Trends Mol Med May 2018 PMID 29661566

Lichen Planopilaris and Frontal Fibrosing Alopecia as Model Epithelial Stem Cell Diseases.

Matthew J Harries, Francisco Jimenez, Ander Izeta, Jonathan Hardman, Sreejith Parameswara Panicker, Enrique Poblet, Ralf Paus

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Mentions

Peak: 1 in Apr 2020

across 3 sources since Apr 2020

Extended reach

11,397

potential audience

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5,807

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Apr 2020 – Mar 2022

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AI synopsis

What people are saying

The discussions highlight the significance of understanding epithelial stem cell diseases by referencing the role of immune pathways such as interferon and PPAR signaling, with mentions of therapeutic implications. The use of phrases like 'model diseases' and hashtags related to alopecia suggest a focused interest, while the tone is analytical yet enthusiastic about future research directions.

AgreementModerate agreement

Most discussions align with the importance of the research, showing support for the models proposed in the publication.

InterestModerate interest

Participants demonstrate moderate curiosity, engaging with specific concepts like immune pathways and potential therapies.

EngagementModerate engagement

The comments reflect some depth, referencing disease mechanisms and implications for treatment strategies.

ImpactModerate impact

The overall tone suggests recognition of the study’s relevance, though without high urgency or widespread advocacy.

Abstract in brief

Lichen Planopilaris (LPP) and Frontal Fibrosing Alopecia (FFA) are closely related diseases that serve as useful models for studying the damage to epithelial stem cells (eSCs) in hair follicles, which leads to scarring and permanent hair loss.
The progression of these diseases involves immune system factors, particularly interferon (IFN) signaling causing loss of immune privilege and PPAR signaling leading to epithelial-mesenchymal transition (EMT), both contributing to disease development.
The authors suggest that targeting these key pathways—IFN and PPAR—could offer new therapeutic strategies for treating LPP, FFA, and other related epithelial stem cell diseases.]

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All mentions

Understanding Frontal Fibrosing Alopecia: Causes and Management Insights

This virtual conference discusses frontal fibrosing alopecia, a scarring hair loss with unknown causes and a rising incidence. The content guides healthcare professionals on therapeutic management and highlights the…

SIDERM · Apr 18, 2020 5,807 views

Trends in Molecular Medicine

@TrendsMolecMed · X

Lichen Planopilaris and Frontal Fibrosing #Alopecia as Model Epithelial Stem Cell Diseases #alopeciaisnojoke https://t.co/nKISnADCUX

Mar 28, 2022 · 1 like · 5,591 followers View post →