Int J Bipolar Disord April 2018 PMID 29619634

Add-on treatment with N-acetylcysteine for bipolar depression: a 24-week randomized double-blind parallel group placebo-controlled multicentre trial (NACOS-study protocol).

Pernille Kempel Ellegaard, Rasmus Wentzer Licht, Henrik Enghusen Poulsen, René Ernst Nielsen, Michael Berk, Olivia May Dean, Mohammadreza Mohebbi, Connie Thuroee Nielsen

Mentions

49
Peak: 17 in May 2022
across 4 sources since Jan 2019

Extended reach

1,065,115
potential audience

Total likes

20,410

Video views

985,452

Mentions per month

Jan 2019 – Oct 2025

Where it's discussed

  • X / Twitter28 posts
  • Reddit17 posts
  • YouTube3 videos
  • News1 articles

AI synopsis

What people are saying

Discussions around the publication are characterized by references to natural remedies, dietary adjustments, and the sharing of videos about holistic approaches, exemplified by words like 'helpful,' 'natural,' and 'recommendations.' The tone is informal and engaged, reflecting a community eager to explore non-traditional avenues for managing bipolar disorder, yet they mainly treat it as supplementary information rather than evidence-changing news.

AgreementModerate agreement

Most discussions acknowledge the potential or importance of natural remedies and dietary considerations, with some references to NAC as a treatment option, indicating a general support or curiosity about integrative approaches.

InterestHigh interest

Posts show high curiosity, especially around natural protocols and the role of diet, with many users sharing videos and advice, reflecting genuine interest in alternative treatments.

EngagementModerate engagement

Several discussions cite specific sources, such as Dr. Berg's videos and the NAC study, highlighting active engagement with the material and attempts to understand and explore treatment options.

ImpactModerate impact

The discussions suggest that the article's topic resonates with those interested in holistic or natural remedies, but mostly at an informational level rather than prompting immediate clinical or policy changes, indicating moderate perceived impact.

Abstract in brief

  • The NACOS study is a 24-week clinical trial testing whether N-acetylcysteine (NAC), given alongside standard treatment, can help reduce depressive symptoms in adults with bipolar disorder experiencing a depressive episode, by measuring changes in depression severity and biological markers of oxidative stress.
  • Participants are randomly assigned to receive either 3 grams of NAC daily or a placebo, with the main focus being the change in depression scores on the MADRS scale from the start to the end of the study.
  • The study also aims to explore NAC's impact on inflammation and oxidative stress by analyzing blood, urine, and DNA samples, and will assess a variety of psychological and functioning scales to understand its broader effects on mood and well-being.

Top posts

Most liked on X and Bluesky
Dr. Eric Berg - Türkçe Kanalı
@DrbergTR · X

Bipolar Bozukluk ve OKB için En İyi Doğal Protokol | Dr.Berg Türkçe https://t.co/QCnxhv3Hpl https://t.co/OFwCOqcGTK

Jan 12, 2024 · 7 likes · 2 shares · 6,154 followers View post →
Salud y Cerebro
@NMCerebral · X

Add-on treatment with N-acetylcysteine for bipolar depression: a 24-week randomized double-blind parallel group placebo-controlled multicentre trial #NACOS-study protocol https://t.co/LRkpCuSVZl Vía International Journal of Bipolar Disorders @SpringerOpen #NAC #BipolarDepression https://t.co/AdKMwUl1xb

Feb 15, 2019 · 4 likes · 4 shares · 1,346 followers View post →
Marilee l Team Vigano l Christ is King
@MSill3 · X

Mood disorders? Some good recommendations towards a shift away from the harmful Standard American Diet of recent years. https://t.co/nOZt1hx4l3

Jun 20, 2022 · 1 like · 3,271 followers View post →
Arsalan
@arsalansa1eem · X

@nidafjaffery @XaaraKazmi https://t.co/0PSlBSwMIU No offence. You might have searched it all over the Internet. I just want to help. Check this out.

