Int J Mol Sci March 2018 PMID 29533978

Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System.

Shenglong Zou, Ujendra Kumar

Mentions

130
Peak: 14 in Nov 2025
across 7 sources since Apr 2018

Extended reach

104,100
potential audience

Total likes

72

Video views

1,023

Mentions per month

Apr 2018 – Dec 2025

Where it's discussed

  • TikTok47 posts
  • X / Twitter39 posts
  • Facebook31 posts
  • News7 articles
  • Instagram3 posts
  • YouTube2 videos
  • Bluesky1 posts

AI synopsis

What people are saying

The discussions reflect an overall positive view towards the article, highlighting aspects like the relevance of the endocannabinoid system and its evolutionary background. For example, phrases like 'safer than alcohol' and references to restoring beneficial bodily functions show enthusiasm, while mentions of scientific terminology indicate engagement with the research's implications.

AgreementModerate agreement

Most discussions acknowledge the importance of the research and support its conclusions about the role of cannabinoids and their potential benefits.

InterestHigh interest

The posts demonstrate high interest, with many emphasizing the significance of the endocannabinoid system and its therapeutic potential.

EngagementModerate engagement

There is some engagement with technical details, such as mentions of signaling pathways and biological effects, showing a moderate depth of discussion.

ImpactModerate impact

Several posts suggest that the research could influence understanding and treatment approaches, indicating a moderate to high potential impact.

Abstract in brief

  • The text explains that cannabinoids, found in marijuana, primarily act through two G-protein coupled receptors: CB1R, which is mainly found in the central nervous system, and CB2, influencing other body parts.
  • CB1R is important because it can affect brain functions and has potential for treating mental and neurodegenerative disorders, but its psychoactive effects have limited medical use.
  • The article discusses recent advances in understanding how cannabinoids influence signaling pathways in the brain and explores strategies to harness their therapeutic benefits while minimizing adverse effects.]

Top posts

Most liked on X and Bluesky
Fallen One, with A Lamp
@OneFallenAngelM · X

Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System

Jul 16, 2019 · 11 likes · 8 shares · 9,315 followers View post →
Madame Weed
@mme_weed · X

= l’#endocannabinoïde que notre corps produit.

Aug 17, 2021 · 10 likes · 1 share · 2,456 followers View post →
IJMS MDPI
@IJMS_MDPI · X

Please read our publication #Cannabinoid Receptors and the #Endocannabinoid System: Signaling and Function in the #CentralNervousSystem at https://t.co/3RTCnN6mS1 https://t.co/1wbm0wIKLz

Jul 20, 2020 · 5 likes · 2 shares · 5,299 followers View post →
Greenthumb_one
@Greenthumb_one · X

More #cannabis studies @dreamgbutterfly

Mar 20, 2019 · 4 likes · 2 shares · 4,512 followers View post →
Canna Cure Cafe
@CannaCureCafe · X

#Cannabinoid Receptors and the #Endocannabinoid System: Signaling and Function in the Central Nervous System https://t.co/0CHx5JqaJb

Sep 11, 2019 · 4 likes · 5 shares · 23 followers View post →
RPB
@randall88888888 · X

@geostylegeo Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System The biological effects of cannabinoids, the major constituents of the ancient medicinal plant Cannabis sativa (marijuana) are mediated by two members of the G-protein———

Nov 11, 2022 · 1 like · 1,837 followers View post →

All mentions

khan Artist
@ShortTimeerr · X

@AubreeAdams4 https://t.co/6uwFtdq9IU

Nov 12, 2025 · 81 followers View post →
✦Good psychopath cat✦
@NEO_n_cats007r · X

カンナビノイド受容体とエンドカンナビノイドシステム:中枢神経系におけるシグナル伝達と機能 https://t.co/rB8LNuByAD

Sep 5, 2025 · 419 followers View post →
khan Artist
@ShortTimeerr · X

@blingdian @SRTJay98 @TopKai360553 @ihysosa https://t.co/6uwFtdq9IU

Apr 13, 2025 · 81 followers View post →
Baggage
@carrieonbaggage.bsky.social · Bluesky

Background: Zou, S.; Kumar, U. Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System. Int. J. Mol. Sci. 2018, 19, 833. doi.org/10.3390/ijms... www.mdpi.com/1422-0067/19...

Apr 11, 2025 · 1 share View post →
khan Artist
@ShortTimeerr · X

@Maryjohaynes @ThrillaRilla369 https://t.co/6uwFtdqHys

Jan 4, 2025 · 1 like · 81 followers View post →
Barrett
@ijustwan2bfree · X

@VP https://t.co/IU18y9iqXb The research is clear, so get the job done.

