BJU Int December 2018 PMID 29694707

Efficacy and safety of a hexanic extract of Serenoa repens (Permixon ) for the treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia (LUTS/BPH): systematic review and meta-analysis of randomised controlled trials and observational studies.

Remigio Vela-Navarrete, Antonio Alcaraz, Alfredo Rodríguez-Antolín, Bernardino Miñana López, Jesús M Fernández-Gómez, Javier C Angulo, David Castro Díaz, Javier Romero-Otero, Francisco J Brenes, Joaquín Carballido, José Mª Molero García, Antonio Fernández-Pro Ledesma, José Manuel Cózar Olmos, José Manasanch Dalmau, Isaac Subirana Cachinero

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Mentions

14
Peak: 4 in Jul 2019
across 3 sources since Feb 2019

Extended reach

426,353
potential audience

Total likes

1,821

Video views

73,338

Mentions per month

Feb 2019 – Sep 2025

Where it's discussed

  • X / Twitter10 posts
  • YouTube2 videos
  • Facebook2 posts

AI synopsis

What people are saying

The group exhibits cautious curiosity with discussions about the herbal origin, safety, and comparative effectiveness, as seen in comments referencing 'mild/moderate benefit' and queries about guidelines removing Serenoa repens; tone varies from neutral to inquisitive, reflecting moderate engagement and interest.

AgreementNeither agree nor disagree

The posts display mixed reactions, with some showing skepticism or noting the limited benefits, while others acknowledge the safety and potential usefulness of the extract.

InterestModerate interest

Most discussions seem mildly interested, focusing on the topic without deep technical details, but there is curiosity about why some guidelines have moved away from Serenoa repens.

EngagementModerate engagement

Several comments reference related research, herbal history, and questions about quality and medicine guidelines, indicating moderate engagement.

ImpactNeutral impact

The overall discussions suggest limited immediate impact, with some questions about clinical relevance and skepticism about standard care changes.

Abstract in brief

  • The study evaluates the effectiveness and safety of a daily dose of 320 mg hexanic extract of Serenoa repens (HESr) for treating lower urinary tract symptoms linked to benign prostatic hyperplasia (BPH).
  • Data from 27 trials involving 5,800 participants indicated that HESr significantly reduced nighttime voids and improved urinary flow compared to placebo, though its efficacy was similar to standard medications like α-blockers.
  • The findings suggest HESr as a viable alternative treatment for LUTS/BPH, with comparable results to established medications over a six-month period.

Top posts

Most liked on X and Bluesky
TheLiverDoc™
@theliverdr · X

Everything is herbal/naturally identified➡️refined Permixon from Saw-Palmetto Berries: Native-American folk medicine Rare cases of liver injury with whole herb https://t.co/Ff9pDjYexD Extract safe Has mild/moderate benefit But not standard of care https://t.co/61AoB7sGz6 https://t.co/NDQANqJlTd

May 25, 2021 · 9 likes · 1 share · 313,541 followers View post →
@dr.antonioferrandez
@editorialayrmed · X

¿Por qué las guías parecen haber "jubilado" a Serenoa repens? Por favor, que algún/a sabio/a me lo explique -> https://t.co/8Ob0H5xqd8 @Froilansao @imoncada @drgarciacruz @JuradoAnaRosa @_CIPSA

Feb 8, 2019 · 1 like · 5,430 followers View post →
Biblioteca HUCA
@BibliotecaHUCA · X

PubMed- https://t.co/v0s28t1K5e Efficacy and safety of a hexanic extract of Serenoa repens (Permixon® ) for the treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia (LUTS/BPH. @HUCA_Asturias #publiHUCA

Jul 17, 2019 · 1 like · 1 share · 1,707 followers View post →
Raúl ZP❁
@zfarma42 · X

@Gilvernet @pacotraver @Nopanaden No ocurre así con Permixon. Por lo que yo creo que el problema está más en la calidad del extracto utilizado que en el Sabal en sí mismo. https://t.co/s8oiMvwHPw

