ACS Nano March 2018 PMID 29505236

Endosomal Size and Membrane Leakiness Influence Proton Sponge-Based Rupture of Endosomal Vesicles.

Lotte M P Vermeulen, Toon Brans, Sangram K Samal, Peter Dubruel, Jo Demeester, Stefaan C De Smedt, Katrien Remaut, Kevin Braeckmans

Mentions

8
Peak: 5 in Apr 2019
across 2 sources since Aug 2018

Extended reach

7,607
potential audience

Total likes

19

Video views

71

Mentions per month

Aug 2018 – Apr 2019

Where it's discussed

  • X / Twitter5 posts
  • YouTube3 videos

AI synopsis

What people are saying

Discussions highlight the relevance of endosomal size and membrane leakiness for nanoparticle escape, using phrases like 'important paper' and 'influence' that reflect recognition of its scientific value. The tone is respectful and acknowledges potential applications, though it lacks strong emotional or critical language, leading to moderate scores across the dimensions.

AgreementModerate agreement

Most discussions acknowledge the significance of the study, particularly noting its focus on the factors influencing nanoparticle escape, aligning with the publication's findings.

InterestModerate interest

The posts show moderate curiosity, emphasizing the importance for research in nanoparticle delivery systems without expressing deep enthusiasm.

EngagementNeutral engagement

There are minimal detailed interactions or debates, indicating a basic recognition rather than deep analysis.

ImpactModerate impact

The discussions suggest that the article could influence future research but do not convey that it has caused a major shift in the field.

Abstract in brief

  • The study examines how the size and leakiness of endosomes affect the ability of nanoparticles to escape into the cytoplasm, which is critical for successful gene therapy.
  • Smaller endosomes, such as those in HeLa cells, are more easily ruptured by the proton sponge effect, leading to higher escape rates compared to larger endosomes like in ARPE19 cells.
  • Membrane leakiness can prevent effective osmotic pressure buildup, limiting rupture regardless of endosomal size, highlighting the importance of both physical and biochemical factors in improving endosomal escape techniques.]

Top posts

Most liked on X and Bluesky
qBionano.org
@qBionano · X

Important paper on nanoparticle ndosomal escape in @acsnano @ACSNanotation “Endosomal Size and Membrane Leakiness Influence Proton Sponge-Based Rupture of Endosomal Vesicles” https://t.co/LbbKCrTtm1

Apr 22, 2019 · 19 likes · 5 shares · 377 followers View post →
CRS NANO
@CRS_FG_NANO · X

RT @qBionano: Important paper on nanoparticle ndosomal escape in @acsnano @ACSNanotation “Endosomal Size and Membrane Leakiness Influence P…

Apr 22, 2019 · 5 shares · 3,049 followers View post →
Gary Beane
@pollinus66 · X

RT @qBionano: Important paper on nanoparticle ndosomal escape in @acsnano @ACSNanotation “Endosomal Size and Membrane Leakiness Influence P…

Apr 22, 2019 · 5 shares · 2,026 followers View post →
Margarida M Barroso
@barrosolab · X

RT @qBionano: Important paper on nanoparticle ndosomal escape in @acsnano @ACSNanotation “Endosomal Size and Membrane Leakiness Influence P…

Apr 22, 2019 · 5 shares · 1,297 followers View post →

All mentions

Rickey Estes
@estes_rickey · X

RT @qBionano: Important paper on nanoparticle ndosomal escape in @acsnano @ACSNanotation “Endosomal Size and Membrane Leakiness Influence P…

Apr 23, 2019 · 5 shares · 738 followers View post →
Margarida M Barroso
@barrosolab · X

RT @qBionano: Important paper on nanoparticle ndosomal escape in @acsnano @ACSNanotation “Endosomal Size and Membrane Leakiness Influence P…

Apr 22, 2019 · 5 shares · 1,297 followers View post →
CRS NANO
@CRS_FG_NANO · X

RT @qBionano: Important paper on nanoparticle ndosomal escape in @acsnano @ACSNanotation “Endosomal Size and Membrane Leakiness Influence P…

Apr 22, 2019 · 5 shares · 3,049 followers View post →
Gary Beane
@pollinus66 · X

RT @qBionano: Important paper on nanoparticle ndosomal escape in @acsnano @ACSNanotation “Endosomal Size and Membrane Leakiness Influence P…

Apr 22, 2019 · 5 shares · 2,026 followers View post →
qBionano.org
@qBionano · X

Important paper on nanoparticle ndosomal escape in @acsnano @ACSNanotation “Endosomal Size and Membrane Leakiness Influence Proton Sponge-Based Rupture of Endosomal Vesicles” https://t.co/LbbKCrTtm1

Apr 22, 2019 · 19 likes · 5 shares · 377 followers View post →