Mar 26, 2024 · 1 followers View post →
Kingdomchild99
@Kingdomchild99 · X

@meme98152675 @bigmadredhatter Our body has an endocannabinoid system which specifically metabolizes components found in it as well as other various plants. It is not evil or of the devil, this is what the government wants us to think to keep the beneficial side of it out of our hands. https://t.co/8ybRITwsRU

Feb 1, 2024 · 1,738 followers View post →
‎Alexandra Jicol ( JICOL aka 仁行了‎)
@Jicol · X

@lizpeek Yet, much safer, & healthier than alcohol (an inflammatory agent); all's about dosage and balance. Cannabis is an ancient plant that has been with mankind from the beginning. Hence is why we have a EndoCanabinoid system. https://t.co/PoIc8PsZjq - https://t.co/kOBi6GDPt2

Dec 13, 2022 · 705 followers View post →
RPB
@randall88888888 · X

@geostylegeo Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System The biological effects of cannabinoids, the major constituents of the ancient medicinal plant Cannabis sativa (marijuana) are mediated by two members of the G-protein———

Nov 11, 2022 · 1 like · 1,837 followers View post →
Amenze’ Uyigue/ MAYMAY
@maymayamenze · X

Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System https://t.co/85j2hPJanf

Apr 28, 2022 · 14 followers View post →
FreedomRocks
@freedom2debate · X

Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System https://t.co/H0GDtIikOv

Dec 17, 2021 · 2,201 followers View post →
Laitue Sévère
@LaitueSevere · X

RT @mme_weed: = l’#endocannabinoïde que notre corps produit.

Aug 17, 2021 · 1 share · 96 followers View post →
Madame Weed
@mme_weed · X

= l’#endocannabinoïde que notre corps produit.

Aug 17, 2021 · 10 likes · 1 share · 2,456 followers View post →
Bold Biologix
@BBiologix · X

Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System https://t.co/lSbBqxDwkE

Nov 23, 2020 · 863 followers View post →
Bioempower Leaders
@bioempowers · X

2. ZOU, Shenglong; KUMAR, Ujendra. Cannabinoid receptors and the endocannabinoid system: signaling and function in the central nervous system. International journal of molecular sciences, 2018, vol. 19, no 3, p. 833. AUTORA: SARA A. Para el concurso #papersen3minutos

Nov 16, 2020 · 1 like · 1,480 followers View post →
Dreamgbutterfly
@dreamgbutterfly · X

Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System https://t.co/JEh2YvvoZ6 https://t.co/uxZgK5jMk3

Jul 28, 2020 · 81 followers View post →
Lee
@greeneyedlizzie · X

RT @IJMS_MDPI: Please read our publication #Cannabinoid Receptors and the #Endocannabinoid System: Signaling and Function in the #CentralNe…

Jul 21, 2020 · 2 shares · 1,278 followers View post →
Dr. Tanaka
@emtanaka · X

RT @IJMS_MDPI: Please read our publication #Cannabinoid Receptors and the #Endocannabinoid System: Signaling and Function in the #CentralNe…

Jul 21, 2020 · 2 shares · 1,331 followers View post →
IJMS MDPI
@IJMS_MDPI · X

Please read our publication #Cannabinoid Receptors and the #Endocannabinoid System: Signaling and Function in the #CentralNervousSystem at https://t.co/3RTCnN6mS1 https://t.co/1wbm0wIKLz

Jul 20, 2020 · 5 likes · 2 shares · 5,299 followers View post →
CODE
@CodePinkHouston · X

Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System https://t.co/EFoCzmi8u0

Feb 11, 2020 · 386 followers View post →
Dreamgbutterfly
@dreamgbutterfly · X

Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System https://t.co/Yh2wdSac3G

Dec 7, 2019 · 81 followers View post →
Dreamgbutterfly
@dreamgbutterfly · X

Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System https://t.co/Yh2wdSac3G

Nov 20, 2019 · 81 followers View post →
Angel
@ZageToast · X

RT @CannaCureCafe: #Cannabinoid Receptors and the #Endocannabinoid System: Signaling and Function in the Central Nervous System https://t.c…

Sep 17, 2019 · 5 shares · 50 followers View post →
AmericannaBlunt♡⁠˖
@AmeriCannaBlunt · X

