shares · 560 followers View post →
Cincinnati Children's Media Lab
@CincyKidsMedArt · X

New Release: Targeting CELA1 in COPD #raredisease #COPD #Cela1 #KF4 #medart #medicaleducation #medicalanimation #sciart #maya #vray #cincychildrens https://t.co/URqaC5AhPW

Feb 4, 2022 · 1 like · 1 share · 560 followers View post →
Cincinnati Children's
@CincyChildrens · X

RT @CincyKidsInvent: Rare day 2-2-22 reminds us how researchers like @BrianVarisco work to slow disease progression in #rare #geneticdisea…

Feb 3, 2022 · 2 shares · 36,177 followers View post →
ScienceStop
@B0tSci · X

RT @CincyKidsMedArt: New Release: Targeting CELA1 in COPD #raredisease #COPD #Cela1 #KF4 #medart #medicaleducation #medicalanimation #sciar…

Feb 4, 2022 · 1 share · 4,072 followers View post →
ScienceStop
@B0tSci · X

RT @CincyKidsMedArt: New Release: Targeting CELA1 in AAT Deficiency #raredisease #AAT #Cela1 #KF4 #medart #medicaleducation #medicalanimati…

Feb 6, 2022 · 4 shares · 4,072 followers View post →

All mentions

ScienceStop
@B0tSci · X

RT @CincyKidsMedArt: New Release: Targeting CELA1 in AAT Deficiency #raredisease #AAT #Cela1 #KF4 #medart #medicaleducation #medicalanimati…

Feb 6, 2022 · 4 shares · 4,072 followers View post →
JuanaSe
@juanitatolea_se · X

RT @CincyKidsMedArt: New Release: Targeting CELA1 in AAT Deficiency #raredisease #AAT #Cela1 #KF4 #medart #medicaleducation #medicalanimati…

Feb 6, 2022 · 4 shares · 88 followers View post →
Cincinnati Children's Innovation Ventures
@CincyKidsInvent · X

RT @CincyKidsMedArt: New Release: Targeting CELA1 in AAT Deficiency #raredisease #AAT #Cela1 #KF4 #medart #medicaleducation #medicalanimati…

Feb 5, 2022 · 4 shares · 337 followers View post →
ScienceStop
@B0tSci · X

RT @CincyKidsMedArt: New Release: Targeting CELA1 in COPD #raredisease #COPD #Cela1 #KF4 #medart #medicaleducation #medicalanimation #sciar…

Feb 4, 2022 · 1 share · 4,072 followers View post →
Cincinnati Children's Media Lab
@CincyKidsMedArt · X

New Release: Targeting CELA1 in COPD #raredisease #COPD #Cela1 #KF4 #medart #medicaleducation #medicalanimation #sciart #maya #vray #cincychildrens https://t.co/URqaC5AhPW

Feb 4, 2022 · 1 like · 1 share · 560 followers View post →
ScienceStop
@B0tSci · X

RT @CincyKidsMedArt: New Release: Targeting CELA1 in AAT Deficiency #raredisease #AAT #Cela1 #KF4 #medart #medicaleducation #medicalanimati…

Feb 4, 2022 · 4 shares · 4,072 followers View post →
Cincinnati Children's Media Lab
@CincyKidsMedArt · X

New Release: Targeting CELA1 in AAT Deficiency #raredisease #AAT #Cela1 #KF4 #medart #medicaleducation #medicalanimation #sciart #maya #vray #cincychildrens https://t.co/WQGgI9mEb3

Feb 4, 2022 · 3 likes · 4 shares · 560 followers View post →
Cincinnati Children's
@CincyChildrens · X

RT @CincyKidsInvent: Rare day 2-2-22 reminds us how researchers like @BrianVarisco work to slow disease progression in #rare #geneticdisea…

Feb 3, 2022 · 2 shares · 36,177 followers View post →
Cincinnati Children's Innovation Ventures
@CincyKidsInvent · X

Rare day 2-2-22 reminds us how researchers like @BrianVarisco work to slow disease progression in #rare #geneticdiseases like alpha1 antitrypsin deficiency https://t.co/KSaJ6UcVtJ

Feb 2, 2022 · 10 likes · 2 shares · 337 followers View post →
lungdevelopment
@lungdevelopmen1 · X

Role for Cela1 in Postnatal Lung Remodeling and Alpha-1 Antitrypsin-Deficient Emphysema. https://t.co/4HVLVQU3cy

Apr 13, 2019 · 62 followers View post →