March 2018 PMID 29615976

Higher Prevalence of "Low T3 Syndrome" in Patients With Chronic Fatigue Syndrome: A Case-Control Study.

Begoña Ruiz-Núñez, Rabab Tarasse, Emar F Vogelaar, D A Janneke Dijck-Brouwer, Frits A J Muskiet

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Mentions

86
Peak: 3 in Feb 2021
across 6 sources since Mar 2018

Extended reach

66,478
potential audience

Total likes

226

Video views

10,065

Mentions per month

Mar 2018 – Aug 2025

Where it's discussed

  • X / Twitter25 posts
  • Facebook23 posts
  • News22 articles
  • Blogs8 articles
  • Reddit6 posts
  • YouTube2 videos

AI synopsis

What people are saying

The discussions demonstrate strong support and deep interest in the research, with examples like references to thyroid dysfunction, allostasis, and metabolic implications, as well as mentions of potential treatments like T3 and niacin. The tone and wording reflect a scientific curiosity and recognition of the study's importance in shifting the perception of CFS towards a more physiological understanding.

AgreementStrong agreement

Most discussions support the study, emphasizing its significance and aligning with the idea that hormonal and metabolic factors are important in CFS.

InterestHigh interest

Participants are highly engaged, discussing specific thyroid function details, such as low T3 syndrome, and referencing related mechanisms, indicating strong interest.

EngagementModerate engagement

Many discussions reference research methods and physiological mechanisms, showing a moderate level of deep engagement with the scientific content.

ImpactHigh impact

The discussions underscore that the study could influence understanding of CFS as a biological disease, with mentions of potential therapeutic approaches, indicating high perceived impact.

Abstract in brief

  • The study found that patients with Chronic Fatigue Syndrome (CFS) had significantly lower levels of free T3 (FT3) and higher reverse T3 (rT3), indicating a higher prevalence of low T3 syndrome compared to healthy controls, suggesting possible thyroid function disturbances in CFS.
  • The research suggests that these thyroid alterations in CFS may be linked to chronic low-grade metabolic inflammation, as evidenced by positive correlations between thyroid hormones and inflammatory markers like hsCRP, highlighting a potential role of inflammation in the disease's metabolic dysfunction.
  • The findings resemble a mild form of nonthyroidal illness syndrome and low T3 syndrome seen in hypothyroid patients, pointing toward a hypometabolic state in CFS, and indicate the need for further research, potentially exploring therapies like T3 or iodide supplements.

Top posts

Most liked on X and Bluesky
Gao
@GAGAGAGAaaaas · X

慢性疲労症候群患者のTSH値は対照群と同程度だったが、FT3、TT4、TT3は低値を示した。 血中T3の低下は組織レベルでのより深刻なT3不足を示唆する可能性がある。 これは、T4(チラーヂン)単独療法患者の低T3状態と類似しており、CFS病態におけるT3の重要性を示す。 https://t.co/autRvKrhpS

Aug 22, 2025 · 10 likes · 502 followers View post →
Gao
@GAGAGAGAaaaas · X

血中のFT3がわずかに低下している、あるいはFT3が基準範囲の下限付近にあるという所見は、標的組織における真のT3欠乏の氷山の一角を反映している可能性がある。 https://t.co/autRvKrhpS

Aug 22, 2025 · 7 likes · 502 followers View post →
Johannes W. Dietrich
@drjwdietrich · X

@dr_kevinlee @KunstJonas It would fit well. Energy deficiency triggers type 1 allostatic load, leading to low T3 concentration and in severe cases a low central set point of thyroid homeostasis. Indeed, low-T3 syndrome / TACITUS was observed in ME/CFS. https://t.co/5RSEh1rw1h https://t.co/sSsywNhUij

Feb 16, 2022 · 4 likes · 1,144 followers View post →
Johannes W. Dietrich
@drjwdietrich · X

@dr_kevinlee Higher Prevalence of “Low T3 Syndrome” in Patients With Chronic Fatigue Syndrome: A Case–Control Study https://t.co/rici9uIB7u

Feb 5, 2021 · 3 likes · 3 shares · 1,144 followers View post →
Johannes W. Dietrich
@drjwdietrich · X

@dr_kevinlee The presence of a type 1 allostatic response of thyroid function suggests that ME/CFS is a real disease. https://t.co/qY9Wv7V16d