RT @CannaCureCafe: #Cannabinoid Receptors and the #Endocannabinoid System: Signaling and Function in the Central Nervous System https://t.c…

Sep 17, 2019 · 5 shares · 18,526 followers View post →
kannabinoidmedicina@gmail.com
@orvosikannabisz · X

RT @CannaCureCafe: #Cannabinoid Receptors and the #Endocannabinoid System: Signaling and Function in the Central Nervous System https://t.c…

Sep 17, 2019 · 5 shares · 42 followers View post →
Jennifer Adams
@jengriffinadams · X

RT @CannaCureCafe: #Cannabinoid Receptors and the #Endocannabinoid System: Signaling and Function in the Central Nervous System https://t.c…

Sep 13, 2019 · 5 shares · 983 followers View post →
Debbie Hampton
@dlhampton · X

RT @CannaCureCafe: #Cannabinoid Receptors and the #Endocannabinoid System: Signaling and Function in the Central Nervous System https://t.c…

Sep 13, 2019 · 5 shares · 11,758 followers View post →
Canna Cure Cafe
@CannaCureCafe · X

#Cannabinoid Receptors and the #Endocannabinoid System: Signaling and Function in the Central Nervous System https://t.co/0CHx5JqaJb

Sep 11, 2019 · 4 likes · 5 shares · 23 followers View post →
Yook Hunt.
@Theonlytait · X

RT @OneFallenAngelM: Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System

Jul 16, 2019 · 8 shares · 1,482 followers View post →
wilbert collins
@collins_wilbert · X

RT @OneFallenAngelM: Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System

Jul 16, 2019 · 8 shares · 1,374 followers View post →
Canna Queen Comedy
@RealCannaQueen · X

RT @OneFallenAngelM: Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System

Jul 16, 2019 · 8 shares · 895 followers View post →
Hit This Note
@note_hit · X

RT @OneFallenAngelM: Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System

Jul 16, 2019 · 8 shares · 395 followers View post →
Tim Yokley
@TSYOKLEY · X

RT @OneFallenAngelM: Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System

Jul 16, 2019 · 8 shares · 640 followers View post →
HITMYNOTE
@mikelarry955 · X

RT @OneFallenAngelM: Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System

Jul 16, 2019 · 8 shares · 407 followers View post →
Giuly Boy
@BoyGiuly · X

RT @OneFallenAngelM: Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System

Jul 16, 2019 · 8 shares · 13,305 followers View post →
K
@Whowaa · X

RT @OneFallenAngelM: Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System

Jul 16, 2019 · 8 shares · 15,344 followers View post →
Fallen One, with A Lamp
@OneFallenAngelM · X

Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System

Jul 16, 2019 · 11 likes · 8 shares · 9,315 followers View post →
Bleeding KS Advocate
@Bleeding4Kansas · X

RT @Greenthumb_one: More #cannabis studies @dreamgbutterfly

Mar 22, 2019 · 2 shares · 2,246 followers View post →
Greenthumb_one
@Greenthumb_one · X

More #cannabis studies @dreamgbutterfly

Mar 20, 2019 · 4 likes · 2 shares · 4,512 followers View post →
Dreamgbutterfly
@dreamgbutterfly · X

Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System https://t.co/Yh2wdSac3G

Mar 20, 2019 · 1 like · 81 followers View post →
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A Importância da Atividade Física para o Cérebro | TikTok
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https://doi.org/10.3390/ijms19030833 Hill, M. N., & Patel, S. (2013). Translational evidence for the involvement of the endocannabinoid ...

Jan 17, 2025 View →
CBD Cream for Pain: For Inflammation and Joint Pain Relief
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doi: 10.3390/ijms19030833. PMID: 29533978; PMCID: PMC5877694. Leweke FM, Piomelli D, Pahlisch F, Muhl D, Gerth CW, Hoyer C, Klosterkötter J ...

Jul 14, 2024 View →
Does THCA Get You High? What to Expect Legal Status & More
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doi: 10.3390/ijms19030833. PMID: 29533978; PMCID: PMC5877694. Benson MJ, Anderson LL, Low IK, Luo JL, Kevin RC, Zhou C, McGregor IS, Arnold ...

Jun 30, 2024 View →
CBD Oil for Pain: Best CBD Oil Brands for Chronic & Joint Pain
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doi: 10.3390/ijms19030833. PMID: 29533978; PMCID: PMC5877694. Schilling JM, Hughes CG, Wallace MS, Sexton M, Backonja M, Moeller-Bertram T ...

