Mol Neurobiol February 2019 PMID 29869197

Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and Synaptogenesis in the Prefrontal Cortex.

Amanda J Sales, Manoela V Fogaça, Ariandra G Sartim, Vitor S Pereira, Gregers Wegener, Francisco S Guimarães, Sâmia R L Joca

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Mentions

74
Peak: 8 in Feb 2020
across 5 sources since Jan 2019

Extended reach

68,065
potential audience

Total likes

82

Video views

828

Mentions per month

Jan 2019 – Sep 2024

Where it's discussed

  • X / Twitter30 posts
  • News23 articles
  • Facebook14 posts
  • Blogs5 articles
  • YouTube2 videos

AI synopsis

What people are saying

Overall, discussions show enthusiasm for the study's findings, with posters highlighting phrases like 'fast-acting and sustained effects' and emphasizing CBD’s potential as a significant breakthrough in depression treatment. The tone and choice of words such as 'promising' and 'research shows' reflect a mixture of support, curiosity, and recognition of potential impact.

AgreementModerate agreement

Most discussions express support or interest in the research, highlighting the positive effects of CBD as an antidepressant, reflecting general agreement with the significance of the findings.

InterestHigh interest

Posts frequently mention promising results and potential applications, indicating high curiosity and intrigue about the article's implications.

EngagementModerate engagement

Several discussions delve into specifics such as BDNF signaling, synaptogenesis, and comparisons to traditional treatments, demonstrating thoughtful engagement.

ImpactModerate impact

Many comments emphasize the potential shift in mental health treatments and mention research methods and implications, indicating perceived meaningful impact.

Abstract in brief

  • This study finds that a single dose of cannabidiol (CBD) can produce rapid and long-lasting antidepressant-like effects in different rodent models, likely by increasing synaptic proteins and BDNF levels in the brain.
  • The antidepressant effects of CBD are linked to promoting synaptic changes in the prefrontal cortex, including increased spine density and synaptic protein expression, which are essential for brain plasticity.
  • Blocking BDNF signaling pathways with specific inhibitors prevents CBD's antidepressant effects, suggesting that activation of the BDNF-TrkB pathway is critical for its therapeutic action.

Top posts

Most liked on X and Bluesky
Dr. Richa Love
@drrichalove · X

CBD is not only a natural alternative to antidepressants, it also delivers sustained effects with faster onset. Research from @usponline shows CBD’s effect in distinct animal models relevant for depression. Journal publication via @SpringerNature https://t.co/41f5EPK4ju #cbd

Feb 5, 2020 · 22 likes · 8 shares · 2,125 followers View post →
CannaWorld
@cannaworldsite · X

Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and Synaptogenesis in the Prefrontal Cortex. - PubMed - NCBI https://t.co/5Zgw1de5Fp

Aug 27, 2019 · 7 likes · 2 shares · 39,911 followers View post →
CBDオタク@初心者の方にも丁寧に解説【CBDに人生全振りした男】
@pot420blog · X

CBDのメリット3選(2/4)

Feb 27, 2023 · 4 likes · 644 followers View post →
Cannabis Seed Bank of ME • R&D
@SeedBankME · X

Cannabis Science: Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and Synaptogenesis in the Prefrontal Cortex https://t.co/E8Sapray37

Feb 20, 2019 · 2 likes · 1 share · 2,582 followers View post →
CBD USA Grown
@cbdusagrown1 · X

Studies show that CBD can be a useful tool in treating those dreadful #mondayblues.

