The discussions reveal a cautious interest in the article's focus, with comments like concerns over the impact of folic acid for people with MTHFR mutations and mentions of variables like DHFR status, indicating a nuanced engagement. The tone and words suggest curiosity mixed with skepticism, emphasizing the relevance of genetic factors in supplementation debates and reflecting ongoing debates rather than conclusive shifts in understanding.
AgreementNeither agree nor disagree
There are subtle hints of skepticism and concern about folic acid, but no strong agreement or disagreement explicitly expressed.
InterestModerate interest
Participants show moderate curiosity, mainly around the implications of genetic factors like MTHFR mutations on folate supplementation.
EngagementModerate engagement
Comments reflect a thoughtful exchange, with references to related health issues and calls for addressing expert opinions.
ImpactNeutral impact
The discussions highlight ongoing debates but do not seem to alter widespread perceptions or prompt immediate action.
Abstract in brief
This case series explored whether supplementing with 5-methyl tetrahydrofolate (5MTHF) instead of synthetic folic acid could improve pregnancy outcomes in couples with fertility issues and MTHFR gene mutations, which affect folate metabolism.
The study involved 30 couples carrying MTHFR isoforms (C677T or A1298C), most of whom had previously failed high doses of folic acid therapy; they were treated with 5MTHF for four months before attempting conception or assisted reproductive techniques (ART).
The results showed promising signs with minimal adverse effects: over half of the couples conceived, mostly spontaneously, suggesting that physiological doses of 5MTHF may be a better alternative to high-dose folic acid for those with MTHFR mutations, potentially reducing issues like unmetabolized folic acid syndrome.]
@Naomi_D_Harvey I suspect DHFR status is a fairly large variable in response to various folates. Of course every branch of this has common abnormalities in ME/CFS
May 17, 2025 · 1 like · 2,142 followersView post →
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UltraViolet
@VioletUltra007 · X
@hubermanlab @ncrawfordmd Please address Dr. Crawford's comments abt folic acid. I keep hearing that it is detrimental for almost half the population with the MTHFR mutation: https://t.co/tzYOj0TdQh
Dr. Natalie Crawford discusses egg quality, its genetic basis, and how environment, diet, and lifestyle influence it. Learn effective strategies to improve egg health and fertility outcomes based on current scientific…
This video discusses how MTHFR gene mutations affect folate metabolism and fertility. It explores the potential benefits of supplementing with 5MTHF instead of synthetic folic acid for improved pregnancy outcomes, based…
@Naomi_D_Harvey I suspect DHFR status is a fairly large variable in response to various folates. Of course every branch of this has common abnormalities in ME/CFS
May 17, 2025 · 1 like · 2,142 followersView post →
U
UltraViolet
@VioletUltra007 · X
@hubermanlab @ncrawfordmd Please address Dr. Crawford's comments abt folic acid. I keep hearing that it is detrimental for almost half the population with the MTHFR mutation: https://t.co/tzYOj0TdQh
pdf Paper on how those with MTHFR polymorphisms should have 5-MTHF - https://link.springer. com/article/10.1007/s10815-018-1225-2 5-MTHF is as effective ...
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