Jun 29, 2024 View →
Can CBD Oil Get You High: Effects + Debunking Common Myths
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doi: 10.3390/ijms19030833. PMID: 29533978; PMCID: PMC5877694. Argueta DA, Ventura CM, Kiven S, Sagi V, Gupta K. A Balanced Approach for ...

Jun 28, 2024 View →
Orto-K: A Lente Que Elimina a Miopia Durante a Noite | TikTok
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DOI 10.3390/ijms19030833 #Glaucoma #SistemaEndocanabinoide #SaúdeOcular #Oftalmologia #ClínicaDoOlho #HonassysRocha #IndiraMatos ...

May 31, 2024 View →
Cannabidiol as a chemotherapy adjunct in cancer treatment - The ...
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https://doi.org/10.3390/ijms19030833. 7. Martinez Naya N, Kelly J, Corna G, et al. Molecular and Cellular Mechanisms of Action of Cannabidiol ...

Mar 12, 2024 View →
Importância do Exame de OCT para Diagnóstico de Glaucoma ...
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DOI 10.3390/ijms19030833 #Glaucoma #SistemaEndocanabinoide ... DOI: 10.3390/ph16081149 Clínica do Olho — Salvador - BA Telefone e ...

Jan 23, 2024 View →
Explorando a Visão Embaçada: Causas e Soluções | TikTok
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DOI 10.3390/ijms19030833 #Glaucoma #SistemaEndocanabinoide ... DOI: 10.3390/ph16081149 Clínica do Olho — Salvador - BA Telefone e ...

Dec 17, 2023 View →
Entenda a escavação do nervo óptico e o glaucoma | TikTok
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DOI 10.3390/ijms19030833 #Glaucoma #SistemaEndocanabinoide #SaúdeOcular #Oftalmologia #ClínicaDoOlho #HonassysRocha #IndiraMatos ...

Dec 1, 2023 View →
Agende seus #ExamesComplementares agora mesmo no nosso ...
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DOI 10.3390/ijms19030833 #Glaucoma #SistemaEndocanabinoide #SaúdeOcular #Oftalmologia #ClínicaDoOlho #HonassysRocha #IndiraMatos ...

Oct 27, 2023 View →
Importância da Saúde Ocular Durante um Eclipse | TikTok
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DOI 10.3390/ijms19030833 #Glaucoma #SistemaEndocanabinoide #SaúdeOcular #Oftalmologia #ClínicaDoOlho #HonassysRocha #IndiraMatos ...

Oct 16, 2023 View →
Did you know serotonin receptors in our brain respond to ...
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What are the benefits of cannabinoids for various health conditions? Summarized by AI from the post below.

Oct 3, 2023 View →
Replying to @Naninha glaucoma pode ser tratado com laser ...
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DOI 10.3390/ijms19030833 #Glaucoma #SistemaEndocanabinoide #SaúdeOcular #Oftalmologia #ClínicaDoOlho #HonassysRocha #IndiraMatos ...

Sep 20, 2023 View →
Como enxerga uma pessoa com Glaucoma: Entenda o Impacto ...
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DOI 10.3390/ijms19030833 #Glaucoma #SistemaEndocanabinoide #SaúdeOcular #Oftalmologia #ClínicaDoOlho #HonassysRocha #IndiraMatos ...

Aug 18, 2023 View →
Glaucoma e Hereditariedade: Descubra a conexão oculta! #Glauc ...
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DOI 10.3390/ijms19030833 #Glaucoma #SistemaEndocanabinoide #SaúdeOcular #Oftalmologia #ClínicaDoOlho #HonassysRocha #IndiraMatos ...

Jul 28, 2023 View →
Comemorando 4 anos de excelência em cuidados visuais no ...
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DOI 10.3390/ijms19030833 #Glaucoma #SistemaEndocanabinoide #SaúdeOcular #Oftalmologia #ClínicaDoOlho #HonassysRocha #IndiraMatos ...

Jul 27, 2023 View →
Compartmentalized cannabinoid signaling in brain
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What is the role of the cb2 receptor in nerve cell communication? Summarized by AI from the post below. Profile photo of Brandon.

Jun 5, 2023 View →
What defines a true cannabinoid?
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https://doi.org/10.3390/ph15020210 · No photo description available. Walter Latzke and 11 others. 12 reactions ·. 2 comments. ·. 5 shares.

Sep 28, 2022 View →
Cannabinoid Pathway Linked to Psychiatric Disorders Findings ...
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Cannabinoid receptors, located throughout the body, are part of the endocannabinoid system, which is involved in a variety of physiological ...

