PubHawk
Sci Signal March 2018 PMID 29535263

Extension of chemotactic pseudopods by nonadherent human neutrophils does not require or cause calcium bursts.

Emmet A Francis, Volkmar Heinrich

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Mentions

7
Peak: 1 in Mar 2018
across 4 sources since Mar 2018

Extended reach

9,737
potential audience

Total likes

88

Video views

9,723

Mentions per month

Mar 2018 – Jul 2021

Where it's discussed

  • YouTube2 videos
  • Facebook2 posts
  • Blogs2 articles
  • X / Twitter1 posts

AI synopsis

What people are saying

The discussions reflect a general agreement with the publication’s significance, highlighted by phrases such as 'does not require or cause calcium bursts,' indicating an appreciation for the challenge to previous assumptions. The tone is analytical but not deeply provocative, with some posts calling the research 'important' and others merely noting its publication, illustrating moderate engagement and perceived impact.

AgreementModerate agreement

Many discussions agree with the findings, emphasizing the novelty that chemotactic pseudopods can extend independently of calcium bursts, which contrasts with previous beliefs.

InterestModerate interest

The posts show moderate curiosity, with some expressing excitement over the scientific implications, but a few demonstrate only basic acknowledgment.

EngagementModerate engagement

Participants are somewhat engaged, referencing specific mechanisms like calcium signaling and cytoskeletal organization, but overall discussions remain surface-level.

ImpactNeutral impact

The overall perception is that the findings could influence understanding of neutrophil behavior, but the posts do not strongly convey immediate practical or broad impacts.

Abstract in brief

  • Neutrophils can extend chemotactic pseudopods without needing or causing calcium bursts, especially when they are not adhering to a substrate.
  • High, pathological levels of C5a can trigger calcium bursts but actually stop the neutrophil's movement, leading to a state similar to neutrophil paralysis seen in sepsis.
  • The ability of neutrophils to extend pseudopods is limited by their cytoskeleton's capacity to generate force without adhesion, and calcium signaling may control a switch between different modes of cytoskeletal organization that involve adhesion-dependent regulation.
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Top posts

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Bedebio
@Biosentido1 · X

RT @heinrich_lab: Just published: Extension of chemotactic pseudopods by nonadherent human neutrophils does not require or cause calcium bu…

Jul 11, 2021 · 3 shares · 8 followers View post →

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Bedebio
@Biosentido1 · X

RT @heinrich_lab: Just published: Extension of chemotactic pseudopods by nonadherent human neutrophils does not require or cause calcium bu…

Jul 11, 2021 · 3 shares · 8 followers View post →