Feb 11, 2019 · 2 likes · 136 followers View post →
PSR
@patousada · X

No batalles con depresión, usa CBD y dale un propósito a tu vida: https://t.co/vqHbB0Ad05

Apr 12, 2021 · 1 like · 690 followers View post →

All mentions

Jasmin Plan
@JasminPlan · X

Washington state has illegal amounts of marijuana and I cannot find the alcohol form that helps when I cannot exercise and I have inflammation. Interesting BDNF regulates inflammation. https://t.co/8S8ixtHZpg

Jun 8, 2023 · 273 followers View post →
CBD Bill
@cbd_bill · X

"Cannabidiol improves cognitive impairment and reverses cortical transcriptional changes induced by ketamine, in schizophrenia-like model in rats" (https://t.co/3LhxMKbY4u)

Mar 22, 2023 · 126 followers View post →
CBDオタク@初心者の方にも丁寧に解説【CBDに人生全振りした男】
@pot420blog · X

CBDはうつ病に役立ちますか?

Mar 20, 2023 · 1 like · 644 followers View post →
CBDオタク@初心者の方にも丁寧に解説【CBDに人生全振りした男】
@pot420blog · X

CBDのメリット3選(2/4)

Feb 27, 2023 · 4 likes · 644 followers View post →
PSR
@patousada · X

No batalles con depresión, usa CBD y dale un propósito a tu vida: https://t.co/vqHbB0Ad05

Apr 12, 2021 · 1 like · 690 followers View post →
Normalisera
@Sverige2019 · X

@Magopeepee @svtnyheter Finns kliniska studier som visar. https://t.co/eKdhkPGDX5

Apr 10, 2021 · 1,465 followers View post →
CBD Review Lab
@cbdreviewlab · X

In this scientific study, CBD demonstrates exceptional promise as an effective and fast-acting anti-depressant: https://t.co/ZLSkGMqcCI #cbd #cannabis #mentalhealth #mentalwellness #feelinggood #zen #peace #stressrelief #anxietyrelief #naturalrelief #plantmedicine https://t.co/HaBN7RY3cq

Mar 11, 2021 · 81 followers View post →
Amol Tayade
@dr_lets_talk · X

@NachikethShetty @Bohecoindia @ItsHemp Ofc. Plz go through WHO report on CBD if you haven't already (https://t.co/deDQmGIMBV) For antidepressant-like effect (https://t.co/R1YUNZVN8I) For chronic pain, vomiting after chemo and MS- related spasms (https://t.co/Gs5yrejqRS) For epilepsies https://t.co/UcGtNNLfhQ

Sep 1, 2020 · 1 like · 82 followers View post →
民族植物学者いさみまし
@isamimasi · X

Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and Synaptogenesis in the Prefrontal Cortex. https://t.co/e8q4Y52RoJ #CBD #hemp #cannabidiol #Antidepressant

Aug 4, 2020 · 1,084 followers View post →
民族植物学者いさみまし
@isamimasi · X

カンナビジオールによる抗不安作用はBDNFシグナリングによりSynaptogenesis (前頭皮質)を段階的に拡大することによる https://t.co/kw5OmPVcLA https://t.co/e8q4Y52RoJ #ヘンプ論文 #不安症

Aug 4, 2020 · 1,084 followers View post →
Jorge Herrera
@Georgeudea · X

RT @drrichalove: CBD is not only a natural alternative to antidepressants, it also delivers sustained effects with faster onset. Research…

Feb 6, 2020 · 8 shares · 929 followers View post →
TaraSterls
@TaraSterls · X

RT @drrichalove: CBD is not only a natural alternative to antidepressants, it also delivers sustained effects with faster onset. Research…

Feb 6, 2020 · 8 shares · 87 followers View post →
LD
@Dayadog · X

RT @drrichalove: CBD is not only a natural alternative to antidepressants, it also delivers sustained effects with faster onset. Research…

Feb 6, 2020 · 8 shares · 1,552 followers View post →
Don Keeney
@DonKeeney3 · X

RT @drrichalove: CBD is not only a natural alternative to antidepressants, it also delivers sustained effects with faster onset. Research…

Feb 6, 2020 · 8 shares · 1,523 followers View post →
Canna Relief (TM)
@cannarelief420 · X