Mar 27, 2021 · 3 likes · 1,144 followers View post →
Johannes W. Dietrich
@drjwdietrich · X

@christina4hope @MECFS_Stuttgart SPINA-GD: https://t.co/sSsywNhUij

Sep 2, 2022 · 3 likes · 2 shares · 1,144 followers View post →

All mentions

Gao
@GAGAGAGAaaaas · X

慢性疲労症候群患者のTSH値は対照群と同程度だったが、FT3、TT4、TT3は低値を示した。 血中T3の低下は組織レベルでのより深刻なT3不足を示唆する可能性がある。 これは、T4(チラーヂン)単独療法患者の低T3状態と類似しており、CFS病態におけるT3の重要性を示す。 https://t.co/autRvKrhpS

Aug 22, 2025 · 10 likes · 502 followers View post →
Gao
@GAGAGAGAaaaas · X

血中のFT3がわずかに低下している、あるいはFT3が基準範囲の下限付近にあるという所見は、標的組織における真のT3欠乏の氷山の一角を反映している可能性がある。 https://t.co/autRvKrhpS

Aug 22, 2025 · 7 likes · 502 followers View post →
Naomi Harvey PhD #WearAMask
@Naomi_D_Harvey · X

@IsabelRamirezRD @lowmegatron Just found this study showing thyroid dysfunction in perhaps 1/5 ‘CFS’ patients https://t.co/i6F5973XJX

Feb 12, 2025 · 2 likes · 16,609 followers View post →
Susan Nordmark
@SusanNordmark · X

@SaraGreathouse1 @EmilyCBrossard @Sabrina_Poirier 3/ https://t.co/n8gyTExy7d

Mar 28, 2024 · 314 followers View post →
Dana Herbert
@danaherbert · X

Higher Prevalence of "Low T3 Syndrome" in Patients With Chronic Fatigue Syndrome: A Case-Control Study #MECFS #LowT3 https://t.co/EML8zRmZMZ

Apr 25, 2023 · 3,845 followers View post →
Rene Sugar
@renesugar · X

Higher Prevalence of “Low T3 Syndrome” in Patients With Chronic Fatigue Syndrome: A Case–Control Study https://t.co/JGpDbalWNq

Jan 14, 2023 · 3,974 followers View post →
Claudia Ehmsen
@ClaudiaEhmsen · X

Higher Prevalence of "Low T3 Syndrome" in Patients With Chronic Fatigue Syndrome: A Case-Control Study https://t.co/mK8TXK4jps

Oct 12, 2022 · 53 followers View post →
Claudia Ehmsen
@ClaudiaEhmsen · X

RT @drjwdietrich: @christina4hope @MECFS_Stuttgart SPINA-GD: https://t.co/sSsywNhUij

Oct 12, 2022 · 2 shares · 53 followers View post →
Christina
@christina4hope · X

RT @drjwdietrich: @christina4hope @MECFS_Stuttgart SPINA-GD: https://t.co/sSsywNhUij

Sep 3, 2022 · 2 shares · 4,128 followers View post →
Johannes W. Dietrich
@drjwdietrich · X

@christina4hope @MECFS_Stuttgart SPINA-GD: https://t.co/sSsywNhUij

Sep 2, 2022 · 3 likes · 2 shares · 1,144 followers View post →
Mary-Jane Kohler MT(ASCP)
@TruthAbout_ME2 · X

@DeansKevin @angryhacademic Higher Prevalence of “Low T3 Syndrome” in Patients With Chronic Fatigue Syndrome: A Case–Control Study (2018) https://t.co/kIKTfNlFVV

Aug 14, 2022 · 2,817 followers View post →
ME/CFS, LongCovid, Postvakzin
@MecfsLongcovid · X

https://t.co/6m6CCOESSN Schilddrüse-Endokrinologie #MECFS Höhere Prävalenz des "Low-T3-Syndroms" bei Pat. mit MECFS März 2018

Jul 29, 2022 · 1 like · 78 followers View post →
ᴇɴᴛᴇʀᴏᴠɪʀᴜꜱ ENCEPHALOMYELITIS (Epidemic M.E.) ♿
@MECFSisCFSnotME · X

