April 2018 PMID 29514871

Interindividual Differences in Caffeine Metabolism and Factors Driving Caffeine Consumption.

Astrid Nehlig

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Mentions

Peak: 3 in Feb 2019

across 7 sources since Feb 2019

Extended reach

200,913

potential audience

Total likes

109

Video views

3,141

Mentions per month

Feb 2019 – Nov 2025

Where it's discussed

X / Twitter10 posts
News7 articles
Blogs5 articles
Facebook4 posts
Instagram3 posts
YouTube2 videos
Reddit1 posts

AI synopsis

What people are saying

The overall tone reflects a strong interest in the genetic and biochemical mechanisms underlying caffeine consumption, exemplified by mentions of GWAS studies and pathways, which shows active engagement. The support for the scientific insights indicates acknowledgment of the research's significance, though conversations remain somewhat technical and exploratory rather than decisively impactful.

AgreementModerate agreement

Most posts recognize the importance of genetic and biological factors in caffeine metabolism, showing general support for the scientific findings.

InterestHigh interest

Posts demonstrate high curiosity, often referencing specific genes and pathways, indicating active engagement with the research details.

EngagementModerate engagement

Some discussions delve into the implications of genetic differences and methodological aspects, reflecting a moderate level of thoughtful engagement.

ImpactModerate impact

The discussions suggest that the article has meaningful implications for personalized health and understanding caffeine effects, but this is expressed with cautious optimism.

Abstract in brief

Individual caffeine intake varies greatly among people based on how caffeine affects them physically and subjectively, and this is influenced by factors like age, sex, hormones, liver health, obesity, smoking, diet, and medication interactions.
Genetic differences, especially polymorphisms in enzymes such as CYP1A2 and acetyltransferase 2, play a key role in how caffeine is metabolized, impacting blood caffeine levels and its effects.
Variations in brain receptors like the adenosine A2A receptor also influence how caffeine affects the body and behavior, with recent genetic studies linking these factors to caffeine consumption, sleep, anxiety, and potential mental health or neurodegenerative issues.

Read the full abstract

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Effective Caffeine Use for Enhanced Energy and Focus

Learn how to optimize caffeine intake for increased energy and focus while minimizing side effects like anxiety and crashes. Discover strategic tips for timing and dosage to boost your mental performance safely.

Nuture · May 3, 2023 3,141 views

Caffeine Dependence and Its Neurochemical Impact Explained

Caffeine enhances alertness by blocking adenosine receptors and boosting dopamine but can lead to tolerance, dependence, and health issues with overuse. Long-term high intake may affect sleep and cardiovascular health.

Paula Hall · Nov 11, 2025 0 views

سعود الشهري

@saud_alshehry_ · X

للاستزادة

Jun 28, 2022 · 5 likes · 178,237 followers View post →

Jorge “Coco” Del-Aguila

@Coco_Lucho2 · X

RT @Eric_Fauman: Here I highlighted all of the relevant GWAS gene-metabolite associations identified in our METSIM study https://t.co/DFyf7…

Jun 1, 2022 · 2 shares · 118 followers View post →

Svati Shah

@SvatiShah · X

RT @Eric_Fauman: Here I highlighted all of the relevant GWAS gene-metabolite associations identified in our METSIM study https://t.co/DFyf7…

May 30, 2022 · 2 shares · 2,572 followers View post →

Eric Fauman (he/him)

@Eric_Fauman · X

May 30, 2022 · 3 likes · 2 shares · 5,689 followers View post →

Razan Baabdullah

@RazanBaabdulla · X

Dec 25, 2020 · 3 likes · 1,941 followers View post →

Rene Sugar

@renesugar · X

Interindividual Differences in Caffeine Metabolism and Factors Driving Caffeine Consumption https://t.co/WiaRqpYZqk

Mar 27, 2020 · 3,989 followers View post →

dxnda

@dxnda · X

Nehlig A. (2018) Interindividual differences in caffeine metabolism and factors driving caffeine consumption. Pharmacol Rev, 70(2):384-411 https://t.co/uZI6nSsF0H

Dec 13, 2019 · 1,248 followers View post →

NootropicReddit

@NootropicReddit · X

Interindividual Differences in Caffeine Metabolism and Factors Driving Caffeine Consumption via /r/Nootropics https://t.co/M3GerxEnwF

Feb 20, 2019 · 793 followers View post →

MedCobra

@medcobracom · X

Interindividual Differences in Caffeine Metabolism and Factors Driving Caffeine Consumption https://t.co/C5zgnH2iJo

Feb 20, 2019 · 929 followers View post →

NZT Social Network

@nzt48nootropics · X

Interindividual Differences in Caffeine Metabolism and Factors Driving Caffeine Consumption https://t.co/6m33IajqbX

Feb 20, 2019 · 2,044 followers View post →

Prof. Baêta

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‎Prof. Baêta‎ - Facebook

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2023.101764 10.1124/pr.117.014407 10.1016/j.neubiorev.2016.09.001.