RT @drrichalove: CBD is not only a natural alternative to antidepressants, it also delivers sustained effects with faster onset. Research…

Feb 5, 2020 · 8 shares · 7,456 followers View post →
Diana Martins-Welch, MD, FACP
@MartinsWelchMD · X

RT @drrichalove: CBD is not only a natural alternative to antidepressants, it also delivers sustained effects with faster onset. Research…

Feb 5, 2020 · 8 shares · 962 followers View post →
HighBar Enterprises
@HighBarLtd · X

RT @drrichalove: CBD is not only a natural alternative to antidepressants, it also delivers sustained effects with faster onset. Research…

Feb 5, 2020 · 8 shares · 34 followers View post →
Dr. Richa Love
@drrichalove · X

CBD is not only a natural alternative to antidepressants, it also delivers sustained effects with faster onset. Research from @usponline shows CBD’s effect in distinct animal models relevant for depression. Journal publication via @SpringerNature https://t.co/41f5EPK4ju #cbd

Feb 5, 2020 · 22 likes · 8 shares · 2,125 followers View post →
bill massie
@bilmas · X

Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and Synaptogenesis in the Prefrontal Cortex. - PubMed - NCBI https://t.co/9nIyhUNZC5

Aug 28, 2019 · 2 followers View post →
bill massie
@bilmas · X

Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and Synaptogenesis in the Prefrontal Cortex. - PubMed - NCBI https://t.co/9nIyhUNZC5

Aug 27, 2019 · 2 followers View post →
Tim Ibsgaard
@grumpytim · X

RT @cannaworldsite: Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and Synaptogenesis…

Aug 27, 2019 · 2 shares · 170 followers View post →
CannaWorld
@cannaworldsite · X

Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and Synaptogenesis in the Prefrontal Cortex. - PubMed - NCBI https://t.co/5Zgw1de5Fp

Aug 27, 2019 · 7 likes · 2 shares · 39,911 followers View post →
CURE Pharmaceutical
@Cure_Pharma_ · X

#CBD for depression? #Study shows that cannabidiol possesses fast-acting and sustained antidepressant properties. https://t.co/tYskMHYzoQ

Jul 23, 2019 · 1 share · 1,404 followers View post →
Weedter.com
@WeedterCom · X

RT @floricerca: Un nuovo studio condotto dall’Università di San Paolo ha scoperto che il #CBD potrebbe essere efficace come antidepressivo.…

Mar 18, 2019 · 1 share · 479 followers View post →
Floricerca
@floricerca · X

Un nuovo studio condotto dall’Università di San Paolo ha scoperto che il #CBD potrebbe essere efficace come antidepressivo. https://t.co/dwrIvEgtY8 #CannabisNews

Mar 18, 2019 · 1 share · 549 followers View post →
Jamie Lea McElroy
@JamieLeaMcElroy · X

Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and Synaptogenesis in the Prefrontal Cortex. - PubMed - NCBI https://t.co/P5f82fdfX6

Feb 27, 2019 · 20 followers View post →
Jorge Herrera
@Georgeudea · X

RT @SeedBankME: Cannabis Science: Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and…

Feb 21, 2019 · 1 share · 929 followers View post →
Cannabis Seed Bank of ME • R&D
@SeedBankME · X

Cannabis Science: Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and Synaptogenesis in the Prefrontal Cortex https://t.co/E8Sapray37

Feb 20, 2019 · 2 likes · 1 share · 2,582 followers View post →
CBD USA Grown
@cbdusagrown1 · X

Studies show that CBD can be a useful tool in treating those dreadful #mondayblues.

Feb 11, 2019 · 2 likes · 136 followers View post →
Core Roots
@CoreRootsCBD · X

WOW! A study published last June found that #CBD had an impact on rats experiencing #depression. Read more: https://t.co/5nvNrLuntA

Jan 4, 2019 · 66 followers View post →