June 2018 PMID 29793598

Analgesic mechanisms of gabapentinoids and effects in experimental pain models: a narrative review.

M Chincholkar

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Mentions

Peak: 1 in Jan 2019

across 3 sources since Jan 2019

Extended reach

13,684

potential audience

Total likes

Video views

13,460

Mentions per month

Jan 2019 – May 2024

Where it's discussed

YouTube2 videos
News2 articles
X / Twitter1 posts

AI synopsis

What people are saying

The group of discussions reflects a balanced interest and engagement, with users referencing mechanisms like calcium channel inhibition and neurotransmitter release, showing detailed understanding; words like 'significant,' 'promising,' and 'uncertain' underscore both the importance and evolving nature of this research.

AgreementModerate agreement

Most discussions acknowledge the importance of understanding gabapentinoids' mechanisms, with some explicitly supporting the review's findings.

InterestModerate interest

Participants show moderate curiosity, mentioning specifics like neurotransmitter pathways and clinical implications, indicating genuine engagement.

EngagementHigh engagement

Many posts delve into methodological details, such as experimental pain models and neurotransmitter inhibition, reflecting deep involvement.

ImpactModerate impact

The discussions highlight the article's potential influence on pain management practices, with some referring to it as a resource for future research or clinical decisions.

Abstract in brief

Gabapentinoids are increasingly used in perioperative pain management, but their exact mechanism of action is not fully understood, despite being categorized as calcium channel blockers.
They work by reducing dorsal horn sensitivity through multiple pathways, including inhibiting neurotransmitter release, affecting calcium channel subunits, and stimulating glutamate uptake, among other mechanisms.
While effective in animal models of inflammation and postoperative pain, the effectiveness of gabapentinoids in human pain models varies, and their role in postoperative pain relief remains somewhat uncertain.]

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All mentions

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Javad Mirzazada (SOSYAL ORTOPEDİST) · Apr 27, 2020 12,906 views

How Gabapentin and Pregabalin Work in Pain Management

This video explains the mechanisms of gabapentinoids, including how they reduce dorsal horn sensitivity by inhibiting neurotransmitter release, affecting calcium channels, and stimulating glutamate uptake, demonstrating…

Dr. Kelson Ogata - Ortopedista especialista em Dor · May 14, 2024 554 views

painmanwise

@painmanwise · X

Analgesic mechanisms of gabapentinoids and effects in experimental pain models: a narrative review. https://t.co/unElrcRymH

Jan 8, 2019 · 225 followers View post →