Correlation of trans fatty acids with the severity of coronary artery disease lesions.

Abstract in brief

• This study investigates the relationship between trans fatty acids (Trans FA) and the severity of coronary artery disease (CAD), showing that higher Trans FA levels are linked to increased inflammation, oxidative stress, and more severe artery lesions according to Gensini scores.
• CAD patients exhibited decreased antioxidant activity and increased markers of oxidative stress, lipid peroxidation, and Trans FA levels compared to controls, with specific Trans FA isomers correlating with inflammatory and lipid parameters.
• The findings suggest that elevated Trans FA not only promote oxidative damage and inflammation but also relate to the progression of CAD, highlighting their potential role in monitoring disease severity.]