Jul 2, 2021 View →
"Recent studies have found that the endocannabinoid signaling ...
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https://doi.org/10.3390/ph15020210 · No photo description available. Walter Latzke and 11 others. 12 reactions ·. 2 comments. ·. 5 shares. Jason ...

Feb 24, 2021 View →
CBD and the Pediatric Population by Kat Joines PT, MSPT, DHSc ...
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org/10.3390/ijms19030833 3. Campbell, C. T., Phillips, M.S., & Manasco, K. (2017). Cannabinoids in pediatrics. The Journal of Pediatric ...

Nov 22, 2020 View →
REPORT 4 OF THE COUNCIL ON SCIENCE AND PUBLIC HEALTH ...
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doi: 10.3390/ijms19030833. Open Access. Page 34. CSAPH Rep. 4, Nov. 2020 -- page 33 of 38. Figure 2. Timeline of legalization and ...

Oct 15, 2020 View →
Institute of Biomolecular Chemistry (ICB), National Research ...
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Institute of Biomolecular Chemistry (ICB), National Research Council (CNR), Pozzuoli,Italy. The new cannabinoid Cannabimovone may ...

Mar 16, 2020 View →
Dog's & Cats, n all on POT Some misleading individuals stated that ...
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https://doi.org/10.3390/ph15020210 · No photo description available. Walter Latzke and 11 others. 12 reactions ·. 2 comments. ·. 5 shares. Angie ...

Jan 15, 2020 View →
"Only a few studies have looked into the use of cannabinoids for ...
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tinnitus is as individual as the person experiencing it, while cannabis may help in some cases, it may well have a detrimental effect for ...

Aug 21, 2019 View →
"Our study shows that cannabidiol can inhibit aggressiveness and ...
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"Our study shows that cannabidiol can inhibit aggressiveness and that it does so by facilitating the activation of two receptors: the 5-HT1A ...

Jul 31, 2019 View →
Cannabinoid 1 receptor modulation in psychotic disorders
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Modulation of cannabinoid 1 receptors has potential for drug development for psychotic disorders! It is important to consider male and ...

Jul 10, 2019 View →
"These approaches are based on the well-characterized role of ...
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https://doi.org/10.3390/ph15020210 · No photo description available. Walter Latzke and 11 others. 12 reactions ·. 2 comments. ·. 5 shares. Emily ...

Jun 6, 2019 View →
Cannabinoids in topicals bind with peripheral cb2 receptors
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This settles a conflict for me. To understand that cannabinoids in topicals do NOT enter the bloodstream and therefore are not useful ...

Oct 21, 2018 View →
"The findings add to the group's previous studies suggesting that ...
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Male tobacco smokers have brain-wide reduction of CB1 receptors: A study examines cannabinoid CB1 ... Chronic, frequent tobacco smokers have ...

Aug 16, 2018 View →
In "Marijuana use differentially affects cannabinoid receptor ...
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In "Marijuana use differentially affects cannabinoid receptor expression in early gestational human endometrium and placenta" is "Human ...

Jun 1, 2018 View →
Scientists discover new cannabinoid receptor, cb3
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Scientists think they've found a new cannabinoid receptor, one that could crack open a smorgasbord of healing possibilities.

May 28, 2018 View →
Most people who have dipped their toe in cannabis science ...
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Activation of the orphan receptor GPR55 by lysophosphatidylinositol promotes metastasis in triple -negative breast cancer.

Apr 11, 2018 View →
G-protein coupled receptors (GPCRs) play a crucial role in cellular ...
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This particular class of proteins is called g-protein coupled receptors (GPCRs), which are some of the most important receptors in the human ...

Dec 27, 2017 View →
"Linking Mitochondria and Synaptic Transmission: The CB1 ...
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Serotonin regulates mitochondrial biogenesis and function in rodent cortical neurons via the 5-HT2A receptor and SIRT1–PGC-1α axis.

Nov 2, 2017 View →
Findings: Effects of Cannabinoids and CBD on Autism ...
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Cannabis Can 'Significantly Improve The Quality Of Life' For Youth With Autism, Epilepsy And Other Conditions, Scientific Review Says ...

Aug 30, 2017 View →
Cannabis positively impacts your eyes by tapping into the ...
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Cannabis positively impacts your eyes by tapping into the endocannabinoid system (ECS), the largest cellular connection network in ...

Jul 16, 2017 View →