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Prof. Baêta - Facebook

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smrv.2023.101764 10.1124/pr.117.014407 10.1016/j.neubiorev.2016.09.001.

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REBEL Cast Archives - REBEL EM - Emergency Medicine Blog

Blogs

... 10.1124/pr.117.014407; U.S. Department of Agriculture and U.S. Department of Health and Human Services. Dietary Guidelines for Americans, 2020-2025. 9th ...

Dec 17, 2025 View →

Dinesh Thesis (Black Book) Final | PDF

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Caffeine Consumption. Pharmacological Reviews,70(2), 384-411. doi:10.1124/pr.117.014407. Nepali Tea - Beverage of the Himalayas - Himal ...

Dec 17, 2025 View →

REBEL Cast

Blogs

... 10.1124/pr.117.014407; U.S. Department of Agriculture and U.S. Department of Health and Human Services. Dietary Guidelines for Americans, 2020-2025. 9th ...

Dec 17, 2025 View →

REBEL Core Archives - REBEL EM - Emergency Medicine Blog

Blogs

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Investigación destacada Un estudio reciente analizó cómo el ...

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DOI: 10.1124/pr.117.014407 #Café #SaludMetabólica #EjercicioParaLaSalud #Ciencia #Bienestar #EntrenamientoInteligente #Genética ...

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Jul 10, 2025 View →

INFLUENCE OF GENDER ON THE PLASMA CONCENTRATION OF ...

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https://doi.org/10.1124/pr.117.014407. 14. Nehlig A, Daval JL, Debry G. Caffeine and the central nervous system: mechanisms of action. Brain ...

Jul 2, 2025 View →

Influence of gender on the plasma concentration of caffeine and its ...

News

https://doi.org/10.1124/pr.117.014407. 14. Nehlig A, Daval JL, Debry G. Caffeine and the central nervous system: mechanisms of action. Brain ...

Jun 6, 2025 View →

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https://doi.org/10.1124/pr.117.014407; Roehrs, T., & Roth, T. (2008). Caffeine: Sleep and daytime sleepiness. Sleep Medicine Reviews, 12(2) ...

Aug 29, 2024 View →

‏فروش آنلاین انواع قهوه-بونوکافی‌گروپ☕️‏ | ‏ انتخاب تو کدومه ...

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☕ منبع: ‏Source: Nehlig, A. (2018). Interindividual Differences in Caffeine Metabolism. Pharmacological Reviews. [DOI: 10.1124/pr.117.014407]

May 20, 2024 View →

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doi:10.1124/pr.117.014407. 34. Kachroo A, Irizarry MC, Schwarzschild MA. Caffeine protects against combined paraquat and maneb-induced ...

Apr 23, 2024 View →

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Blogs

doi:10.1124/pr.117.014407; U.S. Department of Agriculture and U.S. Department of Health and Human Services. Dietary Guidelines for Americans ...

Mar 6, 2024 View →

Kafein Tüketiminin Bireysel Etkileri | Rumeysa Yolcu | Yazı Rehberi

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https://doi.org/10.1124/pr.117.014407. Sağlıklı günler :) Yazımı beğendiyseniz alkış atarak bana destek olabilirsiniz. (Maksimum 50'ye kadar ...

Apr 7, 2023 View →

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Tu respuesta al café no es suerte: es bioquímica + genética. Enlace: https://pubmed.ncbi.nlm.nih.gov/29514871/ DOI: 10.1124/pr.117.014407

Jun 27, 2022 View →

How nutmeg affects caffeine metabolism : r/nutmeg

10.1124/pr.117.014407 · 10.1248/yakushi1947.111.6_311 · 10.1016/j.lfs.2005.05.095. Upvote 6. Downvote 6 Go to comments

Nov 12, 2021 View →

Cafeïne in de sport: zes mythes ontmaskerd | EOS Wetenschap

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doi:10.1124/pr.117.014407. 13. Gonçalves, L. D. S. et al. Dispelling the myth that habitual caffeine consumption influences the performance ...

Sep 27, 2021 View →

Projekt Interakcija - KOFEIN, KAVA IN ZDRAVILA Kofein je ...

Facebook

... 10.1124/pr.117.014407 2. Nieber K. The Impact of Coffee on Health. Planta Med. 2017;83(16):1256-1263. doi:10.1055/s-0043-115007 | Facebook ...

Nov 18, 2020 View →

Interindividual Differences in Caffeine Metabolism and Factors Driving Caffeine Consumption.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Effective Caffeine Use for Enhanced Energy and Focus

Caffeine Dependence and Its Neurochemical Impact Explained