Jun 30, 2022 · 1 like · 2,459 followers View post →
EpicRoxy
@EpicRoxy · X

https://t.co/xq03CvIukH Bipolar & OCD, natural remedies

Jun 21, 2022 · 1 like · 1,868 followers View post →
BPM
@BPM93903833 · X

@Boobaloosh Have you looked into supplements and certain foods to help? He may have other vlogs too. Healthy food is vital. https://t.co/BnXcyk0OKz https://t.co/HUEHu62LUr

Oct 3, 2025 · 1 like · 1,489 followers View post →

All mentions

BPM
@BPM93903833 · X

@Boobaloosh Have you looked into supplements and certain foods to help? He may have other vlogs too. Healthy food is vital. https://t.co/BnXcyk0OKz https://t.co/HUEHu62LUr

Oct 3, 2025 · 1 like · 1,489 followers View post →
!$$$$
@unnamed01011000 · X

https://t.co/SSHO3KDhEJ

Mar 8, 2025 · 4 followers View post →
Stewwyj13
@stewwyj13 · X

https://t.co/kO4OMAN6wF

Nov 4, 2024 · 46 followers View post →
Norman
@nkrystad · X

@Et_smartere_liv Så ikke noe mer ultraprosessert (høyinflammatorisk) gradisfylla fremover?

Feb 10, 2024 · 1 like · 366 followers View post →
Nuri Koçak
@enurikocak · X

RT @DrbergTR: Bipolar Bozukluk ve OKB için En İyi Doğal Protokol | Dr.Berg Türkçe https://t.co/QCnxhv3Hpl https://t.co/OFwCOqcGTK

Jan 12, 2024 · 2 shares · 402 followers View post →
Kaspellion | TibbiЯ
@kaspellion · X

https://t.co/Dko0UmwjUC

Jan 12, 2024 · 231 followers View post →
Ali Gülsoy
@a1958gul · X

Bipolar Bozukluk ve OKB için En İyi Doğal Protokol | Dr.Berg Türkçe https://t.co/VwyQIPnn92 via @YouTube

Jan 12, 2024 · 1 like · 304 followers View post →
Dr. Eric Berg - Türkçe Kanalı
@DrbergTR · X

Bipolar Bozukluk ve OKB için En İyi Doğal Protokol | Dr.Berg Türkçe https://t.co/QCnxhv3Hpl https://t.co/OFwCOqcGTK

Jan 12, 2024 · 7 likes · 2 shares · 6,154 followers View post →
Christine Cockett
@Hcacockett · X

@elonmusk Diet can help with the bipolar. Eric Berg MD has lots of clever short videos, experience led information. https://t.co/2ES986dxmA

Jul 19, 2023 · 427 followers View post →
Drew Blue Drop Box Fitness+
@DbdBFPlus · X

Sources: https://t.co/HjoaaTFwbK https://t.co/CHZUbF8RaR https://t.co/WeaaRDWLKU

May 5, 2023 · 8 followers View post →
University
@University2004 · X

@Ahmdalmaimoni @N_Alrubayia https://t.co/PUnjYzCuLa

Feb 5, 2023 · 1 like · 29 followers View post →
ThomasAgain
@thomasagain13 · X

Great video from Dr Berg for anyone who struggles with OCD/bipolar disorder: https://t.co/YkBwnziEDc

Jan 7, 2023 · 103 followers View post →
Dr. Eric Berg - Türkçe Kanalı
@DrbergTR · X

Bipolar Bozukluk Ve Obsesif Kompulsif Bozukluk İçin En İyi Doğal Tedavi ... https://t.co/aYseKtQkqd via @YouTube https://t.co/j5Zsem6J2V

Jul 25, 2022 · 6,154 followers View post →
Arsalan
@arsalansa1eem · X

@nidafjaffery @XaaraKazmi https://t.co/0PSlBSwMIU No offence. You might have searched it all over the Internet. I just want to help. Check this out.