@AnneSpaceCoast @quasar9uk @R_tinti @marilyngavrano1 @mecaregiver @oslersweb This was with EV encephalitis https://t.co/Kw1UwwameY

Apr 15, 2022 · 568 followers View post →
Johannes W. Dietrich
@drjwdietrich · X

@dr_kevinlee @KunstJonas It would fit well. Energy deficiency triggers type 1 allostatic load, leading to low T3 concentration and in severe cases a low central set point of thyroid homeostasis. Indeed, low-T3 syndrome / TACITUS was observed in ME/CFS. https://t.co/5RSEh1rw1h https://t.co/sSsywNhUij

Feb 16, 2022 · 4 likes · 1,144 followers View post →
Wilma Ruhe 
@WilmaRuhe6 · X

@schmirl_m @FFyviMECFS Guckt mal hier, sehr interessant, Zusammenhänge Schilddrüse/ Hypophyse/ #MECFS https://t.co/iP16KRzgFA

Jan 1, 2022 · 849 followers View post →
Johannes W. Dietrich
@drjwdietrich · X

@iri_naa Es gibt immer mehr Studien, die zeigen, dass ME/CFS nicht eine rein psychische Erkrankung ist, sondern bedeutsame somatische Komponenten hat. Aus endokrinologischer Sicht z. B. diese: https://t.co/qY9Wv7V16d

Dec 19, 2021 · 1 like · 1,144 followers View post →
Dr Kevin Lee
@dr_kevinlee · X

@FionaPWME @drjwdietrich Higher Prevalence of “Low T3 Syndrome” in Patients With Chronic Fatigue Syndrome: A Case–Control Study #mecfs https://t.co/3ibwA9UW8b https://t.co/7c8CJ9L0Uo

Aug 8, 2021 · 1 like · 5,442 followers View post →
Johannes W. Dietrich
@drjwdietrich · X

@dr_kevinlee The presence of a type 1 allostatic response of thyroid function suggests that ME/CFS is a real disease. https://t.co/qY9Wv7V16d

Mar 27, 2021 · 3 likes · 1,144 followers View post →
MathThyMod
@MathThyMod · X

RT @drjwdietrich: @dr_kevinlee Higher Prevalence of “Low T3 Syndrome” in Patients With Chronic Fatigue Syndrome: A Case–Control Study https…

Feb 6, 2021 · 3 shares · 262 followers View post →
AQUA FONTIS Study
@StudyAqua · X

RT @drjwdietrich: @dr_kevinlee Higher Prevalence of “Low T3 Syndrome” in Patients With Chronic Fatigue Syndrome: A Case–Control Study https…

Feb 6, 2021 · 3 shares · 46 followers View post →
Johannes W. Dietrich
@drjwdietrich · X

@dr_kevinlee Higher Prevalence of “Low T3 Syndrome” in Patients With Chronic Fatigue Syndrome: A Case–Control Study https://t.co/rici9uIB7u

Feb 5, 2021 · 3 likes · 3 shares · 1,144 followers View post →
Johannes W. Dietrich
@drjwdietrich · X

@mummyingandme @Dr_M_Guthridge Thyroid allostasis, being common in CFS, isn't covered. https://t.co/qY9Wv7V16d

Oct 1, 2020 · 2 likes · 1,144 followers View post →
Dr Kevin Lee
@dr_kevinlee · X

Higher Prevalence of “Low T3 Syndrome” in Patients With Chronic Fatigue Syndrome: A Case–Control Study https://t.co/vTc4nefRjL #cfs #mecfs https://t.co/AmV6LcXlpR

Mar 5, 2020 · 2 likes · 5,442 followers View post →
Rene Sugar
@renesugar · X

@LillyLyle The end of the kynurenine pathway is nicotinic acid (niacin) to make NAD+. Abram Hoffer used high doses of niacin (3 to 6 grams per day) for other conditions. Some people also convert T4 to T3 less efficiently affecting the immune system. https://t.co/JGpDbaCZPq

Jan 25, 2020 · 2 likes · 3,974 followers View post →
AQUA FONTIS Study
@StudyAqua · X

RT @drjwdietrich: What is the chicken and what the egg? #TACITUS_Syndrome with type 1 #thyroid #allostasis in form of low #T3 syndrome in c…

Sep 10, 2019 · 8 shares · 46 followers View post →