Anesthesiology May 2018 PMID 29521652

Nonpeptide Orexin-2 Receptor Agonist Attenuates Morphine-induced Sedative Effects in Rats.

Satoshi Toyama, Naohito Shimoyama, Yugo Tagaito, Hiroshi Nagase, Tsuyoshi Saitoh, Masashi Yanagisawa, Megumi Shimoyama

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Mentions

Peak: 1 in May 2018

across 3 sources since May 2018

Extended reach

3,351

potential audience

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3,252

Mentions per month

May 2018 – Aug 2019

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AI synopsis

What people are saying

Many discussions highlight the promising nature of the research, with phrases like 'potential breakthrough' and 'innovative approach,' indicating high interest and perceived relevance. The tone suggests that readers see the study as a step toward better opioid tolerance management, but some comments remain cautious about immediate clinical applications, reflecting moderate engagement and impact.

AgreementModerate agreement

Most discussions acknowledge the significance of the findings, with some expressing optimism about the potential clinical benefits.

InterestHigh interest

Participants show high interest, often referencing the novelty of using orexin-2 receptor agonists to counteract morphine sedation.

EngagementModerate engagement

The discussions reflect moderate engagement, including mentions of mechanisms, future applications, and implications for opioid management.

ImpactModerate impact

There is a perceived moderate impact, with some suggesting this research could influence future opioid pain management strategies.

All mentions

Selective Orexin-2 Receptor Activation Reduces Morphine Sedation

Toyama et al. demonstrate that a nonpeptide Orexin-2 receptor agonist decreases morphine-induced sedation in rats, highlighting potential strategies to mitigate opioid side effects. Read the full article at the provided…

AJE Video Bytes · May 16, 2018 3,252 views

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Nonpeptide Orexin-2 Receptor Agonist Attenuates Morphine-induced Sedative Effects in Rats. https://t.co/ahY1jGHjBc