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Front Psychiatry March 2018 PMID 29636708

Antidepressant-Like Effects of Acupuncture-Insights From DNA Methylation and Histone Modifications of Brain-Derived Neurotrophic Factor.

Huili Jiang, Xuhui Zhang, Jun Lu, Hong Meng, Yang Sun, Xinjing Yang, Bingcong Zhao, Tuya Bao

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Abstract in brief

  • The study investigates how acupuncture can influence depression by examining changes in DNA methylation and histone modifications of BDNF, a key protein involved in brain health, in a rat model of depression.
  • Results showed that depression reduced BDNF levels and altered its gene regulation markers, but acupuncture helped restore these levels by normalizing DNA methylation and histone modifications, suggesting its potential as an antidepressant treatment.
  • These findings imply that measuring DNA methylation and histone changes in BDNF could serve as new biomarkers for detecting depression and assessing the effectiveness of treatments like acupuncture.]
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Mikko Nuuttila
@NuuttilaMikko · X

https://t.co/K6ZnP3YMJn

Feb 10, 2022 · 103 followers View post →