Jun 30, 2022 · 1 like · 2,459 followers View post →
jun ma
@genieflower57 · X

The Best Natural Protocol for Bipolar Disorder and OCD https://t.co/oJ7ncwdHF9 来自 @YouTube

Jun 23, 2022 · 1 like · 14 followers View post →
Naciye
@___Naciye___ · X

The Best Natural Protocol for Bipolar Disorder and OCD https://t.co/CCySnjhBwV via @YouTube

Jun 21, 2022 · 2,568 followers View post →
EpicRoxy
@EpicRoxy · X

https://t.co/xq03CvIukH Bipolar & OCD, natural remedies

Jun 21, 2022 · 1 like · 1,868 followers View post →
BoxKingKevin
@BoxKingKevin · X

I'm diagnosed with both of these but this video is really helpful that I wanted to share it. I wish we could watch videos like these once a day in school when I was younger. This is dope! The Best Natural Protocol for Bipolar Disorder and OCD https://t.co/TXHjtwvhOx

Jun 20, 2022 · 286 followers View post →
Chris Milbank
@ChrisMilbank · X

For ocd bipolar and schizophrenia https://t.co/OYDNLZPWlT

Jun 20, 2022 · 45,895 followers View post →
Marilee l Team Vigano l Christ is King
@MSill3 · X

Mood disorders? Some good recommendations towards a shift away from the harmful Standard American Diet of recent years. https://t.co/nOZt1hx4l3

Jun 20, 2022 · 1 like · 3,271 followers View post →
Robyn Ellison
@RobynEl57843819 · X

The Best Natural Protocol for Bipolar Disorder and OCD https://t.co/Nex5HqEHoF via @YouTube

Jun 20, 2022 · 274 followers View post →
Dr Cheryl Meier
@DrCherylM · X

Wow! This just posted 8 minutes ago… (not to replace medical advice) …but this doctor is giving natural remedies for Obsessive Compulsive Disorder, Bipolar and Schizophrenia … #ideas #knowledgeispower #drberg #natural #heal https://t.co/Stati24wlG

Jun 20, 2022 · 3,741 followers View post →
Patrick Duke
@Patrick01007790 · X

Started NAC today. Akathisia is real. #akathisiaisreal https://t.co/Yz6fGfJjiK

Jul 23, 2021 · 15 followers View post →
MarisaM
@MmaPacios · X

RT @NMCerebral: Add-on treatment with N-acetylcysteine for bipolar depression: a 24-week randomized double-blind parallel group placebo-con…

Feb 21, 2019 · 4 shares · 420 followers View post →
Salud y Cerebro
@NMCerebral · X

RT @NMCerebral: Add-on treatment with N-acetylcysteine for bipolar depression: a 24-week randomized double-blind parallel group placebo-con…

Feb 15, 2019 · 4 shares · 1,346 followers View post →
@pilar
@pilardlsh · X

RT @NMCerebral: Add-on treatment with N-acetylcysteine for bipolar depression: a 24-week randomized double-blind parallel group placebo-con…

Feb 15, 2019 · 4 shares · 45 followers View post →
Salud y Cerebro
@NMCerebral · X

Add-on treatment with N-acetylcysteine for bipolar depression: a 24-week randomized double-blind parallel group placebo-controlled multicentre trial #NACOS-study protocol https://t.co/LRkpCuSVZl Vía International Journal of Bipolar Disorders @SpringerOpen #NAC #BipolarDepression https://t.co/AdKMwUl1xb

Feb 15, 2019 · 4 likes · 4 shares · 1,346 followers View post →
EDMKaptain
@EDMKaptain · X

https://t.co/B8ixWA4NeN

Jan 30, 2019 · 179 followers View post →
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... 10.1186/s40345-018-0117-9 ), aber wie ich hier poste, kombiniere ich ihn mit ein paar Dingen; methyliertes Vitamin B und ich habe gerade mit ...

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... 10.1186/s40345-018-0117-9 ), mas ao postar aqui, estou a combiná-lo com umas coisinhas; vitamina B metilada e acabei de começar com Lítio ...

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Jeg fant følgende artikkel som ga klinisk mening for meg (https://journalbipolardisorders.springeropen.com/articles/10.1186/s40345-018-0117-9 ) ...

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Encontrei este artigo que fez sentido clínico para mim (https://journalbipolardisorders.springeropen.com/articles/10.1186/s40345-018-0117-9 ) ...

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