PubHawk
Cell March 2018 PMID 29570999

Impairment of an Endothelial NAD-HS Signaling Network Is a Reversible Cause of Vascular Aging.

Abhirup Das, George X Huang, Michael S Bonkowski, Alban Longchamp, Catherine Li, Michael B Schultz, Lynn-Jee Kim, Brenna Osborne, Sanket Joshi, Yuancheng Lu, Jose Humberto Treviño-Villarreal, Myung-Jin Kang, Tzong-Tyng Hung, Brendan Lee, Eric O Williams

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Mentions

103
Peak: 1 in Feb 2019
across 6 sources since Feb 2019

Extended reach

46,490
potential audience

Total likes

129

Video views

4,986

Mentions per month

Feb 2019 – Sep 2024

Where it's discussed

  • News72 articles
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  • Facebook10 posts
  • YouTube4 videos
  • X / Twitter3 posts
  • Reddit3 posts

AI synopsis

What people are saying

The group shows moderate interest, exemplified by comments on how NAD precursors might improve human performance, while a post noting blood vessel aging from age 40 highlights the relevance of the research. The tone suggests curiosity without strong endorsement, using words like 'interesting' and noting 'usual caveats,' which indicates awareness of limitations rather than enthusiasm or skepticism.

AgreementNeither agree nor disagree

The discussions show cautious optimism but also recognize limitations, such as the reliance on mouse models, indicating neither full support nor outright skepticism.

InterestModerate interest

Participants demonstrate moderate curiosity, especially with comments on potential benefits for human performance and the relevance of vascular aging.

EngagementModerate engagement

The posts reference specific processes like NAD precursors and their effects, indicating some depth, though the overall engagement remains relatively surface-level.

ImpactNeutral impact

The comments reflect an awareness of the scientific significance, but there is little indication that these discussions are driving immediate practical change or widespread influence.

Abstract in brief

  • The decline in capillary density and blood flow with age is a major health issue, but this can be reversed because the impairment in endothelial NADH signaling is reversible.
  • NAD precursors like NMN activate sirtuin enzymes (SIRT1, SIRT7) that help replicate the benefits of exercise and dietary restriction, leading to improved blood flow and endurance in aged mice.
  • Enhancing endothelial NAD levels, either through NMN, exercise, or hydrogen sulfide, can boost capillary growth and blood flow, which may improve organ health, human performance, and mobility in the elderly.]
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Top posts

Most liked on X and Bluesky
Agingdoc
@agingdoc1 · X

Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging https://t.co/NpvFnciEMt

May 20, 2022 · 2 likes · 41,311 followers View post →
doctornatism
@doctornatism · X

Blood vessel ageing (from 40yo!) decreases muscle mass

Feb 26, 2019 · 1 like · 7 followers View post →

All mentions

Agingdoc
@agingdoc1 · X

Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging https://t.co/NpvFnciEMt

May 20, 2022 · 2 likes · 41,311 followers View post →
vsouders
@vsouders · X

Interesting paper that provides some evidence that NAD precursors may eventually improve human performance in the elderly (and not so elderly). The research was performed using a mouse model, so usual caveats apply. #aging #endurance https://t.co/a0uSlvITTV

Jan 23, 2022 · 187 followers View post →
doctornatism
@doctornatism · X

Blood vessel ageing (from 40yo!) decreases muscle mass

Feb 26, 2019 · 1 like · 7 followers View post →