PubHawk
IUBMB Life July 2018 PMID 29667297

The glutathione cycle: Glutathione metabolism beyond the γ-glutamyl cycle.

Anand Kumar Bachhawat, Shambhu Yadav

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Mentions

10
Peak: 2 in May 2020
across 3 sources since May 2020

Extended reach

28,976
potential audience

Total likes

564

Video views

22,278

Mentions per month

May 2020 – May 2025

Where it's discussed

  • Facebook6 posts
  • X / Twitter2 posts
  • YouTube2 videos

AI synopsis

What people are saying

The discussions highlight ongoing interest in the revisited roles of the glutathione cycle, with mentions of recent reviews of GGT and concerns about how chronic activation affects metabolite levels, such as 5-oxoproline. The tone is cautious and inquisitive, focusing on clarifying and questioning the implications for glutathione metabolism based on new research.

AgreementNeither agree nor disagree

The discussions show a cautious recognition that the article updates or revises prior understanding but do not fully agree or oppose its claims.

InterestModerate interest

The tweets indicate curiosity, particularly about the role of the cycle and the effect of chronic exposure, suggesting moderate interest.

EngagementModerate engagement

Participants are engaging with specific scientific details, such as the role of GGT and pyroglutamic acid, reflecting some depth.

ImpactNeutral impact

The conversations are primarily focused on scientific questions and implications without indicating broad or immediate impact.

Abstract in brief

  • The understanding of glutathione's functions and metabolism has significantly advanced over the past decade, moving beyond the traditional glutamyl cycle proposed in 1970.
  • New research has shown that many aspects of the glutamyl cycle, especially concerning glutathione transport and degradation, are inaccurate, yet these errors have persisted in scientific literature.
  • This review critically examines the shortcomings of the classic glutamyl cycle and proposes a revised, comprehensive model of glutathione metabolism reflecting current scientific knowledge.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Hannah Abrams
@HannahRAbrams · X

OK, but what about this subacute/chronic exposure? For not entirely certain reasons, chronic activation of the cycle that generates glutathione causes an increase in 5‐oxoproline (pyroglutamic acid). 3/7 https://t.co/7RGnUnBBGi https://t.co/6AD1rueLlc

Oct 14, 2020 · 2 likes · 6,205 followers View post →
Chris Weston
@Chris_West0n · X

@ebtapper @ProfJohnDillon Don't forget that the Alton Meister cycle has been revisited and the role for GGT modified in recent years: https://t.co/qL83rAF8ju

Mar 31, 2021 · 1 like · 434 followers View post →

All mentions

Chris Weston
@Chris_West0n · X

@ebtapper @ProfJohnDillon Don't forget that the Alton Meister cycle has been revisited and the role for GGT modified in recent years: https://t.co/qL83rAF8ju

Mar 31, 2021 · 1 like · 434 followers View post →
Hannah Abrams
@HannahRAbrams · X

OK, but what about this subacute/chronic exposure? For not entirely certain reasons, chronic activation of the cycle that generates glutathione causes an increase in 5‐oxoproline (pyroglutamic acid). 3/7 https://t.co/7RGnUnBBGi https://t.co/6AD1rueLlc

Oct 14, 2020 · 2 likes · 6,205 followers View post →
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