April 2018 PMID 29726344

Effectiveness of theta burst versus high-frequency repetitive transcranial magnetic stimulation in patients with depression (THREE-D): a randomised non-inferiority trial.

Daniel M Blumberger, Fidel Vila-Rodriguez, Kevin E Thorpe, Kfir Feffer, Yoshihiro Noda, Peter Giacobbe, Yuliya Knyahnytska, Sidney H Kennedy, Raymond W Lam, Zafiris J Daskalakis, Jonathan Downar

Download social card

Mentions

60
Peak: 4 in Aug 2021
across 5 sources since Aug 2021

Extended reach

54,230
potential audience

Total likes

162

Video views

10,256

Mentions per month

Aug 2021 – Nov 2024

Where it's discussed

  • News35 articles
  • X / Twitter8 posts
  • Facebook8 posts
  • Blogs6 articles
  • YouTube3 videos

AI synopsis

What people are saying

The overall tone suggests a genuine interest in understanding TMS’s effectiveness, as seen in comments referencing specific studies like Blumberger et al. (2018) and phrases like 'breaking down the science' and 'better treatments for mental health.' The discussion's tone and use of technical language indicate deep engagement, while acknowledging the potential impact on clinical practices reflects recognition of its significance.

AgreementModerate agreement

Most discussions acknowledge the study’s comparison of theta burst versus high-frequency rTMS, showing general agreement with its relevance.

InterestModerate interest

The posts display moderate curiosity, especially in scientific explanations and implications of TMS treatments.

EngagementHigh engagement

Many discussions include detailed references to specific studies and mechanisms, indicating deep engagement.

ImpactModerate impact

The findings are viewed as potentially influential for treatment approaches, though some posts emphasize the need for further research.

Abstract in brief

  • This study compares the effectiveness, safety, and tolerability of two types of repetitive transcranial magnetic stimulation (rTMS) treatments—standard 10 Hz rTMS and the newer theta burst stimulation (iTBS)—for adults with treatment-resistant depression.
  • It was a multicenter, randomized clinical trial involving patients from Canadian hospitals, where participants received treatments over 4–6 weeks, with the main goal of seeing if iTBS was not worse than the standard treatment in reducing depression symptoms.
  • The primary measure for success was the change in depression severity scores (HRSD17), assessed to determine if iTBS could be considered a viable, quicker alternative to the traditional 10 Hz rTMS.

Top posts

Most liked on X and Bluesky
Miles Wischnewski - Psyched!
@MilesWischnews1 · X

In our latest video we break down the science behind TMS therapy for depression. Specifically the study by Blumberger et al. (2018) comparing high-frequency rTMS and intermittent theta burst stimulation (iTBS) #scicomm #brainstim #rtms #depression https://t.co/riJp131LEL

Feb 15, 2022 · 8 likes · 1,252 followers View post →
プリンパン
@emthbls · X

TMSの刺激方法としてシータバースト法という短時間(約3分)で従来法と同等の効果を得たというLancetの論文を根拠に高回転を謳っている。ただ、対象は治療抵抗性うつ病患者であり、従来と変わらない。SBCのような安易な適応拡大は害をもたらすものではないかと危惧する。 https://t.co/BqRLc5dbor

Jul 4, 2022 · 7 likes · 2 shares · 12,020 followers View post →
Miles Wischnewski - Psyched!
@MilesWischnews1 · X

We need better treatments for mental health! In a series of videos we will cover how Transcranial Magnetic Stimulation (TMS) received FDA approval for treatment of depression, OCD, and more. #TMS #depression #scicomm Here is the first video: https://t.co/AZCbQutZRn

Aug 10, 2021 · 5 likes · 2 shares · 1,252 followers View post →
medRxiv
@medrxivpreprint · X

Effectiveness of theta burst versus high frequency repetitive transcranial magnetic stimulation in reducing symptoms of post-traumatic stress disorder in Veterans with depression: a retrospective case series. https://t.co/jJWyn2syAs #medRxiv

Sep 12, 2022 · 17,464 followers View post →
Leonhard Schilbach
@leoschilbach · X

Effectiveness of theta burst versus high-frequency repetitive transcranial magnetic stimulation in patients with depression (THREE-D): a randomised non-inferiority trial https://t.co/TtMn2mAVY8

Nov 29, 2024 · 6,739 followers View post →
ScienceStop
@B0tSci · X

RT @MilesWischnews1: We need better treatments for mental health! In a series of videos we will cover how Transcranial Magnetic Stimulati…

Aug 10, 2021 · 2 shares · 4,083 followers View post →

All mentions

Leonhard Schilbach
@leoschilbach · X

Effectiveness of theta burst versus high-frequency repetitive transcranial magnetic stimulation in patients with depression (THREE-D): a randomised non-inferiority trial https://t.co/TtMn2mAVY8

Nov 29, 2024 · 6,739 followers View post →
medRxiv
@medrxivpreprint · X

Effectiveness of theta burst versus high frequency repetitive transcranial magnetic stimulation in reducing symptoms of post-traumatic stress disorder in Veterans with depression: a retrospective case series. https://t.co/jJWyn2syAs #medRxiv

Sep 12, 2022 · 17,464 followers View post →
日本じん
@yoshin0120 · X

RT @emthbls: TMSの刺激方法としてシータバースト法という短時間(約3分)で従来法と同等の効果を得たというLancetの論文を根拠に高回転を謳っている。ただ、対象は治療抵抗性うつ病患者であり、従来と変わらない。SBCのような安易な適応拡大は害をもたらすものではないか…

Jul 4, 2022 · 2 shares · 1,102 followers View post →
プリンパン
@emthbls · X

TMSの刺激方法としてシータバースト法という短時間(約3分)で従来法と同等の効果を得たというLancetの論文を根拠に高回転を謳っている。ただ、対象は治療抵抗性うつ病患者であり、従来と変わらない。SBCのような安易な適応拡大は害をもたらすものではないかと危惧する。 https://t.co/BqRLc5dbor

Jul 4, 2022 · 7 likes · 2 shares · 12,020 followers View post →
Miles Wischnewski - Psyched!
@MilesWischnews1 · X

In our latest video we break down the science behind TMS therapy for depression. Specifically the study by Blumberger et al. (2018) comparing high-frequency rTMS and intermittent theta burst stimulation (iTBS) #scicomm #brainstim #rtms #depression https://t.co/riJp131LEL

Feb 15, 2022 · 8 likes · 1,252 followers View post →
ScienceStop
@B0tSci · X

RT @MilesWischnews1: We need better treatments for mental health! In a series of videos we will cover how Transcranial Magnetic Stimulati…

Aug 10, 2021 · 2 shares · 4,083 followers View post →
Michael Hörberg, MSc - Psyched!
@michaelhoy123 · X

RT @MilesWischnews1: We need better treatments for mental health! In a series of videos we will cover how Transcranial Magnetic Stimulati…

Aug 10, 2021 · 2 shares · 43 followers View post →
Miles Wischnewski - Psyched!
@MilesWischnews1 · X

We need better treatments for mental health! In a series of videos we will cover how Transcranial Magnetic Stimulation (TMS) received FDA approval for treatment of depression, OCD, and more. #TMS #depression #scicomm Here is the first video: https://t.co/AZCbQutZRn

Aug 10, 2021 · 5 likes · 2 shares · 1,252 followers View post →