April 2018 PMID 29677301

Association Between Baseline LDL-C Level and Total and Cardiovascular Mortality After LDL-C Lowering: A Systematic Review and Meta-analysis.

Eliano P Navarese, Jennifer G Robinson, Mariusz Kowalewski, Michalina Kolodziejczak, Felicita Andreotti, Kevin Bliden, Udaya Tantry, Jacek Kubica, Paolo Raggi, Paul A Gurbel

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Mentions

Peak: 10 in May 2024

across 6 sources since Apr 2018

Extended reach

169,576

potential audience

Total likes

7,384

Video views

48,860

Mentions per month

Apr 2018 – Sep 2025

Where it's discussed

X / Twitter25 posts
News22 articles
Facebook18 posts
Blogs4 articles
YouTube2 videos
Reddit2 posts

AI synopsis

What people are saying

The overall tone indicates a high level of interest and engagement, with posts discussing the significance of LDL-C levels in relation to mortality, citing specific studies, and debating interpretations. Words like 'conclusively shown,' 'significantly benefit,' and references to meta-analyses emphasize both impact and engagement, demonstrating that these discussions are centered on evaluating and understanding the research's implications.

AgreementModerate agreement

Most discussions reference the study and accept its findings that LDL-C lowering correlates with reduced mortality in certain groups, showing general agreement.

InterestHigh interest

Posts show high interest by discussing specific research details, referencing meta-analyses, and debating implications, indicating active engagement.

EngagementHigh engagement

Many discussions include technical details, citations of studies, and critical commentary, reflecting deep engagement with the research and its nuances.

ImpactModerate impact

The debates and references suggest these discussions could influence medical opinions and clinical practices, especially given their reliance on scientific evidence.

Abstract in brief

A systematic review and meta-analysis examined how baseline LDL cholesterol (LDL-C) levels influence the effectiveness of LDL-lowering drugs, like statins, ezetimibe, and PCSK9 inhibitors, on reducing total and cardiovascular mortality.
Results showed that more intensive LDL-C lowering therapy was associated with lower overall and cardiovascular mortality, especially in patients with baseline LDL-C levels of 100 mg/dL or higher.
The study indicates that patients with higher initial LDL-C levels may benefit more significantly from aggressive LDL-lowering treatments to reduce the risk of death.

Read the full abstract

All mentions

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Impact of Baseline LDL-C Levels on Mortality Risk and Treatment Outcomes

A systematic review and meta-analysis examined how baseline LDL cholesterol levels influence the effectiveness of LDL-lowering drugs on reducing total and cardiovascular mortality. Patients with higher initial LDL-C…

CardioLearning · Apr 23, 2018 1,475 views

Christoffer Baustad Nilsen

@ChristofferBN · X

@realDaveFeldman @hubermanlab @PeterAttiaMD MR studies & clinical trials shows trend towards ↓ risk for ACM https://t.co/e1lWGTVzvo https://t.co/r4vygPQYye https://t.co/rZfq2oagB6 https://t.co/c5HpTxMYgm https://t.co/V2TeMqOwlx https://t.co/aV1mARbyv9 https://t.co/dFL8ZSAgw6 https://t.co/eHDHHDUJgw https://t.co/DrtIuHs99s https://t.co/FxSDWnFKbg

Sep 2, 2025 · 2 likes · 585 followers View post →

The Dose Whisperer

@DoseWhisperer · X

@ValerieAnne1970 Here are just 2 references for example: 1. Navarese EP, Robinson JG, Kowalewski M, Kolodziejczak M, Andreotti F, Bliden K, Tantry U, Kubica J, Raggi P, Gurbel PA. Association Between Baseline LDL-C Level and Total and Cardiovascular Mortality After LDL-C Lowering: A Systematic

Feb 10, 2025 · 2,544 followers View post →

Travis Smith, D.O. FAAEM

@RosenelliEM · X

@nntaleb @bryan_johnson Your LDL theory is elementary & a reason you should not give medical advice. In those w/⬆️ LDL, For every 39mg/dl reduction, there is a 10% ⬇️ in all cause mortality. Those w/ really low to start are likely older, frail & don’t have high LDL to start https://t.co/2NbqQgIN12

Jan 18, 2025 · 5,104 followers View post →

Adrian Rangel

@acrogenesis · X

@MasalaFry69 @levelsio @BradStanfieldMD Research has conclusively shown that actively lowering a person's LDL-cholesterol and ApoB levels can decrease their risk of heart attacks. https://t.co/Wb1e0CvdwS

Sep 15, 2024 · 351 followers View post →