Jun 14, 2020 · 1 like · 202 followers View post →
Michaël
@mimiryudo · X

@docdu16 @RipeurMasque Non franchement j’en sais rien, je ne me suis jamais vraiment posé la question. Là une meta-analyse qui dit que ça réduit les levers nocturnes, mais j’ai juste lu le résumé… https://t.co/s4sdA2urGL

Apr 23, 2023 · 17,445 followers View post →
SystematicReviewBot
@EvidenceRobot · X

RT @APmadridpublica: Artículo CS Madrid→ Efficacy and safety of a hexanic extract of Serenoa repens (Permixon® ) for the treatment of lower…

Jul 17, 2019 · 1 share · 6,709 followers View post →

All mentions

Enrique Levichek
@Levichek666616 · X

https://t.co/tWK0F7FnoN

Sep 2, 2025 · 287 followers View post →
Michaël
@mimiryudo · X

@docdu16 @RipeurMasque Non franchement j’en sais rien, je ne me suis jamais vraiment posé la question. Là une meta-analyse qui dit que ça réduit les levers nocturnes, mais j’ai juste lu le résumé… https://t.co/s4sdA2urGL

Apr 23, 2023 · 17,445 followers View post →
TheLiverDoc™
@theliverdr · X

Everything is herbal/naturally identified➡️refined Permixon from Saw-Palmetto Berries: Native-American folk medicine Rare cases of liver injury with whole herb https://t.co/Ff9pDjYexD Extract safe Has mild/moderate benefit But not standard of care https://t.co/61AoB7sGz6 https://t.co/NDQANqJlTd

May 25, 2021 · 9 likes · 1 share · 313,541 followers View post →
Raúl ZP❁
@zfarma42 · X

@Gilvernet @pacotraver @Nopanaden No ocurre así con Permixon. Por lo que yo creo que el problema está más en la calidad del extracto utilizado que en el Sabal en sí mismo. https://t.co/s8oiMvwHPw

Jun 14, 2020 · 1 like · 202 followers View post →
Pablo I. Fdez. Muñiz
@pifermu · X

RT @BibliotecaHUCA: PubMed- https://t.co/v0s28t1K5e Efficacy and safety of a hexanic extract of Serenoa repens (Permixon® ) for the treatme…

Jul 17, 2019 · 1 share · 6,332 followers View post →
SystematicReviewBot
@EvidenceRobot · X

RT @APmadridpublica: Artículo CS Madrid→ Efficacy and safety of a hexanic extract of Serenoa repens (Permixon® ) for the treatment of lower…

Jul 17, 2019 · 1 share · 6,709 followers View post →
Atención Primaria Madrid
@APmadridpublica · X

Artículo CS Madrid→ Efficacy and safety of a hexanic extract of Serenoa repens (Permixon® ) for the treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia (LUTS/BPH): systematic review and meta-analysis of randomised… https://t.co/xuBnIXK64D

Jul 17, 2019 · 1 share · 387 followers View post →
Biblioteca HUCA
@BibliotecaHUCA · X

PubMed- https://t.co/v0s28t1K5e Efficacy and safety of a hexanic extract of Serenoa repens (Permixon® ) for the treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia (LUTS/BPH. @HUCA_Asturias #publiHUCA

Jul 17, 2019 · 1 like · 1 share · 1,707 followers View post →
Dr. LoBisco
@DrLoBisco · X

How saw palmetto helps men "flow" a little more comfortably, great research here! https://t.co/TSWndYLxks https://t.co/nhvmSpbuAS https://t.co/jTGtEjYR8d

Jun 3, 2019 · 966 followers View post →
@dr.antonioferrandez
@editorialayrmed · X

¿Por qué las guías parecen haber "jubilado" a Serenoa repens? Por favor, que algún/a sabio/a me lo explique -> https://t.co/8Ob0H5xqd8 @Froilansao @imoncada @drgarciacruz @JuradoAnaRosa @_CIPSA

Feb 8, 2019 · 1 like · 5,430 followers View post →