Nat Neurosci April 2018 PMID 29556028

Cortico-reticulo-spinal circuit reorganization enables functional recovery after severe spinal cord contusion.

Leonie Asboth, Lucia Friedli, Janine Beauparlant, Cristina Martinez-Gonzalez, Selin Anil, Elodie Rey, Laetitia Baud, Galyna Pidpruzhnykova, Mark A Anderson, Polina Shkorbatova, Laura Batti, Stephane Pagès, Julie Kreider, Bernard L Schneider, Quentin Barraud

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Mentions

Peak: 2 in Mar 2018

across 5 sources since Mar 2018

Extended reach

19,020

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Total likes

105

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Mar 2018 – May 2022

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AI synopsis

What people are saying

The group mainly praises the study’s focus on circuit reorganization and recovery, with phrases like 'enables functional recovery' and 'potential for human application.' Words such as 'significant,' 'breakthrough,' and 'hope' reflect a tone of optimism and recognition of its transformative potential, indicating active and meaningful engagement with the article’s content.

AgreementModerate agreement

Posts largely acknowledge the importance of the research, with some expressing strong support for its implications.

InterestModerate interest

Discussions show moderate interest, highlighting curiosity about the mechanisms and potential clinical benefits.

EngagementModerate engagement

Comments engage with the core findings, referencing specific pathways like the reticulospinal, indicating thoughtful participation.

ImpactModerate impact

Users recognize that the study could potentially influence future treatments for spinal cord injuries, suggesting a positive outlook on its significance.

Abstract in brief

Severe spinal cord contusions typically cut off brain signals to the legs, causing paralysis, with little natural recovery.
In a rodent model, researchers found that even after injury, the motor cortex could regain control over the legs through neuromodulation, especially by relaying signals via residual reticulospinal neurons.
The study shows that gravity-assisted rehab and neuromodulation can reroute cortical commands through the reticulospinal pathway, leading to natural walking and swimming recovery, which could be applicable to humans.]

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All mentions

Neuroprosthetic Therapy Restores Walking in Paraplegic Rats

Paraplegic rats walk again in response to neuroprosthetic rehabilitation that allows the brain to elaborate new routes so that motor commands about walking, swimming, and climbing stairs reach spinal cord centers below…

EPFL · Mar 19, 2018 16,577 views

Neuroprosthetic Rehabilitation Reverses Paralysis in Animal Study

The therapy triggers new connections from the motor cortex to the brain stem and spinal cord, enabling rats to regain hindlimb control after injury. This approach suggests potential for neural circuit reorganization and…

VHFILM · Mar 24, 2018 410 views

ToJaWiola

@tojawiola · X

RT @ReliefInstitute: Cortico–reticulo–spinal circuit reorganization enables functional recovery after severe spinal c #spinalcordinjury htt…

May 12, 2022 · 1 share · 414 followers View post →

The Relief Institute

@ReliefInstitute · X

Cortico–reticulo–spinal circuit reorganization enables functional recovery after severe spinal c #spinalcordinjury https://t.co/O2scwoPnOV

May 11, 2022 · 1 like · 1 share · 805 followers View post →

The Relief Institute

@ReliefInstitute · X

Cortico–reticulo–spinal circuit reorganization enables functional recovery after severe spinal c #spinalcordinjury https://t.co/XWNF8zrk9b

Oct 30, 2021 · 805 followers View post →

sc4bestpractice

@Mariedu973 · X

https://t.co/SlJjvFLNB9

Sep 29, 2021 · 7 followers View post →